{"id":47842,"date":"2022-08-31T13:02:05","date_gmt":"2022-08-31T11:02:05","guid":{"rendered":"https:\/\/pharma-trend.com\/en\/iavi-announces-first-vaccinations-at-liberia-site-in-phase-i-clinical-trial-of-lassa-fever-vaccine-candidate\/"},"modified":"2022-08-31T13:02:05","modified_gmt":"2022-08-31T11:02:05","slug":"iavi-announces-first-vaccinations-at-liberia-site-in-phase-i-clinical-trial-of-lassa-fever-vaccine-candidate","status":"publish","type":"post","link":"https:\/\/pharma-trend.com\/en\/iavi-announces-first-vaccinations-at-liberia-site-in-phase-i-clinical-trial-of-lassa-fever-vaccine-candidate\/","title":{"rendered":"IAVI Announces First Vaccinations at Liberia Site in Phase I Clinical Trial of Lassa Fever Vaccine Candidate"},"content":{"rendered":"
\n

\nThe trial is designed to evaluate the candidate\u2019s safety, tolerability, and immunogenicity<\/i>\n<\/p>\n

<\/a><\/p>\n

NEW YORK–(BUSINESS WIRE)–#OutsmartEpidemics<\/a>–IAVI, a nonprofit scientific research organization, announces that volunteers at the PREVAIL clinical trial site at Redemption Hospital (RH1<\/sup>) in Monrovia, Liberia, have been vaccinated with IAVI\u2019s novel vaccine candidate against Lassa fever virus (LASV) in a Phase I clinical trial, named IAVI C102, supported by the Coalition for Epidemic Preparedness Innovations (CEPI).\n<\/p>\n

\nLASV causes significant annual outbreaks of an acute viral illness called Lassa fever<\/a>, which is endemic, or consistently present, in many parts of West Africa. Outbreaks in Guinea, Liberia, Nigeria, Sierra Leone, South Africa, and Togo have resulted in nearly 6,000 suspected cases and more than 180 deaths since early 2022, according to reports<\/a> by the World Health Organization (WHO). The WHO also reported<\/a> three recently confirmed cases of and one death from Lassa fever in the U.K. No vaccine for LASV is currently available. An estimated 300,000 to 500,000 Lassa fever cases are reported annually, resulting in approximately 5,000 deaths. However, the true disease burden is currently unknown, and efforts are ongoing to provide a more accurate estimate of disease incidence.\n<\/p>\n

\nThe IAVI-sponsored trial is part of the existing partnership with CEPI<\/a>, launched in 2018, providing up to US$61.7 million to support IAVI and a global consortium of partners to advance IAVI\u2019s LASV vaccine candidate through Phase I and II clinical trials. CEPI\u2019s ultimate goal, as part of its plan to minimize or even eliminate the risk of future epidemic and pandemic threats, is to produce a licensed Lassa vaccine for routine immunization.\n<\/p>\n

\nClinical evaluation of IAVI\u2019s LASV vaccine candidate is also supported by the Partnership for Research on Vaccines and Infectious Diseases in Liberia (PREVAIL2<\/sup>), a Liberia-U.S. clinical research collaboration established in 2014 by the U.S. National Institute of Allergy and Infectious Diseases (NIAID) and the Ministry of Health in Liberia. In 2015, PREVAIL participated in a clinical trial (PREVAIL 1<\/a>) of Merck\u2019s now-licensed Ebola Zaire vaccine ERVEBO\u00ae, which uses the same recombinant vesicular stomatitis virus (rVSV) vector backbone as the candidates in IAVI\u2019s emerging infectious diseases<\/a> (EIDs) vaccine development portfolio, including the IAVI LASV vaccine candidate being evaluated in C102. Read more: https:\/\/bit.ly\/EIDvaxFacts<\/a>.\n<\/p>\n

\n\u201cContinued Lassa fever outbreaks underscore the need to realize rapid vaccine development and plan for widespread access before and during disease outbreaks. We believe that IAVI\u2019s rVSV technology offers a promising and validated new platform for development of vaccines that target outbreak-associated pathogens like Lassa fever virus,\u201d said Swati Gupta, Dr.P.H., MPH, vice president and head of emerging infectious diseases and epidemiology, IAVI. \u201cThe experienced, broader network of collaborators in the IAVI C102 trial bring expertise in both rVSV vaccine development and in conducting clinical trials in endemic settings. Together, we\u2019ll glean important safety, tolerability, and immunogenicity data while strengthening the individuals, institutions, and technology needed to develop urgently needed Lassa fever vaccines.\u201d\n<\/p>\n

