{"id":49700,"date":"2022-10-17T17:01:49","date_gmt":"2022-10-17T15:01:49","guid":{"rendered":"https:\/\/pharma-trend.com\/en\/orange-county-research-institute-enrolling-patients-in-anaheim-for-clinical-trial-of-promising-new-investigational-treatment-for-alzheimers-disease\/"},"modified":"2022-10-17T17:01:49","modified_gmt":"2022-10-17T15:01:49","slug":"orange-county-research-institute-enrolling-patients-in-anaheim-for-clinical-trial-of-promising-new-investigational-treatment-for-alzheimers-disease","status":"publish","type":"post","link":"https:\/\/pharma-trend.com\/en\/orange-county-research-institute-enrolling-patients-in-anaheim-for-clinical-trial-of-promising-new-investigational-treatment-for-alzheimers-disease\/","title":{"rendered":"Orange County Research Institute Enrolling Patients in Anaheim for Clinical Trial of Promising New Investigational Treatment for Alzheimer\u2019s Disease"},"content":{"rendered":"<div>\n<p class=\"bwalignc\">\n<i>Individuals with memory problems encouraged to learn more about study<\/i>\n<\/p>\n<p>ANAHEIM, Calif.&#8211;(BUSINESS WIRE)&#8211;Orange County Research Institute (OCRI) is initiating a clinical trial for a promising new investigational treatment for Alzheimer\u2019s disease (AD) in Anaheim.\n<\/p>\n<p><a href=\"https:\/\/mms.businesswire.com\/media\/20221017005182\/en\/1602994\/4\/Dr._Steve_Sitar.jpg\"><img decoding=\"async\" src=\"https:\/\/mms.businesswire.com\/media\/20221017005182\/en\/1602994\/21\/Dr._Steve_Sitar.jpg\"><\/a><\/p>\n<p>\nThe Phase I study will determine the safety and tolerability of a single intravenous (IV) dose and multiple IV doses of ACU193. We are asking individuals who have memory problems to consider participating in the trial to assist in evaluating this medication for the treatment of Alzheimer\u2019s disease. There is no cost to participate. <a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Facumenpharm.com%2F&amp;esheet=52945363&amp;newsitemid=20221017005182&amp;lan=en-US&amp;anchor=Acumen+Pharmaceuticals+Inc.&amp;index=1&amp;md5=c00ce1acb9ae91f2c8bd6ebf06cdb56b\" rel=\"nofollow noopener\" shape=\"rect\">Acumen Pharmaceuticals Inc.<\/a>, a clinical stage biopharmaceutical company focused on the development of novel targeted therapeutics for AD, is sponsoring the clinical trial.\n<\/p>\n<p>\nACU193 targets amyloid-beta oligomers and is a different approach to treating Alzheimer\u2019s disease than currently approved medications. ACU193 is designed to locate and bind to amyloid-beta oligomers \u2013 proteins that build up in the brain in people with Alzheimer\u2019s disease. These proteins are thought to be involved in Alzheimer\u2019s disease symptoms and progression.\n<\/p>\n<p>\nThe trial site, located at 1801 W. Romneya Dr., Suite 409, Anaheim, CA 92801, is led by principal investigator Dr. Steve Sitar at OCRI.<strong> <\/strong>Patients who believe they qualify for the study are asked to call Cassandra at (714) 635-7100 or email <a target=\"_blank\" href=\"ma&#105;&#108;&#116;&#111;&#x3a;&#x63;&#x76;&#x61;&#x6c;de&#122;&#64;&#111;&#99;&#x72;&#x69;&#x2e;&#x75;&#x73;\" rel=\"nofollow noopener\" shape=\"rect\">&#x63;&#118;&#97;l&#x64;&#x65;&#122;&#64;&#x6f;&#x63;&#114;i&#46;&#x75;&#115;<\/a> to learn more.\n<\/p>\n<p>\n\u201cWe\u2019re excited to open this trial in Anaheim to study ACU193 for the treatment of Alzheimer\u2019s disease,\u201d Dr. Sitar said. \u201cIf you or a loved one is experiencing memory problems, contact us to find out more about the study. More than 6 million Americans are living with Alzheimer\u2019s disease. New, safe and effective treatments are needed more than ever. Participating in clinical trials is one way members of our community can help make a difference.\u201d\n<\/p>\n<p>\n<b>Key Eligibility Criteria:<\/b>\n<\/p>\n<ul class=\"bwlistdisc\">\n<li>\nAge 55 to 90 years of age.\n<\/li>\n<li>\nHave memory problems that might be a sign of mild cognitive impairment (usually mild memory loss) or mild dementia. The underlying cause of these memory problems may or may not be due to Alzheimer\u2019s disease. Tests given within the study will help to determine this.\n<\/li>\n<li>\nHave a caregiver or study partner; someone who knows the participant very well, who is willing to assist with participation in the study and can attend the study visits with the participant.\n<\/li>\n<li>\nThe staff at the study center will explain the complete list of requirements.\n<\/li>\n<\/ul>\n<p>\nThis study is the first time ACU193 will be given to people. As all drugs and medical procedures carry a risk of side effects, it is possible that participants may experience some discomfort or other reactions from use of ACU193. The study staff will explain these potential risks before potential participants decide whether to participate in the study. The safety of participants will be closely monitored throughout the study.