{"id":50187,"date":"2022-10-27T19:01:53","date_gmt":"2022-10-27T17:01:53","guid":{"rendered":"https:\/\/pharma-trend.com\/en\/bayers-kerendia-finerenone-recommended-as-part-of-comprehensive-treatment-strategy-for-chronic-kidney-disease-associated-with-type-2-diabetes-in-newly-published-clinical-recommendatio\/"},"modified":"2022-10-27T19:01:53","modified_gmt":"2022-10-27T17:01:53","slug":"bayers-kerendia-finerenone-recommended-as-part-of-comprehensive-treatment-strategy-for-chronic-kidney-disease-associated-with-type-2-diabetes-in-newly-published-clinical-recommendatio","status":"publish","type":"post","link":"https:\/\/pharma-trend.com\/en\/bayers-kerendia-finerenone-recommended-as-part-of-comprehensive-treatment-strategy-for-chronic-kidney-disease-associated-with-type-2-diabetes-in-newly-published-clinical-recommendatio\/","title":{"rendered":"Bayer\u2019s KERENDIA\u00ae (finerenone) Recommended as Part of Comprehensive Treatment Strategy for Chronic Kidney Disease Associated With Type 2 Diabetes in Newly Published Clinical Recommendations"},"content":{"rendered":"<div>\n<ul class=\"bwlistdisc\">\n<li>\nNew guidelines from Kidney Disease: Improving Global Outcomes (KDIGO) and a consensus report jointly issued from KDIGO and the American Diabetes Association (ADA) include KERENDIA as part of a comprehensive treatment strategy for patients with chronic kidney disease (CKD) associated with type 2 diabetes (T2D) who have an estimated glomerular filtration rate of <span class=\"bwuline\">&gt;<\/span>25 mL\/min\/1.73 m<sup>2<\/sup>, normal serum potassium concentration and albuminuria (urine albumin-to-creatinine ratio <span class=\"bwuline\">&gt;<\/span>30 mg\/g) despite taking a maximum tolerated dose of renin-angiotensin system inhibitor<sup>1-3<\/sup>\n<\/li>\n<li>\nKERENDIA\u2019s inclusion is supported by data from comprehensive Phase III clinical trial program (FIGARO-DKD and FIDELIO-DKD) investigating kidney and cardiovascular outcomes in more than 13,000 patients with CKD associated with T2D<sup>1-4<\/sup>\n<\/li>\n<li>\nKERENDIA\u2019s inclusion in new consensus report and updated KDIGO guideline follows additional support in ADA\u2019s Standards of Medical Care in Diabetes\u20142022 and the American Association of Clinical Endocrinology\u2019s (AACE) Developing a Diabetes Mellitus Comprehensive Care Plan guideline<sup>5,6<\/sup>\n<\/li>\n<\/ul>\n<p>WHIPPANY, N.J.&#8211;(BUSINESS WIRE)&#8211;Bayer\u2019s KERENDIA<sup>\u00ae<\/sup> (finerenone), a first-in-class, non-steroidal mineralocorticoid receptor antagonist (ns-MRA), was recommended as part of a comprehensive treatment strategy for patients with chronic kidney disease (CKD) associated with type 2 diabetes (T2D) in a newly published update to the Kidney Disease: Improving Global Outcomes (KDIGO) <a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Fkdigo.org%2Fwp-content%2Fuploads%2F2022%2F10%2FKDIGO-2022-Clinical-Practice-Guideline-for-Diabetes-Management-in-CKD.pdf&amp;esheet=52954702&amp;newsitemid=20221027005889&amp;lan=en-US&amp;anchor=Clinical+Practice+Guideline+for+Diabetes+Management+in+Chronic+Kidney+Disease&amp;index=1&amp;md5=d2d448fdb5d759ab63d6289aea56a12c\" rel=\"nofollow noopener\" shape=\"rect\">Clinical Practice Guideline for Diabetes Management in Chronic Kidney Disease<\/a> and in a <a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Fdiabetesjournals.org%2Fcare%2Farticle%2Fdoi%2F10.2337%2Fdci22-0027%2F147614%2FDiabetes-Management-in-Chronic-Kidney-Disease-A&amp;esheet=52954702&amp;newsitemid=20221027005889&amp;lan=en-US&amp;anchor=consensus+report+jointly+issued+by+KDIGO+and+the+American+Diabetes+Association+%28ADA%29&amp;index=2&amp;md5=a50fcccc1c6cc7e71dcadc025a94b7bc\" rel=\"nofollow noopener\" shape=\"rect\">consensus report jointly issued by KDIGO and the American Diabetes Association (ADA)<\/a>.<sup>1-3<\/sup>\n<\/p>\n<p><a href=\"https:\/\/mms.businesswire.com\/media\/20221027005889\/en\/1616869\/4\/Bayer_Logo.jpg\"><img decoding=\"async\" src=\"https:\/\/mms.businesswire.com\/media\/20221027005889\/en\/1616869\/21\/Bayer_Logo.jpg\"><\/a><\/p>\n<p>\nKDIGO and the ADA in their combined statement as well as KDIGO in its new clinical guidelines recommended KERENDIA\u2019s inclusion in the treatment plans of patients with CKD associated with T2D who have an estimated glomerular filtration rate (eGFR) of \u226525 mL\/min\/1.73 m<sup>2<\/sup>, normal serum potassium concentration and albuminuria (urine albumin-to-creatinine ratio [ACR] \u226530 mg\/g) despite taking a maximum tolerated dose of a renin-angiotensin system (RAS) inhibitor.