{"id":45559,"date":"2022-06-27T22:01:36","date_gmt":"2022-06-27T20:01:36","guid":{"rendered":"https:\/\/pharma-trend.com\/en\/bubbles-bring-miracles-to-sick-ukrainian-children\/"},"modified":"2022-06-27T22:01:36","modified_gmt":"2022-06-27T20:01:36","slug":"bubbles-bring-miracles-to-sick-ukrainian-children","status":"publish","type":"post","link":"https:\/\/pharma-trend.com\/en\/bubbles-bring-miracles-to-sick-ukrainian-children\/","title":{"rendered":"Bubbles Bring Miracles to Sick Ukrainian Children"},"content":{"rendered":"
\n

L\u2019VIV, Ukraine–(BUSINESS WIRE)–#BubbleMtg2021<\/a>–Miracles have been few and far between for Ukrainian children who are fleeing war zones while facing cancer and other life threatening diseases.\n<\/p>\n

<\/a>
<\/a><\/p>\n

\nBut tiny ultrasound microbubbles are now saving young lives and bringing hope to children like Nastya, a 15 year old girl from a small village near Kiev, who was evacuated to L\u2019viv and had the good fortune to end up in the care of Dr. Viktor Zhelov, a pediatric radiologist at the Western Ukrainian Specialized Children\u2019s Medical Centre in L\u2019viv, Ukraine.\n<\/p>\n

\n\u201cThis poor child was without parents, was in kidney failure and had a large mass on her right kidney that was suspect for cancer,\u201d Dr. Zhelov said.\n<\/p>\n

\nShould Nastya be put on a list for a kidney transplant? Should she undergo chemotherapy? Will she survive?\n<\/p>\n

\nThose questions and more depended on accurate diagnostic imaging, but conventional contrast computed tomography (CT) was not an option. For patients like Nastya, who have impaired kidneys, a contrast-CT exam is not feasible because of the potentially nephrotoxic nature of CT contrast agents. And expensive CT equipment is often unavailable or subject to long waiting lists, even during peaceful times.\n<\/p>\n

\nFortunately, ultrasound equipment was readily available at Dr. Zhelov\u2019s hospital, as it is in many medical centers around the world.\n<\/p>\n

\nDr. Zhelov, an expert in ultrasound imaging, knew that microbubble \u201ccontrast agents\u201d are safely and routinely used worldwide to enhance ultrasound scans and identify abnormal microvascular blood flow patterns in real time \u2013 with images equivalent to those obtained by contrast CT.\n<\/p>\n

\nDr. Zhelov also is a member of the International Contrast Ultrasound Society (ICUS), a global nonprofit medical society that is dedicated to advancing the safe and appropriate use of contrast-enhanced ultrasound (CEUS) in order to improve patient care and save lives. ICUS galvanizes the global ultrasound \u201cbubble community\u201d \u2013 cardiologists, radiologists, sonographers, nurses and other physicians and imaging professionals. Membership in ICUS is free, and all ICUS educational programs and newsletters are offered free of charge to ICUS members in 60 countries.\n<\/p>\n

\nDr. Zhelov joined ICUS in 2017, when he first became aware of the benefits of CEUS for his patients.\n<\/p>\n

\nBenefits of ultrasound microbubbles<\/i><\/b>\n<\/p>\n

\nCEUS is a non-invasive ultrasound-based diagnostic imaging tool that is safely and routinely used worldwide to help pinpoint and characterize cancers, diagnose heart and vascular disease, monitor chronic gastro-intestinal diseases, evaluate other serious medical conditions and monitor therapy.\n<\/p>\n

\nDuring the CEUS exam, a biocompatible ultrasound contrast agent is injected into the patient\u2019s arm vein and conventional ultrasound equipment is used to scan the organ of interest, such as Nastya\u2019s kidney.\n<\/p>\n

\nThe ultrasound contrast agent is a liquid suspension of microscopic \u201cbubbles\u201d comprised of a lipid or albumin shell with a gas core. The microbubbles are smaller than red blood cells and flow unobstructed through the body\u2019s tiniest blood vessels. During transit, the gas core reflects ultrasound waves, producing images that represent blood flow patterns. Within minutes after the microbubbles are injected, the gas core is breathed out of the patient\u2019s body and the microbubbles are eliminated. Repeat CEUS examinations are feasible as needed, without waiting times.\n<\/p>\n

\nUnlike contrast agents used for other forms of medical imaging, ultrasound contrast agents do not contain dye and create no known risk of kidney damage or deposit of contrast media in the brain. In addition, CEUS scans do not expose patients or hospital staff to ionizing radiation.\n<\/p>\n