\n\u201cThe prospect of developing a vaccine that will prevent Lassa fever is a great step forward,\u201d said Mark Kieh, M.D., PREVAIL principal investigator for IAVI C102. \u201cA Lassa fever vaccine will greatly reduce the disease burden by flattening the epidemic curve of seasonal outbreaks, offering hope and relief to local populations, especially rural communities who continue to suffer the brunt of this disease.\u201d\n<\/p>\n

\nIAVI C102 (PREVAIL 12)<\/a> is designed to evaluate the vaccine candidate\u2019s safety, tolerability, and ability to elicit an immune response against Lassa fever among approximately 100 healthy adults in the U.S. and Liberia. Vaccinations have already begun at the Brigham and Women’s Hospital, East-West Medical Research Institute, and George Washington University School of Medicine and Health Sciences in the U.S. Each participant will receive at least one dose of either the study product or placebo and will be monitored for safety for up to one year following vaccination.\n<\/p>\n

\nIAVI and CEPI are united in their commitment to global equitable access to vaccines, with IAVI\u2019s LASV vaccine candidate to be accessible to all populations that need it, should it be found safe and efficacious in clinical testing. Following IAVI C102, a Phase II trial of the vaccine candidate is also planned in partnership with CEPI, with funding<\/a> already announced by CEPI and the European & Developing Countries Clinical Trials Partnership (EDCTP) for a Phase IIb trial in West Africa.\n<\/p>\n

\nTo better inform the design of future late-stage Lassa vaccine trials, CEPI has initiated Enable<\/a>, the largest-ever Lassa fever research program launched to increase knowledge of the disease burden across West Africa.\n<\/p>\n

\nCEPI\u2019s Executive Director Vaccine R&D Dr. Melanie Saville, said: \u201cThe rapid emergence of severe global outbreaks in recent years serves as a stark reminder of the disruptive power of infectious diseases. They can strike at any point and spread around the world \u2014 and the potentially deadly Lassa fever is case in point. While infections are typically reported across West Africa, the increase in global travel enabled the disease to also appear in the U.K. earlier this year. In recognition of its epidemic potential, the world urgently needs a vaccine against this worrisome threat. IAVI\u2019s exciting and important milestone, announced today, is a great step forward in this ambition, gathering critical data from Liberia, a nation already known to be affected by the disease. We look forward to seeing the trial results.\u201d\n<\/p>\n

\nMuch of the research and development on IAVI\u2019s rVSV platform is performed at the IAVI Vaccine Design and Development Lab<\/a> (DDL) in Brooklyn, New York. The DDL is located at the bioscience center in the historic Brooklyn Army Terminal. Since its founding in 2008, the IAVI DDL has become one of the world\u2019s leading viral vector vaccine research and development labs, known for innovation and generation of novel vaccine design concepts.\n<\/p>\n

\nIAVI\u2019s LASV vaccine candidate was manufactured by Batavia Biosciences<\/a> in Leiden, The Netherlands, a contract-development and manufacturing organization focused on delivering sustainable, low-cost manufacturing solutions in the field of infectious disease and cancer. Through its partnership<\/a> with Batavia, IAVI intends to develop an end-to-end platform for flexible, low-cost production of epidemic preparedness vaccines.\n<\/p>\n

\nScientists with IAVI\u2019s Human Immunology Laboratory<\/a> at Imperial College London validated the key laboratory tests, or assays, needed to measure immune responses in IAVI C102 and conducted technology transfer of these assays to scientists at RH. Additional critical assay work will be conducted by Scripps Research; Tulane University; Viral Hemorrhagic Fever Consortium; The Ragon Institute of MGH, MIT and Harvard; and the Center for Infectious Disease Research.\n<\/p>\n

\nResults from IAVI C102 are expected in 2023 and will be made available through open-access publications and via scientific meetings to ensure all can benefit from the research.\n<\/p>\n

