{"id":48019,"date":"2022-09-06T18:02:00","date_gmt":"2022-09-06T16:02:00","guid":{"rendered":"https:\/\/pharma-trend.com\/en\/scallop-derived-plasmalogens-enhance-memory-and-learning-in-mice-the-mechanism-elucidated\/"},"modified":"2022-09-06T18:02:00","modified_gmt":"2022-09-06T16:02:00","slug":"scallop-derived-plasmalogens-enhance-memory-and-learning-in-mice-the-mechanism-elucidated","status":"publish","type":"post","link":"https:\/\/pharma-trend.com\/en\/scallop-derived-plasmalogens-enhance-memory-and-learning-in-mice-the-mechanism-elucidated\/","title":{"rendered":"Scallop-derived Plasmalogens Enhance Memory and Learning in Mice: the Mechanism Elucidated"},"content":{"rendered":"
\n

FUKUOKA, Japan–(BUSINESS WIRE)–The Japanese Plasmalogen Society (Office: Higashi-ku, Fukuoka, Japan; President: Yutaka Oomura) announced the research results that scallop-derived plasmalogens enhanced memory and learning with the elucidation of its underlying mechanism.\n<\/p>\n

<\/a><\/p>\n

\nPlasmalogens, a class of phospholipids, are abundant in brain, heart, skeletal muscle and immune cells. They can be extracted from various animals including scallops, chickens and sea squirts. Of particular note is that scallop-derived plasmalogens abundantly contain DHA-rich plasmalogens, thereby having higher functionality.\n<\/p>\n

\nKey findings are as follows:\n<\/p>\n

    \n
  1. \nOral administration of scallop-derived plasmalogens increased hippocampal plasmalogens and thus enhanced memory and learning in mice, which was proved by the Morris Water Maze Test (a test of spatial learning) and the Novel Object Recognition Test (a test of recognition memory).<\/b>\n<\/li>\n
  2. \nReduction of hippocampal plasmalogens promoted learning and memory loss along with a decrease in memory-related gene expression.<\/b>\n<\/li>\n
  3. \nScallop-derived plasmalogens increased BDNF (an important regulator of neural development, maintenance and function) expression through the activation of ERK and Akt proteins (memory-related signals).<\/b>\n<\/li>\n
  4. \nScallop-derived plasmalogens increased hippocampal neurons in mice, which means there has occurred neurogenesis.<\/b>\n<\/li>\n<\/ol>\n

    \nAll these findings show that plasmalogens in the brain activate hippocampal neurons, and thus enhance memory.\n<\/p>\n

    \nThe research team led by Dr. Takehiko Fujino, Professor emeritus of Kyushu University, previously reported* that oral ingestion of scallop-derived plasmalogens improved cognitive function in patients with mild-to-severe Alzheimer\u2019s disease or mild cognitive impairment. This study has elucidated the mechanism underlying the effect of scallop-derived plasmalogens on memory and learning.\n<\/p>\n

    \nThe findings were published in Frontiers in Cell and Developmental Biology, a leading, open-access, peer-reviewed scientific journal (Impact Factor 6.081).\n<\/p>\n

    \nArticle Title:\u00a0<\/b>Plasmalogens, the Vinyl Ether-Linked Glycerophospholipids, Enhance Learning and Memory by Regulating Brain-Derived Neurotrophic Factor
    \n
    https:\/\/www.frontiersin.org\/articles\/10.3389\/fcell.2022.828282\/full<\/a>\n<\/p>\n

    \n* Fujino T et al. Efficacy and Blood Plasmalogen Changes by Oral Administration of Plasmalogen in Patients with Mild Alzheimer’s Disease and Mild Cognitive Impairment: A Multicenter, Randomized, Double-blind, Placebo-controlled Trial. EBioMedicine 2017; 17:199-205. https:\/\/www.thelancet.com\/journals\/ebiom\/article\/PIIS2352-3964(17)30071-3\/fulltext<\/a>
    Fujino T et al. Effects of Plasmalogen on Patients with Mild Cognitive Impairment: A Randomized, Placebo-Controlled Trial in Japan. J Alzheimers Dis Parkinsonism 2018; 8:419.     https:\/\/www.omicsonline.org\/open-access\/effects-of-plasmalogen-on-patients-with-mild-cognitive-impairment-a-randomized-placebocontrolled-trial-in-japan-2161-0460-1000419-97982.html<\/a>
    Fujino T et al. Effects of Plasmalogen on Patients with Moderate-to-Severe Alzheimer\u2019s Disease and Blood Plasmalogen Changes: A Multi-Center, Open-Label Study. J Alzheimers Dis Parkinsonism 2019; 9:474.     https:\/\/www.omicsonline.org\/open-access\/effects-of-plasmalogen-on-patients-with-moderatetosevere-alzheimers-disease-and-blood-plasmalogen-changes-a-multicenter-openlabel-109356.html<\/a>\n<\/p>\n

    \nFor more details, please visit https:\/\/pls.jp\/wp-content\/uploads\/PressRelease202209.pdf<\/a>.\n<\/p>\n

    Contacts<\/b> <\/p>\n

    \nNaoe Hiraishi
    \n
    The Japanese Plasmalogen Society
    \n
    info@pls.jp<\/a>
    +81 92 273 2411\n<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

    FUKUOKA, Japan–(BUSINESS WIRE)–The Japanese Plasmalogen Society (Office: Higashi-ku, Fukuoka, Japan; President: Yutaka Oomura) announced the research results that scallop-derived plasmalogens enhanced memory and learning with the elucidation of its underlying mechanism. Plasmalogens, a class of phospholipids, are abundant in brain, heart, skeletal muscle and immune cells. They can be extracted from various animals including scallops, … [Read more…]<\/a><\/span><\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[13],"tags":[],"class_list":{"0":"entry","1":"post","2":"publish","3":"author-business","4":"post-48019","6":"format-standard","7":"category-industry"},"yoast_head":"\nScallop-derived Plasmalogens Enhance Memory and Learning in Mice: the Mechanism Elucidated - Pharma Trend<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/pharma-trend.com\/en\/scallop-derived-plasmalogens-enhance-memory-and-learning-in-mice-the-mechanism-elucidated\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Scallop-derived Plasmalogens Enhance Memory and Learning in Mice: the Mechanism Elucidated - Pharma Trend\" \/>\n<meta property=\"og:description\" content=\"FUKUOKA, Japan–(BUSINESS WIRE)–The Japanese Plasmalogen Society (Office: Higashi-ku, Fukuoka, Japan; President: Yutaka Oomura) announced the research results that scallop-derived plasmalogens enhanced memory and learning with the elucidation of its underlying mechanism. 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