<sup>1-3<\/sup>\n<\/p>\n<p>\nKERENDIA was approved by the FDA in July 2021 to reduce the risk of sustained eGFR decline, end-stage kidney disease, cardiovascular (CV) death, non-fatal myocardial infarction (MI) and hospitalization for heart failure in adult patients with CKD associated with T2D, based on the results of the FIDELIO-DKD pivotal trial.<sup>4 <\/sup>In September 2022, the FDA approved an updated label for KERENDIA to include findings from the Phase III FIGARO-DKD CV outcomes study.<sup>4<\/sup> The KERENDIA label contains a Warning and Precaution that KERENDIA can cause hyperkalemia.<sup>4<\/sup> For more information, see \u201cImportant Safety Information\u201d below.\n<\/p>\n<p>\nRecommendations in both clinical guidance documents were based on evidence from the Phase III FIDELIO-DKD and FIGARO-DKD studies as well as results from FIDELITY, the prespecified, exploratory, pooled analysis of both trials, which comprise one of the largest cardiorenal outcomes programs to investigate the occurrence of fatal and non-fatal CV events and progression of kidney disease in patients with CKD associated with T2D in more than 13,000 patients. The program investigated the impact of finerenone in adults with CKD associated with T2D across a range of disease severity (CKD stages 1-4).<sup>1-3,7<\/sup>\n<\/p>\n<p>\n\u201c<!-- no quote -->KERENDIA\u2019s inclusion in the KDIGO guideline update and ADA and KDIGO consensus report reinforces its foundational and critical role in a multi-pillar treatment strategy for patients with chronic kidney disease associated with type 2 diabetes who seek cardiorenal risk reduction and continue to struggle with persistent albuminuria despite current standard of care treatment,\u201d<sup>1-3<\/sup> said report coauthor George Bakris, Director of the Comprehensive Hypertension Center at the University of Chicago, Illinois. \u201c<!-- no quote -->It is compelling that we now have a general agreement between diabetologists and nephrologists on the use of KERENDIA as part of a treatment plan for patients with chronic kidney disease associated with type 2 diabetes.\u201d<sup>8<\/sup>\n<\/p>\n<p>\nOver the past year, KERENDIA has been included in clinical recommendations from both the ADA and<sup> <\/sup>the American Association of Clinical Endocrinology.<sup>5,6<\/sup>\n<\/p>\n<p>\n\u201c<!-- no quote -->There has been a longstanding need in the chronic kidney disease space for treatment options and multimodal approaches to patient care,\u201d said Daniel J. Wilson, M.D., FACP, FCCP, Senior Medical Director, Cardiovascular and Renal, U.S. Medical Affairs at Bayer. \u201c<!-- no quote -->Bayer is committed to delivering more treatment options to help patients with chronic kidney disease associated with type 2 diabetes make informed decisions about their health. KERENDIA\u2019s comprehensive clinical trial program, inclusive of patients comprising a range of disease severity and demonstrated evidence in providing cardiorenal risk reduction, has helped establish its place as an important piece of a comprehensive treatment paradigm for chronic kidney disease associated with type 2 diabetes.\u201d<sup>1-3<\/sup>\n<\/p>\n<p>\n<b><span class=\"bwuline\">About KDIGO Guideline Update<\/span><\/b>\n<\/p>\n<p>\nThe recently published Kidney Disease: Improving Global Outcomes (KDIGO) 2022 Clinical Practice Guideline for Diabetes Management in Chronic Kidney Disease provides evidence-based recommendations for the management of chronic kidney disease associated with diabetes.<sup>1<\/sup>\n<\/p>\n<p>\n<b><span class=\"bwuline\">About ADA and KDIGO\u2019s Consensus Report<\/span><\/b>\n<\/p>\n<p>\nA joint group of ADA and KDIGO representatives reviewed and developed a series of consensus statements to guide clinical care. With a healthy lifestyle at the core of all treatment, the report aligns clinical recommendations on CKD screening and diagnosis, glycemia monitoring, lifestyle therapies, treatment goals, and pharmacologic management.