{"id":44407,"date":"2022-05-27T00:01:35","date_gmt":"2022-05-26T22:01:35","guid":{"rendered":"https:\/\/pharma-trend.com\/en\/aura-biosciences-announces-publication-of-preclinical-data-of-the-combination-of-vdcs-with-immune-checkpoint-inhibitors-at-the-2022-asco-annual-meeting\/"},"modified":"2022-05-27T00:01:35","modified_gmt":"2022-05-26T22:01:35","slug":"aura-biosciences-announces-publication-of-preclinical-data-of-the-combination-of-vdcs-with-immune-checkpoint-inhibitors-at-the-2022-asco-annual-meeting","status":"publish","type":"post","link":"https:\/\/pharma-trend.com\/en\/aura-biosciences-announces-publication-of-preclinical-data-of-the-combination-of-vdcs-with-immune-checkpoint-inhibitors-at-the-2022-asco-annual-meeting\/","title":{"rendered":"Aura Biosciences Announces Publication of Preclinical Data of the Combination of VDCs with Immune Checkpoint Inhibitors at the 2022 ASCO Annual Meeting"},"content":{"rendered":"
\n

CAMBRIDGE, Mass.–(BUSINESS WIRE)–Aura Biosciences Inc. (NASDAQ: AURA), a clinical-stage biotechnology company developing a novel class of virus-like drug conjugate (VDC) therapies for multiple oncology indications, today announced the publication of preclinical data on AU-011, its first VDC product candidate, in combination with immune checkpoint inhibitors. AU-011 is being developed for the treatment of life-threatening cancers with high unmet need, including primary choroidal melanoma and non-muscle invasive bladder cancer (NMIBC). The abstract has been published online as part of the 2022 American Society of Clinical Oncology (ASCO) Annual Meeting, being held June 3-7, 2022, in Chicago, IL.\n<\/p>\n

\n\u201cThese data show that AU-011, a first in class VDC, in combination with immune checkpoint inhibition is effective against both primary tumors and distant metastases in a preclinical model, demonstrating its clinical potential for the treatment of choroidal melanoma and certain other cancers. This includes the potential to treat both the primary tumor in early-stage disease and to treat metastatic lesions, whether clinically present or not at initial treatment.\u201d \u201cWe are so appreciative of our collaboration with the scientists and clinicians at Leiden University Medical Center in The Netherlands, one of the top European clinical and research centers in ocular oncology,\u201d said Dr. Cadmus Rich, Chief Medical officer and Head of R&D of Aura Biosciences.\n<\/p>\n

\n\u201cIt is promising to see the results of these experiments, as we have shown that in murine models, the previously observed positive effects of AU-011 as a single agent could be enhanced with the addition of immune checkpoint inhibitors,\u201d said Dr. Martine Jager, Professor of Ophthalmology at Leiden University. \u201cIn addition, we show that not only the primary tumor, but also distant lesions, are targeted. Our survival data in murine models show that the combination of VDCs with immune checkpoint inhibitors is a potential new treatment modality that may generate a potent targeted cytotoxicity on local tumors as well as potential metastases.”\n<\/p>\n

\nAbstract details:<\/b>\n<\/p>\n

\nTitle:<\/b> A novel Virus-Like-Drug Conjugate (VDC) in combination with immune checkpoint inhibitors for the treatment of primary tumors and distant metastasis
\n
Authors: <\/b>Ruben Victor Huis in ‘t Veld1<\/sup>, Sen Ma1<\/sup>, Rhonda Kines2<\/sup>, Anneli Savinainen2<\/sup>, Cadmus Collins Rich2<\/sup>, Ferry Ossendorp3<\/sup>, Martine Jager1<\/sup>; 1<\/sup>Leiden University Medical Center, Leiden, Netherlands; 2<\/sup>Aura Biosciences, Cambridge, MA; 3<\/sup>Department of Immunology, Leiden University Medical Center, Leiden, Netherlands
\n
Session Category: <\/b>Publication – 2022 ASCO Annual Meeting Proceedings
\n
<\/i>Session Title: <\/b>Developmental Therapeutics \u2013 Immunotherapy
\n
Abstract Number: <\/b>e14544
\n
The published abstract is available here<\/a>.\n<\/p>\n

\nAbout Aura Biosciences<\/b>\n<\/p>\n

\nAura Biosciences, Inc. is a clinical-stage biotechnology company developing virus-like drug conjugates (VDCs), a novel class of therapies, for the treatment of multiple oncology indications. Aura\u2019s lead VDC candidate, AU-011 (belzupacap sarotalocan), consists of a virus-like particle conjugated with an anti-cancer agent. AU-011 selectively targets and destroys cancer cells and activates the immune system with the potential to create long-lasting anti-tumor immunity. AU-011 is currently in development for ocular cancers, with an ongoing Phase 2 dose escalation clinical trial evaluating first-line treatment of choroidal melanoma, a vision- and life-threatening form of eye cancer where standard of care with radiotherapy leaves patients with severe comorbidities, including major vision loss. Aura plans to develop AU-011 across its ocular oncology franchise including for the treatment of patients with choroidal metastases. In addition, leveraging Aura\u2019s technology platform, Aura is developing AU-011 more broadly across multiple cancers, starting with a planned Phase 1 clinical trial in patients with non-muscle invasive bladder cancer. Aura is headquartered in Cambridge, MA.\n<\/p>\n

