{"id":46572,"date":"2022-07-26T14:01:43","date_gmt":"2022-07-26T12:01:43","guid":{"rendered":"https:\/\/pharma-trend.com\/en\/published-ucla-and-spectrum-solutions-saliva-liquid-biopsy-research-highlights-signal-amplifying-ability-and-clear-detection-of-cancer-biomarkers\/"},"modified":"2022-07-26T14:01:43","modified_gmt":"2022-07-26T12:01:43","slug":"published-ucla-and-spectrum-solutions-saliva-liquid-biopsy-research-highlights-signal-amplifying-ability-and-clear-detection-of-cancer-biomarkers","status":"publish","type":"post","link":"https:\/\/pharma-trend.com\/en\/published-ucla-and-spectrum-solutions-saliva-liquid-biopsy-research-highlights-signal-amplifying-ability-and-clear-detection-of-cancer-biomarkers\/","title":{"rendered":"Published UCLA and Spectrum Solutions Saliva Liquid Biopsy Research Highlights Signal Amplifying Ability and Clear Detection of Cancer Biomarkers"},"content":{"rendered":"
\n

SALT LAKE CITY–(BUSINESS WIRE)–Spectrum Solutions<\/a>, LLC today announced the publishing of findings from their research collaboration with the University of California at Los Angeles (UCLA) and Dr. David Wong, UCLA School of Dentistry. The project has successfully demonstrated a superior ability to detect circulating tumor DNA (ctDNA) from saliva. Specifically, amplified EGFR mutations associated with non-small cell lung cancer (NSCLC) using Spectrum\u2019s saliva collection and preservation system with the Electric Field\u2013Induced Release and Measurement (EFRIM) electrostatic platform.\n<\/p>\n

<\/a><\/p>\n

\nThe BIO Journal<\/i> is the first journal to provide comprehensive peer-reviewed coverage of biospecimen procurement, processing, preservation, and banking, including ethical, legal, and societal considerations. The published research, “Proficiency Testing of Epidermal Growth Factor Receptor Mutations Detection in Saliva Using Spectrum Saliva Collector (SDNA-1000) and Preservative Solution Detected by Electric Field-Induced Release and Measurement,” Feng Li et al, can be found in the Ahead of Print<\/b><\/a> section online and Manuscript ID: BIO-2022-0093 \u2013 VOLUME 20, ISSUE 4 \/ AUGUST 2022<\/b><\/a>.<\/b>\n<\/p>\n

\nMost lung cancers (85 percent) fall into the category called non-small cell lung cancer (NSCLC). Though this form of lung cancer progresses more slowly than small cell lung cancer (SCLC), 40 percent of those living with NSCLC will have it spread beyond the lungs by the time it is diagnosed. Many advances in targeted treatments for lung cancer are based on the evaluation of three EGFR gene mutations. Current methods for diagnosis and monitoring include invasive tissue biopsies, which create clinical obstacles for ongoing mutation analysis and cancer treatment. The less invasive liquid biopsy options using free floating cell-free DNA (cfDNA) or circulating tumor DNA (ctDNA) in solid tumor cancers, have quickly become an important part of the screening, diagnosis and monitoring process for cancer patients.\n<\/p>\n

\n\u201cThe ability to detect EGFR mutations using ctDNA enables a broad range of clinical applications for laboratory medicine such as the early detection of disease, practical applications of personalized treatments, predicting treatment response and monitoring resistance,\u201d said Rohit Gupta, Chief Medical Officer for Spectrum Solutions. \u201cProving it can be done using saliva is groundbreaking.\u201d\n<\/p>\n

