{"id":46121,"date":"2022-07-13T14:01:52","date_gmt":"2022-07-13T12:01:52","guid":{"rendered":"https:\/\/pharma-trend.com\/en\/bio-thera-solutions-announces-first-patient-dosed-in-phase-1-study-for-bat8006-an-antibody-drug-conjugate-targeting-folate-receptor-%ce%b1-for-the-treatment-of-advanced-solid-tumors\/"},"modified":"2022-07-13T14:01:52","modified_gmt":"2022-07-13T12:01:52","slug":"bio-thera-solutions-announces-first-patient-dosed-in-phase-1-study-for-bat8006-an-antibody-drug-conjugate-targeting-folate-receptor-%ce%b1-for-the-treatment-of-advanced-solid-tumors","status":"publish","type":"post","link":"https:\/\/pharma-trend.com\/en\/bio-thera-solutions-announces-first-patient-dosed-in-phase-1-study-for-bat8006-an-antibody-drug-conjugate-targeting-folate-receptor-%ce%b1-for-the-treatment-of-advanced-solid-tumors\/","title":{"rendered":"Bio-Thera Solutions Announces First Patient Dosed in Phase 1 Study for BAT8006, an Antibody Drug Conjugate Targeting Folate Receptor \u03b1 for the Treatment of Advanced Solid Tumors"},"content":{"rendered":"
\n

GUANGZHOU, China–(BUSINESS WIRE)–#ADC<\/a>–Bio-Thera Solutions, Ltd. (SH: 688177), a commercial-stage pharmaceutical company, today announced that dosing has begun in a Phase 1 clinical study evaluating BAT8006, an antibody drug conjugate (ADC) that targets folic acid receptor \u03b1 (FR\u03b1). The clinical trial is a multicenter, open-label Phase 1 clinical study in patients with advanced solid tumors to evaluate the safety and tolerability of BAT8006 and to determine the recommended phase 2 dose.\n<\/p>\n

<\/a><\/p>\n

\nFR\u03b1 is a folic acid-binding protein located on cell membranes that is overexpressed in a variety of solid tumors such as ovarian, lung, breast cancer, etc., but has a limited distribution and a lower level of expression in normal human tissues. Differences in expression levels make FR\u03b1 an ideal target for ADC drug development. BAT8006 was developed using Bio-Thera’s anti-FR\u03b1 antibody and Bio-Thera\u2019s proprietary ADC linker-payload combination that includes a systemically stable and cleavable linker and a small molecule topoisomerase I inhibitor. A series of preclinical studies have shown that BAT8006 has good stability and safety and has high anti-tumor activity. The small molecule topoisomerase I inhibitor payload carried by BAT8006 has a strong cell membrane penetration ability, so when the target cancer cells are killed, the payload can be released and further kill nearby cancer cells, producing a bystander effect and effectively overcoming the heterogeneity of the tumor. BAT8006 has demonstrated high anti-tumor activity and good safety in both in vitro and in vivo pharmacological studies and is a potential “best-in-class” ADC that targets FR\u03b1. BAT8006 is the first ADC drug using Bio-Thera\u2019s proprietary new ADC platform administered to patients, representing another important milestone in the company’s research and development in the field of innovative oncology drugs.\n<\/p>\n

\nThe Phase 1, multi-center, open-label, dose-escalation clinical trial of BAT8006 is designed to assess the safety and tolerability of BAT8006. Key objectives of the study are to determine the maximum tolerated dose and recommended Phase 2 dose (RP2D), and to evaluate pharmacokinetics and preliminary efficacy in patients with advanced solid tumor. In addition, Bio-Thera Solutions is developing several additional ADCs targeting B7H3, Her2 and two other targets along with additional innovative oncology assets directed at important IO targets, including PD-1, OX40, CTLA-4, and TIGIT, all in early-stage clinical studies.\n<\/p>\n

\nAbout Bio-Thera Solutions<\/b>\n<\/p>\n

\nBio-Thera Solutions, Ltd., a leading global biotechnology company in Guangzhou, China, is dedicated to researching and developing novel therapeutics for the treatment of cancer, autoimmune, cardiovascular diseases, and other serious unmet medical needs, as well as biosimilars for existing, branded biologics to treat a range of cancer and autoimmune diseases. A leader in next generation antibody discovery and engineering, the company has advanced six candidates into late-stage clinical trials and has two approved products, QLETLI\u00ae<\/sup> and POBEVCY\u00ae<\/sup> in China. In addition, the company has multiple promising candidates in early clinical trials and IND-enabling studies, focusing on immuno-oncology, ADC targeted therapies, autoimmune diseases, and other severe and emerging unmet medical needs. For more information, please visit www.bio-thera.com\/en\/<\/a> or follow us on Twitter (@bio_thera_sol) and WeChat (Bio-Thera).\n<\/p>\n

