{"id":45848,"date":"2022-07-06T12:01:43","date_gmt":"2022-07-06T10:01:43","guid":{"rendered":"https:\/\/pharma-trend.com\/en\/turnstone-biologics-and-moffitt-cancer-center-announce-strategic-alliance-to-advance-next-generation-til-therapies-for-solid-tumors\/"},"modified":"2022-07-06T12:01:43","modified_gmt":"2022-07-06T10:01:43","slug":"turnstone-biologics-and-moffitt-cancer-center-announce-strategic-alliance-to-advance-next-generation-til-therapies-for-solid-tumors","status":"publish","type":"post","link":"https:\/\/pharma-trend.com\/en\/turnstone-biologics-and-moffitt-cancer-center-announce-strategic-alliance-to-advance-next-generation-til-therapies-for-solid-tumors\/","title":{"rendered":"Turnstone Biologics and Moffitt Cancer Center Announce Strategic Alliance to Advance Next-Generation TIL Therapies for Solid Tumors"},"content":{"rendered":"
\n

\nStrategic alliance significantly expands ongoing multi-year collaboration by granting Turnstone broader access and enhanced benefits at Moffitt<\/i>\n<\/p>\n

\nIND approval received for a Moffitt-sponsored Phase 1 study of TIDAL-01 in melanoma<\/i>\n<\/p>\n

NEW YORK & TAMPA, Fla.–(BUSINESS WIRE)–#TIL<\/a>–Turnstone Biologics Corp., a clinical-stage biotechnology company developing next-generation immunotherapies to treat and cure solid tumors, and Moffitt Cancer Center (\u201cMoffitt\u201d), a world leader in advancing cellular immunotherapies for the treatment of cancer, today announced the formation of a broad strategic alliance, deepening their existing multi-year research collaboration<\/a>. As part of this expanded partnership, Turnstone will have priority access to Moffitt\u2019s scientific research, manufacturing, and clinical capabilities for the development of novel tumor infiltrating lymphocyte (\u201cTIL\u201d) therapies. The parties also announced U.S. Food and Drug Administration (\u201cFDA\u201d) clearance of an Investigational New Drug (\u201cIND\u201d) application for a Moffitt-sponsored Phase 1 clinical study of TIDAL-01, Turnstone\u2019s lead TIL therapy candidate, in cutaneous and non-cutaneous melanoma. The trial is expected to commence later this year.\n<\/p>\n

<\/a><\/p>\n

\n\u201cOur landmark strategic alliance with Turnstone underscores Moffitt\u2019s commitment to bold research initiatives and groundbreaking clinical studies for the benefit of cancer patients who have limited or no effective treatment options,\u201d said Patrick Hwu, M.D., President and CEO, Moffitt Cancer Center. \u201cCell therapy is a key area of focus at Moffitt, and we are impressed by Turnstone\u2019s novel approach to TIL therapy. Our combined team has made strong progress as part of our ongoing partnership, particularly with the IND clearance of TIDAL-01. We look forward to initiating the clinical study in melanoma and continuing to grow this valuable relationship with Turnstone.\u201d\n<\/p>\n

\nSelected TILs represent the foundational therapeutic modality driving Turnstone\u2019s cancer immunotherapy pipeline and leverage decades of work anchored in academia that have demonstrated the promise of this approach. By identifying, selecting, and expanding the most potent subsets of patient specific tumor-reactive T-cells, Turnstone aims to improve and broaden the clinical efficacy of TILs and overcome the limitations of current treatments to achieve positive outcomes in harder to treat, lower mutational burden, cancers. TIDAL-01 builds on the historical clinical success of Selected TIL treatment protocols and is the initial focus of the Turnstone-Moffitt collaboration as the parties advance the program into a Phase 1 clinical study.\n<\/p>\n

\nUnder the terms of the agreement, Moffitt will grant Turnstone prioritized clinical trial activation, enhanced patient screening and data sharing, full access to Moffitt\u2019s cellular therapies research and development infrastructure and expanded molecular data sets and biospecimens for research. Moffitt will also provide extended governance support and allocated GMP manufacturing capacity for Turnstone product candidates. Turnstone will contribute resources and expertise to the partnership and fund research and development activities at Moffitt. Additional financial terms were not disclosed.\n<\/p>\n