\nBy improving the reliability of real-time ultrasound scans, these microbubble contrast agents often reduce the need for more expensive downstream tests, speed up the time to diagnosis and access to appropriate therapy, reduce the length of hospital stays, and improve patient care, outcomes and experiences.\n<\/p>\n

\n\u201cUltrasound contrast agents have a strong safety record and offer an exquisite window into the patient in real time, while also reducing health care costs,\u201d said Dr. Dirk Clevert, a member of the ICUS board and professor of radiology who serves as Section Chief of the Interdisciplinary Ultrasound-Center at the University of Munich.\n<\/p>\n

\n\u201cThere is no question that CEUS is a simple to use, powerful and indispensable diagnostic imaging tool that saves countless lives,\u201d added Dr. Fabio Piscaglia, an ICUS board member, and professor and director of the Unit of Internal Medicine at the University of Bologna.\n<\/p>\n

\nContrast-enhanced ultrasound (CEUS) \u201cis a simple to use, powerful and indispensable diagnostic imaging tool that saves countless lives.\u201d — Dr. Fabio Piscaglia<\/i><\/b>\n<\/p>\n

\nAlthough ultrasound microbubbles are predominantly used for imaging adults, \u201cthey offer a huge advantage for pediatric patients because they can completely eliminate radiation exposure associated with other forms of diagnostic imaging, avoid sedation or anesthesia, and depict pathology clearly and reliably,\u201d according to Dr. Kassa Darge, who also serves on the ICUS board and is a professor of radiology and Radiologist-in-Chief at Children\u2019s Hospital of Philadelphia (CHOP).\n<\/p>\n

\nUltrasound contrast agents \u201coffer a huge advantage for pediatric patients because they can completely eliminate radiation exposure associated with other forms of diagnostic imaging, avoid sedation or anesthesia, and depict pathology clearly and reliably.\u201d — Dr. Kassa Darge<\/i><\/b>\n<\/p>\n

\nDr. Darge said that the excellent safety profile of CEUS in children is now well established, based on scientific publications evaluating the use of microbubbles in thousands of children.\n<\/p>\n

\nFour microbubble contrast agents are available in various countries around the world: Definity (Luminity in Europe), manufactured and sold by Lantheus Medical Imaging; Sonovue (Lumason in the USA), manufactured and sold by Bracco; and Optison and Sonazoid, manufactured and sold by GE Healthcare.\n<\/p>\n

\nInflux of patients from all over Ukraine<\/i><\/b>\n<\/p>\n

\nAs rockets blasted the outskirts of his city, Dr. Zhelov logged onto the ICUS website and asked the organization to help him obtain free vials of Sonovue, which is sold in many European countries and is the only ultrasound contrast agent approved for pediatric use.\n<\/p>\n

\n\u201cDue to the war in my country, we collect pediatric oncological patients from all over Ukraine,\u201d Dr. Zhelov explained. His medical center is among the most prominent Ukrainian pediatric clinics in the fields of oncology, immunology and rare diseases.\n<\/p>\n

\nDr. Zhelov also told ICUS that CEUS may be the only practical modality for providing a reliable clinical diagnosis under the challenging circumstances facing children like Nastya.\n<\/p>\n

\n\u201cOn behalf of our patients I\u2019d like to ask you to help us,\u201d he wrote.\n<\/p>\n

\nMobilization of \u201cBubble Community\u201d<\/i><\/b>\n<\/p>\n

\nWithin hours, ICUS, through its advisors at Dentons, a global law firm, reached the highest levels of leadership of Bracco, the Milan-based company that manufactures and sells Sonovue. The response to Dentons was quickly delivered in two words by CEO Fulvio Renoldi Bracco:\n<\/p>\n

\n\u201cFull support.\u201d\n<\/p>\n

\nIn record time, Bracco\u2019s medical, legal and supply chain departments mobilized and hundreds of vials found their way from Italy via Belgium and Poland to Dr. Zhelov in L\u2019viv.\n<\/p>\n

\nThat was just the start.\n<\/p>\n

\nICUS also mobilized its own world-renowned CEUS experts to provide remote technical support for Dr. Zhelov and his colleagues.\n<\/p>\n

\nDr. Stephanie Wilson, Co-President of ICUS, immediately emailed Dr. Zhelov and offered guidance in scanning and using ultrasound contrast agents for oncology or other objectives. Dr. Wilson is a clinical professor of radiology and gastroenterology at the University of Calgary.\n<\/p>\n

\n\u201cOur hearts and best wishes are with you,\u201d Dr. Wilson wrote, adding her \u201cdeepest admiration for your courage in such difficult times.\u201d\n<\/p>\n