<sup>2,3<\/sup>\n<\/p>\n<p>\n<b>About KERENDIA (finerenone)<\/b>\n<\/p>\n<p>\n<b>INDICATION:<\/b>\n<\/p>\n<ul class=\"bwlistdisc\">\n<li>\nKERENDIA is indicated to reduce the risk of sustained eGFR decline, end-stage kidney disease, cardiovascular death, non-fatal myocardial infarction, and hospitalization for heart failure in adult patients with chronic kidney disease (CKD) associated with type 2 diabetes (T2D).<sup>4<\/sup>\n<\/li>\n<\/ul>\n<p>\n<b>IMPORTANT SAFETY INFORMATION<\/b>\n<\/p>\n<p>\n<b>CONTRAINDICATIONS:<\/b>\n<\/p>\n<ul class=\"bwlistdisc\">\n<li>\nConcomitant use with strong CYP3A4 inhibitors<sup>4<\/sup>\n<\/li>\n<li>\nPatients with adrenal insufficiency<sup>4<\/sup>\n<\/li>\n<\/ul>\n<p>\n<b>WARNINGS AND PRECAUTIONS:<\/b>\n<\/p>\n<ul class=\"bwlistdisc\">\n<li>\n<b><i>Hyperkalemia:<\/i><\/b> KERENDIA can cause hyperkalemia. The risk for developing hyperkalemia increases with decreasing kidney function and is greater in patients with higher baseline potassium levels or other risk factors for hyperkalemia. Measure serum potassium and eGFR in all patients before initiation of treatment with KERENDIA and dose accordingly. Do not initiate KERENDIA if serum potassium is &gt;5.0 mEq\/L.<sup>4<\/p>\n<p><\/sup>Measure serum potassium periodically during treatment with KERENDIA and adjust dose accordingly. More frequent monitoring may be necessary for patients at risk for hyperkalemia, including those on concomitant medications that impair potassium excretion or increase serum potassium.<sup>4<\/sup>\n<\/li>\n<\/ul>\n<p>\n<b>MOST COMMON ADVERSE REACTIONS:<\/b>\n<\/p>\n<ul class=\"bwlistdisc\">\n<li>\nFrom the pooled data of 2 placebo-controlled studies, the adverse reactions reported in \u22651% of patients on KERENDIA and more frequently than placebo were hyperkalemia (14% vs 6.9%), hypotension (4.6% vs 3.9%), and hyponatremia (1.3% vs 0.7%).<sup>4<\/sup>\n<\/li>\n<\/ul>\n<p>\n<b>DRUG INTERACTIONS:<\/b>\n<\/p>\n<ul class=\"bwlistdisc\">\n<li>\n<b><i>Strong CYP3A4 Inhibitors: <\/i><\/b>Concomitant use of KERENDIA with strong CYP3A4 inhibitors is contraindicated. Avoid concomitant intake of grapefruit or grapefruit juice.<sup>4<\/sup>\n<\/li>\n<li>\n<b><i>Moderate and Weak CYP3A4 Inhibitors:<\/i><\/b> Monitor serum potassium during drug initiation or dosage adjustment of either KERENDIA or the moderate or weak CYP3A4 inhibitor and adjust KERENDIA dosage as appropriate.<sup>4<\/sup>\n<\/li>\n<li>\n<b><i>Strong and Moderate CYP3A4 Inducers:<\/i><\/b><i> <\/i>Avoid concomitant use of KERENDIA with strong or moderate CYP3A4 inducers.<sup>4<\/sup>\n<\/li>\n<\/ul>\n<p>\n<b>USE IN SPECIFIC POPULATIONS:<\/b>\n<\/p>\n<ul class=\"bwlistdisc\">\n<li>\n<b><i>Lactation:<\/i><\/b> Avoid breastfeeding during treatment with KERENDIA and for 1 day after treatment.<sup>4<\/sup>\n<\/li>\n<li>\n<b><i>Hepatic Impairment: <\/i><\/b>Avoid use of KERENDIA in patients with severe hepatic impairment (Child Pugh C) and consider additional serum potassium monitoring with moderate hepatic impairment (Child Pugh B).<sup>4<\/sup>\n<\/li>\n<\/ul>\n<p>\n<b>Please read the <\/b><a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Flabeling.bayerhealthcare.com%2Fhtml%2Fproducts%2Fpi%2FKerendia_PI.pdf&amp;esheet=52954702&amp;newsitemid=20221027005889&amp;lan=en-US&amp;anchor=Prescribing+Information&amp;index=3&amp;md5=e0f83490cc59c3fa1d0414db07692f4e\" rel=\"nofollow noopener\" shape=\"rect\"><b>Prescribing Information<\/b><\/a><b> for KERENDIA.<\/b>\n<\/p>\n<p>\n<b>About Finerenone Phase III Clinical Trials Program<\/b>\n<\/p>\n<p>\nHaving randomized more than 13,000 patients with CKD associated with T2D around the world, the Phase III program with finerenone in CKD associated with T2D comprises two studies, evaluating the effect of finerenone versus placebo on top of standard of care on both renal and CV outcomes.<sup>4<\/sup>\n<\/p>\n<p>\nFIDELIO-DKD (<b><span class=\"bwuline\">FI<\/span><\/b>nerenone in reducing ki<b><span class=\"bwuline\">D<\/span><\/b>n<b><span class=\"bwuline\">E<\/span><\/b>y fai<b><span class=\"bwuline\">L<\/span><\/b>ure and d<b><span class=\"bwuline\">I<\/span><\/b>sease pr<b><span class=\"bwuline\">O<\/span><\/b>gression in <b><span class=\"bwuline\">D<\/span><\/b>iabetic <b><span class=\"bwuline\">K<\/span><\/b>idney <b><span class=\"bwuline\">D<\/span><\/b>isease) and FIGARO-DKD (<b><span class=\"bwuline\">FI<\/span><\/b>nerenone in reducin<b><span class=\"bwuline\">G<\/span><\/b> c<b><span class=\"bwuline\">A<\/span><\/b>rdiovascular mo<b><span class=\"bwuline\">R<\/span><\/b>tality and m<b><span class=\"bwuline\">O<\/span><\/b>rbidity in <b><span class=\"bwuline\">D<\/span><\/b>iabetic <b><span class=\"bwuline\">K<\/span><\/b>idney <b><span class=\"bwuline\">D<\/span><\/b>isease) studies were randomized, double-blind, placebo-controlled, multicenter studies in adult patients with chronic kidney disease (CKD) associated with type 2 diabetes (T2D).