{"id":49187,"date":"2022-10-05T15:01:43","date_gmt":"2022-10-05T13:01:43","guid":{"rendered":"https:\/\/pharma-trend.com\/en\/high-frequency-electrical-stimulation-helps-reduce-inflammation-pain-in-new-feinstein-institutes-study\/"},"modified":"2022-10-05T15:01:43","modified_gmt":"2022-10-05T13:01:43","slug":"high-frequency-electrical-stimulation-helps-reduce-inflammation-pain-in-new-feinstein-institutes-study","status":"publish","type":"post","link":"https:\/\/pharma-trend.com\/en\/high-frequency-electrical-stimulation-helps-reduce-inflammation-pain-in-new-feinstein-institutes-study\/","title":{"rendered":"High-frequency Electrical Stimulation Helps Reduce Inflammation, Pain in New Feinstein Institutes Study"},"content":{"rendered":"
\n

MANHASSET, N.Y.–(BUSINESS WIRE)–A bump, bruise or broken bone is painful. And while pain is an important defense mechanism to protect the body and promote healing, chronic pain can be debilitating. In the United States alone, 20-50 million<\/a> adults suffer from chronic pain. New research published by scientists at The Feinstein Institutes for Medical Research<\/a> in the journal Bioelectronic Medicine<\/a> <\/i>sheds light on the molecular mechanisms that occur when high-frequency electrical stimulation (HFES) is applied transcutaneously (over the skin), which reduces inflammation and pain.\n<\/p>\n

<\/a>
<\/a><\/p>\n

\nHFES therapy, like TrueRelief\u2019s\u00ae device, which received U.S. Food and Drug Administration clearance in 2021 for acute, chronic and post-operative pain and has been shown to reduce discomfort. However, understanding the molecular reasons behind how the device works remained unknown until now. The research, led by Feinstein Institutes\u2019 Sangeeta Chavan, PhD<\/a>, showed in preclinical mice models that HFES inhibits neuroinflammatory mediator release by sensory neurons, called nociceptors, to reduce pain.\n<\/p>\n

\n\u201cFor your body to feel pain, neurons release molecules that kickstart the body\u2019s immune response causing inflammation and pain. High-frequency stimulation therapies have shown to be effective in reducing pain, but the \u2018how\u2019 it works remained in question,\u201d said Dr. Chavan, professor at the Institute of Bioelectronic Medicine<\/a> at the Feinstein Institutes. \u201cThis study reveals a previously unidentified mechanism for the pain-modulating effect of HFES, which seems to reset sensory neurons by stopping the release of neuroinflammatory molecules, resulting in less inflammation and pain.\u201d\n<\/p>\n

\nThe team uses optogenetics \u2013 light to control the activity of neurons \u2013 along with pharmacologic and injury-related activation of nociceptors measured the release of calcitonin gene related peptide (CGRP), substance P and high mobility group box 1 (HMGB1), which are pro-inflammatory molecules. The results show that HFES lessens neuroinflammatory mediator release by activated sensory neurons, which suggests that HFES could be used as a preventative therapy for those at high-risk for chronic pain.\n<\/p>\n

\n\u201cChronic pain can limit a person\u2019s daily activities and is associated with reduced work productivity, anxiety and depression, suicide and overall reduced quality of life. Beyond potentially addictive opioids, chronic pain sufferers struggle to find relief,\u201d said Huan Yang, PhD,<\/a> associate professor at the Institute of Bioelectronic Medicine at the Feinstein Institutes. \u201cWe now have a better understanding as to why high-frequency stimulation helps attenuate inflammation and associated pain.\u201d\n<\/p>\n

\n\u201cUntil now, assessment of pain has been largely subjective. We now have a quantitative biomarker that correlates directly with pain symptoms and allows us to develop more effective treatments,\u201d added Timir Datta, PhD,<\/a> assistant professor at the Institute of Bioelectronic Medicine at the Feinstein Institutes. \u201cThis inflammatory biomarker released by neurons gives us new insight into the role of neuroinflammation in chronic pain.\u201d\n<\/p>\n

\nFurther research is needed to understand better the effect HFES has on reducing pain and inflammation, including the potential for HFES to be used as an alternative for opioids. More complete evaluations on the timing (how long, how frequently), ideal waveform and determination placement of electrodes will help advance this novel technology as a viable therapy for chronic pain.\n<\/p>\n

\n\u201cThe discovery that neurons produce molecules that cause inflammation represents a major advance,\u201d said Kevin J. Tracey, MD,<\/a> president and CEO of the Feinstein Institutes, Karches Family Distinguished Chair in Medical Research and senior author on the paper. \u201cNow this exciting new work shows it is possible to stop inflammation by targeting these neurons with bioelectronic devices.\u201d\n<\/p>\n

\nDrs. Chavan and Yang continue to advance the field of bioelectronic medicine, which combines identifying molecular targets, neuroscience and bioengineering to study how to use devices to treat diseases and injury. In a 2021 study published in Proceedings of the National Academy of Sciences of the United States of America (PNAS)<\/i><\/a>, the researchers showed that nerves release a molecule, HMGB1, to produce inflammation in the body, which could lead to a new strategy to develop pharmaceutical and bioelectronic therapies. This observation has been advanced in the current study utilizing HFES to target HMGB1 released by nerves.\n<\/p>\n

\nThe research study was funded in part by TrueRelief\u00ae.\n<\/p>\n

\nAbout the Feinstein Institutes
\n
<\/i><\/b>The Feinstein Institutes for Medical Research<\/i><\/a> is the home of the research institutes <\/i>of Northwell Health, the largest health care provider and private employer in New York State.<\/i> Encompassing <\/i>50 research labs, 3,000 clinical research studies and 5,000 researchers and staff, the Feinstein Institutes raises the standard of medical innovation through its five institutes of behavioral science, bioelectronic medicine, cancer, health system science, and molecular medicine. We make breakthroughs in genetics, oncology, brain research, mental health, autoimmunity, and are the global scientific leader in bioelectronic medicine \u2013 a new field of science that has the potential to revolutionize medicine. For more information about how we produce knowledge to cure disease, visit<\/i> <\/i>http:\/\/feinstein.northwell.edu<\/i><\/a> <\/i>and follow us on<\/i> <\/i>LinkedIn<\/i><\/a>.<\/i>\n<\/p>\n

Contacts<\/b> <\/p>\n

\nMatthew Libassi
\n
631-793-5325
\n
mlibassi@northwell.edu<\/a>\n<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

MANHASSET, N.Y.–(BUSINESS WIRE)–A bump, bruise or broken bone is painful. And while pain is an important defense mechanism to protect the body and promote healing, chronic pain can be debilitating. In the United States alone, 20-50 million adults suffer from chronic pain. New research published by scientists at The Feinstein Institutes for Medical Research in … [Read more…]<\/a><\/span><\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[13],"tags":[],"class_list":{"0":"entry","1":"post","2":"publish","3":"author-business","4":"post-49187","6":"format-standard","7":"category-industry"},"yoast_head":"\nHigh-frequency Electrical Stimulation Helps Reduce Inflammation, Pain in New Feinstein Institutes Study - Pharma Trend<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/pharma-trend.com\/en\/high-frequency-electrical-stimulation-helps-reduce-inflammation-pain-in-new-feinstein-institutes-study\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"High-frequency Electrical Stimulation Helps Reduce Inflammation, Pain in New Feinstein Institutes Study - Pharma Trend\" \/>\n<meta property=\"og:description\" content=\"MANHASSET, N.Y.–(BUSINESS WIRE)–A bump, bruise or broken bone is painful. 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