{"id":49069,"date":"2022-10-03T12:03:11","date_gmt":"2022-10-03T10:03:11","guid":{"rendered":"https:\/\/pharma-trend.com\/en\/incyte-announces-agreement-to-acquire-medicxi-backed-villaris-therapeutics-and-auremolimab-vm6-an-anti-il-15r%ce%b2-monoclonal-antibody\/"},"modified":"2022-10-03T12:03:11","modified_gmt":"2022-10-03T10:03:11","slug":"incyte-announces-agreement-to-acquire-medicxi-backed-villaris-therapeutics-and-auremolimab-vm6-an-anti-il-15r%ce%b2-monoclonal-antibody","status":"publish","type":"post","link":"https:\/\/pharma-trend.com\/en\/incyte-announces-agreement-to-acquire-medicxi-backed-villaris-therapeutics-and-auremolimab-vm6-an-anti-il-15r%ce%b2-monoclonal-antibody\/","title":{"rendered":"Incyte Announces Agreement to Acquire Medicxi-backed Villaris Therapeutics and Auremolimab (VM6), an Anti-IL-15R\u03b2 Monoclonal Antibody"},"content":{"rendered":"
\n

\n\u2013 Villaris shareholders to receive upfront payment of $70 million, with potential for up to $1.36 billion in additional milestone payments<\/i>\n<\/p>\n

\n\u2013 Pre-clinical data for auremolimab demonstrate high potency, selectivity and efficacy in vitiligo<\/i>\n<\/p>\n

\n\u2013 Acquisition will complement Incyte\u2019s existing Inflammation and AutoImmunity portfolio with potential applications for auremolimab beyond Dermatology<\/i>\n<\/p>\n

WILMINGTON, Del.–(BUSINESS WIRE)–$INCY<\/a>–Incyte (NASDAQ:INCY) today announced that the Company has entered into an agreement to acquire Villaris Therapeutics, an asset-centric biopharmaceutical company seeded by Medicxi and focused on the development of novel antibody therapeutics for vitiligo. Its lead asset, auremolimab (VM6), an anti-IL-15R\u03b2 monoclonal antibody (mAb), is expected to enter clinical development in 2023.\n<\/p>\n

<\/a><\/p>\n

\nUnder the terms of the agreement, Incyte will acquire Villaris and the exclusive global rights to develop and commercialize auremolimab for all uses, including in vitiligo and other autoimmune and inflammatory diseases. Incyte will make an upfront payment of $70 million, and Villaris shareholders will be eligible for up to $310 million upon achievement of certain development and regulatory milestones, as well as up to an additional $1.05 billion in commercial milestones on net sales of the product.\n<\/p>\n

\n\u201cThis acquisition complements our current portfolio, providing us the opportunity to further enhance treatment options for people with vitiligo, leveraging the expertise we established in the Dermatology space through our successful launch of Opzelura\u2122 (ruxolitinib) Cream,\u201d said Herv\u00e9 Hoppenot, Chief Executive Officer, Incyte. \u201cPeople living with immune-mediated dermatologic diseases like vitiligo face significant challenges and we are committed to developing novel therapies like auremolimab, which may address these unmet needs.\u201d\u3000\n<\/p>\n

\nJohn E. Harris, M.D., Ph.D., Professor and Chair of Dermatology at the University of Massachusetts Chan Medical School and Founder of Villaris, commented, \u201cI am really excited by the potential for auremolimab to treat vitiligo and other diseases with significant unmet need, and to see that it will now be driven forward with the capabilities and resources of Incyte. Back in 2019, I was very pleased to partner with Mich\u00e8le Ollier and the Medicxi team to create Villaris as a single-purpose, asset-centric company with a laser focus on developing auremolimab for people with vitiligo who are in desperate need of better treatments. This next phase of development with Incyte will help to make that a reality.\u201d\n<\/p>\n