<sup>4<\/sup> In FIDELIO-DKD, patients needed to either have an UACR of 30 to &lt; 300 mg\/g, eGFR 25 to &lt; 60 mL\/min\/1.73 m<sup>2<\/sup> and diabetic retinopathy, or an UACR of \u2265 300 mg\/g and an eGFR of 25 to &lt; 75 mL\/min\/1.73 m<sup>2<\/sup> to qualify for enrollment.<sup>4<\/sup> In FIGARO-DKD, patients needed to have an UACR of 30 mg\/g to &lt; 300 mg\/g and an eGFR of 25 to 90 mL\/min\/1.73 m<sup>2<\/sup>, or an UACR \u2265 300 mg\/g and an eGFR \u2265 60 mL\/min\/1.73 m<sup>2<\/sup>.<sup>4<\/sup>\n<\/p>\n<p>\nBoth trials excluded patients with known significant non-diabetic kidney disease.<sup>4<\/sup> All patients were to have a serum potassium \u2264 4.8 mEq\/L at screening and be receiving standard of care background therapy, including a maximum tolerated labeled dose of an angiotensin-converting enzyme inhibitor (ACEi) or angiotensin receptor blocker (ARB).<sup>4<\/sup> Patients with a clinical diagnosis of chronic heart failure with reduced ejection fraction and persistent symptoms (New York Heart Association class II to IV) were excluded.<sup>4 <\/sup>The starting dose of KERENDIA was based on screening eGFR (10 mg once daily in patients with an eGFR of 25 to &lt; 60 mL\/min\/1.73 m<sup>2<\/sup> and 20 mg once daily in patients with an eGFR \u2265 60 mL\/min\/1.73 m<sup>2<\/sup>).<sup>4<\/sup> The dose of KERENDIA could be titrated during the study, with a target dose of 20 mg daily.<sup>4<\/sup>\n<\/p>\n<p>\nThe primary objective of the FIDELIO-DKD study was to determine whether KERENDIA reduced the incidence of a sustained decline in eGFR of \u2265 40%, kidney failure (defined as chronic dialysis, kidney transplantation, or a sustained decrease in eGFR to &lt; 15 mL\/min\/1.73 m<sup>2<\/sup>), or renal death.<sup>4<\/sup> The secondary outcome was a composite of time to first occurrence of CV death, non-fatal MI, non-fatal stroke or hospitalization for heart failure.<sup>4<\/sup> The primary objective of the FIGARO-DKD study was to determine whether KERENDIA reduced the time to first occurrence of CV death, non-fatal MI, non-fatal stroke or hospitalization for heart failure.<sup>4<\/sup> The secondary outcome was a composite of time to kidney failure, a sustained decline in eGFR of 40% or more compared to baseline over at least 4 weeks, or renal death.<sup>4<\/sup>\n<\/p>\n<p>\nIn FIDELIO-DKD, a total of 5674 patients were randomized to receive KERENDIA (N=2833) or placebo (N=2841) and were followed for a median of 2.6 years.<sup>4<\/sup> The mean age of the study population was 66 years, and 70% of patients were male.<sup>4 <\/sup>This global trial population was 63% White, 25% Asian, and 5% Black (24% Black in the US).<sup>4<\/sup> At baseline, the mean eGFR was 44 mL\/min\/1.73 m<sup>2<\/sup>, with 55% of patients having an eGFR &lt; 45 mL\/min\/1.73 m<sup>2<\/sup>.<sup>4<\/sup> Median urine albumin-to-creatinine ratio (UACR) was 852 mg\/g, mean glycated hemoglobin A1c (HbA1c) was 7.7%, and the mean blood pressure was 138\/76 mmHg.<sup>4<\/sup> Approximately 46% of patients had a history of atherosclerotic cardiovascular disease and 8% had a history of heart failure.<sup>4<\/sup> At baseline, 99.8% of patients were treated with an ACEi or ARB.<sup>4<\/sup> Approximately 97% were on an antidiabetic agent (insulin [64.1%], biguanides [44%], glucagon-like peptide-1 [GLP-1] receptor agonists [7%], sodium-glucose cotransporter 2 [SGLT2] inhibitors [5%]), 74% were on a statin, and 57% were on an antiplatelet agent.<sup>4<\/sup>\n<\/p>\n<p>\nIn FIGARO-DKD, a total of 7352 patients were randomized to receive KERENDIA (N=3686) or placebo (N=3666) and were followed for 3.4 years.<sup>4<\/sup> As compared to FIDELIO-DKD, baseline eGFR was higher in FIGARO-DKD (mean eGFR 68, with 62% of patients having an eGFR \u2265 60 mL\/min\/1.73 m<sup>2<\/sup>) and median UACR was lower (308 mg\/g).<sup>4<\/sup> Otherwise, baseline patient characteristics and background therapies were similar in the two trials.