\nThe ctDNA associated with NSCLC, termed \u2018ultra-short\u2019 ctDNA (usctDNA), is a third smaller in size than the average fragment. This has made it extremely hard to detect using current liquid biopsy technology, especially without additional amplification. Prior to this study, Wong\u2019s team published<\/a> on the successful detection of the same usctDNA EGFR mutations from both early and late-stage patients living with NSCLC in both blood and saliva. When paired with new technology developed at UCLA by Dr. Wong, known as EFIRM, study findings have demonstrated an impressive 14-fold amplification of detectable usctDNA from saliva collected and stabilized using Spectrum\u2019s SDNA-1000 compared to raw or neat saliva. Additionally, after diluting the signal down to 10 percent of the original concentration, the team continued to see enhanced amplification benefits from the Spectrum device, leading scientists to believe detection of a single ctDNA fragment may now be possible.\n<\/p>\n

\n\u201cAchieving detectable concentrations of ctDNA in body fluids is not an easy task. The significance of successfully demonstrating this capability with saliva is the holy grail of liquid biopsy research,\u201d said Dr. David Wong, UCLA School of Dentistry. \u201cThe discovery delivers, for the first time, a noninvasive opportunity for detection and the ongoing \u2018real-time\u2019 understanding of somatic mutation activity to direct and redirect successful treatment strategies.\u201d\n<\/p>\n

\n\u201cUnderstanding how many face the likelihood of treatment resistance, it is actually life changing to know the results from this research collaboration with Dr. Wong and UCLA has real power to positively impact patient outcomes,\u201d said Steve Fanning, CEO of Spectrum Solutions. \u201cFor patients, the ability to use the self-collection of saliva empowers a new, safer, easier and pain-free era of detection and treatment innovation with real at-home remote care possibilities.\u201d\n<\/p>\n

\nABOUT SPECTRUM SOLUTIONS<\/b>\n<\/p>\n

\nHeadquartered in Salt Lake City, Utah, Spectrum Solutions is a laboratory medicine life science company using its focused industry expertise to drive noninvasive molecular diagnostic and screening IVD innovation. Our pioneering research, products, engineering, and development-to-delivery test kit commercialization capabilities are setting new standards of modernized care for patients, providers, and clinical laboratories in the testing, managing, and treatment of disease. We believe when you bridge the gap between science and real direct-to-patient medical solutions you deliver innovation with the practical power to impact and change outcomes. For more information, please visit spectrumsolution.com<\/a>.\n<\/p>\n

Contacts<\/b> <\/p>\n

\nTim Rush
\n
Springboard5 for Spectrum Solutions
\n
801-208-1100
\n
tim.rush@springboard5.com<\/a>\n<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

SALT LAKE CITY–(BUSINESS WIRE)–Spectrum Solutions, LLC today announced the publishing of findings from their research collaboration with the University of California at Los Angeles (UCLA) and Dr. David Wong, UCLA School of Dentistry. The project has successfully demonstrated a superior ability to detect circulating tumor DNA (ctDNA) from saliva. Specifically, amplified EGFR mutations associated with … [Read more…]<\/a><\/span><\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[13],"tags":[],"class_list":{"0":"entry","1":"post","2":"publish","3":"author-business","4":"post-46572","6":"format-standard","7":"category-industry"},"yoast_head":"\nPublished UCLA and Spectrum Solutions Saliva Liquid Biopsy Research Highlights Signal Amplifying Ability and Clear Detection of Cancer Biomarkers - Pharma Trend<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/pharma-trend.com\/en\/published-ucla-and-spectrum-solutions-saliva-liquid-biopsy-research-highlights-signal-amplifying-ability-and-clear-detection-of-cancer-biomarkers\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Published UCLA and Spectrum Solutions Saliva Liquid Biopsy Research Highlights Signal Amplifying Ability and Clear Detection of Cancer Biomarkers - Pharma Trend\" \/>\n<meta property=\"og:description\" content=\"SALT LAKE CITY–(BUSINESS WIRE)–Spectrum Solutions, LLC today announced the publishing of findings from their research collaboration with the University of California at Los Angeles (UCLA) and Dr. David Wong, UCLA School of Dentistry. 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