{"id":47880,"date":"2022-09-01T11:01:43","date_gmt":"2022-09-01T09:01:43","guid":{"rendered":"https:\/\/pharma-trend.com\/en\/avacta-announces-phase-i-clinical-study-of-ava6000-to-advance-to-the-fourth-cohort\/"},"modified":"2022-09-01T11:01:43","modified_gmt":"2022-09-01T09:01:43","slug":"avacta-announces-phase-i-clinical-study-of-ava6000-to-advance-to-the-fourth-cohort","status":"publish","type":"post","link":"https:\/\/pharma-trend.com\/en\/avacta-announces-phase-i-clinical-study-of-ava6000-to-advance-to-the-fourth-cohort\/","title":{"rendered":"Avacta Announces Phase I Clinical Study of AVA6000 to Advance to the Fourth Cohort"},"content":{"rendered":"
\n

LONDON & WETHERBY, England–(BUSINESS WIRE)–Avacta Group plc (AIM: AVCT), a clinical stage oncology drug company and developer of powerful diagnostics based on its innovative Affimer\u00ae<\/sup> and pre|CISION\u2122 platforms, announces that the first-in-human Phase I trial (ALS-6000-101) of AVA6000 Pro-doxorubicin will advance to the fourth dose cohort of patients following a positive review of the safety and tolerability data from the dosing of the third cohort.\n<\/p>\n

<\/a><\/p>\n

\nAvacta\u2019s Safety Data Monitoring Committee (SDMC), comprised of clinicians currently recruiting patients, has completed its review of the safety data from the third cohort dosed with AVA6000 at 160mg\/m2 in the ongoing Phase I trial. Following this review, the SDMC has recommended that the clinical trial continues as planned and escalates to the next dose of AVA6000 at 200mg\/m2.\n<\/p>\n

\nAVA6000 is a novel form of doxorubicin that has been modified with Avacta\u2019s pre|CISION\u2122 FAP-activated delivery platform to improve its safety and therapeutic index. AVA6000 has been designed to limit cell penetration of the drug, and therefore its cell killing effect, until it is specifically activated by fibroblast activation protein \u03b1 (FAP) which is in high concentration in many solid tumours compared with healthy tissues. The resulting reduced exposure of healthy tissues to active doxorubicin has the potential to significantly increase its therapeutic index by reducing the incidence of adverse effects, including cardiotoxicity and myelosuppression. Anthracyclines such as doxorubicin, a generic chemotherapeutic agent, with a market size that is expected to grow to $1.38bn by 20241<\/sup>, are widely used as part of standard of care in several tumour types, but its use is limited by cumulative dose toxicity associated with cardiomyopathy.\n<\/p>\n

\nDr Alastair Smith, Chief Executive Officer of Avacta, commented:<\/b> \u201cWe are very much encouraged by this recommendation from the SDMC to move onto the fourth dose cohort in our ongoing ALS-6000-101 Phase 1 dose escalation study. This very positive progress reflects the safety profile and tolerability demonstrated in patients enrolled in the study to date.\u201d<\/i>\n<\/p>\n

\n1. Press Release: Doxorubicin Market Size is Expected to Reach $1.38 Billion by 2024: Grand View Research, Inc.<\/a> (23 November 2016)\n<\/p>\n

Contacts<\/b> <\/p>\n

\nZyme Communications
\n
Lily Jeffery
\n
lily.jeffery@zymecommunications.com<\/a>
+44 (0)7891 477 378\n<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

LONDON & WETHERBY, England–(BUSINESS WIRE)–Avacta Group plc (AIM: AVCT), a clinical stage oncology drug company and developer of powerful diagnostics based on its innovative Affimer\u00ae and pre|CISION\u2122 platforms, announces that the first-in-human Phase I trial (ALS-6000-101) of AVA6000 Pro-doxorubicin will advance to the fourth dose cohort of patients following a positive review of the safety … [Read more…]<\/a><\/span><\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[13],"tags":[],"class_list":{"0":"entry","1":"post","2":"publish","3":"author-business","4":"post-47880","6":"format-standard","7":"category-industry"},"yoast_head":"\nAvacta Announces Phase I Clinical Study of AVA6000 to Advance to the Fourth Cohort - Pharma Trend<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/pharma-trend.com\/en\/avacta-announces-phase-i-clinical-study-of-ava6000-to-advance-to-the-fourth-cohort\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Avacta Announces Phase I Clinical Study of AVA6000 to Advance to the Fourth Cohort - Pharma Trend\" \/>\n<meta property=\"og:description\" content=\"LONDON & WETHERBY, England–(BUSINESS WIRE)–Avacta Group plc (AIM: AVCT), a clinical stage oncology drug company and developer of powerful diagnostics based on its innovative Affimer\u00ae and pre|CISION\u2122 platforms, announces that the first-in-human Phase I trial (ALS-6000-101) of AVA6000 Pro-doxorubicin will advance to the fourth dose cohort of patients following a positive review of the safety ... 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