<sup>4<\/sup>\n<\/p>\n<p>\nIn FIDELIO-DKD, KERENDIA reduced the incidence of the primary composite endpoint of a sustained decline in eGFR of \u2265 40%, kidney failure, or renal death (HR 0.82, 95% CI 0.73-0.93, P=0.001).<sup>4<\/sup> The treatment effect reflected a reduction in a sustained decline in eGFR of \u2265 40% and progression to kidney failure.<sup>4<\/sup> There were few renal deaths during the trial.<sup>4<\/sup> KERENDIA also reduced the incidence of the secondary composite endpoint of cardiovascular (CV) death, non-fatal myocardial infarction (MI), non-fatal stroke or hospitalization for heart failure (HR 0.86, 95% CI 0.75-0.99, P=0.034).<sup>4 <\/sup>The treatment effect reflected a reduction in CV death, non-fatal MI, and hospitalization for heart failure.<sup>4<\/sup> The treatment effect on the primary and secondary composite endpoints was generally consistent across subgroups.<sup>4<\/sup>\n<\/p>\n<p>\nIn FIGARO-DKD, KERENDIA reduced the incidence of the primary composite endpoint of CV death, non-fatal MI, non-fatal stroke or hospitalization for heart failure (HR 0.87, 95% CI 0.76-0.98, P=0.026).<sup>4<\/sup> The treatment effect was mainly driven by an effect on hospitalization for heart failure, though CV death also contributed to the treatment effect.<sup>4<\/sup> The treatment effect on the primary composite endpoint was generally consistent across subgroups, including patients with and without pre-existing cardiovascular disease.<sup>4 <\/sup>The secondary composite outcome of kidney failure, sustained eGFR decline of 40% or more or renal death occurred in 350 patients (9.5%) in the finerenone group and in 395 (10.8%) in the placebo group (HR=0.87, 95% CI 0.76-1.01).<sup>4,9<\/sup>\n<\/p>\n<p>\nThe safety of KERENDIA was evaluated in 2 randomized, double-blind, placebo-controlled, multicenter pivotal phase 3 studies, FIDELIO-DKD and FIGARO-DKD, in which a total of 6510 patients were treated with 10 or 20 mg once daily over a mean duration of 2.2 and 2.9 years, respectively.<sup>4<\/sup> Overall, serious adverse events occurred in 32% of patients receiving KERENDIA and in 34% of patients receiving placebo in the FIDELIO-DKD study; the findings were similar in the FIGARO-DKD study.<sup>4<\/sup> Permanent discontinuations due to adverse events also occurred in a similar proportion of patients in the two studies (6-7% of patients receiving KERENDIA and in 5-6% of patients receiving placebo).<sup>4<\/sup> From the pooled data of 2 placebo-controlled studies, the adverse reactions reported in \u22651% of patients on KERENDIA and more frequently than placebo were hyperkalemia (14% vs 6.9%), hypotension (4.6% vs 3.9%), and hyponatremia (1.3% vs 0.7%).<sup>4 <\/sup>The most frequently reported (\u2265 10%) adverse reaction in both studies was hyperkalemia<i>.<\/i><sup>4<\/sup> Hospitalization due to hyperkalemia for the KERENDIA group was 0.9% vs 0.2% in the placebo group across both studies.<sup>4<\/sup> Hyperkalemia led to permanent discontinuation of treatment in 1.7% receiving KERENDIA versus 0.6% of patients receiving placebo across both studies.<sup>4<\/sup>\n<\/p>\n<p>\n<b>About Chronic Kidney Disease Associated With Type 2 Diabetes<\/b>\n<\/p>\n<p>\nPatients with CKD associated with T2D are three times more likely to die from a CV-related cause than those with T2D alone.<sup>10<\/sup> CKD is a serious and progressive condition that is generally underrecognized.<sup>11<\/sup> CKD is a frequent complication arising from T2D and is also an independent risk factor of CV disease.<sup>12-14 <\/sup>Approximately 40% of all patients with T2D develop CKD.<sup>14<\/sup> Despite guideline-directed therapies, patients with CKD associated with T2D remain at high risk of CKD progression and CV events.<sup>12,13,15,16<\/sup> T2D is the leading cause of end-stage kidney disease, which requires dialysis or a kidney transplant to stay alive.<sup>17-19<\/sup>\n<\/p>\n<p>\n<b>About Bayer\u2019s Commitment in Cardiovascular and Kidney Diseases<\/b>\n<\/p>\n<p>\nA leader in the CV space, Bayer upholds a long-standing commitment to delivering science for a better life by advancing innovative treatments.\n<\/p>\n<p>\nBayer\u2019s cardiorenal franchise, which began with the discovery and development of a number of vital therapies, now includes a number of products and compounds in various stages of preclinical and clinical development with the potential to impact the way that CV and kidney diseases are treated.