{"id":47827,"date":"2022-08-31T01:01:46","date_gmt":"2022-08-30T23:01:46","guid":{"rendered":"https:\/\/pharma-trend.com\/en\/parsemus-foundation-common-and-affordable-drug-can-drastically-reduce-covid-complications-study-shows\/"},"modified":"2022-08-31T01:01:46","modified_gmt":"2022-08-30T23:01:46","slug":"parsemus-foundation-common-and-affordable-drug-can-drastically-reduce-covid-complications-study-shows","status":"publish","type":"post","link":"https:\/\/pharma-trend.com\/en\/parsemus-foundation-common-and-affordable-drug-can-drastically-reduce-covid-complications-study-shows\/","title":{"rendered":"Parsemus Foundation: Common and Affordable Drug Can Drastically Reduce COVID Complications, Study Shows"},"content":{"rendered":"
\n

\nMetformin reduced emergency room visits, hospitalization, and death from COVID-19 by more than half if started within 4 days of symptoms<\/i>\n<\/p>\n

<\/a><\/p>\n

SAN FRANCISCO–(BUSINESS WIRE)–The widely available diabetes drug metformin reduced serious COVID outcomes by more than half if started within 4 days of symptoms, in a large, double-blind, randomized, controlled trial conducted by the University of Minnesota and published Aug. 18 in the New England Journal of Medicine<\/i>, according to the Parsemus Foundation.\n<\/p>\n

\nThe multi-site COVID-OUT study compared three medications that have been considered promising\u2014low-dose fluvoxamine, an antidepressant; ivermectin, an antiparasitic drug; and metformin, a low-cost diabetes drug. Only metformin produced statistically significant results. Metformin reduced severe outcomes (hospitalization, emergency room visits, and death) by 42% \u2013 or 55% if started within 4 days of symptoms.\n<\/p>\n

\nThe study included 1,323 individuals over 30 years old at elevated risk of severe outcomes. It was among the first randomized clinical trials for COVID-19 that included pregnant women and the first published trial that had a majority of vaccinated participants.\n<\/p>\n

\nThese metformin results compare favorably with other approved COVID treatments. For example, a recent analysis of Paxlovid in 721 vaccinated individuals indicated a reduction of hospitalization or death of 57%.\n<\/p>\n

\nThe option to use metformin to treat COVID-19 is a game-changer thanks to its low cost, wide availability, and long history of safe use. Paxlovid is not available to many patients in low-income countries, making metformin potentially their only effective option.\n<\/p>\n

\n\u201cAlthough we know COVID-19 vaccines are highly effective, we know that some new strains of the virus may evade immunity and vaccines may not be available worldwide. So we felt we should study safe, available and inexpensive outpatient treatment options as soon as possible,\u201d said Carolyn Bramante, MD, principal investigator of the study and an assistant professor of internal medicine and pediatrics at the University of Minnesota Medical School.\n<\/p>\n

\nThe primary outcome studied included whether someone had low oxygen on a home oxygen monitor, and none of the medications in the trial prevented the primary outcome. The encouraging findings regarding metformin were a secondary outcome. Unfortunately, the distinction between primary and secondary outcomes has led to some contradictory interpretations and commentary. The Parsemus Foundation is working to ensure that the good metformin results are not overlooked.\n<\/p>\n

\n\u201cWe don\u2019t have the luxury of ignoring these results,\u201d commented Elaine Lissner, founder and trustee of the Parsemus Foundation, a small California nonprofit that works on low-cost solutions neglected by the pharmaceutical industry. \u201cThis would be the first universally available treatment for COVID, giving lower-income countries a tool to combat the disproportionate impact of this disease.\u201d\n<\/p>\n

\nFor more information see: https:\/\/www.parsemus.org\/humanhealth\/covid-19\/<\/a>\n<\/p>\n

Contacts<\/b> <\/p>\n

\nLinda Brent, 415-738-2211
\n
media@parsemusfoundation.org<\/a>\n<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Metformin reduced emergency room visits, hospitalization, and death from COVID-19 by more than half if started within 4 days of symptoms SAN FRANCISCO–(BUSINESS WIRE)–The widely available diabetes drug metformin reduced serious COVID outcomes by more than half if started within 4 days of symptoms, in a large, double-blind, randomized, controlled trial conducted by the University … [Read more…]<\/a><\/span><\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[13],"tags":[],"class_list":{"0":"entry","1":"post","2":"publish","3":"author-business","4":"post-47827","6":"format-standard","7":"category-industry"},"yoast_head":"\nParsemus Foundation: Common and Affordable Drug Can Drastically Reduce COVID Complications, Study Shows - Pharma Trend<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/pharma-trend.com\/en\/parsemus-foundation-common-and-affordable-drug-can-drastically-reduce-covid-complications-study-shows\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Parsemus Foundation: Common and Affordable Drug Can Drastically Reduce COVID Complications, Study Shows - Pharma Trend\" \/>\n<meta property=\"og:description\" content=\"Metformin reduced emergency room visits, hospitalization, and death from COVID-19 by more than half if started within 4 days of symptoms SAN FRANCISCO–(BUSINESS WIRE)–The widely available diabetes drug metformin reduced serious COVID outcomes by more than half if started within 4 days of symptoms, in a large, double-blind, randomized, controlled trial conducted by the University ... 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