{"id":44449,"date":"2022-05-27T19:01:29","date_gmt":"2022-05-27T17:01:29","guid":{"rendered":"https:\/\/pharma-trend.com\/en\/city-of-hope-doctors-present-novel-treatments-for-bladder-blood-and-other-cancers-at-american-society-of-clinical-oncology-annual-conference\/"},"modified":"2022-05-27T19:01:29","modified_gmt":"2022-05-27T17:01:29","slug":"city-of-hope-doctors-present-novel-treatments-for-bladder-blood-and-other-cancers-at-american-society-of-clinical-oncology-annual-conference","status":"publish","type":"post","link":"https:\/\/pharma-trend.com\/en\/city-of-hope-doctors-present-novel-treatments-for-bladder-blood-and-other-cancers-at-american-society-of-clinical-oncology-annual-conference\/","title":{"rendered":"City of Hope Doctors Present Novel Treatments for Bladder, Blood and Other Cancers at American Society of Clinical Oncology Annual Conference"},"content":{"rendered":"
\n

\nDoctors with Cancer Treatment Centers of America, part of City of Hope, will also share innovative research<\/i>\n<\/p>\n

<\/a><\/p>\n

LOS ANGELES–(BUSINESS WIRE)–#asco2022<\/a>–City of Hope, one of the largest cancer research and treatment organizations in the United States, today announced it would present research on promising treatments for bladder and blood cancers, as well as studies on precision medicine and an experimental cancer vaccine, at the 2022 American Society of Clinical Oncology\u2019s (ASCO) annual conference from June 3 to 7 in Chicago.\n<\/p>\n

\nMore than 40,000 oncology professionals and others will attend the conference, or join virtually, to learn about the latest scientific research on cancer treatment, detection and prevention.\n<\/p>\n

\n\u201cFor the first time in two years, our doctors and scientists will meet in person to present the innovative cancer research that City of Hope is known for and learn from colleagues,\u201d said Steven T. Rosen<\/a>, M.D., City of Hope provost and chief scientific officer and Irell & Manella Cancer Center Director’s Distinguished Chair. \u201cCity of Hope\u2019s commitment to expand access to specialty cancer care and remove barriers for underserved patients also aligns closely with ASCO\u2019s conference theme this year to advance equitable care through innovation.\u201d\n<\/p>\n

\nCity of Hope doctors and scientists will present oral and poster presentations on a wide range of topics:\n<\/p>\n

\nCabozantinib shows enhanced response to checkpoint inhibitor in patients with solid tumors<\/b><\/a>\n<\/p>\n

\nFindings from three groups of the COSMIC-021 study show benefit of cabozantinib plus atezolizumab in certain patients with locally advanced or metastatic urothelial carcinoma.\n<\/p>\n

\nCabozantinib is a tyrosine kinase inhibitor that may enhance a patient\u2019s response to immune checkpoint inhibitors, which can help the body\u2019s immune system fight cancer. COSMIC-021 is a multicenter Phase 1b study evaluating cabozantinib plus atezolizumab (an anti\u2012PD-L1 therapy) in patients with various solid tumors (NCT03170960). The findings from cohorts 3, 4 and 5 will be presented during an oral presentation<\/a> at ASCO\u2019s Annual Meeting on Friday, June 3, at 3:57 p.m. CDT<\/a>.\n<\/p>\n

\nThe study enrolled patients with locally advanced or metastatic urothelial carcinoma, including cancer of the bladder, renal pelvis, ureter and urethra. Patients in cohorts 3 and 4 had not undergone previous therapy and were either eligible for cisplatin-based chemotherapy, cohort 4, or were not eligible for it, cohort 3. Patients in cohort 5 had been previously treated with an immune-checkpoint inhibitor, but not with a vascular endothelial growth factor receptor-tyrosine kinase inhibitor.\n<\/p>\n

\n\u201cCabozantinib plus atezolizumab demonstrated encouraging clinical activity with manageable toxicity in patients with inoperable locally advanced or metastatic urothelial carcinoma,\u201d said Sumanta Kumar Pal<\/a>, M.D., co-director of City of Hope’s Kidney Cancer Program and the study\u2019s primary investigator. \u201cThe therapy has promise both as a first-line systemic therapy in patients who haven\u2019t been treated with cisplatin-based chemotherapy and as a second-line therapy in patients who have been treated with an immune-checkpoint inhibitor.\u201d\n<\/p>\n