\nAbout Lassa fever
\n
<\/b>Lassa fever is caused by Lassa fever virus, an emerging zoonotic virus that can cause a range of symptoms in humans, including hemorrhage, vomiting, swelling of the face, and pain in the chest, back, and abdomen. Lassa fever virus is most commonly transmitted to humans from an infected rodent known as the multimammate rat (Mastomys natalensis<\/i>). However, the virus can also spread from person to person via bodily fluids. LASV also has the potential to spread more widely if infected individuals travel and become ill outside the endemic region. The WHO has identified Lassa fever virus as one of the top emerging pathogens likely to cause severe outbreaks in the near future in its Research and Development Blueprint for Action to Prevent Epidemics<\/a>.\n<\/p>\n

\nAbout the rVSV\u2206G-LASV-GPC vaccine
\n
<\/b>This vaccine is based on an attenuated, or weakened, strain of vesicular stomatitis virus (VSV) that has been modified to express a Lassa fever virus protein that plays an essential role in establishing viral infection. IAVI licensed<\/a> the vaccine technology underlying rVSV\u2206G-LASV-GPC from the Public Health Agency of Canada (PHAC). rVSV\u2206G-LASV-GPC is based on an rVSV vector and was developed by scientists at PHAC\u2019s National Microbiology Laboratory.\n<\/p>\n

\nAbout CEPI
\n
<\/b>CEPI is an innovative partnership between public, private, philanthropic, and civil organisations, launched at Davos in 2017, to develop vaccines against future epidemics. Prior to COVID-19, CEPI\u2019s work focused on developing vaccines against Ebola virus, Lassa virus, Middle East Respiratory Syndrome coronavirus, Nipah virus, Rift Valley Fever virus and Chikungunya virus \u2014 it has over 20 vaccine candidates against these pathogens in development. CEPI has also invested in new platform technologies for rapid vaccine development against unknown pathogens (Disease X).\n<\/p>\n

\nDuring the current pandemic, CEPI initiated multiple programmes to develop vaccines against SARS-CoV-2 and its variants with a focus on speed, scale and access. These programmes leverage the rapid response platforms developed by CEPI\u2019s partners prior to the emergence of COVID-19 as well as new collaborations. The aim is to advance clinical development of a diverse portfolio of safe and effective COVID-19 candidates and to enable fair allocation to these vaccines worldwide through COVAX.\n<\/p>\n

\nCEPI\u2019s 5-year plan lays out a $3.5 billion roadmap to compress vaccine development timelines to 100 days, develop a universal vaccine against COVID-19 and other Betacoronaviruses<\/i>, and create a \u201clibrary\u201d of vaccine candidates for use against known and unknown pathogens. The plan is available at endpandemics.cepi.net<\/a>.\n<\/p>\n

\nFollow our news page<\/a> for the latest updates. Follow us @CEPIvaccines<\/a>, @DrRHatchett<\/a>, and LinkedIn<\/a>.\n<\/p>\n

\nAbout IAVI
\n
<\/b>IAVI is a nonprofit scientific research organization dedicated to addressing urgent, unmet global health challenges including HIV, tuberculosis, and emerging infectious diseases. Its mission is to translate scientific discoveries into affordable, globally accessible public health solutions. Read more at iavi.org<\/a>.\n<\/p>\n

\nIAVI initially used rVSV vector technology for HIV vaccine development and now leverages the technology beyond HIV, including for rVSV\u2206G-LASV-GPC development. Funders who have made the development of the rVSV vector possible include the Bill & Melinda Gates Foundation; the Government of Canada; the Danish Ministry of Foreign Affairs; the Government of Japan, in partnership with the World Bank; the Irish Department of Foreign Affairs and Trade; the Netherlands Ministry of Foreign Affairs; the Norwegian Agency for Development Cooperation; the U.K Department for International Development; the U.S. National Institutes of Health (NIH); and through the generous support of the American people from the United States Agency for International Development (USAID).\n<\/p>\n

\nFollow IAVI on Twitter<\/a>, Facebook<\/a>, LinkedIn<\/a>, Instagram<\/a>, and YouTube<\/a>, and subscribe<\/a> to our news updates.\n<\/p>\n

