{"id":46276,"date":"2022-07-18T16:02:12","date_gmt":"2022-07-18T14:02:12","guid":{"rendered":"https:\/\/pharma-trend.com\/en\/fresenius-kabi-introduces-generic-iodixanol-contrast-media-agent\/"},"modified":"2022-07-18T16:02:12","modified_gmt":"2022-07-18T14:02:12","slug":"fresenius-kabi-introduces-generic-iodixanol-contrast-media-agent","status":"publish","type":"post","link":"https:\/\/pharma-trend.com\/en\/fresenius-kabi-introduces-generic-iodixanol-contrast-media-agent\/","title":{"rendered":"Fresenius Kabi Introduces Generic Iodixanol Contrast Media Agent"},"content":{"rendered":"<div>\n<p class=\"bwalignc\">\n<b>Fresenius Kabi Iodixanol Injection, USP is the first FDA-approved generic that is fully substitutable for Visipaque<sup>\u00ae<\/sup><\/b>\n<\/p>\n<p>LAKE ZURICH, Ill.&#8211;(BUSINESS WIRE)&#8211;<a href=\"https:\/\/twitter.com\/hashtag\/FreseniusKabi?src=hash\" target=\"_blank\" rel=\"noopener\">#FreseniusKabi<\/a>&#8211;Fresenius Kabi announced today it will introduce a portfolio of generic contrast media agents in the United States, starting immediately with the launch of Iodixanol Injection, USP, a product the U.S. Food and Drug Administration (FDA) lists as being in shortage nationwide.\n<\/p>\n<p><a href=\"https:\/\/mms.businesswire.com\/media\/20220718005543\/en\/1516143\/5\/Iodixanol_FK_GROUP%5B1%5D.jpg\"><img decoding=\"async\" src=\"https:\/\/mms.businesswire.com\/media\/20220718005543\/en\/1516143\/21\/Iodixanol_FK_GROUP%5B1%5D.jpg\"><\/a><br \/><a href=\"https:\/\/mms.businesswire.com\/media\/20220718005543\/en\/341705\/5\/Logo.jpg\"><img decoding=\"async\" src=\"https:\/\/mms.businesswire.com\/media\/20220718005543\/en\/341705\/21\/Logo.jpg\"><\/a><\/p>\n<p>\nIodixanol Injection, USP is the first U.S. FDA-approved generic iso-osmolar, dimeric iodinated contrast media agent, which is used during diagnostic x-ray-based imaging such as computed tomography (CT) scans.\n<\/p>\n<p>\nIodixanol and other contrast media agents are in shortage across the U.S. due to COVID-19 related supply-chain disruptions. Fresenius Kabi is committed to preventing and mitigating shortages by working closely with its customers, suppliers, and the FDA, and by making long-term investments that support the supply chain of care in the United States.\n<\/p>\n<p>\nContrast media agents are essential to patient diagnosis. An estimated 50 million examinations with contrast agents are performed each year in the United States, and as many as half the nation\u2019s hospitals have been affected by this shortage.<sup>1<\/sup>\n<\/p>\n<p>\nIodixanol Injection, USP is bioequivalent and therapeutically equivalent to Visipaque<sup>\u00ae<\/sup>, rendering it fully substitutable to the brand, and is the first generic iodinated contrast media agent available exclusively from Fresenius Kabi, a global health care company that specializes in medicines and technologies for infusion, transfusion, and clinical nutrition.\n<\/p>\n<p>\n\u201cFresenius Kabi is pleased to help expand access to affordable, high-quality contrast media agents for the radiology community,\u201d said John Ducker, president and CEO of Fresenius Kabi USA. \u201cThe approval and U.S. availability of Fresenius Kabi Iodixanol Injection, USP is expected to provide immediate relief to the current shortage. As a company committed to the purpose of \u2018caring for life,\u2019 we\u2019re honored to help patients receive the timely care they need.