\nAfter enrollment in the trial, the patients were followed by computed tomography and magnetic resonance imaging scans performed every six weeks for the first year and every 12 weeks thereafter. The study sought to measure the objective response rate, which is the proportion of patients with a complete or partial response, as assessed by use of Response Evaluation Criteria in Solid Tumors (RECIST) version 1.1, a standard way to measure a tumor\u2019s response to treatment. Thirty patients were enrolled in both cohorts 3 and 4. Thirty-one patients were enrolled in cohort 5.\n<\/p>\n

\nCabozantinib plus atezolizumab demonstrated clinical benefit in all groups. The objective response rate was 20%, 30% and 10% in cohorts 3, 4 and 5, respectively. One patient in cohort 3 (3%) and two patients in cohort 4 (7%) achieved a complete response. Median overall survival was approximately 14 months in cohorts 3 and 4 and eight months in cohort 5.\n<\/p>\n

\nThe most common treatment-related side effects were diarrhea, aspartate aminotransferase increase, decreased appetite, alanine aminotransferase increased, fatigue and nausea. Grade 3 or 4 side effects, which can be more severe, were reported by 63%, 43% and 45% of cohorts 3, 4 and 5, respectively.\n<\/p>\n

\nEarly results show efficacy of acalabrutinib in patients with marginal zone lymphoma<\/b><\/a>\n<\/p>\n

\nResults from a clinical trial of acalabrutinib in patients with relapsed or refractory marginal zone lymphoma will be presented at this year\u2019s ASCO meeting in a poster session<\/a> on Saturday, June 4, at 8 a.m. CDT.\n<\/p>\n

\nMarginal zone lymphomas are a type of B cell non-Hodgkin lymphoma. Few treatment options are available for patients whose disease reappears after a period of remission, known as a relapse, or in those whose lymphoma does not respond to treatment, known as refractory.\n<\/p>\n

\nAcalabrutinib is a potent next-generation Bruton tyrosine kinase (BTK) inhibitor. These inhibitors block an enzyme in a signaling pathway involved in the growth and survival of some B cell leukemias and lymphomas. BTK inhibitors have been shown to have durable responses in patients with relapsed or refractory marginal zone lymphoma.\n<\/p>\n

\nAcalabrutinib monotherapy is being studied in a Phase 2 clinical trial at City of Hope and other comprehensive cancer centers across the country. In the trial, patients received 100 mg of acalabrutinib twice daily until their disease progressed or they experienced negative effects.\n<\/p>\n

\n\u201cOur early results indicate that acalabrutinib is efficacious and well-tolerated in patients with relapsed or refractory marginal zone lymphoma,\u201d said Elizabeth Budde<\/a>, M.D., Ph.D., City of Hope associate professor, Division of Lymphoma, Department of Hematology & Hematopoietic Cell Transplantation, and the abstract\u2019s lead author. \u201cWe now have data from 42 patients who were treated through October 2021, and all of them tolerated the therapy well.\u201d\n<\/p>\n

\nThe overall response rate in the 37 patients in whom this outcome measure could be evaluated was 54%. Of those patients, six had a complete response, 14 had partial responses and 17 patients had stable disease.\n<\/p>\n

\nMost side effects were mild. Sixteen patients experienced side effects of grade 3 or higher, most commonly anemia, shortness of breath, fatigue, and reduced numbers of white blood cells, platelets and neutrophils. Two patients discontinued treatment because of serious side effects.\n<\/p>\n

\nThe study concluded that acalabrutinib is a promising treatment in patients with relapsed or refractory marginal zone lymphoma, which is considered incurable when it recurs.\n<\/p>\n

\nRacial differences in the mutational landscape of serous endometrial cancer<\/b><\/a>\n<\/p>\n

\nRacial disparities persist in outcomes of endometrial cancer, the most common form of uterine cancer. To identify genetic differences in tumors that may contribute to worse prognosis, a team at Cancer Treatment Centers of America (CTCA), part of City of Hope, has analyzed comprehensive genomic profiling data from a large series of patients with serous endometrial cancer. The team is led by Julian Schink<\/a>, M.D., chief medical officer of CTCA.\n<\/p>\n

\nTumors have genetic changes unique to an individual patient that can be targeted for therapy as part of a precision medicine approach. The 2022 National Comprehensive Cancer Network (NCCN) Guidelines for uterine neoplasms recommend genetic evaluation of tumors as part of the initial evaluation of a patient. In this study, the team analyzed data from 86 patients, of whom 37% were white, 58% were Black and 5% were Asian.\n<\/p>\n

\nSchink and his team found genetic alterations in 94% of the patients. TP53<\/i> mutations, which are characteristic of serous cancer, were present in 93% of the patients.\n<\/p>\n