\n\u201cThis industry-leading partnership with Moffitt is a direct result of our unwavering efforts to develop promising new cancer medicines in the most innovative and impactful ways possible,\u201d said Sammy Farah, Ph.D., M.B.A., President and CEO, Turnstone Biologics. \u201cWe believe Moffitt\u2019s translational insights and clinical execution capabilities coupled with our next-generation Selected TIL technology will accelerate the development of our differentiated TIL therapies and increases our opportunity to create curative outcomes for patients with solid tumors.\u201d\n<\/p>\n

\nAbout Turnstone Biologics<\/b>\n<\/p>\n

\nTurnstone Biologics, a clinical stage biotechnology company, is developing new medicines to treat and cure solid tumors by pioneering differentiated approaches with two clinically validated technologies, tumor infiltrating lymphocyte (\u201cTIL\u201d) therapy and viral immunotherapy. Turnstone\u2019s innovative TIL therapy, which is designed to extend the efficacy of TILs to multiple solid tumor indications by selecting and manufacturing the most potent tumor-reactive T-cells (\u201cSelected TILs\u201d) for tumor eradication, represents the Company\u2019s foundational therapeutic modality driving its cancer immunotherapy pipeline. The Company\u2019s lead Selected TIL therapy candidate, TIDAL-01, is expected to enter clinical trials in 2022. Turnstone is developing additional strategies to further potentiate the clinical benefit of Selected TILs, including use in combination with their novel viral immunotherapy.\n<\/p>\n

\nFor more information, please visit www.turnstonebio.com<\/a>, and follow us on LinkedIn<\/a>.\n<\/p>\n

\nAbout Moffitt Cancer Center<\/b>\n<\/p>\n

\nMoffitt is dedicated to one lifesaving mission: to contribute to the prevention and cure of cancer. The Tampa-based facility is one of only 52 National Cancer Institute-designated Comprehensive Cancer Centers, a distinction that recognizes Moffitt\u2019s scientific excellence, multidisciplinary research, and robust training and education. Moffitt\u2019s expert nursing staff is recognized by the American Nurses Credentialing Center with Magnet\u00ae status, its highest distinction. With more than 7,500 team members, Moffitt has an economic impact in the state of $2.4 billion.\n<\/p>\n

\nFor more information, call 1-888-MOFFITT (1-888-663-3488), visit MOFFITT.org, and follow the momentum on Facebook, Twitter, Instagram and YouTube.\n<\/p>\n

Contacts<\/b> <\/p>\n

\nAhmed Aneizi
\n
Turnstone Biologics
\n
613-421-8930
\n
ahmed.aneizi@turnstonebio.com<\/a>\n<\/p>\n

\nKim Polacek
\n
Moffitt Cancer Center
\n
813-745-7408
\n
kim.polacek@moffitt.org<\/a>\n<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Strategic alliance significantly expands ongoing multi-year collaboration by granting Turnstone broader access and enhanced benefits at Moffitt IND approval received for a Moffitt-sponsored Phase 1 study of TIDAL-01 in melanoma NEW YORK & TAMPA, Fla.–(BUSINESS WIRE)–#TIL–Turnstone Biologics Corp., a clinical-stage biotechnology company developing next-generation immunotherapies to treat and cure solid tumors, and Moffitt Cancer Center … [Read more…]<\/a><\/span><\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[13],"tags":[],"class_list":{"0":"entry","1":"post","2":"publish","3":"author-business","4":"post-45848","6":"format-standard","7":"category-industry"},"yoast_head":"\nTurnstone Biologics and Moffitt Cancer Center Announce Strategic Alliance to Advance Next-Generation TIL Therapies for Solid Tumors - Pharma Trend<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/pharma-trend.com\/en\/turnstone-biologics-and-moffitt-cancer-center-announce-strategic-alliance-to-advance-next-generation-til-therapies-for-solid-tumors\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Turnstone Biologics and Moffitt Cancer Center Announce Strategic Alliance to Advance Next-Generation TIL Therapies for Solid Tumors - Pharma Trend\" \/>\n<meta property=\"og:description\" content=\"Strategic alliance significantly expands ongoing multi-year collaboration by granting Turnstone broader access and enhanced benefits at Moffitt IND approval received for a Moffitt-sponsored Phase 1 study of TIDAL-01 in melanoma NEW YORK & TAMPA, Fla.–(BUSINESS WIRE)–#TIL–Turnstone Biologics Corp., a clinical-stage biotechnology company developing next-generation immunotherapies to treat and cure solid tumors, and Moffitt Cancer Center ... 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