\nCautionary Note Regarding Forward-Looking Statements<\/b>\n<\/p>\n

\nThis news release contains certain forward-looking statements relating to BAT8006 or the product pipelines in general of Bio-Thera Solutions. Readers are strongly cautioned that reliance on any forward-looking statements involves known and unknown risks and uncertainties. The forward-looking statements include, among others, those containing \u201ccould,\u201d \u201cmay,\u201d \u201cshould,\u201d \u201cwill,\u201d \u201cwould,\u201d \u201canticipate,\u201d \u201cbelieve,\u201d \u201cplan,\u201d \u201cpromising,\u201d \u201cpotentially,\u201d or similar expressions. They reflect the company\u2019s current views with respect to future events that are based on what the company believes are reasonable assumptions in view of information currently available to Bio-Thera Solutions, and are not a guarantee of future performance or developments. Actual results and events may differ materially from information contained in the forward-looking statements as a result of a number of factors, including, but not limited to, risks and uncertainties inherent in pharmaceutical research and development, such as the uncertainties of pre-clinical and clinical studies, for example, the development processes could be lengthy and high in vitro<\/i> affinity may not translate to desired results in vivo <\/i>or successful clinical studies. Other risks and uncertainties include challenges in obtaining regulatory approvals, manufacturing, marketing, competition, intellectual property, product efficacy or safety, changes in global healthcare situation, changes in the company\u2019s financial conditions, and changes to applicable laws and regulations, etc. Forward-looking statements contained herein are made only as of the date of their initial publication. Unless required by laws or regulations, Bio-Thera Solutions undertakes no obligation to publicly update any forward-looking statement, whether as a result of new information, future events, changes in the company\u2019s views or otherwise.\n<\/p>\n

Contacts<\/b> <\/p>\n

\nBio-Thera Solutions, Ltd.:
\n
Bert E. Thomas IV +1.410.627.1734
\n
bethomas@bio-thera.com<\/a>\n<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

GUANGZHOU, China–(BUSINESS WIRE)–#ADC–Bio-Thera Solutions, Ltd. (SH: 688177), a commercial-stage pharmaceutical company, today announced that dosing has begun in a Phase 1 clinical study evaluating BAT8006, an antibody drug conjugate (ADC) that targets folic acid receptor \u03b1 (FR\u03b1). The clinical trial is a multicenter, open-label Phase 1 clinical study in patients with advanced solid tumors to … [Read more…]<\/a><\/span><\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[13],"tags":[],"class_list":{"0":"entry","1":"post","2":"publish","3":"author-business","4":"post-46121","6":"format-standard","7":"category-industry"},"yoast_head":"\nBio-Thera Solutions Announces First Patient Dosed in Phase 1 Study for BAT8006, an Antibody Drug Conjugate Targeting Folate Receptor \u03b1 for the Treatment of Advanced Solid Tumors - Pharma Trend<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/pharma-trend.com\/en\/bio-thera-solutions-announces-first-patient-dosed-in-phase-1-study-for-bat8006-an-antibody-drug-conjugate-targeting-folate-receptor-\u03b1-for-the-treatment-of-advanced-solid-tumors\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Bio-Thera Solutions Announces First Patient Dosed in Phase 1 Study for BAT8006, an Antibody Drug Conjugate Targeting Folate Receptor \u03b1 for the Treatment of Advanced Solid Tumors - Pharma Trend\" \/>\n<meta property=\"og:description\" content=\"GUANGZHOU, China–(BUSINESS WIRE)–#ADC–Bio-Thera Solutions, Ltd. (SH: 688177), a commercial-stage pharmaceutical company, today announced that dosing has begun in a Phase 1 clinical study evaluating BAT8006, an antibody drug conjugate (ADC) that targets folic acid receptor \u03b1 (FR\u03b1). The clinical trial is a multicenter, open-label Phase 1 clinical study in patients with advanced solid tumors to ... 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(SH: 688177), a commercial-stage pharmaceutical company, today announced that dosing has begun in a Phase 1 clinical study evaluating BAT8006, an antibody drug conjugate (ADC) that targets folic acid receptor \u03b1 (FR\u03b1). The clinical trial is a multicenter, open-label Phase 1 clinical study in patients with advanced solid tumors to ... 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