{"id":46693,"date":"2022-07-28T17:01:49","date_gmt":"2022-07-28T15:01:49","guid":{"rendered":"https:\/\/pharma-trend.com\/en\/nervgen-pharmas-nvg-291-r-demonstrates-significant-functional-repair-from-a-stroke-7-days-after-onset-in-landmark-preclinical-study-by-university-of-cincinnati-and-case-western-reserve-univer\/"},"modified":"2022-07-28T17:01:49","modified_gmt":"2022-07-28T15:01:49","slug":"nervgen-pharmas-nvg-291-r-demonstrates-significant-functional-repair-from-a-stroke-7-days-after-onset-in-landmark-preclinical-study-by-university-of-cincinnati-and-case-western-reserve-univer","status":"publish","type":"post","link":"https:\/\/pharma-trend.com\/en\/nervgen-pharmas-nvg-291-r-demonstrates-significant-functional-repair-from-a-stroke-7-days-after-onset-in-landmark-preclinical-study-by-university-of-cincinnati-and-case-western-reserve-univer\/","title":{"rendered":"NervGen Pharma\u2019s NVG-291-R Demonstrates Significant Functional Repair From a Stroke 7 Days After Onset in Landmark Preclinical Study by University of Cincinnati and Case Western Reserve University"},"content":{"rendered":"<div>\n<ul class=\"bwlistdisc\">\n<li>\nThe independent peer-reviewed study showed improved memory as well as motor and sensory functions in rodents when treatment with NVG-291-R began 7 days after stroke onset\n<\/li>\n<li>\nThere is currently no FDA-approved drug for the repair of damage from a stroke\n<\/li>\n<li>\nNVG-291, currently in a Phase 1 clinical trial in healthy human subjects, could provide a completely new treatment paradigm for stroke patients\n<\/li>\n<\/ul>\n<p>VANCOUVER, British Columbia&#8211;(BUSINESS WIRE)&#8211;<a href=\"https:\/\/twitter.com\/search?q=%24NGEN.V&amp;src=ctag\" target=\"_blank\" rel=\"noopener\">$NGEN.V<\/a> <a href=\"https:\/\/twitter.com\/hashtag\/biotech?src=hash\" target=\"_blank\" rel=\"noopener\">#biotech<\/a>&#8212;<b>NervGen Pharma Corp., (TSX-V: NGEN) (OTCQX: NGENF), <\/b>is pleased to announce the University of Cincinnati and Case Western Reserve University (CWRU) have published a pioneering preclinical study in the peer-reviewed scientific journal <a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Fwww.cell.com%2Fcell-reports%2Ffulltext%2FS2211-1247%252822%252900946-9&amp;esheet=52794128&amp;newsitemid=20220727006174&amp;lan=en-US&amp;anchor=Cell+Reports&amp;index=1&amp;md5=425589ebabd4855fc7571015935f3666\" rel=\"nofollow noopener\" shape=\"rect\">Cell Reports<\/a> demonstrating that NervGen\u2019s proprietary drug, NVG-291-R, promotes nervous system repair and significant functional recovery in a <a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Fwww.youtube.com%2Fwatch%3Fv%3DXLet_K8ymtc&amp;esheet=52794128&amp;newsitemid=20220727006174&amp;lan=en-US&amp;anchor=mouse+model+of+severe+ischemic+stroke&amp;index=2&amp;md5=dfe74b379f9a6a684e131ef21c929034\" rel=\"nofollow noopener\" shape=\"rect\">mouse model of severe ischemic stroke<\/a>, even when treatment was initiated up to 7 days after onset. Currently there are no United States Food and Drug Administration (FDA) approved drugs that repair damage from a stroke. NervGen holds the exclusive worldwide rights to NVG-291, which is currently in a Phase 1 clinical trial in healthy human subjects and is preparing to initiate Phase 1b\/2 clinical trials for the repair of nervous system damage from spinal cord injury, Alzheimer\u2019s disease and multiple sclerosis.\n<\/p>\n<p><a href=\"https:\/\/mms.businesswire.com\/media\/20220727006174\/en\/1527387\/19\/Animal_video_-_stroke_study_July_27_2022.mp4\"><img decoding=\"async\" src=\"https:\/\/mms.businesswire.com\/media\/20220727006174\/en\/1527387\/21\/Animal_video_-_stroke_study_July_27_2022.jpg\"><\/a><br \/><a href=\"https:\/\/mms.businesswire.com\/media\/20220727006174\/en\/1527369\/5\/NervGen-logo-2022_Gradient.jpg\"><img decoding=\"async\" src=\"https:\/\/mms.businesswire.com\/media\/20220727006174\/en\/1527369\/21\/NervGen-logo-2022_Gradient.jpg\"><\/a><\/p>\n<p>\n\u201cWe are very excited about the data showing significant improvement in motor function, sensory function, spatial learning, and memory, even when treatment was initiated as late as 7 days after stroke onset,\u201d stated the senior author of the paper, Dr. Agnes (Yu) Luo, Associate Professor, Department of Molecular Genetics and Biochemistry at the University of Cincinnati.