\u201d\n<\/p>\n<p>\nFresenius Kabi Iodixanol Injection, USP is an option for hospitals and clinics to use in the diagnosis of certain disorders of the brain, blood vessels, heart, kidneys, and other internal organs.<sup>2<\/sup> It is free of preservatives and comes in a polymer bottle. The container closure is not made with natural rubber latex. Fresenius Kabi Iodixanol Injection, USP is currently available in six presentations for intra-arterial and intravenous procedures:\n<\/p>\n<ul class=\"bwlistdisc\">\n<li>\n<b>270 mg Iodine per mL:<\/b><\/p>\n<ul class=\"bwlistcircle\">\n<li>\n100 mL polymer bottle\n<\/li>\n<li>\n150 mL polymer bottle<br \/>\n\n<\/li>\n<\/ul>\n<\/li>\n<li>\n<b>320 mg Iodine per mL:<\/b><\/p>\n<ul class=\"bwlistcircle\">\n<li>\n50 mL polymer bottle\n<\/li>\n<li>\n100 mL polymer bottle\n<\/li>\n<li>\n150 mL polymer bottle\n<\/li>\n<li>\n200 mL polymer bottle\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>\n\u201cThe U.S. availability of Iodixanol Injection, USP is the first offering from our generic radiology portfolio,\u201d said Lindsey Thomas, senior vice president of Pharmaceutical Marketing at Fresenius Kabi USA and the company\u2019s representative on the <a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Fwww.businesswire.com%2Fnews%2Fhome%2F20220503005389%2Fen%2FEnd-Drug-Shortages-Alliance-Announces-Board-of-Directors-Mission-Vision-Statements-in-First-All-Member-Meeting&amp;esheet=52783956&amp;newsitemid=20220718005543&amp;lan=en-US&amp;anchor=End+Drug+Shortage+Alliance+Board+of+Directors&amp;index=1&amp;md5=80b4c0ccf93c95d53403edcbdf972ade\" rel=\"nofollow noopener\" shape=\"rect\">End Drug Shortage Alliance Board of Directors<\/a>. \u201cWe are doing everything we can to accelerate product availability to help our customers during this acute contrast media agent shortage, including air shipping product. We are also actively working to bring additional affordable contrast agents to U.S. clinicians to help ensure patient access to essential diagnostic imaging procedures.\u201d\n<\/p>\n<p>\n<b>INDICATIONS AND USAGE<\/b>\n<\/p>\n<p>\nIodixanol injection is a radiographic contrast agent indicated for the following:\n<\/p>\n<p>\n<b>Intra-arterial Procedures<\/b>\n<\/p>\n<p>\nAdults and pediatric patients 12 years of age and over\n<\/p>\n<ul class=\"bwlistdisc\">\n<li>\nIntra-arterial digital subtraction angiography (270 mg Iodine\/mL and 320 mg Iodine\/mL).\n<\/li>\n<li>\nAngiocardiography (left ventriculography and selective coronary arteriography), peripheral arteriography, visceral arteriography, and cerebral arteriography (320 mg Iodine\/mL).\n<\/li>\n<\/ul>\n<p>\nPediatric patients less than 12 years of age\n<\/p>\n<ul class=\"bwlistdisc\">\n<li>\nAngiocardiography, cerebral arteriography, and visceral arteriography (320 mg Iodine\/mL).\n<\/li>\n<\/ul>\n<p>\n<b>Intravenous Procedures<\/b>\n<\/p>\n<p>\nAdults and pediatric patients 12 years of age and over\n<\/p>\n<ul class=\"bwlistdisc\">\n<li>\nComputed tomography (CT) imaging head and body (270 mg Iodine\/mL and 320 mg Iodine\/mL).