\nHowever, they noted some racial differences in the genomic alterations identified. Alterations that are predicted to activate the phosphatidylinositol 3-kinase signaling pathway, which regulates cell proliferation and survival, were significantly more common in white women than in Black women (41% vs. 16%). These alterations included mutations in the genes PIK3CA<\/i>, PIK3R1<\/i> and PTEN<\/i>.\n<\/p>\n

\nAmplification of CCNE1<\/i> was also noted more often in Black women, although this difference was not statistically significant.\n<\/p>\n

\n\u201cPIK3CA<\/i> mutations are an important factor in resistance to anti-HER2 therapy, a treatment that targets the HER2 protein. Also, increased CCNE1<\/i> amplification has been linked to the racial disparities seen in cancer outcomes,\u201d said Schink, the abstract\u2019s lead author. \u201cThus, identifying these racial differences in genomic alterations may help to explain the disparities we see with endometrial cancer and better inform therapy selection.\u201d\n<\/p>\n

\nStudy data on abstract 5600<\/a> will be presented in a poster session at the ASCO conference on Saturday, June 4, beginning at 1:15 p.m. CDT.\n<\/p>\n

\nInitial findings for Nous-209 cancer vaccine combined with pembrolizumab<\/b><\/a>\n<\/p>\n

\nA promising off-the-shelf cancer vaccine called Nous-209 is being studied at City of Hope in patients with dMMR\/MSI-H tumors (defective DNA mismatch repair\/high microsatellite instability). These tumors have abnormalities that affect a cell\u2019s ability to repair DNA, resulting in an accumulation of errors in a tumor\u2019s genetic sequences.\n<\/p>\n

\nInitial clinical outcomes in 20 patients enrolled in the Phase 1 study of Nous-209 in combination with the immune checkpoint inhibitor pembrolizumab will be presented in a poster discussion session<\/a> at the ASCO conference on Sunday, June 5, at 11:42 a.m. CDT. Pembrolizumab is an antibody that blocks a protein called programmed death receptor-1 (PD-1). Marwan Fakih<\/a>, M.D., City of Hope\u2019s Judy & Bernard Briskin Distinguished Director of Clinical Research and professor, Department of Medical Oncology & Therapeutics Research, is the abstract\u2019s lead author.\n<\/p>\n

\n\u201cThe combination of the NOUS-209 cancer vaccine and pembrolizumab continues to be found to be safe and highly immunogenic,\u201d Fakih said. \u201cOur promising findings for the early and long-term clinical efficacy of this combination may be attributable to the vaccine contribution.\u201d\n<\/p>\n

\nPatients in the trial had dMMR\/MSI-H colorectal, gastric or gastro-esophageal junction tumors that were metastatic or could not be removed with surgery. The drug combination was tested as a second-line therapy in patients whose disease had progressed despite prior treatment and as a first-line therapy in patients who refused or were ineligible for chemotherapy. None of the patients had previously been treated with pembrolizumab.\n<\/p>\n

\nInvestigators assessed tumor responses to the drug combination using the RECIST v1.1 guidelines. To date, 10 patients have shown a durable partial response to treatment, four showed durable stable disease and six showed progressive disease. Four of the six patients who showed disease progression did not receive the full vaccination schedule.\n<\/p>\n

\nNous-209 plus pembrolizumab was well tolerated and had a favorable safety profile. The most common treatment-related adverse events were nausea, diarrhea and fatigue, in 35%, 25% and 25% of the patients, respectively.\n<\/p>\n

\ndMMR\/MSI tumors carry tumor-specific frameshift peptides, which are produced as the result of the errors in the tumor\u2019s DNA sequence. The Nous-209 vaccine carries the instructions to target 209 different frameshift peptides that dMMR\/MSI tumors have in common. A tumor in any one patient will share 50 frameshift peptides on average with the Nous-209 vaccine. Thus, a patient\u2019s own anti-tumor immune response can be activated after vaccination with Nous-209.\n<\/p>\n

\nFuture analyses are planned to further test the efficacy of Nous-209 and explore endpoints, such as the quality of the patient\u2019s T cell responses to the vaccine.<\/i>\n<\/p>\n

\nCity of Hope oncology chair receives prestigious ASCO award and experts serve on ASCO panels discussing health equity, cancer and aging, CAR T cell therapy and supportive care<\/b>\n<\/p>\n

\nRavi Salgia<\/a>, M.D., Ph.D, City of Hope\u2019s Arthur & Rosalie Kaplan Chair in Medical Oncology, will receive the Excellence in Teaching Award<\/a> on Saturday, June 4 at 1:34 p.m. CDT.\n<\/p>\n