\n<\/p>\n<p>\n\u201cIf these results translate to the clinic, NVG-291 would be a substantial breakthrough in the treatment of stroke patients for multiple reasons because the only current FDA-approved drug for treatment of stroke does not repair damage and must be administered within 4.5 hours of stroke onset.\u201d Dr. Luo continued, \u201cMost therapies being researched today primarily focus on reducing the early damage from stroke. However, we have shown that treatment with NVG-291-R not only results in neuroprotection to reduce neuronal death but also robust neuroreparative effects. Also, importantly, most therapies being researched need to be applied within 24 to 48 hours of a stroke\u2019s onset; in contrast, our preclinical data shows that treatment with NVG-291-R is effective even if applied as late as 7 days after the stroke\u2019s onset.\u201d\n<\/p>\n<p>\n\u201cThis is another remarkable demonstration of NVG-291\u2019s potential to repair damage to the nervous system,\u201d stated Dr. Jerry Silver, Professor of Neurosciences at CWRU\u2019s School of Medicine, co-author of the Cell Reports paper, and inventor of NervGen\u2019s technology. \u201cIn these studies, we demonstrated that NVG-291-R repaired damage using at least two modes of repair: first by substantially increasing plasticity resulting in the creation of new neuronal connections, and second by enhanced migration of newly born neurons derived from neuronal stem cells to the site of damage. NVG-291-R\u2019s ability to enhance plasticity was demonstrated by using staining techniques that clearly showed an increase in axonal sprouting to the damaged part of the brain. This enhanced plasticity is an excellent validation of the same powerful mechanisms that we and other researchers were able to demonstrate using NVG-291-R in spinal cord injury.\u201d\n<\/p>\n<p>\n\u201cThe fact that NVG-291-R showed an effect in an animal model seven days after the onset of stroke is very encouraging,\u201d stated Dr. S. Claiborne Johnston, a leading specialist in stroke care and research, formerly the inaugural Dean at Dell Medical School and now a professor in the Department of Neurology at Dell Medical School at The University of Texas at Austin. \u201cAn agent that works this late and through this mechanism could be much easier to test in trials and could ultimately help many more stroke patients than current therapies.\u201d\n<\/p>\n<p>\n\u201cMost therapies in development for stroke focus on minimizing the extent of initial damage from a stroke, which means that to be effective they must be administered within the first hours after symptom onset,\u201d continued Dr. Johnston. \u201cMost patients don\u2019t arrive soon enough to benefit from the few drugs we have, whether in current practice or those we are testing in clinical trials. A long treatment window will make recruitment easier and faster for future clinical trials.\u201d\n<\/p>\n<p>\n\u201cThis is a very important development for NervGen as, for the first time in a peer-reviewed publication, NVG-291-R demonstrated improvements in memory and spatial learning which may be relevant for other indications affecting cognition, such as Alzheimer\u2019s disease, where it might improve cognition rather than simply slowing cognitive decline,\u201d stated Paul Brennan, NervGen\u2019s President &amp; CEO. Mr. Brennan continued, \u201cWhile we remain committed to developing NVG-291 in our core indications of spinal cord injury, Alzheimer\u2019s and multiple sclerosis, this paper provides a very strong argument to undertake a stroke study with NVG-291. Given this compelling new preclinical data, we believe there is a solid opportunity to secure non-dilutive funding to advance the program through a partnership, either with industry or government.