\n<\/li>\n<li>\nExcretory urography (270 mg Iodine\/mL and 320 mg Iodine\/mL).\n<\/li>\n<li>\nPeripheral venography (270 mg Iodine\/mL).\n<\/li>\n<li>\nCoronary computed tomography angiography (CCTA) to assist diagnostic evaluation of patients with suspected coronary artery disease (320 mg Iodine\/mL).\n<\/li>\n<\/ul>\n<p>\nPediatric patients less than 12 years of age\n<\/p>\n<ul class=\"bwlistdisc\">\n<li>\nCT imaging of the head and body (270 mg Iodine\/mL).\n<\/li>\n<li>\nExcretory urography (270 mg Iodine\/mL).\n<\/li>\n<\/ul>\n<p>\n<b>IMPORTANT SAFETY INFORMATION<\/b>\n<\/p>\n<table cellspacing=\"0\" class=\"bwtablemarginb bwblockalignc\">\n<tr>\n<td class=\"bwvertalignt bwpadl0 bwalignc bwtopsingle bwleftsingle bwrightsingle\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwcellpmargin bwalignc\">\n<b>WARNING: NOT FOR INTRATHECAL USE<\/b>\n<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"bwpadl0 bwleftsingle bwrightsingle\" colspan=\"1\" rowspan=\"1\">\u00a0<\/td>\n<\/tr>\n<tr>\n<td class=\"bwvertalignt bwpadl0 bwleftsingle bwrightsingle\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwcellpmargin bwalignc\">\n<b><i>See full prescribing information for complete boxed warning<\/i><\/b>\n<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"bwpadl0 bwleftsingle bwrightsingle\" colspan=\"1\" rowspan=\"1\">\u00a0<\/td>\n<\/tr>\n<tr>\n<td class=\"bwvertalignt bwpadl0 bwleftsingle bwrightsingle bwsinglebottom\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwcellpmargin bwalignc\">\n<b>Inadvertent intrathecal administration may cause death, convulsions\/seizures,<br \/>\n<br \/>cerebral hemorrhage, coma, paralysis, arachnoiditis, acute renal failure, cardiac<br \/>\n<br \/>arrest, rhabdomyolysis, hyperthermia, and brain edema.<\/b>\n<\/p>\n<\/td>\n<\/tr>\n<\/table>\n<p>\nIodixanol is contraindicated for intrathecal use.\n<\/p>\n<ul class=\"bwlistdisc\">\n<li>\nHypersensitivity Reactions: Life-threatening or fatal reactions can occur. Always have emergency equipment and trained personnel available.\n<\/li>\n<li>\nContrast-Induced Acute Kidney Injury: Acute injury including renal failure can occur. Minimize dose and maintain adequate hydration to minimize risk.\n<\/li>\n<li>\nCardiovascular Adverse Reactions: Hemodynamic disturbances including shock and cardiac arrest may occur during or after administration.\n<\/li>\n<li>\nThyroid Dysfunction in Pediatric Patients 0 to 3 Years of Age: Monitor these patients for thyroid function abnormalities and treat as clinically needed.\n<\/li>\n<\/ul>\n<p>\nAdverse Events: Most common adverse reactions (incidence greater than 0.5%) in adult patients after iodixanol injection: Discomfort, warmth, pain; Cardiovascular: angina. Gastrointestinal: diarrhea, nausea, vomiting. Nervous System: agitation, anxiety, insomnia, nervousness, dizziness, headache, migraine, unusual skin sensations, sensory disturbance, fainting, sensation of spinning. Skin: itchy rash, severe itching, hives. Special Senses: Smell, taste, and vision alteration. Pediatric patients experienced similar adverse reactions.