{"id":47434,"date":"2022-08-18T14:02:13","date_gmt":"2022-08-18T12:02:13","guid":{"rendered":"https:\/\/pharma-trend.com\/en\/cell-stress-and-mitochondrial-dysfunction-found-in-early-alzheimers-disease-patients-findings-published-in-science-translational-medicine\/"},"modified":"2022-08-18T14:02:13","modified_gmt":"2022-08-18T12:02:13","slug":"cell-stress-and-mitochondrial-dysfunction-found-in-early-alzheimers-disease-patients-findings-published-in-science-translational-medicine","status":"publish","type":"post","link":"https:\/\/pharma-trend.com\/en\/cell-stress-and-mitochondrial-dysfunction-found-in-early-alzheimers-disease-patients-findings-published-in-science-translational-medicine\/","title":{"rendered":"Cell Stress and Mitochondrial Dysfunction Found in Early Alzheimer\u2019s Disease Patients, Findings Published in Science Translational Medicine"},"content":{"rendered":"
\n

NEEDHAM, Mass.–(BUSINESS WIRE)–#AlzheimersDisease<\/a>—Invicro LLC<\/a> (Invicro), a global, industry-leading imaging CRO, and a subsidiary of REALM IDx, Inc.<\/a>, today announced the publication of the paper \u201cWidespread cell stress and mitochondrial dysfunction occur in patients with early Alzheimer\u2019s disease1<\/sup><\/a>\u201d in Science Translational Medicine.\n<\/p>\n

<\/a>
<\/a><\/p>\n

\nThe study provides novel in vivo<\/i> evidence for widespread, clinically relevant cellular stress and bioenergetic abnormalities in patients with early-stage Alzheimer\u2019s Disease (AD) and highlights the potential value of mitochondrial imaging in longitudinal studies of AD.\n<\/p>\n

\n\u201cInvicro\u2019s research and novel biomarkers are significant for the progression of clinical trials in AD and neurodegenerative disorders, and we are delighted to see this important work published in Science Translational Medicine,\u201d said Dr. Roger Gunn, CSO, Neuroscience, for Invicro. \u201cThis work further extends Invicro\u2019s repertoire of biomarkers for use in AD clinical trials.\u201d\n<\/p>\n

\nPosition emission tomography and magnetic resonance imaging markers were utilized to show that cell stress and impaired oxidative phosphorylation are central to mechanisms of synaptic loss and neurodegeneration in the cellular pathology of AD. Compared to controls, AD patients had widespread increases in sigma 1 receptor, along with regional decreases in mitochondrial complex I, SV2A, brain volume and cerebral blood flow. Furthermore, significant reductions in mitochondrial density were seen in AD patients over a 12\u201318-month period, indicating this biomarker may be suitable for use in early-stage trials of novel disease-modifying treatment for this devastating disease.\n<\/p>\n

\nThis study was led by Professor Paul Matthews of the UK Dementia Research Institute and Imperial College London as part of the multi-arm, pre-competitive consortium, Molecular Imaging of Neurodegenerative Disease \u2014 Mitochondria Associated Proteins and Synapses (MIND MAPS) AD cohort. The MIND MAPS consortium was developed and is headed by Dr. Eugenii Rabiner, EVP for Translational Imaging at Invicro.\n<\/p>\n

\n\u201cMIND MAPS is an important industry-academic collaboration that is bringing together experts from across the globe. It was developed with the aim of characterizing imaging biomarkers of the neurodegenerative process to address important problems in the development of novel medication for neurodegenerative disease,\u201d said Dr. Rabiner. \u201cTogether, we have shown that mitochondrial and cellular stress biomarkers open the promise of better monitoring of the therapeutic potential of these drugs.\u201d\n<\/p>\n

\nScience Translational Medicine is the leading weekly online journal publishing translational research at the intersection of science, engineering and medicine. The goal of Science Translational Medicine is to promote human health by providing a forum for communicating the latest research advances from biomedical, translational and clinical researchers from all established and emerging disciplines relevant to medicine. Science Translational Medicine published \u201cWidespread cell stress and mitochondrial dysfunction occur in patients with early Alzheimer\u2019s disease\u201d on August 17, 2022.\n<\/p>\n

