{"id":44081,"date":"2022-05-18T18:01:21","date_gmt":"2022-05-18T16:01:21","guid":{"rendered":"https:\/\/pharma-trend.com\/en\/research-confirms-patients-with-essential-tremor-and-parkinsons-disease-have-higher-comorbidities-and-costs\/"},"modified":"2022-05-18T18:01:21","modified_gmt":"2022-05-18T16:01:21","slug":"research-confirms-patients-with-essential-tremor-and-parkinsons-disease-have-higher-comorbidities-and-costs","status":"publish","type":"post","link":"https:\/\/pharma-trend.com\/en\/research-confirms-patients-with-essential-tremor-and-parkinsons-disease-have-higher-comorbidities-and-costs\/","title":{"rendered":"Research Confirms Patients with Essential Tremor and Parkinson\u2019s Disease Have Higher Comorbidities and Costs"},"content":{"rendered":"
\n

\nReal-world claims data connects patients with essential tremor and Parkinson\u2019s disease with a higher prevalence of comorbidities, including psychiatric disorders, a greater number of falls, and rates of substance abuse<\/i>\n<\/p>\n

SAN MATEO, Calif.–(BUSINESS WIRE)–Cala Health<\/a>, the bioelectronic medicine leader setting a new standard of patient care for chronic disease, today announced new clinical research presented at ISPOR 2022<\/a>.\n<\/p>\n

<\/a><\/p>\n

\nThe study<\/a>, titled \u201cCo-Morbidities and Mechanistic Similarities of Essential Tremor and Parkinson\u2019s Disease and Resulting Diagnostic Challenges,\u201d analyzed comorbidities among patients diagnosed with essential tremor and Parkinson\u2019s disease using claims data from Truven Health Analytics MarketScan\u00ae Commercial and Medicare Supplemental databases (2013-2019).\n<\/p>\n

\nThe results show that patients 65 years or older in the essential tremor (ET) and Parkinson\u2019s disease cohorts had a higher prevalence of the following disorders compared to those without ET or Parkinson\u2019s disease: accidental falls (14.1% vs. 24.5% vs. 2.0%); bradykinesia (14.9% vs. 10.0% vs. 0.3%); depression (22.4% vs. 25.1% vs. 14.4%); fatigue (28.1% vs. 35.7% vs. 17.4%); and sleep disorders (30.3% vs. 30.5% vs. 14.3%). These findings are consistent with Cala\u2019s earlier research<\/a>, presented at The American Academy of Neurology Annual Meeting in April 2022,1<\/sup> which shows that patients with ET (compared to those without ET) have a higher prevalence of depression (25.6% vs. 15.3%), anxiety (27.7% vs. 15.5%) and total psychiatric disorders (45.9% vs. 31.1%).\n<\/p>\n

\nAdditionally, of those patients who had pharmacy and medical records \u226512-months prior to and \u226524-months following the index date, only 10.7% of ET patients did not have a diagnosis claim at any point for Parkinson\u2019s disease in their history, and 20.4% of Parkinson\u2019s disease patients did not have a diagnosis claim at any point for ET in their history. These shared characteristics may explain why many patients often have a diagnosis of both ET and Parkinson\u2019s disease within two years of their index date and suggest that the similarities between these patients may contribute to misdiagnosis.\n<\/p>\n

\n\u201cThese findings suggest that ET and Parkinson\u2019s disease action tremor may have similar central origins,\u201d said Dhira Khosla, DO, co-author of the abstract and medical director at Cala Health. \u201cThis builds upon our earlier research presented at ISPOR last year,2<\/sup> which found that the average patient with ET has 5.3 comorbidities, further demonstrating the need for better therapeutic offerings for this population.\u201d\n<\/p>\n

\nOn average, people living with ET have multiple comorbidities, traditionally requiring several medications that care teams need to consider when making clinical decisions. Prior to Cala TAPS therapy, 94% of patients in the study tried medication and 77% tried more than one.3<\/sup> Available pharmacological treatments are often inadequate as they frequently do not effectively reduce tremor severity and can cause adverse events leading to discontinuation. Based on clinical evidence and peer-recommended treatment guidelines, Cala TAPS therapy is a valid treatment option as an add-on or follow-up to first-line pharmacologic therapy prior to invasive surgical approaches.4<\/sup>\n<\/p>\n