\nAbout PREVAIL
\n
<\/b>The Partnership for Research on Vaccines and Infectious Diseases in Liberia (PREVAIL) is a joint Liberia-United States biomedical research program internationally recognized for impacting health care delivery. PREVAIL’s mission is to conduct collaborative biomedical and public health research in accordance with best practices, to advance science, strengthen health policy and practice, and improve the health of Liberians and people worldwide.\n<\/p>\n

\n1<\/sup> RH is part of the National Public Health Institute of Liberia (NPHIL). NPHIL was created in response to the Ebola epidemic in West Africa in 2014-2016. Some of the key goals of the NPHIL include disease surveillance and response and improving epidemic preparedness.
\n
2<\/sup> The Liberian Ministry of Health and the U.S. Department of Health and Human Services (through the National Institute of Allergy and Infectious Diseases) agreed to establish PREVAIL in 2014 to conduct clinical research on Ebola therapeutics and vaccines. PREVAIL has since expanded to address other diseases of public health importance in Liberia.\n<\/p>\n

Contacts<\/b> <\/p>\n

\nMedia:<\/b>\n<\/p>\n

\nC<\/b>EPI
\n
<\/b>press@cepi.net<\/a>
+44 7387 055214\n<\/p>\n

\nIAVI<\/b>
Rose Catlos
\n
+1 212 847 1049
\n
RCatlos@iavi.org<\/a>\n<\/p>\n

\nPREVAIL<\/b>
Joseph Boye Cooper
\n
T: +231 770.951200
\n
Jcooper@prevailcr.org<\/a>\n<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