\n<\/p>\n<p>\nBayer is focused on advancing new treatment approaches for areas of high unmet medical need in CV and kidney diseases by identifying resources and programs aimed at better understanding the real-world management of CKD, expanding screening and early care management for CKD, aligning with and supporting groups and institutions that share the common goals of improving health outcomes, promoting health literacy and education and promoting research and initiatives that represent the diversity required to address the needs of all patients.\n<\/p>\n<p>\n<b>About Bayer<\/b>\n<\/p>\n<p>\nBayer is a global enterprise with core competencies in the life science fields of health care and nutrition. Its products and services are designed to help people and the planet thrive by supporting efforts to master the major challenges presented by a growing and aging global population. Bayer is committed to drive sustainable development and generate a positive impact with its businesses. At the same time, the Group aims to increase its earning power and create value through innovation and growth. The Bayer brand stands for trust, reliability and quality throughout the world. In fiscal 2021, the Group employed around 100,000 people and had sales of 44.1 billion euros. R&amp;D expenses before special items amounted to 5.3 billion euros. For more information, go to <a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=http%3A%2F%2Fwww.bayer.com&amp;esheet=52954702&amp;newsitemid=20221027005889&amp;lan=en-US&amp;anchor=www.bayer.com&amp;index=4&amp;md5=404a95ce1855fd33fd12f8a758012af1\" rel=\"nofollow noopener\" shape=\"rect\">www.bayer.com<\/a>.\n<\/p>\n<p>\nFind more information at <a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=http%3A%2F%2Fwww.pharma.bayer.com&amp;esheet=52954702&amp;newsitemid=20221027005889&amp;lan=en-US&amp;anchor=www.pharma.bayer.com&amp;index=5&amp;md5=1e252c1d3576c0bd0fdf8f4dfd7277d7\" rel=\"nofollow noopener\" shape=\"rect\">www.pharma.bayer.com<\/a><br \/>Our online press service is just a click away: <a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=http%3A%2F%2Fwww.bayer.us%2Fen%2Fnewsroom&amp;esheet=52954702&amp;newsitemid=20221027005889&amp;lan=en-US&amp;anchor=www.bayer.us%2Fen%2Fnewsroom&amp;index=6&amp;md5=7551fdd9b2321cb1e0cc5c6ad04d99ea\" rel=\"nofollow noopener\" shape=\"rect\">www.bayer.us\/en\/newsroom<\/a><br \/>Follow us on Facebook: <a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=http%3A%2F%2Fwww.facebook.com%2Fpharma.bayer&amp;esheet=52954702&amp;newsitemid=20221027005889&amp;lan=en-US&amp;anchor=http%3A%2F%2Fwww.facebook.com%2Fpharma.bayer&amp;index=7&amp;md5=13d3f742f97727573100444832613750\" rel=\"nofollow noopener\" shape=\"rect\">http:\/\/www.facebook.com\/pharma.bayer<\/a><br \/>Follow us on Twitter: <a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Ftwitter.com%2FBayerUS&amp;esheet=52954702&amp;newsitemid=20221027005889&amp;lan=en-US&amp;anchor=https%3A%2F%2Ftwitter.com%2FBayerUS&amp;index=8&amp;md5=72467e112f014a44cd43e2b9e0ee3f2f\" rel=\"nofollow noopener\" shape=\"rect\">https:\/\/twitter.com\/BayerUS<\/a>\n<\/p>\n<p>\n<b><span class=\"bwuline\">Forward-Looking Statements<\/span><\/b>\n<\/p>\n<p>\nThis release may contain forward-looking statements based on current assumptions and forecasts made by Bayer management. Various known and unknown risks, uncertainties and other factors could lead to material differences between the actual future results, financial situation, development or performance of the company and the estimates given here. These factors include those discussed in Bayer\u2019s public reports which are available on the Bayer website at <a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=http%3A%2F%2Fwww.bayer.com&amp;esheet=52954702&amp;newsitemid=20221027005889&amp;lan=en-US&amp;anchor=www.bayer.com&amp;index=9&amp;md5=bb71f493f95cb913ad9f701d05326688\" rel=\"nofollow noopener\" shape=\"rect\">www.bayer.com<\/a>. The company assumes no liability whatsoever to update these forward-looking statements or to conform<b> <\/b>them to future events or developments.\n<\/p>\n<p>\n<span class=\"bwuline\">References<\/span>:\n<\/p>\n<ol class=\"bwlistdecimal\">\n<li>\nKDIGO 2022 clinical practice guideline for diabetes management in chronic kidney disease. <i>Kidney Int<\/i>. 