{"id":44776,"date":"2022-06-07T03:01:16","date_gmt":"2022-06-07T01:01:16","guid":{"rendered":"https:\/\/pharma-trend.com\/en\/latest-data-of-innocares-robust-oncology-pipelines-presented-at-the-2022-asco-annual-meeting\/"},"modified":"2022-06-07T03:01:16","modified_gmt":"2022-06-07T01:01:16","slug":"latest-data-of-innocares-robust-oncology-pipelines-presented-at-the-2022-asco-annual-meeting","status":"publish","type":"post","link":"https:\/\/pharma-trend.com\/en\/latest-data-of-innocares-robust-oncology-pipelines-presented-at-the-2022-asco-annual-meeting\/","title":{"rendered":"Latest Data of InnoCare\u2019s Robust Oncology Pipelines Presented at the 2022 ASCO Annual Meeting"},"content":{"rendered":"
\n

BEIJING–(BUSINESS WIRE)–Latest data of InnoCare\u2019s robust oncology pipeline were presented at the 2022 American Society of Clinical Oncology (ASCO) Annual Meeting.\n<\/p>\n

\nPoster Presentation 1:
\n
<\/b>Phase I results of gunagratinib (ICP-192), a highly selective irreversible FGFR 1-4 inhibitor in patients with head and neck cancer (HNC) harboring FGF\/FGFR gene aberrations
\n
<\/b>Abstract Number: 6039\n<\/p>\n

\nIn the dose-escalation study, patients with advanced solid tumors (including HNC) with or without FGF\/FGFR gene alterations were treated with escalating doses (range: 2mg-26mg) of gunagratinib once daily in 21-day cycles.\n<\/p>\n

\n12 HNC patients were treated with escalating doses (range: 14mg-22mg) of gunagratinib. Among the 9 HNC patients with FGF\/FGFR gene aberrations including FGF amplification and FGFR mutation, who have completed at least one tumor assessment, the overall response rate (ORR) was 33.3%, and the disease control rate (DCR) was 66.7%. The treatment-related adverse events (TRAEs) were manageable and gunagratinib was generally safe and well tolerated.\n<\/p>\n

\nThe most common treatment-related adverse events (TRAEs) included hyperphosphatemia, diarrhea, increased ALT or AST, etc. No serious TRAE were reported in HNC patients.\n<\/p>\n

\nProfessor Ye Guo from Shanghai East Hospital of Tongji University said, \u201cThis study showed the anti-tumor activity of gunagratinib in HNC patients carrying FGF\/FGFR gene aberrations. Gunagratinib is safe and well-tolerated in patients with advanced solid tumors including HNC in this study.\n<\/p>\n

\nPoster Presentation 2:
\n
<\/b>Safety, pharmacokinetics (PK) and clinical efficacy of ICP-723, a highly selective next-generation pan-TRK inhibitor, in patients with solid tumor
\n
<\/b>Abstract Number: 3106\n<\/p>\n

\nAs of 11 Feb 2022, a total of 17 patients in phase I dose escalation were treated with ICP-723 at doses of 1 mg QD, 2mg QD, 3mg QD, 4mg QD, 6mg QD and 8 mg QD. There is no DLT observed in the 6 dose groups. Six of 17 patients were confirmed as NTRK gene fusion positive tumors by either prior gene test reports or the central lab gene test.\n<\/p>\n

\nAccording to RECIST 1.1 criteria, among the 6 patients with NTRK fusion, the overall response rate (ORR) was 66.7% (4 patients with partial response (PR)), the disease control rate (DCR) was 100%. The ORR was 100% in dose groups of 4mg and above. All patients who achieved PR responded to ICP-723 at the first tumor assessment after 4-week treatment and maintained sustained responses to the date of data cutoff. One patient with lung adenocarcinoma and brain metastasis achieved PR with the target brain lesion shrunk from 10 mm to 3 mm.\n<\/p>\n

\nDr. Xiaoli Wei from Sun Yat-sen University Cancer Center said, \u201cICP-723 is safe and well-tolerated in patients with advanced solid tumors. Encouraging clinical efficacy including intracranial activity was demonstrated in patients with NTRK gene fusion in various tumor types.\u201d\n<\/p>\n