\n<\/p>\n<p>\n<b>To report SUSPECTED ADVERSE REACTIONS, contact Fresenius Kabi USA, LLC at 1-800-551-7176, option 5, or FDA at 1-800-FDA-1088 or <a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=http%3A%2F%2Fwww.fda.gov%2Fmedwatch&amp;esheet=52783956&amp;newsitemid=20220718005543&amp;lan=en-US&amp;anchor=www.fda.gov%2Fmedwatch&amp;index=2&amp;md5=65027a20e99df20cfe215b233f7ce99d\" rel=\"nofollow noopener\" shape=\"rect\">www.fda.gov\/medwatch<\/a>.<\/b>\n<\/p>\n<ul class=\"bwlistdisc\">\n<li>\nLactation: A lactating woman may pump and discard breast milk for 10 hours after iodixanol administration.\n<\/li>\n<li>\nGeriatrics: Exercise caution in dose selection for elderly patients.\n<\/li>\n<\/ul>\n<p>\n<b>This Important Safety Information does not include all the information needed to use Iodixanol Injection, USP safely and effectively. Please see full prescribing information, including BOXED WARNING, for Iodixanol Injection, USP at <a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=http%3A%2F%2Fwww.fresenius-kabi.com%2Fus&amp;esheet=52783956&amp;newsitemid=20220718005543&amp;lan=en-US&amp;anchor=www.fresenius-kabi.com%2Fus&amp;index=3&amp;md5=fd0874b3c4492ce9d943313a2964169c\" rel=\"nofollow noopener\" shape=\"rect\">www.fresenius-kabi.com\/us<\/a>.<\/b>\n<\/p>\n<p>\nTo report SUSPECTED ADVERSE REACTIONS, contact Fresenius Kabi USA, LLC at 1-800-551-7176, option 5, or FDA at 1-800-FDA-1088 or <a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=http%3A%2F%2Fwww.fda.gov%2Fmedwatch&amp;esheet=52783956&amp;newsitemid=20220718005543&amp;lan=en-US&amp;anchor=www.fda.gov%2Fmedwatch&amp;index=4&amp;md5=e42eb1908faa49e2bda09ef428541b80\" rel=\"nofollow noopener\" shape=\"rect\">www.fda.gov\/medwatch<\/a>.\n<\/p>\n<p>\n<b>About Fresenius Kabi<\/b>\n<\/p>\n<p>\nFresenius Kabi (<a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=http%3A%2F%2Fwww.fresenius-kabi.com%2Fus&amp;esheet=52783956&amp;newsitemid=20220718005543&amp;lan=en-US&amp;anchor=www.fresenius-kabi.com%2Fus&amp;index=5&amp;md5=3d10d12cce7883585519b5e7eb3084d4\" rel=\"nofollow noopener\" shape=\"rect\">www.fresenius-kabi.com\/us<\/a>) is a global health care company that specializes in medicines and technologies for infusion, transfusion, and clinical nutrition. The company\u2019s products and services are used to help care for critically and chronically ill patients. The company\u2019s U.S. headquarters is in Lake Zurich, Illinois. The company\u2019s global headquarters is in Bad Homburg, Germany. To learn about U.S. career opportunities at Fresenius Kabi, visit us at <a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=http%3A%2F%2Fwww.fresenius-kabi.com%2Fus%2Fjoin-us&amp;esheet=52783956&amp;newsitemid=20220718005543&amp;lan=en-US&amp;anchor=www.fresenius-kabi.com%2Fus%2Fjoin-us.&amp;index=6&amp;md5=9b10580e4e4432f5b8878856c64df14f\" rel=\"nofollow noopener\" shape=\"rect\">www.fresenius-kabi.com\/us\/join-us.<\/a>\n<\/p>\n<p>\n<b>References<\/b>\n<\/p>\n<p>\n1. Abelson, R. (2022, May 26). <i>Patients Face Long Delays for Imaging of Cancers and Other Diseases<\/i>. The New York Times. Retrieved June 21, 2022, from <a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Fwww.nytimes.com%2F2022%2F05%2F26%2Fhealth%2Fdye-contrast-scan-shortage.html&amp;esheet=52783956&amp;newsitemid=20220718005543&amp;lan=en-US&amp;anchor=https%3A%2F%2Fwww.nytimes.com%2F2022%2F05%2F26%2Fhealth%2Fdye-contrast-scan-shortage.html.