\n\u201cOur mission at Medicxi is to partner with world-class innovators like John Harris, who are developing novel treatments for major unmet needs,\u201d said Nick Williams, Partner at Medicxi. \u201cAuremolimab has the potential to transform the lives of people living with vitiligo, and we are extremely excited to be partnering with Incyte, a pioneering company in this indication with the capabilities to explore the broader potential of auremolimab.\u201d\n<\/p>\n

\nThe agreement is subject to clearance by the U.S. antitrust authorities under the Hart-Scott-Rodino Act and will become effective as soon as this condition has been met.\n<\/p>\n

\nPJT Partners advised Villaris on the transaction.\n<\/p>\n

\nAbout Auremolimab<\/b>\n<\/p>\n

\nAuremolimab (VM6) is a novel, ultra-humanized, anti-IL-15R\u03b2 (CD122) antibody designed to target and deplete autoreactive resident memory T cells (TRM<\/sub>) that has demonstrated efficacy as a treatment for vitiligo in preclinical models. IND-enabling studies are currently underway, and clinical development is expected to begin in 2023.\n<\/p>\n

\nAbout Incyte Dermatology<\/b>\n<\/p>\n

\nIncyte\u2019s science-first approach and expertise in immunology has formed the foundation of the company. In Dermatology, the Company\u2019s research and development efforts are focused on leveraging our knowledge of the JAK-STAT pathway to identify and develop topical and oral therapies with the potential to modulate immune pathways driving uncontrolled inflammation and help restore normal immune function.\n<\/p>\n

\nCurrently, Incyte is exploring the potential of JAK inhibition for additional immune-mediated dermatologic conditions with a high unmet medical need, including hidradenitis suppurativa. To learn more, visit the Dermatology section of Incyte.com<\/a>.\n<\/p>\n

\nAbout Incyte<\/b>\n<\/p>\n

\nIncyte is a Wilmington, Delaware-based, global biopharmaceutical company focused on finding solutions for serious unmet medical needs through the discovery, development and commercialization of proprietary therapeutics. For additional information on Incyte, please visit Incyte.com<\/a> and follow @Incyte<\/a>.\n<\/p>\n

\nAbout Villaris<\/b>\n<\/p>\n

\nBased in Cary, North Carolina, Villaris was founded in 2019 by Medicxi and John Harris, M.D., Ph.D. to develop a potentially transformational new treatment to improve the lives of people living with vitiligo. Villaris is a paradigmatic example of Medicxi\u2019s asset-centric development model, which combines world-class insights and experience with capital and expertise to fully power the program from its initial design to its improvement through ultra-humanization.\n<\/p>\n

\nAbout Medicxi<\/b>\n<\/p>\n

\nMedicxi is a healthcare-focused investment firm with the mission to create and invest in companies across the full drug development continuum. Medicxi invests in early and late-stage therapeutics with a product vision that can fulfill a clear unmet medical need. Many of its portfolio companies have been acquired including: Impact Biomedicines (acquired by Celgene); XO1 (acquired by Janssen Pharmaceuticals); SynthorX (acquired by Sanofi); Miro Bio (acquired by Gilead); and PanGenetics (acquired by Abbott). Several portfolio companies are now publicly listed, including: GenMab (Copenhagen: GEN.CO); Molecular Partners (SIX: MOLN); Vaxcyte (NASDAQ: PCVX); Aura Biosciences (NASDAQ: AURA); and Centessa Pharmaceuticals (NASDAQ: CNTA). For more information, please visit: https:\/\/www.medicxi.com<\/a>.\n<\/p>\n

\nIncyte Forward-Looking Statements<\/b>\n<\/p>\n

\nExcept for the historical information set forth herein, the matters set forth in this press release, including statements regarding whether and when auremolimab will be approved for use; whether and when Incyte will bring auremolimab to market; the potential of auremolimab to treat patients with vitiligo or for any other indication; the potential for Villaris and its shareholders to receive payments from Incyte for development, regulatory and commercial milestones; and the potential for Incyte to broaden its ability to bring new medicines to patients, contain predictions, estimates and other forward-looking statements.\n<\/p>\n