\u201d\n<\/p>\n<p>\nThe full article on the study of NVG-291-R in ischemic stroke is available online in Cell Reports in the article entitled \u201c<a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Fwww.cell.com%2Fcell-reports%2Ffulltext%2FS2211-1247%252822%252900946-9&amp;esheet=52794128&amp;newsitemid=20220727006174&amp;lan=en-US&amp;anchor=Inhibition+of+CSPG+receptor+PTP%26%23963%3B+promotes+migration+of+newly+born+neuroblasts%2C+axonal+sprouting+and+recovery+from+stroke&amp;index=3&amp;md5=c8d953c8609a1ca022a0e2a2c3584533\" rel=\"nofollow noopener\" shape=\"rect\"><i>Inhibition of CSPG receptor PTP\u03c3 promotes migration of newly born neuroblasts, axonal sprouting and recovery from stroke<\/i><\/a>\u201d.\n<\/p>\n<p>\n<b>About NervGen<\/b>\n<\/p>\n<p>\nNervGen (TSX-V: NGEN, OTCQX: NGENF) is a clinical stage biotech company dedicated to developing innovative treatments that enable the nervous system to repair itself following damage, whether due to injury or disease. NervGen\u2019s lead drug candidate, NVG-291, is currently in a Phase 1 clinical trial. The company\u2019s initial target indications are spinal cord injury, Alzheimer\u2019s disease and multiple sclerosis. For more information, go to <a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Fnervgen.com%2F&amp;esheet=52794128&amp;newsitemid=20220727006174&amp;lan=en-US&amp;anchor=www.nervgen.com&amp;index=4&amp;md5=baff81cd35d7e6dddc372406c8d2627a\" rel=\"nofollow noopener\" shape=\"rect\">www.nervgen.com<\/a>.\n<\/p>\n<p>\n<b>About NVG-291<\/b>\n<\/p>\n<p>\nNervGen holds the exclusive worldwide rights to NVG-291 and is developing a unique new class of drugs around the technology. NVG-291 is a therapeutic peptide that mimics the intracellular domain of the receptor protein tyrosine phosphatase sigma (PTP\u03c3), a cell surface receptor known to interact with chondroitin sulfate proteoglycans (CSPGs). Both PTP\u03c3 and CSPGs have been shown to inhibit neural repair mechanisms following nervous system damage. NVG-291-R, the rodent form of NVG-291, has been shown to promote functional recovery and enable nervous system repair in a range of animal models, including models of spinal cord injury, peripheral nerve injury, multiple sclerosis and stroke, through enhanced plasticity, axonal regeneration, and remyelination.\n<\/p>\n<p>\n<b>About Stroke<\/b>\n<\/p>\n<p>\nStroke is a disease that affects the blood vessels leading to and within the brain. A stroke occurs when a blood vessel that carries oxygen and nutrients to the brain is either blocked by a clot or bursts (or ruptures). When that happens, part of the brain cannot get the blood (and oxygen) it needs, such that brain cells in that area die. A stroke can cause lasting brain damage, long-term disability, or even death.\n<\/p>\n<p>\nAccording to the U.S. Center for Diseases, Control and Prevention (CDC), every year more than 795,000 people in the United States have a stroke. Approximately 610,000 of these are first or new strokes, and 185,000 strokes are in people who have had a previous stroke. Stroke is a leading cause of serious long-term disability and reduces mobility in more than half of stroke survivors aged 65 and over. Stroke-related costs in the United States came to nearly $46 billion between 2014 and 2015, which includes the cost of health care services, medicines to treat stroke, and missed days of work.\n<\/p>\n<p>\n<b><i>Neither the TSX Venture Exchange nor its Regulation Services Provider (as that term is defined in the policies of the TSX Venture Exchange) accepts responsibility for the adequacy or accuracy of this release.<\/i><\/b>\n<\/p>\n<p>\n<b>Cautionary Note Regarding Forward-Looking Statements<\/b>\n<\/p>\n<p>\nThis news release may contain \u201cforward-looking information\u201d and \u201cforward-looking statements\u201d within the meaning of applicable Canadian and United States securities legislation. Such forward-looking statements and information herein include, but are not limited to, the Company\u2019s current and future plans, expectations and intentions, results, levels of activity, performance, goals or achievements, or any other future events or developments constitute forward-looking statements, and the words \u201cmay\u201d, \u201cwill\u201d, \u201cwould\u201d, \u201cshould\u201d, \u201ccould\u201d, \u201cexpect\u201d, \u201cplan\u201d, \u201cintend\u201d, \u201ctrend\u201d, \u201cindication\u201d, \u201canticipate\u201d, \u201cbelieve\u201d, \u201cestimate\u201d, \u201cpredict\u201d, \u201clikely\u201d or \u201cpotential\u201d, or the negative or other variations of these words or other comparable words or phrases, are intended to identify forward-looking statements. Forward-looking statements include, without limitation, statements relating to: the timing, objectives and study design of the clinical development of NVG-291, including the planned Phase 2 clinical trials in multiple indications and the ongoing Phase 1 study in healthy volunteers; our development of a unique new class of drugs around the technology of NVG-291; our belief that if these results translate from animals to human trials, that NVG-291 could revolutionize clinical trials in stroke and will be a substantial breakthrough in a completely new treatment paradigm for stroke patients; the results in the stroke study are an excellent validation of the same powerful mechanisms demonstrated using NVG-291-R in spinal cord injury; the mechanism of NVG-291 could be much easier to test in trials and could ultimately help many more stroke patients than current therapies; a long treatment window will make recruitment easier and faster for future clinical trials; our belief that there is a very strong argument to undertake a Phase 2 stroke study with NVG-291 and provide a solid opportunity to seek non-dilutive funding to support our development of NVG-291 in stroke; the Phase 1 results reported to date; our confidence that the results shown in this study may be relevant for other indications that affect cognition; the timing and requirements to remove the partial clinical hold initiated by the FDA; the clinical development of NVG-291 for Alzheimer\u2019s disease, multiple sclerosis and spinal cord injury; the belief that inhibiting the activity of PTP\u03c3 is a promising target for reducing the clinical effects of nervous system damage through multiple mechanisms; the estimates of the incidence and prevalence of stroke in the United States; and the creation of innovative treatments of nervous system damage due to injury or disease.\n<\/p>\n<p>\nForward-looking statements are based on estimates and assumptions made by the Company in light of management\u2019s experience and perception of historical trends, current conditions and expected future developments, as well as other factors that we believe are appropriate and reasonable in the circumstances. In making forward-looking statements, the Company has relied on various assumptions, including, but not limited to: the Company\u2019s ability to manage the effects of the COVID-19 pandemic; the accuracy of the Company\u2019s financial projections; the Company obtaining positive results in its clinical and other trials; the Company obtaining necessary regulatory approvals; and general business, market and economic conditions.\n<\/p>\n<p>\nMany factors could cause our actual results, level of activity, performance or achievements or future events or developments to differ materially from those expressed or implied by the forward-looking statements, including without limitation, a lack of revenue, insufficient funding, the impact of the COVID-19 pandemic, reliance upon key personnel, the uncertainty of the clinical development process, competition, and other factors set forth in the \u201cRisk Factors\u201d section of the Company\u2019s Annual Information Form, Prospectus Supplement, financial statements and Management Discussion and Analysis which can be found on SEDAR.com. All clinical development plans are subject to additional funding.\n<\/p>\n<p>\nReaders should not place undue reliance on forward-looking statements made in this news release. Furthermore, unless otherwise stated, the forward-looking statements contained in this news release are made as of the date of this news release, and we have no intention and undertake no obligation to update or revise any forward-looking statements, whether as a result of new information, future events or otherwise, except as required by applicable law. The forward-looking statements contained in this news release are expressly qualified by this cautionary statement.