&amp;index=7&amp;md5=b988c81c7d996c630c27a8b319db7ce6\" rel=\"nofollow noopener\" shape=\"rect\">https:\/\/www.nytimes.com\/2022\/05\/26\/health\/dye-contrast-scan-shortage.html.<\/a>\n<\/p>\n<p>\n2. Drugs.com [<i>Internet<\/i>]. <i>Iodixanol Uses, Side Effects &amp; Warnings<\/i>; c1996-2022 [Updated: 3 November 2021, Cited: 19 May 2022]. <a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Fwww.drugs.com%2Fmtm%2Fiodixanol.html&amp;esheet=52783956&amp;newsitemid=20220718005543&amp;lan=en-US&amp;anchor=https%3A%2F%2Fwww.drugs.com%2Fmtm%2Fiodixanol.html&amp;index=8&amp;md5=4fefc1f6376428fc4d3242db39de93b9\" rel=\"nofollow noopener\" shape=\"rect\">https:\/\/www.drugs.com\/mtm\/iodixanol.html<\/a>.\n<\/p>\n<p>\n*Visipaque<sup>\u00ae<\/sup> is a registered trademark of GE Healthcare.\n<\/p>\n<p> <b>Contacts<\/b> <\/p>\n<p>\n<b>Media contact<\/b><br \/>Joanie Clougherty (614) 717-5741<br \/>\n<br \/><a target=\"_blank\" href=\"m&#97;&#x69;&#x6c;t&#111;&#x3a;&#x6a;o&#97;&#110;&#x2e;&#x63;l&#111;&#x75;&#x67;h&#101;&#x72;&#x74;y&#64;&#102;&#x72;&#x65;s&#101;&#x6e;&#x69;u&#115;&#x2d;&#x6b;a&#98;&#105;&#x2e;&#x63;o&#109;\" rel=\"nofollow noopener\" shape=\"rect\">j&#111;&#x61;&#x6e;&#x2e;c&#108;&#x6f;&#x75;&#x67;h&#101;&#x72;&#x74;&#x79;&#64;&#102;&#x72;&#x65;&#x73;e&#110;&#x69;&#x75;&#x73;-&#107;&#x61;&#x62;&#x69;&#46;&#99;&#x6f;&#x6d;<\/a>\n<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Fresenius Kabi Iodixanol Injection, USP is the first FDA-approved generic that is fully substitutable for Visipaque\u00ae LAKE ZURICH, Ill.&#8211;(BUSINESS WIRE)&#8211;#FreseniusKabi&#8211;Fresenius Kabi announced today it will introduce a portfolio of generic contrast media agents in the United States, starting immediately with the launch of Iodixanol Injection, USP, a product the U.S. Food and Drug Administration (FDA) &#8230; <span class=\"more\"><a class=\"more-link\" href=\"https:\/\/pharma-trend.com\/en\/fresenius-kabi-introduces-generic-iodixanol-contrast-media-agent\/\">[Read more&#8230;]<\/a><\/span><\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[13],"tags":[],"class_list":{"0":"entry","1":"post","2":"publish","3":"author-business","4":"post-46276","6":"format-standard","7":"category-industry"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Fresenius Kabi Introduces Generic Iodixanol Contrast Media Agent - Pharma Trend<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/pharma-trend.com\/en\/fresenius-kabi-introduces-generic-iodixanol-contrast-media-agent\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Fresenius Kabi Introduces Generic Iodixanol Contrast Media Agent - Pharma Trend\" \/>\n<meta property=\"og:description\" content=\"Fresenius Kabi Iodixanol Injection, USP is the first FDA-approved generic that is fully substitutable for Visipaque\u00ae LAKE ZURICH, Ill.&#8211;(BUSINESS WIRE)&#8211;#FreseniusKabi&#8211;Fresenius Kabi announced today it will introduce a portfolio of generic contrast media agents in the United States, starting immediately with the launch of Iodixanol Injection, USP, a product the U.S. Food and Drug Administration (FDA) ... 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