{"id":48969,"date":"2022-09-29T14:02:05","date_gmt":"2022-09-29T12:02:05","guid":{"rendered":"https:\/\/pharma-trend.com\/en\/meliora-therapeutics-raises-11m-seed-financing-to-develop-first-mechanism-of-action-atlas-in-oncology\/"},"modified":"2022-09-29T14:02:05","modified_gmt":"2022-09-29T12:02:05","slug":"meliora-therapeutics-raises-11m-seed-financing-to-develop-first-mechanism-of-action-atlas-in-oncology","status":"publish","type":"post","link":"https:\/\/pharma-trend.com\/en\/meliora-therapeutics-raises-11m-seed-financing-to-develop-first-mechanism-of-action-atlas-in-oncology\/","title":{"rendered":"Meliora Therapeutics Raises $11M Seed Financing to Develop First Mechanism Of Action Atlas in Oncology"},"content":{"rendered":"
\n

MENLO PARK, Calif.–(BUSINESS WIRE)–#MOA<\/a>—Meliora Therapeutics<\/a>, a biotech company pioneering a machine learning-driven platform to decipher oncology drugs\u2019 true mechanisms-of-action, announced today the close of an $11M seed financing round led by HOF Capital and ZhenFund, with participation from Obvious Ventures, Village Global, BrightEdge (the impact investment arm of the American Cancer Society), Pebblebed (fund of Keith Adams, former Chief Architect at Slack), Axial, Olive Capital, and prominent individual investors Michael Polansky (co-founder of Parker Institute for Cancer Immunotherapy and ArsenalBio), Wes Sterman (founding investor for Gilead), and others.\n<\/p>\n

<\/a><\/p>\n

\nFounded in September 2021, Meliora\u2019s computational platform enables researchers to develop a precise understanding of a drug\u2019s true mechanism of action (MOA) based on data and not guesswork. The company aims to improve the current success rate of oncology drugs in development by building the industry\u2019s first atlas of drug mechanisms and their impact on cancer biology through the use of machine learning. The founding team includes David Li, CEO & Co-Founder, Jason Sheltzer, Ph.D., Scientific Co-Founder and Joan Smith, Technical Co-Founder.\n<\/p>\n

\nOut of all the areas of medicine, clinical trials in oncology have the absolute lowest success rate\u20143%.<\/a> One reason for the high failure rate is that many cancer drugs in development have an incorrect characterization of their mechanism of action, according to a paper<\/a> published by Meliora co-founder Jason Sheltzer, Ph.D., in Science Translational Medicine<\/i>.\n<\/p>\n

\n\u201cModern cancer drug development is often not mechanism driven, leading to clinical development failures down the line. Meliora is using a novel molecular fingerprint matching method to determine the true mechanism of action of precision cancer therapies,\u201d said David Li, CEO & Co-Founder, Meliora Therapeutics. \u201cBy using machine learning to connect MOA with specific therapeutic molecules, we will increase the overall probability of success. We\u2019re thrilled to have the support of this top-tier investor syndicate, and the funds will be used to expand our team and accelerate development of our proprietary computational platform.\u201d\n<\/p>\n

\n“We believe AI will bring revolutionary changes to the drug discovery industry, and are impressed by Meliora’s approach to develop a mechanism fingerprint atlas. We are glad to have the opportunity to partner with the amazing team at Meliora,\u201d said Anna Fang, CEO and founding partner at ZhenFund.\n<\/p>\n

\n\u201cMeliora\u2019s computational platform allows companies to identify the true mechanism of action in small molecule compounds, and uncover mischaracterized compounds in the process,\u201d said Jason Sheltzer, Ph.D., Co-Founder, Meliora Therapeutics. \u201cBy expanding the therapeutic window of these molecules with known safety profiles, the Meliora team has built a flywheel of precision medicine oncology assets with a higher potential for clinical success by understanding how the drug really works.\u201d\n<\/p>\n