2022;120(suppl 5S):S1-S127. <a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Fkdigo.org%2Fwp-content%2Fuploads%2F2022%2F10%2FKDIGO-2022-Clinical-Practice-Guideline-for-Diabetes-Management-in-CKD.pdf&amp;esheet=52954702&amp;newsitemid=20221027005889&amp;lan=en-US&amp;anchor=https%3A%2F%2Fkdigo.org%2Fwp-content%2Fuploads%2F2022%2F10%2FKDIGO-2022-Clinical-Practice-Guideline-for-Diabetes-Management-in-CKD.pdf&amp;index=10&amp;md5=84679c72668968b2877e45f0656d5779\" rel=\"nofollow noopener\" shape=\"rect\">https:\/\/kdigo.org\/wp-content\/uploads\/2022\/10\/KDIGO-2022-Clinical-Practice-Guideline-for-Diabetes-Management-in-CKD.pdf<\/a>\n<\/li>\n<li>\nde Boer IH, Khunti K, Sadusky T, et al. Diabetes management in chronic kidney disease: a consensus report by the American Diabetes Association (ADA) and Kidney Disease: Improving Global Outcomes (KDIGO). <i>Diabetes Care<\/i>. 2022:dci220027. doi:10.2337\/dci22-0027\n<\/li>\n<li>\nde Boer IH, Khunti K, Sadusky T, et al. Diabetes management in chronic kidney disease: a consensus report by the American Diabetes Association (ADA) and Kidney Disease: Improving Global Outcomes (KDIGO). <i>Kidney Int. <\/i>2022:S0085-2538(22)00634-2. doi: 10.1016\/j.kint.2022.08.012.\n<\/li>\n<li>\nKERENDIA (finerenone) [prescribing information]. Whippany, NJ: Bayer HealthCare Pharmaceuticals, Inc.; September 2022.\n<\/li>\n<li>\nADA Professional Practice Committee. Addendum. 10. Cardiovascular disease and risk management: standards of medical care in diabetes\u20142022. <i>Diabetes Care<\/i>. 2022;45(suppl 1):S144-S174<i>. <\/i>doi:10.2337\/dc22-ad08\n<\/li>\n<li>\nBlonde L, Umpierrez GE, McGill JB, et al. American Association of Clinical Endocrinology clinical practice guideline: developing a diabetes mellitus comprehensive care plan\u20142022 update. <i>Endocr Pract<\/i>. 2022;S1530-891X(22)00576-6. doi:10.1016\/j.eprac.2022.08.002\n<\/li>\n<li>\nRuilope LM, Agarwal R, Anker S, et al. Design and baseline characteristics of the finerenone in reducing cardiovascular mortality and morbidity in diabetic kidney disease trial. <i>Am J Nephrol.<\/i> 2019;50(5)345-356.\n<\/li>\n<li>\nKidney Disease: Improving Global Outcomes (KIDGO). The American Diabetes Association and Kidney Disease: Improving Global Outcomes release a consensus report on diabetes management in chronic kidney disease. Accessed October 2022. <a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Fkdigo.org%2Fnews-release-ada-kdigo-release-joint-consensus-report-on-diabetes-management-in-ckd%2F&amp;esheet=52954702&amp;newsitemid=20221027005889&amp;lan=en-US&amp;anchor=https%3A%2F%2Fkdigo.org%2Fnews-release-ada-kdigo-release-joint-consensus-report-on-diabetes-management-in-ckd%2F&amp;index=11&amp;md5=c9bab320fc0dc198e527909715c4ab00\" rel=\"nofollow noopener\" shape=\"rect\">https:\/\/kdigo.org\/news-release-ada-kdigo-release-joint-consensus-report-on-diabetes-management-in-ckd\/<\/a>\n<\/li>\n<li>\nPitt B, Filippatos G, Agarwal R, et al. Cardiovascular events with finerenone in kidney disease and type 2 diabetes. <i>N Engl J Med<\/i>. 2021;385(24):2252-2263. doi:10.1056\/NEJMoa2110956\n<\/li>\n<li>\nAfkarian M, Sachs MC, Kestenbaum B, et al. Kidney disease and increased mortality risk in type 2 diabetes. <i>J Am Soc Nephrol<\/i>. 2013;24(2):302-308.\n<\/li>\n<li>\nBreyer MD, Susztak K. Developing treatments for chronic kidney disease in the 21st century. <i>Semin Nephrol.<\/i> 2016;36(6):436-447.\n<\/li>\n<li>\nAnders HJ, Huber TB, Isermann B, et al. CKD in diabetes: diabetic kidney disease versus nondiabetic kidney disease<i>. Nat Rev Nephrol.<\/i> 2018;14:361-377.\n<\/li>\n<li>\nThomas MC, Brownlee M, Susztak K, et al. Diabetic kidney disease. <i>Nat Rev Dis Primers.<\/i> 2015;1:1-20.\n<\/li>\n<li>\nBailey RA, Wang Y, Zhu V, et al. Chronic kidney disease in US adults with type 2 diabetes: an updated national estimate of prevalence based on Kidney Disease: Improving Global Outcomes (KDIGO) staging. <i>BMC Res Notes.<\/i> 2014;7(1):415. doi:10.1186\/1756-0500-7-415\n<\/li>\n<li>\nKDIGO 2012 clinical practice guideline for the evaluation and management of chronic kidney disease. <i>Kidney Int<\/i>. 2013;3:1-150. <a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Fkdigo.org%2Fguidelines%2Fckd-evaluation-and-management%2F&amp;esheet=52954702&amp;newsitemid=20221027005889&amp;lan=en-US&amp;anchor=https%3A%2F%2Fkdigo.org%2Fguidelines%2Fckd-evaluation-and-management%2F&amp;index=12&amp;md5=339c79a23cd99419b06bc873c41ae5e6\" rel=\"nofollow noopener\" shape=\"rect\">https:\/\/kdigo.org\/guidelines\/ckd-evaluation-and-management\/<\/a>\n<\/li>\n<li>\nAmerican Diabetes Association. Standards of medical care in diabetes\u20142021. <i>Diabetes Care<\/i>. 