The trial is designed to evaluate the candidate\u2019s safety, tolerability, and immunogenicity NEW YORK–(BUSINESS WIRE)–#OutsmartEpidemics–IAVI, a nonprofit scientific research organization, announces that volunteers at the PREVAIL clinical trial site at Redemption Hospital (RH1) in Monrovia, Liberia, have been vaccinated with IAVI\u2019s novel vaccine candidate against Lassa fever virus (LASV) in a Phase I clinical trial, … [Read more…]<\/a><\/span><\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[13],"tags":[],"class_list":{"0":"entry","1":"post","2":"publish","3":"author-business","4":"post-47842","6":"format-standard","7":"category-industry"},"yoast_head":"\nIAVI Announces First Vaccinations at Liberia Site in Phase I Clinical Trial of Lassa Fever Vaccine Candidate - Pharma Trend<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/pharma-trend.com\/en\/iavi-announces-first-vaccinations-at-liberia-site-in-phase-i-clinical-trial-of-lassa-fever-vaccine-candidate\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"IAVI Announces First Vaccinations at Liberia Site in Phase I Clinical Trial of Lassa Fever Vaccine Candidate - Pharma Trend\" \/>\n<meta property=\"og:description\" content=\"The trial is designed to evaluate the candidate\u2019s safety, tolerability, and immunogenicity NEW YORK–(BUSINESS WIRE)–#OutsmartEpidemics–IAVI, a nonprofit scientific research organization, announces that volunteers at the PREVAIL clinical trial site at Redemption Hospital (RH1) in Monrovia, Liberia, have been vaccinated with IAVI\u2019s novel vaccine candidate against Lassa fever virus (LASV) in a Phase I clinical trial, ... [Read more...]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/pharma-trend.com\/en\/iavi-announces-first-vaccinations-at-liberia-site-in-phase-i-clinical-trial-of-lassa-fever-vaccine-candidate\/\" \/>\n<meta property=\"og:site_name\" content=\"Pharma Trend\" \/>\n<meta property=\"article:published_time\" content=\"2022-08-31T11:02:05+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/mms.businesswire.com\/media\/20220831005145\/en\/811577\/21\/IAVI-logo-blue-USE-ON-WHITE-BACKGROUND-ONLY.jpg\" \/>\n<meta name=\"author\" content=\"Business Wire\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Business Wire\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"9 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/pharma-trend.com\\\/en\\\/iavi-announces-first-vaccinations-at-liberia-site-in-phase-i-clinical-trial-of-lassa-fever-vaccine-candidate\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/pharma-trend.com\\\/en\\\/iavi-announces-first-vaccinations-at-liberia-site-in-phase-i-clinical-trial-of-lassa-fever-vaccine-candidate\\\/\"},\"author\":{\"name\":\"Business Wire\",\"@id\":\"https:\\\/\\\/pharma-trend.com\\\/en\\\/#\\\/schema\\\/person\\\/02d41342c7a74fa7f0032bb35ef0bb24\"},\"headline\":\"IAVI Announces First Vaccinations at Liberia Site in Phase I Clinical Trial of Lassa Fever Vaccine Candidate\",\"datePublished\":\"2022-08-31T11:02:05+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/pharma-trend.com\\\/en\\\/iavi-announces-first-vaccinations-at-liberia-site-in-phase-i-clinical-trial-of-lassa-fever-vaccine-candidate\\\/\"},\"wordCount\":1894,\"publisher\":{\"@id\":\"https:\\\/\\\/pharma-trend.com\\\/en\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/pharma-trend.com\\\/en\\\/iavi-announces-first-vaccinations-at-liberia-site-in-phase-i-clinical-trial-of-lassa-fever-vaccine-candidate\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/mms.businesswire.com\\\/media\\\/20220831005145\\\/en\\\/811577\\\/21\\\/IAVI-logo-blue-USE-ON-WHITE-BACKGROUND-ONLY.jpg\",\"articleSection\":[\"Industry\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/pharma-trend.com\\\/en\\\/iavi-announces-first-vaccinations-at-liberia-site-in-phase-i-clinical-trial-of-lassa-fever-vaccine-candidate\\\/\",\"url\":\"https:\\\/\\\/pharma-trend.com\\\/en\\\/iavi-announces-first-vaccinations-at-liberia-site-in-phase-i-clinical-trial-of-lassa-fever-vaccine-candidate\\\/\",\"name\":\"IAVI Announces First Vaccinations at Liberia Site in Phase I Clinical Trial of Lassa Fever Vaccine Candidate - Pharma