{"id":44413,"date":"2022-05-27T08:02:09","date_gmt":"2022-05-27T06:02:09","guid":{"rendered":"https:\/\/pharma-trend.com\/en\/ionctura-to-present-at-asco-ioa-244-showing-highly-promising-impact-on-overall-survival-for-patients-with-metastatic-and-refractory-uveal-melanoma\/"},"modified":"2022-05-27T08:02:09","modified_gmt":"2022-05-27T06:02:09","slug":"ionctura-to-present-at-asco-ioa-244-showing-highly-promising-impact-on-overall-survival-for-patients-with-metastatic-and-refractory-uveal-melanoma","status":"publish","type":"post","link":"https:\/\/pharma-trend.com\/en\/ionctura-to-present-at-asco-ioa-244-showing-highly-promising-impact-on-overall-survival-for-patients-with-metastatic-and-refractory-uveal-melanoma\/","title":{"rendered":"iOnctura to Present at ASCO IOA-244 Showing Highly Promising Impact on Overall Survival for Patients With Metastatic and Refractory Uveal Melanoma"},"content":{"rendered":"<div>\n<ul class=\"bwlistdisc\">\n<li>\n<b><i>13 of 16 metastatic Uveal Melanoma (UM) patients continue in trial with promising overall survival rate at 1 year<\/i><\/b>\n<\/li>\n<li>\n<b><i>Excellent safety allowed for chronic administration with no dose alterations, achieving intended pharmacological effect<\/i><\/b>\n<\/li>\n<li>\n<b><i>Tregs reduced by IOA-244 in peripheral blood and tumor tissue, supporting mechanism of action<\/i><\/b>\n<\/li>\n<\/ul>\n<p>GENEVA, Switzerland&#8211;(BUSINESS WIRE)&#8211;iOnctura SA, a clinical-stage oncology company targeting key resistance mechanisms in solid tumours, will present at the 2022 ASCO (American Society of Clinical Oncology) Annual Meeting, taking place June 3-7 in Chicago, new interim Phase I data from completed study Part A and ongoing study Part B showing stable disease and improved overall survival compared to historical controls, with IOA-244 treatment.\n<\/p>\n<p><a href=\"https:\/\/mms.businesswire.com\/media\/20220526005556\/en\/1468559\/5\/iOnctura_Logo.jpg\"><img decoding=\"async\" src=\"https:\/\/mms.businesswire.com\/media\/20220526005556\/en\/1468559\/21\/iOnctura_Logo.jpg\"><\/a><\/p>\n<p>\n\u201cWe observed, in patients who progressed on prior therapies, that IOA-244 stabilized their disease and halted the progression after we had exhausted all prior therapies,\u201d said Dr Jeff Evans, Professor of Translational Cancer Research and Clinical Lead of the Institute of Cancer Sciences, University of Glasgow (UK). \u201cWe are pleased to be offering patients such a well-tolerated therapeutic candidate with potentially meaningful clinical benefit.\u201d\n<\/p>\n<p>\n\u201cLife expectancy in metastatic UM patients refractory to immunotherapy is severely limited: These patients have a median survival of just 7.2 months. Patients receiving the Recommended Phase 2 Dose of IOA-244 in the DIONE-01 study have already demonstrated a median treatment time exceeding this and encouragingly, the majority of patients are continuing on treatment,\u201d said Catherine Pickering, PhD, CEO of iOnctura. \u201cThe data in this study also show that daily oral IOA-244 has potentially best-in-class tolerability, which has allowed us to continue treating patients without the need for dose alterations. Based on these highly encouraging data in this Orphan indication, and with the full support of our current investors, we are now focusing on raising our Series B venture financing to fuel future development of IOA-244 and the other anti-cancer resistance products in our pipeline\u201d\n<\/p>\n<p>\nDIONE-01 is a two-part, first-in-human dose-escalation study evaluating oral IOA-244 in advanced metastatic cancers and as a combination partner for conventional and immune-therapies (ClinicalTrials.gov: NCT04328844). The objective of Part A, now complete, was to determine the safety, tolerability, the biologically effective dose range and consequently the dosage of IOA-244 in solid tumor cancer patients. The subsequent and continuing Part B of the study consists of expansion cohorts of patients with different solid tumor types, including patients with metastatic UM.