\nThese forward-looking statements are based on the Company’s current expectations and are subject to risks and uncertainties that may cause actual results to differ materially, including unanticipated developments in and risks related to: unanticipated delays; further research and development and the results of clinical trials possibly being unsuccessful or insufficient to meet applicable regulatory standards or warrant continued development; the ability to enroll sufficient numbers of subjects in clinical trials; the effects of the COVID-19 pandemic and measures to address the pandemic on the Company\u2019s clinical trials, supply chain, other third-party providers and development and discovery operations; determinations made by regulatory authorities; the Company\u2019s dependence on its relationships with its collaboration partners; the efficacy or safety of the Company\u2019s products and the products of the Company\u2019s collaboration partners; the acceptance of the Company\u2019s products and the products of the Company\u2019s collaboration partners in the marketplace; market competition; sales, marketing, manufacturing and distribution requirements; and other risks detailed from time to time in the Company\u2019s reports filed with the Securities and Exchange Commission, including its annual report and its quarterly report on Form 10-Q for the quarter ended June 30, 2022. The Company disclaims any intent or obligation to update these forward-looking statements.\n<\/p>\n

Contacts<\/b> <\/p>\n

\nIncyte:<\/span><\/b>\n<\/p>\n

\nM<\/b>edia<\/b>
Catalina Loveman
\n
+1 302 498 6171
\n
cloveman@incyte.com<\/a>\n<\/p>\n

\nInvestors<\/b>
Christine Chiou
\n
+1 302 274 4773
\n
cchiou@incyte.com<\/a>\n<\/p>\n

\nMedicxi:<\/span><\/b>\n<\/p>\n

\nO<\/b>ptimum Strategic Communications<\/b>
Mary Clark\/Nick Bastin\/Manel Mateus
\n
+44 (0) 20 8148 3040
\n
medicxi@optimumcomms.com<\/a>\n<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

\u2013 Villaris shareholders to receive upfront payment of $70 million, with potential for up to $1.36 billion in additional milestone payments \u2013 Pre-clinical data for auremolimab demonstrate high potency, selectivity and efficacy in vitiligo \u2013 Acquisition will complement Incyte\u2019s existing Inflammation and AutoImmunity portfolio with potential applications for auremolimab beyond Dermatology WILMINGTON, Del.–(BUSINESS WIRE)–$INCY–Incyte (NASDAQ:INCY) … [Read more…]<\/a><\/span><\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[13],"tags":[],"class_list":{"0":"entry","1":"post","2":"publish","3":"author-business","4":"post-49069","6":"format-standard","7":"category-industry"},"yoast_head":"\nIncyte Announces Agreement to Acquire Medicxi-backed Villaris Therapeutics and Auremolimab (VM6), an Anti-IL-15R\u03b2 Monoclonal Antibody - Pharma Trend<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/pharma-trend.com\/en\/incyte-announces-agreement-to-acquire-medicxi-backed-villaris-therapeutics-and-auremolimab-vm6-an-anti-il-15r\u03b2-monoclonal-antibody\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Incyte Announces Agreement to Acquire Medicxi-backed Villaris Therapeutics and Auremolimab (VM6), an Anti-IL-15R\u03b2 Monoclonal Antibody - Pharma Trend\" \/>\n<meta property=\"og:description\" content=\"\u2013 Villaris shareholders to receive upfront payment of $70 million, with potential for up to $1.36 billion in additional milestone payments \u2013 Pre-clinical data for auremolimab demonstrate high potency, selectivity and efficacy in vitiligo \u2013 Acquisition will complement Incyte\u2019s existing Inflammation and AutoImmunity portfolio with potential applications for auremolimab beyond Dermatology WILMINGTON, Del.–(BUSINESS WIRE)–$INCY–Incyte (NASDAQ:INCY) ... 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