Trend\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/pharma-trend.com\\\/en\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/pharma-trend.com\\\/en\\\/iavi-announces-first-vaccinations-at-liberia-site-in-phase-i-clinical-trial-of-lassa-fever-vaccine-candidate\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/pharma-trend.com\\\/en\\\/iavi-announces-first-vaccinations-at-liberia-site-in-phase-i-clinical-trial-of-lassa-fever-vaccine-candidate\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/mms.businesswire.com\\\/media\\\/20220831005145\\\/en\\\/811577\\\/21\\\/IAVI-logo-blue-USE-ON-WHITE-BACKGROUND-ONLY.jpg\",\"datePublished\":\"2022-08-31T11:02:05+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/pharma-trend.com\\\/en\\\/iavi-announces-first-vaccinations-at-liberia-site-in-phase-i-clinical-trial-of-lassa-fever-vaccine-candidate\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/pharma-trend.com\\\/en\\\/iavi-announces-first-vaccinations-at-liberia-site-in-phase-i-clinical-trial-of-lassa-fever-vaccine-candidate\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/pharma-trend.com\\\/en\\\/iavi-announces-first-vaccinations-at-liberia-site-in-phase-i-clinical-trial-of-lassa-fever-vaccine-candidate\\\/#primaryimage\",\"url\":\"https:\\\/\\\/mms.businesswire.com\\\/media\\\/20220831005145\\\/en\\\/811577\\\/21\\\/IAVI-logo-blue-USE-ON-WHITE-BACKGROUND-ONLY.jpg\",\"contentUrl\":\"https:\\\/\\\/mms.businesswire.com\\\/media\\\/20220831005145\\\/en\\\/811577\\\/21\\\/IAVI-logo-blue-USE-ON-WHITE-BACKGROUND-ONLY.jpg\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/pharma-trend.com\\\/en\\\/iavi-announces-first-vaccinations-at-liberia-site-in-phase-i-clinical-trial-of-lassa-fever-vaccine-candidate\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Startseite\",\"item\":\"https:\\\/\\\/pharma-trend.com\\\/en\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"IAVI Announces First Vaccinations at Liberia Site in Phase I Clinical Trial of Lassa Fever Vaccine Candidate\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/pharma-trend.com\\\/en\\\/#website\",\"url\":\"https:\\\/\\\/pharma-trend.com\\\/en\\\/\",\"name\":\"Pharma Trend\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\\\/\\\/pharma-trend.com\\\/en\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/pharma-trend.com\\\/en\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/pharma-trend.com\\\/en\\\/#organization\",\"name\":\"Pharma Trend\",\"url\":\"https:\\\/\\\/pharma-trend.com\\\/en\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/pharma-trend.com\\\/en\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"\",\"contentUrl\":\"\",\"caption\":\"Pharma Trend\"},\"image\":{\"@id\":\"https:\\\/\\\/pharma-trend.com\\\/en\\\/#\\\/schema\\\/logo\\\/image\\\/\"}},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/pharma-trend.com\\\/en\\\/#\\\/schema\\\/person\\\/02d41342c7a74fa7f0032bb35ef0bb24\",\"name\":\"Business Wire\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"IAVI Announces First Vaccinations at Liberia Site in Phase I Clinical Trial of Lassa Fever Vaccine Candidate - Pharma Trend","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/pharma-trend.com\/en\/iavi-announces-first-vaccinations-at-liberia-site-in-phase-i-clinical-trial-of-lassa-fever-vaccine-candidate\/","og_locale":"en_US","og_type":"article","og_title":"IAVI Announces First Vaccinations at Liberia Site in Phase I Clinical Trial of Lassa Fever Vaccine Candidate - Pharma Trend","og_description":"The trial is designed to evaluate the candidate\u2019s safety, tolerability, and immunogenicity NEW YORK–(BUSINESS WIRE)–#OutsmartEpidemics–IAVI, a nonprofit scientific research organization, announces that volunteers at the PREVAIL clinical trial site at Redemption Hospital (RH1) in Monrovia, Liberia, have been vaccinated with IAVI\u2019s novel vaccine candidate against Lassa fever virus (LASV) in a Phase I clinical trial, ... [Read more...]","og_url":"https:\/\/pharma-trend.com\/en\/iavi-announces-first-vaccinations-at-liberia-site-in-phase-i-clinical-trial-of-lassa-fever-vaccine-candidate\/","og_site_name":"Pharma Trend","article_published_time":"2022-08-31T11:02:05+00:00","og_image":[{"url":"https:\/\/mms.businesswire.com\/media\/20220831005145\/en\/811577\/21\/IAVI-logo-blue-USE-ON-WHITE-BACKGROUND-ONLY.jpg","type":"","width":"","height":""}],"author":"Business Wire","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Business Wire","Est. reading time":"9 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/pharma-trend.com\/en\/iavi-announces-first-vaccinations-at-liberia-site-in-phase-i-clinical-trial-of-lassa-fever-vaccine-candidate\/#article","isPartOf":{"@id":"https:\/\/pharma-trend.com\/en\/iavi-announces-first-vaccinations-at-liberia-site-in-phase-i-clinical-trial-of-lassa-fever-vaccine-candidate\/"},"author":{"name":"Business Wire","@id":"https:\/\/pharma-trend.com\/en\/#\/schema\/person\/02d41342c7a74fa7f0032bb35ef0bb24"},"headline":"IAVI Announces First Vaccinations at Liberia Site in Phase I Clinical Trial of Lassa Fever Vaccine