\n<\/p>\n<p>\nThe poster presented at ASCO by lead author, Prof. Anna Maria Di Giacomo, Department of Medical Oncology, University Hospital of Siena, Italy, shows interim Phase I data in refractory UM patients, confirming safety and tolerability observed in Part A as well as longer than expected overall survival (OS). This OS trend is also being observed in subsequent Part B. Together and across both parts 16 UM patients have been treated to date. The one-year OS rate was 66.7% for patients in Part A (n=9). It is still too early to estimate the 1-year OS rate in Part B (n=7); at 6-months the OS rate is 100%. Significant reduction of Tregs in peripheral blood and tumor tissue was observed confirming the expected mechanism of action of a precision targeted PI3K\u03b4 inhibitor.\n<\/p>\n<p>\n\u201cIOA-244 is a therapy which appeals to our patients, who come from various parts of the country. It allows patients to stay at home while receiving a well-tolerated and potentially effective treatment.\u201d added Professor Maio, Department of Medical Oncology, University Hospital of Siena, Italy. \u201dWe are eager to explore in greater detail the mechanism of action of IOA-244, its contribution in modulating T regulatory cells in cancer patients and applying new imaging approaches to document the effects of this novel immunotherapy.\u201d\n<\/p>\n<p>\n<b>Details of the presentation:<\/b>\n<\/p>\n<ul class=\"bwlistdisc\">\n<li>\nTitle: First-in-human (FIH) phase I study of the highly selective phosphoinositide 3-kinase inhibitor delta (PI3K\u03b4) inhibitor IOA-244 in patients with advanced cancer: Safety, activity, pharmacokinetic (PK), pharmacodynamic (PD) results.\n<\/li>\n<li>\nType: Poster\n<\/li>\n<li>\nSession: Developmental Therapeutics-Molecularly Targeted Agents and Tumor Biology\n<\/li>\n<li>\nTime: Sunday, June 5, 2022, 8:00 AM-11:00 AM CDT\n<\/li>\n<\/ul>\n<p>\n<b>PI3K\u03b4 and IOA-244<\/b>\n<\/p>\n<p>\nHigh expression of PI3K\u03b4 in both cancer cells and in the tumor immune landscape is a contributing factor to many solid tumor types escaping the host\u2019s immune response. This is achieved by tumors, in part, through PI3k\u03b4-mediated upregulation of T regulatory (Treg) cells, making the tumors \u201dcold\u201d, or difficult to detect by the body\u2019s immune system. IOA-244 selective inhibition of PI3k\u03b4 blocks proliferation of Treg cells, thus making \u201ccold\u201d tumors \u201chot\u201d, unveiling them to immune system detection and facilitating an anti-tumour immune response.\n<\/p>\n<p>\nExquisite selectivity for PI3K\u03b4 over other PI3 Kinase subtypes, including the closely related PI3K\u03b3, taken together with IOA-244\u2019s unique semi-allosteric mechanism, which is achieved through differentiated binding to the PI3k\u03b4 protein\u2019s kinase domain, represents a unique first-in-class mechanism in solid tumors. This mechanism may allow IOA-244 to lock the kinase in its resting state, preventing initiation of downstream cell signalling pathways normally triggered when it is activated at the cell membrane. The Company is investigating whether IOA-244\u2019s semi-allosteric non-ATP competitive mechanism may block Treg upregulation and simultaneously avoid affecting other signalling cascades that may lead to toxicities. Other PI3k\u03b4 inhibitors are thought to act on PI3k\u03b4 by blocking the ATP pocket without preventing the kinase from being activated at the cell membrane.\n<\/p>\n<p>\n<b>Uveal melanoma <\/b>(UM) is a rare malignancy arising within the uveal tract of the eye. There are approximately 7,000 newly diagnosed cases of uveal melanoma each year (around 2,000 in the United States). Over 50% of patients will progress to metastatic disease. Median overall survival for metastatic patients refractory to immunotherapy, the population included in the DIONE-01 trial, is approximately 7 months.