\n<\/p>\n<p>\nStudy participants will receive a full diagnostic work-up, including an amyloid PET scan and MRI that can provide a more accurate diagnosis and help guide future treatment options. After finishing this study, participants may consider participating in future studies of ACU193 in which all participants could receive ACU193 at some point in the study.\n<\/p>\n<p>\n<strong>About ACU193<\/strong>\n<\/p>\n<p>\nACU193 is a monoclonal antibody (mAb) discovered and developed based on its selectivity for soluble A\u03b2Os, which Acumen believes are the most toxic and pathogenic form of A\u03b2 relative to A\u03b2 monomers and amyloid plaques. Soluble A\u03b2Os have been observed to be potent neurotoxins that bind to neurons, inhibit synaptic function and induce neurodegeneration. By selectively targeting toxic soluble A\u03b2Os, ACU193 aims to directly address what a growing body of evidence indicates is a primary underlying cause of the neurodegenerative process in AD.\n<\/p>\n<p>\n<b>About Orange County Research Institute<\/b>\n<\/p>\n<p>\nOrange County Research Institute is a clinical research center that has been serving the community since 2011. We participated and partnered with pharmaceutical companies that led to groundbreaking research trials that have paved the way to new, safe and efficacious drugs that have introduced and improved treatment of various conditions such as Diabetes, Hypertension, Hypercholesterolemia, Chronic Low Back Pain, Osteoarthritis, Fibromyalgia, Neuropathy, Insomnia, Alzheimer\u2019s Disease and various other medical conditions. Our team is led by Dr. Steve Sitar who specializes in Internal Medicine and has served patients in Orange County for 28 years. He is affiliated with Anaheim Regional Medical Center.\n<\/p>\n<p> <b>Contacts<\/b> <\/p>\n<p>\n<strong>Media:<br \/>\n<br \/><\/strong>Recruitment Coordinator: Cassandra<br \/>\n<br \/>Phone number: 714-635-7100<br \/>\n<br \/>Email : <a target=\"_blank\" href=\"&#109;&#x61;&#x69;l&#116;&#x6f;:&#99;&#x76;a&#108;&#x64;e&#122;&#x40;&#x6f;&#99;&#x72;&#x69;&#46;&#117;&#x73;\" rel=\"nofollow noopener\" shape=\"rect\">cv&#97;&#108;&#100;&#101;&#x7a;&#x40;&#x6f;&#x63;&#x72;i&#46;&#117;&#115;<\/a><br \/>Website: <a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Fwww.orangecountyresearchinstitute.com%2F&amp;esheet=52945363&amp;newsitemid=20221017005182&amp;lan=en-US&amp;anchor=https%3A%2F%2Fwww.orangecountyresearchinstitute.com%2F&amp;index=2&amp;md5=72fad118ecfc35e68027db5dc2c4f7de\" rel=\"nofollow noopener\" shape=\"rect\">https:\/\/www.orangecountyresearchinstitute.com\/<\/a>\n<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Individuals with memory problems encouraged to learn more about study ANAHEIM, Calif.&#8211;(BUSINESS WIRE)&#8211;Orange County Research Institute (OCRI) is initiating a clinical trial for a promising new investigational treatment for Alzheimer\u2019s disease (AD) in Anaheim. The Phase I study will determine the safety and tolerability of a single intravenous (IV) dose and multiple IV doses of &#8230; <span class=\"more\"><a class=\"more-link\" href=\"https:\/\/pharma-trend.com\/en\/orange-county-research-institute-enrolling-patients-in-anaheim-for-clinical-trial-of-promising-new-investigational-treatment-for-alzheimers-disease\/\">[Read more&#8230;]<\/a><\/span><\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[13],"tags":[],"class_list":{"0":"entry","1":"post","2":"publish","3":"author-business","4":"post-49700","6":"format-standard","7":"category-industry"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Orange County Research Institute Enrolling Patients in Anaheim for Clinical Trial of Promising New Investigational Treatment for Alzheimer\u2019s Disease - Pharma Trend<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/pharma-trend.com\/en\/orange-county-research-institute-enrolling-patients-in-anaheim-for-clinical-trial-of-promising-new-investigational-treatment-for-alzheimers-disease\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Orange County Research Institute Enrolling Patients in Anaheim for Clinical Trial of Promising New Investigational Treatment for Alzheimer\u2019s Disease - Pharma Trend\" \/>\n<meta property=\"og:description\" content=\"Individuals with memory problems encouraged to learn more about study ANAHEIM, Calif.&#8211;(BUSINESS WIRE)&#8211;Orange County Research Institute (OCRI) is initiating a clinical trial for a promising new investigational treatment for Alzheimer\u2019s disease (AD) in Anaheim. 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