\nEdward Kim,<\/a> M.D., M.B.A., physician-in-chief, City of Hope Orange County, and vice physician-in-chief, City of Hope National Medical Center, will speak on an education session titled \u201cExpanding Clinical Trial Eligibility to Improve Their Generalizability and Advance Equity<\/a>\u201d on Sunday, June 5, at 9:45 a.m. CDT.\n<\/p>\n

\nWilliam Dale<\/a>, M.D, Ph.D., City of Hope\u2019s Arthur M. Coppola Family Chair in Supportive Care Medicine, will speak on a geriatric oncology education session<\/a> to discuss early integration of palliative medicine for locally advanced and metastatic genitourinary malignancies on Sunday, June 5, at 4:48 p.m. CDT.\n<\/p>\n

\nTanya Dorff<\/a>, M.D., City of Hope\u2019s section chief, Genitourinary Disease Program, will speak on a case-based panel titled \u201cCAR T for Prostate Cancer: Current Strategies to Improve Efficacy<\/a>\u201d on Monday, June 6, at 9:00 a.m. CDT.\n<\/p>\n

\nRichard T. Lee<\/a>, M.D., medical director of City of Hope\u2019s Integrative Medicine Program, will serve on a panel titled \u201cHighlights of the Care Delivery and Regulatory Policy Track<\/a>\u201d on Tuesday, June 7, at 9:12 a.m. CDT.\n<\/p>\n

\nAbout City of Hope<\/b>\n<\/p>\n

\nCity of Hope’s mission is to deliver the cures of tomorrow to the people who need them today. Founded in 1913, City of Hope<\/a> has grown into one of the largest cancer research and treatment organizations in the U.S. and one of the leading research centers for diabetes and other life-threatening illnesses. As an independent, National Cancer Institute-designated comprehensive cancer center, City of Hope brings a uniquely integrated model to patients, spanning cancer care, research and development, academics and training, and innovation initiatives. Research and technology developed at City of Hope has been the basis for numerous breakthrough cancer medicines<\/a>, as well as human synthetic insulin and monoclonal antibodies. A leader in bone marrow transplantation<\/a> and immunotherapy, such as CAR T cell therapy<\/a>, City of Hope\u2019s personalized treatment protocols help advance cancer care throughout the world.\n<\/p>\n

\nWith a goal of expanding access to the latest discoveries and leading-edge care to more patients, families and communities, City of Hope\u2019s growing national system includes its main Los Angeles campus, a network of clinical care locations across Southern California, a new cancer center in Orange County, California, scheduled to open in 2022, and Cancer Treatment Centers of America<\/a>. City of Hope\u2019s affiliated family of organizations includes Translational Genomics Research Institute<\/a> and AccessHopeTM<\/sup><\/a>. For more information about City of Hope, follow us on Facebook<\/a>, Twitter<\/a>, YouTube<\/a>, Instagram<\/a> and LinkedIn<\/a>.\n<\/p>\n

Contacts<\/b> <\/p>\n

\nLetisia Marquez
\n
626-476-7593
\n
lemarquez@coh.org<\/a>\n<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Doctors with Cancer Treatment Centers of America, part of City of Hope, will also share innovative research LOS ANGELES–(BUSINESS WIRE)–#asco2022–City of Hope, one of the largest cancer research and treatment organizations in the United States, today announced it would present research on promising treatments for bladder and blood cancers, as well as studies on precision … [Read more…]<\/a><\/span><\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[13],"tags":[],"class_list":{"0":"entry","1":"post","2":"publish","3":"author-business","4":"post-44449","6":"format-standard","7":"category-industry"},"yoast_head":"\nCity of Hope Doctors Present Novel Treatments for Bladder, Blood and Other Cancers at American Society of Clinical Oncology Annual Conference - Pharma Trend<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/pharma-trend.com\/en\/city-of-hope-doctors-present-novel-treatments-for-bladder-blood-and-other-cancers-at-american-society-of-clinical-oncology-annual-conference\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"City of Hope Doctors Present Novel Treatments for Bladder, Blood and Other Cancers at American Society of Clinical Oncology Annual Conference - Pharma Trend\" \/>\n<meta property=\"og:description\" content=\"Doctors with Cancer Treatment Centers of America, part of City of Hope, will also share innovative research LOS ANGELES–(BUSINESS WIRE)–#asco2022–City of Hope, one of the largest cancer research and treatment organizations in the United States, today announced it would present research on promising treatments for bladder and blood cancers, as well as studies on precision ... 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