\n\u201cWe are excited about Meliora’s machine-learning-based approach to mechanism-driven drug discovery. We believe that their novel approach will be a game-changer in the oncology drug development space,” said Fady Yacoub, Co-Founder, Managing Partner at HOF Capital.\n<\/p>\n

\n\u201cWith better knowledge of a drug\u2019s unique mechanism, scientists can improve drug discovery and increase the success rate of precision therapies in oncology. Additionally companies may also find new vulnerabilities in cancer cells to target or new ways to identify patients who are most likely to respond to a particular targeted therapy. We believe Meliora’s novel approach will be highly impactful in the oncology drug development space,\u201d said Michael Polansky, co-founder of Parker Institute for Cancer Immunotherapy and ArsenalBio.\n<\/p>\n

\nAlice Pomponio, Managing Director of BrightEdge, the impact investment arm of the American Cancer Society (ACS) said, \u201cWe celebrate the achievements of our ACS grantees and now, through BrightEdge, we are deepening our innovation acceleration capabilities that enable scientific founders like Dr. Jason Sheltzer to translate their research into emerging biotech companies that accelerate ACS\u2019s mission to defeat cancer and advance health equity.\u201d\n<\/p>\n

\nThe seed funding will be used to expand Meliora\u2019s computational platform, which includes building a proprietary data moat and selecting mischaracterized scaffolds as strong starting points for its lead precision therapeutic programs. The company has already built a computational prototype which identifies the correct mechanism of action (MOA) for small molecule drugs and generated in-vitro wet lab data for dozens of compounds computationally identified as having an alternate mechanism of action, with many of these compounds generating strong potency against the in silico predicted target. The funding will also be used to expand the team, operations, and build industry partnerships.\n<\/p>\n

\nAbout Meliora Therapeutics<\/b>\n<\/p>\n

\nMeliora is reimagining modern cancer drug development by putting genomics and cutting-edge computational approaches as first class principles of product development. The company has developed “molecular fingerprints” for tens of thousands of compounds in order to build an inference engine that identifies risk-adjusted small molecule compound and target mechanism of action (MOA) pairs. This proprietary discovery engine converts the existing world of optimized chemistry into an asset generating flywheel with high potential for clinical success. The company is headquartered in Menlo Park, CA. For more information, visit www.melioratx.com<\/a>.\n<\/p>\n

Contacts<\/b> <\/p>\n

\nMedia<\/b>
Kimberly Ha
\n
KKH Advisors
\n
917-291-5744
\n
kimberly.ha@kkhadvisors.com<\/a>\n<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

MENLO PARK, Calif.–(BUSINESS WIRE)–#MOA—Meliora Therapeutics, a biotech company pioneering a machine learning-driven platform to decipher oncology drugs\u2019 true mechanisms-of-action, announced today the close of an $11M seed financing round led by HOF Capital and ZhenFund, with participation from Obvious Ventures, Village Global, BrightEdge (the impact investment arm of the American Cancer Society), Pebblebed (fund of … [Read more…]<\/a><\/span><\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[13],"tags":[],"class_list":{"0":"entry","1":"post","2":"publish","3":"author-business","4":"post-48969","6":"format-standard","7":"category-industry"},"yoast_head":"\nMeliora Therapeutics Raises $11M Seed Financing to Develop First Mechanism Of Action Atlas in Oncology - Pharma Trend<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/pharma-trend.com\/en\/meliora-therapeutics-raises-11m-seed-financing-to-develop-first-mechanism-of-action-atlas-in-oncology\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Meliora Therapeutics Raises $11M Seed Financing to Develop First Mechanism Of Action Atlas in Oncology - Pharma Trend\" \/>\n<meta property=\"og:description\" content=\"MENLO PARK, Calif.–(BUSINESS WIRE)–#MOA—Meliora Therapeutics, a biotech company pioneering a machine learning-driven platform to decipher oncology drugs\u2019 true mechanisms-of-action, announced today the close of an $11M seed financing round led by HOF Capital and ZhenFund, with participation from Obvious Ventures, Village Global, BrightEdge (the impact investment arm of the American Cancer Society), Pebblebed (fund of ... 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