Candidate","datePublished":"2022-08-31T11:02:05+00:00","mainEntityOfPage":{"@id":"https:\/\/pharma-trend.com\/en\/iavi-announces-first-vaccinations-at-liberia-site-in-phase-i-clinical-trial-of-lassa-fever-vaccine-candidate\/"},"wordCount":1894,"publisher":{"@id":"https:\/\/pharma-trend.com\/en\/#organization"},"image":{"@id":"https:\/\/pharma-trend.com\/en\/iavi-announces-first-vaccinations-at-liberia-site-in-phase-i-clinical-trial-of-lassa-fever-vaccine-candidate\/#primaryimage"},"thumbnailUrl":"https:\/\/mms.businesswire.com\/media\/20220831005145\/en\/811577\/21\/IAVI-logo-blue-USE-ON-WHITE-BACKGROUND-ONLY.jpg","articleSection":["Industry"],"inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/pharma-trend.com\/en\/iavi-announces-first-vaccinations-at-liberia-site-in-phase-i-clinical-trial-of-lassa-fever-vaccine-candidate\/","url":"https:\/\/pharma-trend.com\/en\/iavi-announces-first-vaccinations-at-liberia-site-in-phase-i-clinical-trial-of-lassa-fever-vaccine-candidate\/","name":"IAVI Announces First Vaccinations at Liberia Site in Phase I Clinical Trial of Lassa Fever Vaccine Candidate - Pharma Trend","isPartOf":{"@id":"https:\/\/pharma-trend.com\/en\/#website"},"primaryImageOfPage":{"@id":"https:\/\/pharma-trend.com\/en\/iavi-announces-first-vaccinations-at-liberia-site-in-phase-i-clinical-trial-of-lassa-fever-vaccine-candidate\/#primaryimage"},"image":{"@id":"https:\/\/pharma-trend.com\/en\/iavi-announces-first-vaccinations-at-liberia-site-in-phase-i-clinical-trial-of-lassa-fever-vaccine-candidate\/#primaryimage"},"thumbnailUrl":"https:\/\/mms.businesswire.com\/media\/20220831005145\/en\/811577\/21\/IAVI-logo-blue-USE-ON-WHITE-BACKGROUND-ONLY.jpg","datePublished":"2022-08-31T11:02:05+00:00","breadcrumb":{"@id":"https:\/\/pharma-trend.com\/en\/iavi-announces-first-vaccinations-at-liberia-site-in-phase-i-clinical-trial-of-lassa-fever-vaccine-candidate\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/pharma-trend.com\/en\/iavi-announces-first-vaccinations-at-liberia-site-in-phase-i-clinical-trial-of-lassa-fever-vaccine-candidate\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/pharma-trend.com\/en\/iavi-announces-first-vaccinations-at-liberia-site-in-phase-i-clinical-trial-of-lassa-fever-vaccine-candidate\/#primaryimage","url":"https:\/\/mms.businesswire.com\/media\/20220831005145\/en\/811577\/21\/IAVI-logo-blue-USE-ON-WHITE-BACKGROUND-ONLY.jpg","contentUrl":"https:\/\/mms.businesswire.com\/media\/20220831005145\/en\/811577\/21\/IAVI-logo-blue-USE-ON-WHITE-BACKGROUND-ONLY.jpg"},{"@type":"BreadcrumbList","@id":"https:\/\/pharma-trend.com\/en\/iavi-announces-first-vaccinations-at-liberia-site-in-phase-i-clinical-trial-of-lassa-fever-vaccine-candidate\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Startseite","item":"https:\/\/pharma-trend.com\/en\/"},{"@type":"ListItem","position":2,"name":"IAVI Announces First Vaccinations at Liberia Site in Phase I Clinical Trial of Lassa Fever Vaccine Candidate"}]},{"@type":"WebSite","@id":"https:\/\/pharma-trend.com\/en\/#website","url":"https:\/\/pharma-trend.com\/en\/","name":"Pharma Trend","description":"","publisher":{"@id":"https:\/\/pharma-trend.com\/en\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/pharma-trend.com\/en\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/pharma-trend.com\/en\/#organization","name":"Pharma Trend","url":"https:\/\/pharma-trend.com\/en\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/pharma-trend.com\/en\/#\/schema\/logo\/image\/","url":"","contentUrl":"","caption":"Pharma Trend"},"image":{"@id":"https:\/\/pharma-trend.com\/en\/#\/schema\/logo\/image\/"}},{"@type":"Person","@id":"https:\/\/pharma-trend.com\/en\/#\/schema\/person\/02d41342c7a74fa7f0032bb35ef0bb24","name":"Business Wire"}]}},"_links":{"self":[{"href":"https:\/\/pharma-trend.com\/en\/wp-json\/wp\/v2\/posts\/47842","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pharma-trend.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pharma-trend.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pharma-trend.com\/en\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/pharma-trend.com\/en\/wp-json\/wp\/v2\/comments?post=47842"}],"version-history":[{"count":0,"href":"https:\/\/pharma-trend.com\/en\/wp-json\/wp\/v2\/posts\/47842\/revisions"}],"wp:attachment":[{"href":"https:\/\/pharma-trend.com\/en\/wp-json\/wp\/v2\/media?parent=47842"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pharma-trend.com\/en\/wp-json\/wp\/v2\/categories?post=47842"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pharma-trend.com\/en\/wp-json\/wp\/v2\/tags?post=47842"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}