{"id":47617,"date":"2022-08-24T15:01:54","date_gmt":"2022-08-24T13:01:54","guid":{"rendered":"https:\/\/pharma-trend.com\/en\/research-provides-new-insight-into-als\/"},"modified":"2022-08-24T15:01:54","modified_gmt":"2022-08-24T13:01:54","slug":"research-provides-new-insight-into-als","status":"publish","type":"post","link":"https:\/\/pharma-trend.com\/en\/research-provides-new-insight-into-als\/","title":{"rendered":"Research Provides New Insight into ALS"},"content":{"rendered":"
\n

\nTisch MS Research Center of New York identifies key protein that causes motor disability and motor neuron degeneration in sALS, paving the way for first-of-its-kind treatment target for the disease<\/i>\n<\/p>\n

NEW YORK–(BUSINESS WIRE)–The Larry G. Gluck Division of ALS Research, located at the Tisch MS Research Center of New York, has published research in Brain Communications identifying apolipoprotein B-100 (ApoB) as a key agent responsible for causing permanent motor disability, motor neuron degeneration, and other hallmark pathology in sporadic amyotrophic lateral sclerosis (sALS), a fatal neurodegenerative disease affecting 90% of ALS patients. Using an innovative experimental approach to deliver cerebrospinal fluid (CSF) from ALS patients, researchers developed a novel CSF-mediated mouse model to investigate pathophysiological mechanisms in different ALS subtypes.\n<\/p>\n

\nIn the study, researchers compared the neurotoxic capacity of CSF obtained from patients with sALS and those with the less prevalent familial ALS (fALS) with mutations in the SOD1<\/i>, C9orf72<\/i>, and TARDBP<\/i> genes. Using the mouse model to detect motor impairments and pathological changes in the spinal cord, the researchers discovered that sALS CSF was neurotoxic but fALS CSF was not. Researchers refined the list of potential neurotoxic candidates by systematically filtering out components from sALS CSF by size, then reassessing neurotoxicity of the filtered CSF in mice. Global proteome profiling of CSF helped identify ApoB as the neurotoxic protein responsible for inducing motor disability and motor neuron degeneration. The researchers showed that targeted removal of ApoB from sALS CSF via filtration or immunodepletion prevented the process of motor neuron degeneration, possibly identifying a new treatment target for ALS patients.\n<\/p>\n

\n\u201cThe impact of this research is potentially groundbreaking for patients with sporadic ALS, the predominant form of this devastating disease,\u201d said Dr. Saud A. Sadiq, Director and Chief Research Scientist at the Tisch MS Research Center of New York. \u201cFor the first time ever, our novel animal model has identified the protein responsible for causing debilitating symptoms like motor disability and motor neuron degeneration in sALS. Targeted reduction of this protein from CSF could open up a new and potentially promising avenue to treat thousands of ALS patients.\u201d\n<\/p>\n

\n\u201cWe are excited to build upon the foundation established with this novel sALS animal model, as we now have the opportunity to further investigate sALS CSF-induced pathophysiological mechanisms and test potential therapies in a sALS-specific model,\u201d added Tisch principal investigator and lead author, Dr. Jamie K. Wong. \u201cAdditionally, our team is using a CSF-induced animal model to investigate primary progressive multiple sclerosis, and this approach may potentially be useful for studying other neurodegenerative diseases as well.\u201d\n<\/p>\n

\nThis study was performed in collaboration with Dr. Merit E. Cudkowicz, the Director of the Sean M. Healey and AMG Center for ALS, Chief of Neurology at Massachusetts General Hospital, and the Julieanne Dorn Professor of Neurology at Harvard Medical school. Cerebrospinal fluid was obtained from a total of 18 ALS patients, 11 of whom had sALS and seven of whom had fALS. The patients were seen at the Sean M. Healey and AMG Center for ALS at Massachusetts General Hospital, as well as the Tisch MS Research Center of New York\u2019s Larry G. Gluck Division of ALS Research.\n<\/p>\n

\nThe full study can be accessed here<\/a> in Brain Communications.\n<\/p>\n

\nAbout the Tisch MS Research Center of New York<\/b>\n<\/p>\n

\nThe mission of the Tisch Multiple Sclerosis Research Center of New York is to conduct groundbreaking medical research to ensure unparalleled care and positive outcomes for MS patients. Its integrated relationship with the International MS Management Practice (IMSMP) accelerates the pace at which research discoveries translate from lab bench to bedside. The Center aims to identify the cause of MS, understand disease mechanisms, optimize therapies, and repair the damage caused by MS while offering patients access to the best and most advanced treatments possible.\n<\/p>\n

Contacts<\/b> <\/p>\n

\nMedia:
\n
Kerry Close
\n
kclose@groupgordon.com<\/a>
732-609-2644\n<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Tisch MS Research Center of New York identifies key protein that causes motor disability and motor neuron degeneration in sALS, paving the way for first-of-its-kind treatment target for the disease NEW YORK–(BUSINESS WIRE)–The Larry G. Gluck Division of ALS Research, located at the Tisch MS Research Center of New York, has published research in Brain … [Read more…]<\/a><\/span><\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[13],"tags":[],"class_list":{"0":"entry","1":"post","2":"publish","3":"author-business","4":"post-47617","6":"format-standard","7":"category-industry"},"yoast_head":"\nResearch Provides New Insight into ALS - Pharma Trend<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/pharma-trend.com\/en\/research-provides-new-insight-into-als\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Research Provides New Insight into ALS - Pharma Trend\" \/>\n<meta property=\"og:description\" content=\"Tisch MS Research Center of New York identifies key protein that causes motor disability and motor neuron degeneration in sALS, paving the way for first-of-its-kind treatment target for the disease NEW YORK–(BUSINESS WIRE)–The Larry G. 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