\nOnline Publication:
\n
<\/b>Efficacy and safety of orelabrutinib in diffuse large B-cell lymphoma (DLBCL): a real-world analysis
\n
<\/b>Abstract Number: e19556\n<\/p>\n

\nFourteen patients with MCD DLBCL were included in the study. All patients received orelabrutinib 150 mg once daily. Among them, 8 were treated with R-CHOP or R-EPOCH as first-line therapy, and 6 with RICE, R-CHOP or R2 as second-line therapy. The complete response rate (CRR) for the first-line and second-line therapy were 75.00% and 66.67%, respectively.\n<\/p>\n

\nReported AEs were generally manageable and resolved soon after supportive treatment.\n<\/p>\n

\nThe leading PI concluded that orelabrutinib-containing regimens demonstrated encouraging efficacy and well-tolerated safety profile among patients with MCD DLBCL. A large-scale prospective clinical study is on registration, which would offer a new potential therapeutic option for patients with MCD DLBCL.\n<\/p>\n

\nMore information can be found at ASCO official website.\n<\/p>\n

\nAbout InnoCare<\/b>\n<\/p>\n

\nInnoCare is a commercial stage biopharmaceutical company committed to discovering, developing, and commercializing first-in-class and\/or best-in-class drugs for the treatment of cancer and autoimmune diseases. We strategically focus on lymphoma, solid tumors, and autoimmune diseases with high unmet medical needs in China and worldwide. InnoCare has branches in Beijing, Nanjing, Shanghai, Guangzhou, Hong Kong and United States.\n<\/p>\n

\nForward-looking Statements<\/b>\n<\/p>\n

\nThis report contains the disclosure of some forward-looking statements. Except for statements of facts, all other statements can be regarded as forward-looking statements, that is, about our or our management’s intentions, plans, beliefs, or expectations that will or may occur in the future. Such statements are assumptions and estimates made by our management based on its experience and knowledge of historical trends, current conditions, expected future development and other related factors. This forward-looking statement does not guarantee future performance, and actual results, development and business decisions may not match the expectations of the forward-looking statement. Our forward-looking statements are also subject to a large number of risks and uncertainties, which may affect our short-term and long-term performance.\n<\/p>\n

Contacts<\/b> <\/p>\n

\nMedia<\/b>
Chunhua Lu
\n
86-10-66609879
\n
chunhua.lu@innocarepharma.com<\/a>\n<\/p>\n

\nInvestor Relations
\n
\n<\/b>
86-10-66609999
\n
ir@innocarepharma.com<\/a>\n<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

BEIJING–(BUSINESS WIRE)–Latest data of InnoCare\u2019s robust oncology pipeline were presented at the 2022 American Society of Clinical Oncology (ASCO) Annual Meeting. Poster Presentation 1: Phase I results of gunagratinib (ICP-192), a highly selective irreversible FGFR 1-4 inhibitor in patients with head and neck cancer (HNC) harboring FGF\/FGFR gene aberrations Abstract Number: 6039 In the dose-escalation … [Read more…]<\/a><\/span><\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[13],"tags":[],"class_list":{"0":"entry","1":"post","2":"publish","3":"author-business","4":"post-44776","6":"format-standard","7":"category-industry"},"yoast_head":"\nLatest Data of InnoCare\u2019s Robust Oncology Pipelines Presented at the 2022 ASCO Annual Meeting - Pharma Trend<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/pharma-trend.com\/en\/latest-data-of-innocares-robust-oncology-pipelines-presented-at-the-2022-asco-annual-meeting\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Latest Data of InnoCare\u2019s Robust Oncology Pipelines Presented at the 2022 ASCO Annual Meeting - Pharma Trend\" \/>\n<meta property=\"og:description\" content=\"BEIJING–(BUSINESS WIRE)–Latest data of InnoCare\u2019s robust oncology pipeline were presented at the 2022 American Society of Clinical Oncology (ASCO) Annual Meeting. 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