{"id":49461,"date":"2022-10-11T09:01:58","date_gmt":"2022-10-11T07:01:58","guid":{"rendered":"https:\/\/pharma-trend.com\/en\/oni-and-the-university-of-pennsylvania-start-research-collaboration-to-identify-unique-biomarkers-and-characteristics-to-guide-next-generation-car-t-development\/"},"modified":"2022-10-11T09:01:58","modified_gmt":"2022-10-11T07:01:58","slug":"oni-and-the-university-of-pennsylvania-start-research-collaboration-to-identify-unique-biomarkers-and-characteristics-to-guide-next-generation-car-t-development","status":"publish","type":"post","link":"https:\/\/pharma-trend.com\/en\/oni-and-the-university-of-pennsylvania-start-research-collaboration-to-identify-unique-biomarkers-and-characteristics-to-guide-next-generation-car-t-development\/","title":{"rendered":"ONI and the University of Pennsylvania Start Research Collaboration to Identify Unique Biomarkers and Characteristics to Guide Next Generation CAR-T Development"},"content":{"rendered":"
\n

\nONI\u2019s Super-resolution Nanoimager will be used to identify predictive CAR-T biomarkers and characteristics related to treatment outcomes<\/i>\n<\/p>\n

SAN DIEGO & OXFORD, England–(BUSINESS WIRE)–ONI<\/a>, a single-molecule imaging platform biotech, today announced a research collaboration with the University of Pennsylvania, one of the true pioneers of CAR-T (chimeric antigen t-cell) research and clinical trials. The collaboration aims to enhance the understanding of CAR-T therapies using super-resolution microscopy, identifying predictive biomarkers and characteristics related to CAR-T treatment efficacy and safety, with the goal of improving patient outcomes. ONI\u2019s flagship product, the Nanoimager, will allow these researchers to visualize living cells and track how single molecules interact. With a resolution down to 20 nanometres (a 10-fold improvement vs traditional microscopy), the presence and distribution of these biomarkers on CAR-T and tumor cells from patient samples can also be quantified.\n<\/p>\n

<\/a><\/p>\n

\nThe University of Pennsylvania, which includes the Center for Cellular Immunotherapies and the Abramson Cancer Center (ACC), is one of the world\u2019s leading centers in CAR-T research, having developed the first CAR-T therapy approved by the FDA. At the ACC, Marco Ruella, MD, leads a team that focuses on the study of the mechanisms of resistance to CAR-T therapy and the development of next-generation CAR-T treatments.\n<\/p>\n

\n\u201cThis important collaboration with the University of Pennsylvania and Dr. Ruella using our Nanoimager technology will leverage super-resolution imaging to help guide development of better CAR-T therapies and hopefully positively impact patients\u2019 lives in the future,\u201d said Bo Jing, CEO of ONI. \u201cThe precise data obtained from viewing living cells as they interact and the light it sheds on disease mechanisms allow enormous strides to be made in the design of novel therapeutics and diagnostics.\u201d\n<\/p>\n

\n\u201cDespite great progress, following CAR-T treatment, a subset of patients do not respond or eventually suffer relapses. Subsequently, there is significant interest in further understanding the key factors associated with outcome and toxicity after CAR-T therapy and how these observations could help guide next-generation CAR-T therapies,\u201d Dr. Ruella said. \u201cThe use of next-generation imaging technologies that can visualize the interaction between CAR-T and tumor cells could provide key insights into mechanisms of action not available with other technologies.\u201d\n<\/p>\n

\nAbout ONI<\/b>\n<\/p>\n

\nONI\u2019s mission is to accelerate scientific discovery and fight disease by enabling everyone to visualize, understand, and share the microscopic details of life. ONI\u2019s first product, the Nanoimager, is the world\u2019s first desktop, super-resolution, single-molecule imaging platform capable of visualizing and tracking individual molecules in complex systems such as nanoparticles, living cells, and tissue with 20 nm resolution. ONI was founded as a spin-out from Oxford University and has rapidly grown since its inception with offices now in San Diego, CA (HQ) and Oxford, UK. For more information, visit oni.bio<\/a> and follow ONI on Twitter @oniHQ and LinkedIn @ONI.\n<\/p>\n

Contacts<\/b> <\/p>\n

\nONI
\n
Sophia Mowla
\n
sophia@oni.bio<\/a>\n<\/p>\n

\nHalsin Partners
\n
Mike Sinclair
\n
+44 (0)7968 022075
\n
msinclair@halsin.com<\/a>\n<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

ONI\u2019s Super-resolution Nanoimager will be used to identify predictive CAR-T biomarkers and characteristics related to treatment outcomes SAN DIEGO & OXFORD, England–(BUSINESS WIRE)–ONI, a single-molecule imaging platform biotech, today announced a research collaboration with the University of Pennsylvania, one of the true pioneers of CAR-T (chimeric antigen t-cell) research and clinical trials. The collaboration aims … [Read more…]<\/a><\/span><\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[13],"tags":[],"class_list":{"0":"entry","1":"post","2":"publish","3":"author-business","4":"post-49461","6":"format-standard","7":"category-industry"},"yoast_head":"\nONI and the University of Pennsylvania Start Research Collaboration to Identify Unique Biomarkers and Characteristics to Guide Next Generation CAR-T Development - Pharma Trend<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/pharma-trend.com\/en\/oni-and-the-university-of-pennsylvania-start-research-collaboration-to-identify-unique-biomarkers-and-characteristics-to-guide-next-generation-car-t-development\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"ONI and the University of Pennsylvania Start Research Collaboration to Identify Unique Biomarkers and Characteristics to Guide Next Generation CAR-T Development - Pharma Trend\" \/>\n<meta property=\"og:description\" content=\"ONI\u2019s Super-resolution Nanoimager will be used to identify predictive CAR-T biomarkers and characteristics related to treatment outcomes SAN DIEGO & OXFORD, England–(BUSINESS WIRE)–ONI, a single-molecule imaging platform biotech, today announced a research collaboration with the University of Pennsylvania, one of the true pioneers of CAR-T (chimeric antigen t-cell) research and clinical trials. 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