\nDr. Zhelov replied that he was surprised to hear from her. \u201cI have followed all your available articles, webinars and presentations,\u201d he wrote. \u201cIt\u2019s hard to overestimate my respect and gratitude to you.\u201d\n<\/p>\n

\nDr. Wilson\u2019s colleague, Christine Merrill, a sonographer at the University of Calgary and member of the ICUS board, also provided remote advice to Dr. Zhelov.\n<\/p>\n

\nMeanwhile, ICUS and Bracco identified the ultrasound equipment on site in L\u2019viv, and Dr. Christian Greis and Luca Frazzoli, of Bracco, reached out to their contacts with the ultrasound vendors. Numerous emails followed, offering additional technical guidance on optimal equipment settings and protocols for scanning children with the benefit of ultrasound contrast agents.\n<\/p>\n

\n\u201cThe ICUS bubble community exists to do the right thing for patients throughout the world, and there can be no doubt that microbubble-based ultrasound contrast agents will improve care, change outcomes and save young lives entrusted to Dr. Zhelov,\u201d according to Dr. Steven Feinstein, a cardiologist in Chicago and CEUS expert who, along with Dr. Wilson, is Co-President of ICUS.\n<\/p>\n

\n\u201cThe ICUS bubble community exists to do the right thing for patients throughout the world, and there can be no doubt that microbubble-based ultrasound contrast agents will improve care, change outcomes and save young lives entrusted to Dr. Zhelov.\u201d — Dr. Steven Feinstein<\/i><\/b>\n<\/p>\n

\nNastya receives her CEUS diagnosis<\/i><\/b>\n<\/p>\n

\nArmed with microbubbles and remote technical support, Dr. Zhelov then proceeded to examine Nastya.\n<\/p>\n

\nEarlier imaging, without the benefit of ultrasound microbubbles, showed moderate hydronephrosis (swelling) of the left kidney and multicystic dysplasia of the right kidney. In addition, these earlier scans showed an incidental solid lesion on the right kidney.\n<\/p>\n

\nNastya was brought to the hospital\u2019s ultrasound laboratory, where she received an arm vein injection of the microbubble contrast agent to reflect kidney blood flow patterns and help Dr. Zhelov determine whether the mass was malignant or benign.\n<\/p>\n

\n\u201cWe performed CEUS without complication twice for both kidneys,\u201d said Dr. Zhelov.\n<\/p>\n

\nThe result, for Nastya, was a miracle. CEUS showed that her kidney mass was merely a benign cyst \u2013 not cancer.\n<\/p>\n

\n\u201cExclusion of cancer is one of the most important indications of CEUS,\u201d according to Dr. Richard Barr, a professor of radiology at the Northeast Ohio Medical University and officer of ICUS.\n<\/p>\n

\nNow, thanks to tiny microbubbles, Nastya will not receive unnecessary chemotherapy. Instead, she is scheduled for a kidney transplant — and has the chance of leading an almost normal life.\n<\/p>\n

\n\u201cYou give our children an additional chance to survive,\u201d Dr. Zhelov said.\n<\/p>\n

\n\u201cYou give our children an additional chance to survive.\u201d — Dr. Viktor Zhelov<\/i><\/b>\n<\/p>\n

\nWith hope for more positive CEUS stories, Dr. Zhelov closed a recent email to ICUS by saying, \u201cUkrainians never give up and appreciate very much your help.\u201d\n<\/p>\n

\nABOUT ICUS:<\/b>\n<\/p>\n

\nThe International Contrast Ultrasound Society (ICUS) is an international medical society dedicated to advancing the appropriate use of contrast enhanced ultrasound (CEUS) to improve patient care globally. ICUS members represent diverse specialties such as radiology, cardiology, vascular imaging, gastro-intestinal imaging, oncology, OB-GYN, and hepatology, and include physicians, scientists, and other ultrasound imaging professionals in approximately 60 countries. For more information about ICUS, please visit www.icus-society.org<\/a>.\n<\/p>\n

Contacts<\/b> <\/p>\n

\nInternational Contrast Ultrasound Society<\/b>
Linda Maiman Feinstein, Advisor — 847-624-1844 or 312-876-2563, Linda.Feinstein@Dentons.com<\/a>
Robin J. Adams, Director of Communication — 202-408-3946, Robin.Adams@Dentons.com<\/a>\n<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

L\u2019VIV, Ukraine–(BUSINESS WIRE)–#BubbleMtg2021–Miracles have been few and far between for Ukrainian children who are fleeing war zones while facing cancer and other life threatening diseases. 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