    \n
  1. \n\u201cWidespread cell stress and mitochondrial dysfunction occur in patients with early Alzheimer\u2019s disease\u201d Authors: Ashwin V Venkataraman, Ayla Mansur, Gaia Rizzo, Courtney Bishop, Yvonne Lewis, Ece Kocagoncu, Anne Lingford-Hughes, Mickael Huiban, Jan Passchier, James B. Rowe, Hideo Tsukada, David J. Brooks, Laurent Martarello, Robert A. Comley, Laigao Chen, Adam J. Schwarz, Richard Hargreaves, Roger N. Gunn, Eugenii A. Rabiner, and Paul M. Matthews\n<\/li>\n<\/ol>\n

    \nAbout Invicro<\/b>\n<\/p>\n

    \nHeadquartered in Needham, MA, Invicro, a subsidiary of REALM IDx, was founded in 2008 with the mission of improving the role and function of imaging in translational drug discovery and development across all therapeutic areas. Today, Invicro\u2019s multi-disciplinary team provides solutions to pharmaceutical and biotech companies across all stages of the drug development pipeline (preclinical through Phase 0-IV), all imaging modalities and all therapeutic areas, including neurology, oncology and systemic and rare diseases. Invicro\u2019s quantitative biomarker services, advanced analytics and AI tools, and clinical operational services are backed by Invicro\u2019s industry-leading software informatics platforms, VivoQuant\u00ae<\/sup> and iPACS\u00ae<\/sup>, as well as their pioneering IQ-Analytics Platform, which includes AmyloidIQ<\/sup>, TauIQ<\/sup> and DaTIQ<\/sup>.\n<\/p>\n

    \nInvicro operates out of nine global laboratories, clinics and sites within the United States in Massachusetts, Michigan, California, Connecticut and globally in the United Kingdom, India, Japan and China. For more information visit www.invicro.com<\/a>\n<\/p>\n

    Contacts<\/b> <\/p>\n

    \nBrad Lotterman
    \n
    Communications Director
    \n
    REALM IDx
    \n
    949-401-0465
    \n
    blotterman@realmidx.com<\/a>\n<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

    NEEDHAM, Mass.–(BUSINESS WIRE)–#AlzheimersDisease—Invicro LLC (Invicro), a global, industry-leading imaging CRO, and a subsidiary of REALM IDx, Inc., today announced the publication of the paper \u201cWidespread cell stress and mitochondrial dysfunction occur in patients with early Alzheimer\u2019s disease1\u201d in Science Translational Medicine. The study provides novel in vivo evidence for widespread, clinically relevant cellular stress and … [Read more…]<\/a><\/span><\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[13],"tags":[],"class_list":{"0":"entry","1":"post","2":"publish","3":"author-business","4":"post-47434","6":"format-standard","7":"category-industry"},"yoast_head":"\nCell Stress and Mitochondrial Dysfunction Found in Early Alzheimer\u2019s Disease Patients, Findings Published in Science Translational Medicine - Pharma Trend<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/pharma-trend.com\/en\/cell-stress-and-mitochondrial-dysfunction-found-in-early-alzheimers-disease-patients-findings-published-in-science-translational-medicine\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Cell Stress and Mitochondrial Dysfunction Found in Early Alzheimer\u2019s Disease Patients, Findings Published in Science Translational Medicine - Pharma Trend\" \/>\n<meta property=\"og:description\" content=\"NEEDHAM, Mass.–(BUSINESS WIRE)–#AlzheimersDisease—Invicro LLC (Invicro), a global, industry-leading imaging CRO, and a subsidiary of REALM IDx, Inc., today announced the publication of the paper \u201cWidespread cell stress and mitochondrial dysfunction occur in patients with early Alzheimer\u2019s disease1\u201d in Science Translational Medicine. 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