{"id":49580,"date":"2022-10-13T13:01:36","date_gmt":"2022-10-13T11:01:36","guid":{"rendered":"https:\/\/pharma-trend.com\/en\/genomic-testing-cooperative-and-its-co-op-members-first-to-use-artificial-intelligence-to-distinguish-between-45-hematologic-and-solid-neoplasms-using-targeted-transcriptome\/"},"modified":"2022-10-13T13:01:36","modified_gmt":"2022-10-13T11:01:36","slug":"genomic-testing-cooperative-and-its-co-op-members-first-to-use-artificial-intelligence-to-distinguish-between-45-hematologic-and-solid-neoplasms-using-targeted-transcriptome","status":"publish","type":"post","link":"https:\/\/pharma-trend.com\/en\/genomic-testing-cooperative-and-its-co-op-members-first-to-use-artificial-intelligence-to-distinguish-between-45-hematologic-and-solid-neoplasms-using-targeted-transcriptome\/","title":{"rendered":"Genomic Testing Cooperative and its Co-Op Members First to Use Artificial Intelligence to Distinguish Between 45 Hematologic and Solid Neoplasms Using Targeted Transcriptome"},"content":{"rendered":"
\n

IRVINE, Calif.–(BUSINESS WIRE)–Genomic Testing Cooperative, LCA<\/a> (GTC) announced that its innovative artificial intelligence (AI) algorithms are now formally implemented in daily use to aid pathologists in the diagnosis and interpretation of molecular findings of genomic profiling.\n<\/p>\n

<\/a><\/p>\n

\nGTC\u2019s RNAnalysis algorithm is used to distinguish between 45 different diagnostic classes providing probability scores. This algorithm is complemented by a second algorithm called TraceWork. When needed, TraceWork is used to distinguish between two diagnostic entities determined by RNAnalysis to be of similar high probability score.\n<\/p>\n

\nResults of validation of these algorithms are now published in The American Journal of Pathology<\/i>, a part of Elsevier’s Journal Network (DOI:https:\/\/doi.org\/10.1016\/j.ajpath.2022.09.006<\/a>). <\/b><\/i>For example, independent blind testing of RNAnalysis algorithm showed correct first-choice diagnosis in 100% of acute lymphoblastic leukemia, 88% of acute myeloid leukemia, 85% of diffuse large B-cell lymphoma, 82% of colorectal cancer, 49% of lung cancer, 88% of chronic lymphocytic leukemia and 72% of follicular lymphoma. The TraceWork algorithm distinguished between lung cancer and colorectal cancer with 97.2% sensitivity and 94.5% specificity, between Hodgkin lymphoma and normal lymph node with 95.4% sensitivity and 100% specificity, between follicular lymphoma and diffuse large B-cell lymphoma with 95.9% sensitivity and 93.1% specificity, and between breast cancer and ovarian cancer with 100% sensitivity and 94.2% specificity.\n<\/p>\n

\n\u201cThe information provided by these algorithms are used in the context of clinical and other molecular and pathologic findings and not meant to replace the need for physician\u2019s clinical decision,\u201d said Dr. Maher Albitar, founder, chief medical officer, and chief executive officer of GTC. \u201cWe believe that transcriptomic data when combined with AI provides an efficient and effective information that can replace the need for large number immunohistochemical staining and flow cytometry testing, especially when tissue samples are scant,\u201d Dr. Albitar added.\n<\/p>\n

\nDr. Andre Goy, Chairman & Chief Physician Officer at John Theurer Cancer Center and Academic Chairman of Oncology at Hackensack Meridian School of Medicine, stated, \u201cPrecision diagnosis is extremely important for the practice of precision medicine. Today\u2019s RNA and DNA profiling generates big data that requires sophisticated algorithms to decipher the clinical relevance of this data. GTC\u2019s molecular profiling and algorithms had helped us resolve numerous diagnostically challenging cases and the results made a difference in patients management and outcome.\u201d\n<\/p>\n

