{"id":45328,"date":"2022-06-21T21:01:40","date_gmt":"2022-06-21T19:01:40","guid":{"rendered":"https:\/\/pharma-trend.com\/en\/purdue-pharma-introduces-nalmefene-hcl-injection-2mg-2ml-1mg-1ml-in-the-u-s-for-the-treatment-of-known-or-suspected-overdose-with-natural-or-synthetic-opioids\/"},"modified":"2022-06-21T21:01:40","modified_gmt":"2022-06-21T19:01:40","slug":"purdue-pharma-introduces-nalmefene-hcl-injection-2mg-2ml-1mg-1ml-in-the-u-s-for-the-treatment-of-known-or-suspected-overdose-with-natural-or-synthetic-opioids","status":"publish","type":"post","link":"https:\/\/pharma-trend.com\/en\/purdue-pharma-introduces-nalmefene-hcl-injection-2mg-2ml-1mg-1ml-in-the-u-s-for-the-treatment-of-known-or-suspected-overdose-with-natural-or-synthetic-opioids\/","title":{"rendered":"Purdue Pharma Introduces Nalmefene HCl Injection, 2mg\/2mL (1mg\/1mL) in the U.S. for the Treatment of Known or Suspected Overdose with Natural or Synthetic Opioids"},"content":{"rendered":"
\n

\nCompany will distribute injectable nalmefene for no profit as part of its commitment to help abate the opioid crisis<\/i>\n<\/p>\n

STAMFORD, Conn.–(BUSINESS WIRE)–Purdue Pharma L.P. announced today that Nalmefene Hydrochloride injection, 2mg\/2mL (1mg\/1mL) is now available in the U.S. for use by healthcare professionals. Nalmefene is an opioid antagonist indicated for the complete or partial reversal of opioid drug effects, including respiratory depression, induced by either natural or synthetic opioids, and in the management of known or suspected opioid overdose.1<\/sup>\n<\/p>\n

\nIn February 2022, FDA approved<\/a> Purdue\u2019s abbreviated new drug application (ANDA) for nalmefene hydrochloride injection for the treatment of known or suspected opioid overdose with natural or synthetic opioids. FDA had previously granted Competitive Generic Therapy <\/a>(CGT) designation for the nalmefene hydrochloride injection vial.\n<\/p>\n

\nWith CGT designation and recent FDA approval, Purdue is eligible for 180 days of market exclusivity for nalmefene hydrochloride injection. However, the Company will not exercise this option. Additionally, Purdue will distribute nalmefene for no profit.\n<\/p>\n

\n\u201cWe believe nalmefene will be an important treatment option to help address the growing and continuing crisis of opioid overdose deaths, including those due to fentanyl and other synthetic opioids,\u201d said Craig Landau, MD, President and CEO, Purdue Pharma. \u201cWe decided to provide this medication without market exclusivity because it is in the best interest of the public that other companies also have the ability to quickly introduce similar products if approved by FDA. Additionally, we are distributing this medication for no profit, as part of our commitment to contribute meaningful medicines to help abate the opioid crisis.\u201d\n<\/p>\n

\nHealthcare professionals can learn more about injectable nalmefene at www.nalmefenehcl.com<\/a>.\n<\/p>\n

\nINDICATIONS AND USAGE<\/b>\n<\/p>\n

\nNalmefene Hydrochloride Injection is indicated for the complete or partial reversal of opioid drug effects, including respiratory depression, induced by either natural or synthetic opioids.\n<\/p>\n

\nNalmefene Hydrochloride Injection is indicated in the management of known or suspected opioid overdose.\n<\/p>\n

\nCONTRAINDICATION<\/b>\n<\/p>\n

\nNalmefene Hydrochloride injection is contraindicated in patients with a known hypersensitivity to the product.\n<\/p>\n

\nWARNINGS AND PRECAUTIONS<\/b>\n<\/p>\n

\nUse of Nalmefene Hydrochloride injection<\/b> in Emergencies
\n
<\/b>Nalmefene Hydrochloride injection, like all drugs in this class, is not the primary treatment for ventilatory failure. In most emergency settings, treatment with Nalmefene Hydrochloride injection should follow, not precede, the establishment of a patent airway, ventilatory assistance, administration of oxygen, and establishment of circulatory access.\n<\/p>\n

\nRisk of Recurrent Respiratory Depression
\n
<\/b>Accidental overdose with long acting opioids [such as methadone and levo<\/i>-alpha-acetylmethadol (LAAM)] may result in prolonged respiratory depression. Respiratory depression in both the postoperative and overdose setting may be complex and involve the effects of anesthetic agents, neuromuscular blockers, and other drugs. While Nalmefene Hydrochloride injection has a longer duration of action than naloxone in fully reversing doses, the physician should be aware that a recurrence of respiratory depression is possible, even after an apparently adequate initial response to Nalmefene Hydrochloride injection treatment.\n<\/p>\n

\nPatients treated with Nalmefene Hydrochloride injection<\/b> should be observed until, in the opinion of the physician, there is no reasonable risk of recurrent respiratory depression.<\/b>\n<\/p>\n

\nCardiovascular Risks with Narcotic Antagonists
\n
<\/b>Pulmonary edema, cardiovascular instability, hypotension, hypertension, ventricular tachycardia, and ventricular fibrillation have been reported in connection with opioid reversal in both postoperative and emergency department settings. In many cases, these effects appear to be the result of abrupt reversal of opioid effects.\n<\/p>\n