\n<\/p>\n<p> <b>Contacts<\/b> <\/p>\n<p>\n<i>Huitt Tracey, Corporate Communications<\/i><br \/><a target=\"_blank\" href=\"mail&#116;&#111;&#58;&#104;&#116;&#114;&#97;&#x63;&#x65;&#x79;&#x40;&#x6e;&#x65;&#x72;&#x76;&#x67;en&#46;c&#111;&#109;\" rel=\"nofollow noopener\" shape=\"rect\"><i>&#x68;&#116;&#114;&#x61;&#x63;&#101;&#121;&#x40;&#x6e;&#101;&#114;&#x76;&#x67;&#101;&#110;&#x2e;&#x63;&#111;&#109;<\/i><\/a><br \/><i>604.362.6209<\/i><\/p>\n<p><i>Nancy Thompson, Vorticom Public Relations<\/i><br \/><i><a target=\"_blank\" href=\"&#109;&#x61;i&#108;&#x74;o&#58;&#x6e;a&#110;&#x63;y&#116;&#x40;&#118;&#x6f;&#x72;&#116;&#x69;&#x63;&#111;&#x6d;&#46;&#99;&#x6f;m\" rel=\"nofollow noopener\" shape=\"rect\">&#x6e;a&#x6e;c&#x79;&#116;&#x40;&#118;o&#x72;t&#x69;&#99;&#x6f;&#109;&#x2e;&#99;o&#x6d;<\/a><\/i><br \/><i>212.532.2208<\/p>\n<p><\/i><i>Follow NervGen on <a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Ftwitter.com%2FNervgenP&amp;esheet=52794128&amp;newsitemid=20220727006174&amp;lan=en-US&amp;anchor=Twitter&amp;index=5&amp;md5=67ffc078d29f363fc9be4659d30b7d96\" rel=\"nofollow noopener\" shape=\"rect\">Twitter<\/a>, <a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Fwww.linkedin.com%2Fcompany%2Fnervgen%2F&amp;esheet=52794128&amp;newsitemid=20220727006174&amp;lan=en-US&amp;anchor=LinkedIn&amp;index=6&amp;md5=a0df85fcdb22920e2a8b8bafcdb51b7e\" rel=\"nofollow noopener\" shape=\"rect\">LinkedIn<\/a>, and <a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Fwww.facebook.com%2Fnervgen&amp;esheet=52794128&amp;newsitemid=20220727006174&amp;lan=en-US&amp;anchor=Facebook&amp;index=7&amp;md5=38ffe1f4d5e260ad45c29c51d6cec402\" rel=\"nofollow noopener\" shape=\"rect\">Facebook<\/a> for the latest news on the Company.<\/i>\n<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>The independent peer-reviewed study showed improved memory as well as motor and sensory functions in rodents when treatment with NVG-291-R began 7 days after stroke onset There is currently no FDA-approved drug for the repair of damage from a stroke NVG-291, currently in a Phase 1 clinical trial in healthy human subjects, could provide a &#8230; <span class=\"more\"><a class=\"more-link\" href=\"https:\/\/pharma-trend.com\/en\/nervgen-pharmas-nvg-291-r-demonstrates-significant-functional-repair-from-a-stroke-7-days-after-onset-in-landmark-preclinical-study-by-university-of-cincinnati-and-case-western-reserve-univer\/\">[Read more&#8230;]<\/a><\/span><\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[13],"tags":[],"class_list":{"0":"entry","1":"post","2":"publish","3":"author-business","4":"post-46693","6":"format-standard","7":"category-industry"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>NervGen Pharma\u2019s NVG-291-R Demonstrates Significant Functional Repair From a Stroke 7 Days After Onset in Landmark Preclinical Study by University of Cincinnati and Case Western Reserve University - Pharma Trend<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/pharma-trend.com\/en\/nervgen-pharmas-nvg-291-r-demonstrates-significant-functional-repair-from-a-stroke-7-days-after-onset-in-landmark-preclinical-study-by-university-of-cincinnati-and-case-western-reserve-univer\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"NervGen Pharma\u2019s NVG-291-R Demonstrates Significant Functional Repair From a Stroke 7 Days After Onset in Landmark Preclinical Study by University of Cincinnati and Case Western Reserve University - Pharma Trend\" \/>\n<meta property=\"og:description\" content=\"The independent peer-reviewed study showed improved memory as well as motor and sensory functions in rodents when treatment with NVG-291-R began 7 days after stroke onset There is currently no FDA-approved drug for the repair of damage from a stroke NVG-291, currently in a Phase 1 clinical trial in healthy human subjects, could provide a ... 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