\nDr. Aamir Ehsan, CEO\/ President, Medical Director and board-certified hematopathologist and molecular geneticist of CorePath laboratories, at San Antonio, Texas, who is a collaborator and coauthor on the published work, said, \u201cUnlike AI and imaging, transcriptomic data and AI incorporates immunohistochemistry and flow cytometry data as well as numerous additional biomarkers, but more importantly allows us to look at each biomarker individually to make the final pathologic decision. This represents major advances in the practice of pathology.\u201d\n<\/p>\n

\nIt is estimated that approximately 10% of all cancer cases are misdiagnosed and 4% of solid tumors are presented as cancer of unknown primary \u201cCUP\u201d.\n<\/p>\n

\nAbout Genomic Testing Cooperative, LCA<\/b>\n<\/p>\n

\nGenomic Testing Cooperative (GTC) is a privately-owned molecular testing company located in Irvine, CA. The company operates based on a cooperative (co-op) business model. Members of the co-op hold type A shares with voting rights. The company offers its patron members a full suite of comprehensive genomic profiling based mainly on next generation sequencing. Molecular alterations are identified based on rigorous testing with the aid of specially developed algorithms to increase accuracy and efficiency. The clinical relevance of the detected alterations is pulled from numerous databases using internally developed software. Relevance of findings to diagnosis, prognosis, selecting therapy, and predicting outcome are reported to members. The co-op model allows GTC to make the testing and information platform available to members at a lower cost because of a lower overhead. For more information, please visit https:\/\/genomictestingcooperative.com\/<\/a>.\n<\/p>\n

\nForward Looking Statements<\/b>\n<\/p>\n

\nAll of the statements, expectations and assumptions contained in this press release are forward-looking statements. Such forward-looking statements are based on the GTC management\u2019s current expectations and includes statements regarding the value of comprehensive genomic profiling, RNA profiling, DNA profiling, algorithms, therapy, the ability of testing to provide clinically useful information. All information in this press release is as of the date of the release, and GTC undertakes no duty to update this information unless required by law.\n<\/p>\n

Contacts<\/b> <\/p>\n

\nJeff Owen
\n
Genomic Testing Cooperative.
\n
(714) 271-6548
\n
jowen@genomictestingcooperative.com<\/a>\n<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

IRVINE, Calif.–(BUSINESS WIRE)–Genomic Testing Cooperative, LCA (GTC) announced that its innovative artificial intelligence (AI) algorithms are now formally implemented in daily use to aid pathologists in the diagnosis and interpretation of molecular findings of genomic profiling. GTC\u2019s RNAnalysis algorithm is used to distinguish between 45 different diagnostic classes providing probability scores. This algorithm is complemented … [Read more…]<\/a><\/span><\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[13],"tags":[],"class_list":{"0":"entry","1":"post","2":"publish","3":"author-business","4":"post-49580","6":"format-standard","7":"category-industry"},"yoast_head":"\nGenomic Testing Cooperative and its Co-Op Members First to Use Artificial Intelligence to Distinguish Between 45 Hematologic and Solid Neoplasms Using Targeted Transcriptome - Pharma Trend<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/pharma-trend.com\/en\/genomic-testing-cooperative-and-its-co-op-members-first-to-use-artificial-intelligence-to-distinguish-between-45-hematologic-and-solid-neoplasms-using-targeted-transcriptome\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Genomic Testing Cooperative and its Co-Op Members First to Use Artificial Intelligence to Distinguish Between 45 Hematologic and Solid Neoplasms Using Targeted Transcriptome - Pharma Trend\" \/>\n<meta property=\"og:description\" content=\"IRVINE, Calif.–(BUSINESS WIRE)–Genomic Testing Cooperative, LCA (GTC) announced that its innovative artificial intelligence (AI) algorithms are now formally implemented in daily use to aid pathologists in the diagnosis and interpretation of molecular findings of genomic profiling. 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