\nAlthough Nalmefene Hydrochloride injection has been used safely in patients with pre-existing cardiac disease, all drugs of this class should be used with caution in patients at high cardiovascular risk or who have received potentially cardiotoxic drugs\n<\/p>\n

\nRisk of Precipitated Withdrawal
\n
<\/b>Nalmefene Hydrochloride injection, like other opioid antagonists, is known to produce acute withdrawal symptoms and, therefore, should be used with extreme caution in patients with known physical dependence on opioids or following surgery involving high doses of opioids. Imprudent use or excessive doses of opioid antagonists in the postoperative setting has been associated with hypertension, tachycardia, and excessive mortality in patients at high risk for cardiovascular complications.\n<\/p>\n

\nIncomplete Reversal of Buprenorphine
\n
<\/b>Preclinical studies have shown that nalmefene at doses up to 10 mg\/kg (437 times the maximum recommended human dose) produced incomplete reversal of buprenorphine-induced analgesia in animal models. This appears to be a consequence of a high affinity and slow displacement of buprenorphine from the opioid receptors. Hence, Nalmefene Hydrochloride injection may not completely reverse buprenorphine-induced respiratory depression.\n<\/p>\n

\nUse in Pediatric Patients
\n
<\/b>Safety and effectiveness of nalmefene hydrochloride injection in pediatric patients have not been established.\n<\/p>\n

\nADVERSE REACTIONS<\/b>\n<\/p>\n

\nThe most common adverse reactions (>1%) reported in clinical trials with nalmefene injection were nausea (18%), vomiting (9%), tachycardia (5%), hypertension (5%), postoperative pain (4%), fever (3%), and dizziness (3%).\n<\/p>\n

\nTo report SUSPECTED ADVERSE REACTIONS, contact Purdue Pharma L.P. at 1-888-726-7535 or FDA at 1-800-FDA-1088 or www.fda.gov\/medwatch<\/a>.\n<\/p>\n

\nPlease read Prescribing Information available here<\/a>.
\n
For more information, visit www.nalmefenehcl.com<\/a>.\n<\/p>\n

\nAbout Purdue Pharma L.P.
\n
<\/strong>Purdue Pharma<\/a> and its subsidiaries develop, manufacture and market medications and consumer health products to meet the evolving needs of healthcare professionals, patients, consumers and caregivers. If consummated, Purdue\u2019s plan of reorganization will deliver billions in value to communities across the country to fund programs specifically for abatement of the opioid crisis. The bankruptcy settlement would also deliver funds to private abatement trusts for the benefit of personal injury claimants.\n<\/p>\n

\nSubstantially all of Purdue\u2019s assets would be transferred to a new post-emergence company with a public-minded mission. This new company would be governed by new independent board members, and would operate in a responsible and sustainable manner taking into account long-term public health interests relating to the opioid crisis. The company would continue serving patients and consumers who rely on its medicines and products, pursuing its pipeline, and introducing medicines that will help save and improve lives.\n<\/p>\n

\nReferences<\/b>\n<\/p>\n

    \n
  1. \nNalmefene Hydrochloride Injection 2mg\/2mL (1mg\/1mL) [Full Prescribing Information]. Stamford, CT: Purdue Pharma L.P., 02\/08\/2022. https:\/\/www.accessdata.fda.gov\/spl\/data\/d4bb0797-a4ed-4ed4-9904-604433eea4ff\/d4bb0797-a4ed-4ed4-9904-604433eea4ff.xml<\/a>. Accessed March 15, 2022.\n<\/li>\n<\/ol>\n

    \nMR-07856<\/i>\n<\/p>\n

    Contacts<\/b> <\/p>\n

    \nMedia Contact:<\/b>
    Michele Sharp
    \n
    (203) 588-7584\n<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

    Company will distribute injectable nalmefene for no profit as part of its commitment to help abate the opioid crisis STAMFORD, Conn.–(BUSINESS WIRE)–Purdue Pharma L.P. announced today that Nalmefene Hydrochloride injection, 2mg\/2mL (1mg\/1mL) is now available in the U.S. for use by healthcare professionals. Nalmefene is an opioid antagonist indicated for the complete or partial reversal … [Read more…]<\/a><\/span><\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[13],"tags":[],"class_list":{"0":"entry","1":"post","2":"publish","3":"author-business","4":"post-45328","6":"format-standard","7":"category-industry"},"yoast_head":"\nPurdue Pharma Introduces Nalmefene HCl Injection, 2mg\/2mL (1mg\/1mL) in the U.S. for the Treatment of Known or Suspected Overdose with Natural or Synthetic Opioids - Pharma Trend<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/pharma-trend.com\/en\/purdue-pharma-introduces-nalmefene-hcl-injection-2mg-2ml-1mg-1ml-in-the-u-s-for-the-treatment-of-known-or-suspected-overdose-with-natural-or-synthetic-opioids\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Purdue Pharma Introduces Nalmefene HCl Injection, 2mg\/2mL (1mg\/1mL) in the U.S. for the Treatment of Known or Suspected Overdose with Natural or Synthetic Opioids - Pharma Trend\" \/>\n<meta property=\"og:description\" content=\"Company will distribute injectable nalmefene for no profit as part of its commitment to help abate the opioid crisis STAMFORD, Conn.–(BUSINESS WIRE)–Purdue Pharma L.P. announced today that Nalmefene Hydrochloride injection, 2mg\/2mL (1mg\/1mL) is now available in the U.S. for use by healthcare professionals. 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