\n<\/p>\n<p>\n<b>iOnctura SA<\/b> is clinical stage oncology company targeting core resistance and relapse mechanisms at the tumor-stroma-immune interface. iOnctura\u2019s best-in-class drug development programs combine immune-mediated and direct anti-tumor activity to deliver molecules with superior clinical efficacy and safety in oncology. Its lead program, IOA-244 is the only semi-allosteric PI3K\u03b4 specific, orally dosed, small molecule inhibitor that is being developed in solid and hematological malignancies to address tumor and stroma induced immune suppression. IOA-244 is currently in Part B of a Phase 1 study. iOnctura\u2019s second program, IOA-289, is an oral small molecule that inhibits the crosstalk between the tumor and its stroma and is in a Phase 1 clinical study. iOnctura is backed by blue chip investors including M Ventures, Inkef Capital, VI Partners, Schroders Capital, and 3B Future Health Fund. For more information, please visit <a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Fwww.ionctura.com%2F&amp;esheet=52731972&amp;newsitemid=20220526005556&amp;lan=en-US&amp;anchor=iOnctura%26%238217%3Bs+website&amp;index=1&amp;md5=58b5c0540c9de14ae93e8c73c8b2c3da\" rel=\"nofollow noopener\" shape=\"rect\">iOnctura\u2019s website<\/a>.\n<\/p>\n<p>\n<b>About the Beatson West of Scotland Cancer Centre, UK<\/b>\n<\/p>\n<p>\nThe Beatson West of Scotland Cancer Centre is the largest cancer centre in Scotland and serves a population of 2.6 million and has clinical links with all hospitals in the West of Scotland.\n<\/p>\n<p>\n<a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=http%3A%2F%2Fwww.beatson.scot.nhs.uk&amp;esheet=52731972&amp;newsitemid=20220526005556&amp;lan=en-US&amp;anchor=The+Beatson&amp;index=2&amp;md5=3c02e4c5898e6dac5540bd3ec3d741cc\" rel=\"nofollow noopener\" shape=\"rect\">The Beatson<\/a> is renowned for being the lead centre for delivering non-surgical cancer care.\n<\/p>\n<p>\nThere are approximately 150 innovative clinical trials ongoing at any one time, offering cutting-edge technologies, equipment and access to new cancer treatments.\n<\/p>\n<p>\n<b><i>Professor Jeff Evans<\/i><\/b>\n<\/p>\n<p>\nProfessor Jeff Evans is Professor of Translational Cancer Research and Clinical Lead of the Institute of Cancer Sciences, University of Glasgow. He is also Honorary Consultant in Medical Oncology at the Beatson West of Scotland Cancer Centre, and Lead of the Glasgow Experimental Cancer Medicine Centre (ECMC). His clinical research interests are in clinical development of novel anti-cancer agents including molecular targeted therapies, immunotherapy, and advanced cellular therapies. He leads a multiple number of Phase I clinical trials of innovative anti-cancer agents, including the development of novel therapies for gastro-oesophageal and hepato-biliary-pancreatic cancers and melanoma.\n<\/p>\n<p>\n<b>About University Hospital of Siena, Italy<\/b>\n<\/p>\n<p>\nThe University Hospital of Siena is a centre of reference for clinical research in the field of immune oncology. The centre is involved in some of the most important global immunotherapy trials in solid tumours, with the main purpose of making the latest therapeutic treatments available to patients.\n<\/p>\n<p>\nSince 2017, the University Hospital of Siena established a multidisciplinary entity, <a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=http%3A%2F%2Fwww.toscanalifesciences.org%2Fen%2Fbioincubator%2Fresearch-groups%2Fcenter-for-immuno-oncology-university-hospital-of-siena%2F&amp;esheet=52731972&amp;newsitemid=20220526005556&amp;lan=en-US&amp;anchor=the+Centre+for+Immuno-Oncology+%28CIO%29&amp;index=3&amp;md5=336c0f2fa8c49d0a8f611e2553dadeda\" rel=\"nofollow noopener\" shape=\"rect\">the Centre for Immuno-Oncology (CIO)<\/a>, allowing a complete and successful integration of clinical research services.