\nDisclaimer: Cala TAPS therapy is not currently indicated for treating hand tremor in Parkinson\u2019s Disease patients. Cala was granted breakthrough device designation for TAPS therapy in Parkinson\u2019s disease patients, and these data will be submitted for U.S. FDA review.\n<\/p>\n

\nAbout Cala Health<\/b>\n<\/p>\n

\nCala is a bioelectronic medicine company transforming the standard of care for chronic disease. The company\u2019s wearable neuromodulation therapies merge innovations in neuroscience and technology to deliver individualized peripheral nerve stimulation, and its vertically integrated commercial model is reshaping the delivery of prescription therapies. Cala\u2019s lead product, Cala TAPS therapy, is the only non-invasive prescription therapy for essential tremor. New therapies are under development in Parkinson\u2019s disease and other indications in neurology, as well as targets in psychiatry, cardiology, and autoimmune disorders. The company is headquartered in the San Francisco Bay Area and backed by leading investors in both healthcare and technology.\n<\/p>\n

\nIndication: Cala therapy is indicated to aid in the temporary relief of hand tremors in the treated hand following stimulation in adults with essential tremor.\n<\/p>\n

\nCaution: Federal law restricts this device to sale by or on the order of a physician.\n<\/p>\n

\nPrior to use, refer to the product labeling for complete product instructions for use, contraindications, warnings, and precautions at https:\/\/calatrio.com\/Safety<\/a>.\n<\/p>\n

\n____________________\n<\/p>\n

    \n
  1. \nIncreased Healthcare Cost and Mental Health Burden Among Patients with Essential Tremor: A Retrospective Observational Study in a Large U.S. Commercially Insured and Medicare Advantage Population. Dai, D. et al.<\/a>\n<\/li>\n
  2. \nPatient Characteristics and Comorbidities in Patients with Essential Tremor: A Retrospective Observational Study in a United States Commercially Insured and Medicare Advantage Population. Dai, D. et al. Value in Health, Volume 24, S167<\/a>\n<\/li>\n
  3. \nReal-World Evidence for Symptomatic Relief in Essential Tremor Using Transcutaneous Afferent Patterned Stimulation Therapy. Rajagopal, A. et al. Value in Health, Volume 23, S642<\/a>\n<\/li>\n
  4. \nInternational Essential Tremor Foundation. Essential Tremor in Adult Patients. Accessed at http:\/\/eguideline.guidelinecentral.com\/i\/1380755-essential-tremor-advisory-ietf\/0<\/a>?\n<\/li>\n<\/ol>\n

    \n\u00a0\n<\/p>\n

    Contacts<\/b> <\/p>\n

    \nSydney Sonneville
    \n
    815.307.6511
    \n
    calahealth@highwirepr.com<\/a>\n<\/p>\n

    \n\u00a0\n<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

    Real-world claims data connects patients with essential tremor and Parkinson\u2019s disease with a higher prevalence of comorbidities, including psychiatric disorders, a greater number of falls, and rates of substance abuse SAN MATEO, Calif.–(BUSINESS WIRE)–Cala Health, the bioelectronic medicine leader setting a new standard of patient care for chronic disease, today announced new clinical research presented … [Read more…]<\/a><\/span><\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[13],"tags":[],"class_list":{"0":"entry","1":"post","2":"publish","3":"author-business","4":"post-44081","6":"format-standard","7":"category-industry"},"yoast_head":"\nResearch Confirms Patients with Essential Tremor and Parkinson\u2019s Disease Have Higher Comorbidities and Costs - Pharma Trend<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/pharma-trend.com\/en\/research-confirms-patients-with-essential-tremor-and-parkinsons-disease-have-higher-comorbidities-and-costs\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Research Confirms Patients with Essential Tremor and Parkinson\u2019s Disease Have Higher Comorbidities and Costs - Pharma Trend\" \/>\n<meta property=\"og:description\" content=\"Real-world claims data connects patients with essential tremor and Parkinson\u2019s disease with a higher prevalence of comorbidities, including psychiatric disorders, a greater number of falls, and rates of substance abuse SAN MATEO, Calif.–(BUSINESS WIRE)–Cala Health, the bioelectronic medicine leader setting a new standard of patient care for chronic disease, today announced new clinical research presented ... 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