\nFor more information, visit aurabiosciences.com, or follow us on Twitter and LinkedIn.\n<\/p>\n

\nForward Looking Statement<\/b>\n<\/p>\n

\nThis press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995, as amended, and other federal securities laws. Any statements that are not statements of historical fact may be deemed to be forward looking statements. Words such as \u201cmay,\u201d \u201cwill,\u201d \u201ccould\u201d, \u201cshould,\u201d \u201cexpects,\u201d \u201cintends,\u201d \u201cplans,\u201d \u201canticipates,\u201d \u201cbelieves,\u201d \u201cestimates,\u201d \u201cpredicts,\u201d \u201cprojects,\u201d \u201cseeks,\u201d \u201cendeavor,\u201d \u201cpotential,\u201d \u201ccontinue\u201d or the negative of such words or other similar expressions that can be used to identify forward-looking statements. These forward looking statements include express or implied statements regarding Aura\u2019s future expectations, plans and prospects, including, without limitation, statements regarding the therapeutic potential of AU-011 for the treatment of cancers including choroidal melanoma and NMIBC and expectations with respect to the clinical development of AU-011.\n<\/p>\n

\nThe forward-looking statements in this press release are neither promises nor guarantees, and investors should not place undue reliance on these forward-looking statements because they involve known and unknown risks, uncertainties, and other factors, many of which are beyond Aura\u2019s control and which could cause actual results to differ materially from those expressed or implied by these forward-looking statements, including, without limitation, uncertainties inherent in clinical trials and in the availability and timing of data from ongoing clinical trials; the expected timing for submissions for regulatory approval or review by governmental authorities; the risk that the results of Aura\u2019s clinical trials may not be predictive of future results in connection with future clinical trials; whether Aura will receive regulatory approvals to conduct trials or to market products; whether Aura\u2019s cash resources will be sufficient to fund its foreseeable and unforeseeable operating expenses and capital expenditure requirements; risks, assumptions and uncertainties regarding the impact of the continuing COVID-19 pandemic on Aura\u2019s business, operations, strategy, goals and anticipated timelines; Aura\u2019s ongoing and planned pre-clinical activities; and Aura\u2019s ability to initiate, enroll, conduct or complete ongoing and planned clinical trials. These risks, uncertainties, and other factors include those risks and uncertainties described under the heading \u201cRisk Factors\u201d in Aura\u2019s Quarterly Report on Form 10-Q for the quarter ended March 31, 2022 filed with the U.S. Securities and Exchange Commission (SEC) and in subsequent filings made by Aura with the SEC, which are available on the SEC\u2019s website at www.sec.gov<\/a>. Except as required by law, Aura disclaims any intention or responsibility for updating or revising any forward-looking statements contained in this press release in the event of new information, future developments or otherwise. These forward-looking statements are based on Aura\u2019s current expectations and speak only as of the date hereof and no representations or warranties (express or implied) are made about the accuracy of any such forward-looking statements.\n<\/p>\n

Contacts<\/b> <\/p>\n

\nInvestor and Media Contact:<\/b>
Matthew DeYoung
\n
Argot Partners
\n
212-600-1902 | aura@argotpartners.com<\/a>\n<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

CAMBRIDGE, Mass.–(BUSINESS WIRE)–Aura Biosciences Inc. (NASDAQ: AURA), a clinical-stage biotechnology company developing a novel class of virus-like drug conjugate (VDC) therapies for multiple oncology indications, today announced the publication of preclinical data on AU-011, its first VDC product candidate, in combination with immune checkpoint inhibitors. AU-011 is being developed for the treatment of life-threatening cancers … [Read more…]<\/a><\/span><\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[13],"tags":[],"class_list":{"0":"entry","1":"post","2":"publish","3":"author-business","4":"post-44407","6":"format-standard","7":"category-industry"},"yoast_head":"\nAura Biosciences Announces Publication of Preclinical Data of the Combination of VDCs with Immune Checkpoint Inhibitors at the 2022 ASCO Annual Meeting - Pharma Trend<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/pharma-trend.com\/en\/aura-biosciences-announces-publication-of-preclinical-data-of-the-combination-of-vdcs-with-immune-checkpoint-inhibitors-at-the-2022-asco-annual-meeting\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Aura Biosciences Announces Publication of Preclinical Data of the Combination of VDCs with Immune Checkpoint Inhibitors at the 2022 ASCO Annual Meeting - Pharma Trend\" \/>\n<meta property=\"og:description\" content=\"CAMBRIDGE, Mass.–(BUSINESS WIRE)–Aura Biosciences Inc. 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