\n<\/p>\n<p>\nThe CIO has four integrated units, including the clinical facilities of Medical Oncology and Immunotherapy, the Clinical Research unit for clinical trials and the Translational and Pre-Clinical research laboratories.\n<\/p>\n<p>\n<b><i>Dr. Michele Maio<\/i><\/b>\n<\/p>\n<p>\nDr. Michele Maio is full professor of Oncology at the University of Siena, Director of the Center for Immuno-Oncology, of the Division of Medical Oncology and Immunotherapy, and of the Department of Medical Oncology at the University Hospital of Siena, Italy. His clinical research interests include cancer immunobiology and epigenetics, as well as bioimmunotherapy of solid tumours. Dr. Maio is\/has been Principal Investigator and National Coordinator of more than 100 Phase I\u2010III clinical trials.\n<\/p>\n<p class=\"bwalignc\">\n&#8211; ENDS &#8211;\n<\/p>\n<p> <b>Contacts<\/b> <\/p>\n<p>\n<b>iOnctura<\/b><br \/>Catherine Pickering<br \/>\n<br \/>Chief Executive Officer<br \/>\n<br \/>T : +41 79 952 72 52<br \/>\n<br \/>E: <a target=\"_blank\" href=\"&#x6d;&#97;i&#x6c;&#x74;&#111;:&#x63;&#46;p&#x69;&#x63;&#107;e&#x72;&#105;n&#x67;&#x40;&#105;O&#x6e;&#x63;&#116;&#x75;&#x72;&#97;&#46;&#x63;&#x6f;&#109;\" rel=\"nofollow noopener\" shape=\"rect\">&#99;&#x2e;p&#x69;&#x63;&#107;&#x65;r&#105;&#x6e;&#103;&#x40;i&#79;&#x6e;c&#x74;u&#114;&#x61;&#46;&#x63;&#x6f;&#109;<\/a>\n<\/p>\n<p>\n<b>Press Relations<\/b><br \/>Chris Maggos<br \/>\n<br \/>BioConfidant S\u00e0rl<br \/>\n<br \/>T: +41 79 367 6254<br \/>\n<br \/>E: <a target=\"_blank\" href=\"&#109;&#97;&#x69;&#x6c;&#116;&#111;&#x3a;&#x6d;&#97;&#103;&#x67;&#x6f;&#115;&#64;&#x62;&#x69;&#111;&#99;&#x6f;&#x6e;&#102;&#105;&#x64;&#x61;&#110;&#116;&#x2e;&#x63;&#104;\" rel=\"nofollow noopener\" shape=\"rect\">&#109;&#x61;g&#x67;&#x6f;&#115;&#x40;b&#x69;&#x6f;&#99;&#x6f;n&#x66;&#x69;&#100;&#x61;n&#x74;&#x2e;&#99;&#x68;<\/a>\n<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>13 of 16 metastatic Uveal Melanoma (UM) patients continue in trial with promising overall survival rate at 1 year Excellent safety allowed for chronic administration with no dose alterations, achieving intended pharmacological effect Tregs reduced by IOA-244 in peripheral blood and tumor tissue, supporting mechanism of action GENEVA, Switzerland&#8211;(BUSINESS WIRE)&#8211;iOnctura SA, a clinical-stage oncology company &#8230; <span class=\"more\"><a class=\"more-link\" href=\"https:\/\/pharma-trend.com\/en\/ionctura-to-present-at-asco-ioa-244-showing-highly-promising-impact-on-overall-survival-for-patients-with-metastatic-and-refractory-uveal-melanoma\/\">[Read more&#8230;]<\/a><\/span><\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[13],"tags":[],"class_list":{"0":"entry","1":"post","2":"publish","3":"author-business","4":"post-44413","6":"format-standard","7":"category-industry"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>iOnctura to Present at ASCO IOA-244 Showing Highly Promising Impact on Overall Survival for Patients With Metastatic and Refractory Uveal Melanoma - Pharma Trend<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/pharma-trend.com\/en\/ionctura-to-present-at-asco-ioa-244-showing-highly-promising-impact-on-overall-survival-for-patients-with-metastatic-and-refractory-uveal-melanoma\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"iOnctura to Present at ASCO IOA-244 Showing Highly Promising Impact on Overall Survival for Patients With Metastatic and Refractory Uveal Melanoma - Pharma Trend\" \/>\n<meta property=\"og:description\" content=\"13 of 16 metastatic Uveal Melanoma (UM) patients continue in trial with promising overall survival rate at 1 year Excellent safety allowed for chronic administration with no dose alterations, achieving intended pharmacological effect Tregs reduced by IOA-244 in peripheral blood and tumor tissue, supporting mechanism of action GENEVA, Switzerland&#8211;(BUSINESS WIRE)&#8211;iOnctura SA, a clinical-stage oncology company ... 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