2021;44(1):1-244.\n<\/li>\n<li>\n<i>National Diabetes Statistics Report 2020: Estimates of Diabetes and Its Burden in the United States<\/i>. Centers for Disease Control and Prevention. Accessed July 9, 2021. <a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Fwww.cdc.gov%2Fdiabetes%2Fpdfs%2Fdata%2Fstatistics%2Fnational-diabetes-statistics-report.pdf&amp;esheet=52954702&amp;newsitemid=20221027005889&amp;lan=en-US&amp;anchor=https%3A%2F%2Fwww.cdc.gov%2Fdiabetes%2Fpdfs%2Fdata%2Fstatistics%2Fnational-diabetes-statistics-report.pdf&amp;index=13&amp;md5=7d5bc20701e5c018e0878dab6d420133\" rel=\"nofollow noopener\" shape=\"rect\">https:\/\/www.cdc.gov\/diabetes\/pdfs\/data\/statistics\/national-diabetes-statistics-report.pdf<\/a>\n<\/li>\n<li>\nStages of CKD. American Kidney Fund. Accessed May 11, 2021. <a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Fwww.kidneyfund.org%2Fkidney-disease%2Fchronic-kidney-disease-ckd%2Fstages-of-chronic-kidney-disease%2F&amp;esheet=52954702&amp;newsitemid=20221027005889&amp;lan=en-US&amp;anchor=https%3A%2F%2Fwww.kidneyfund.org%2Fkidney-disease%2Fchronic-kidney-disease-ckd%2Fstages-of-chronic-kidney-disease%2F&amp;index=14&amp;md5=4be2775126e29f864ff9074b5fe25b6f\" rel=\"nofollow noopener\" shape=\"rect\">https:\/\/www.kidneyfund.org\/kidney-disease\/chronic-kidney-disease-ckd\/stages-of-chronic-kidney-disease\/<\/a>\n<\/li>\n<li>\nUnited States Renal Data System. <i>USRDS Annual Data Report<\/i>. National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases; 2020. Accessed November 2021. <a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Fadr.usrds.org%2F2020%2Fchronic-kidney-disease%2F6-healthcare-expenditures-for-persons-with-ckd&amp;esheet=52954702&amp;newsitemid=20221027005889&amp;lan=en-US&amp;anchor=https%3A%2F%2Fadr.usrds.org%2F2020%2Fchronic-kidney-disease%2F6-healthcare-expenditures-for-persons-with-ckd&amp;index=15&amp;md5=a582a3324f6741d7b77be627dee9ec72\" rel=\"nofollow noopener\" shape=\"rect\">https:\/\/adr.usrds.org\/2020\/chronic-kidney-disease\/6-healthcare-expenditures-for-persons-with-ckd<\/a>\n<\/li>\n<\/ol>\n<p> <b>Contacts<\/b> <\/p>\n<p>\n<b><span class=\"bwuline\">Media Contact<\/span>:<\/b><br \/>Elaine Col\u00f3n<br \/>\n<br \/>Tel. +1 732-236-1587<br \/>\n<br \/>Email: <a target=\"_blank\" href=\"&#x6d;&#x61;&#105;&#108;&#116;o&#x3a;&#x65;&#x6c;&#97;&#105;ne&#x2e;&#x63;&#x6f;&#108;&#111;n&#x40;&#x62;&#x61;&#121;&#101;&#114;&#46;&#x63;&#x6f;&#x6d;\" rel=\"nofollow noopener\" shape=\"rect\">&#x65;&#x6c;&#x61;&#105;&#110;e&#46;&#x63;&#x6f;&#x6c;&#x6f;&#110;&#64;ba&#x79;&#x65;&#x72;&#46;&#99;&#111;m<\/a>\n<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>New guidelines from Kidney Disease: Improving Global Outcomes (KDIGO) and a consensus report jointly issued from KDIGO and the American Diabetes Association (ADA) include KERENDIA as part of a comprehensive treatment strategy for patients with chronic kidney disease (CKD) associated with type 2 diabetes (T2D) who have an estimated glomerular filtration rate of &gt;25 mL\/min\/1.73 &#8230; <span class=\"more\"><a class=\"more-link\" href=\"https:\/\/pharma-trend.com\/en\/bayers-kerendia-finerenone-recommended-as-part-of-comprehensive-treatment-strategy-for-chronic-kidney-disease-associated-with-type-2-diabetes-in-newly-published-clinical-recommendatio\/\">[Read more&#8230;]<\/a><\/span><\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[13],"tags":[],"class_list":{"0":"entry","1":"post","2":"publish","3":"author-business","4":"post-50187","6":"format-standard","7":"category-industry"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Bayer\u2019s KERENDIA\u00ae (finerenone) Recommended as Part of Comprehensive Treatment Strategy for Chronic Kidney Disease Associated With Type 2 Diabetes in Newly Published Clinical Recommendations - Pharma Trend<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/pharma-trend.com\/en\/bayers-kerendia-finerenone-recommended-as-part-of-comprehensive-treatment-strategy-for-chronic-kidney-disease-associated-with-type-2-diabetes-in-newly-published-clinical-recommendatio\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Bayer\u2019s KERENDIA\u00ae (finerenone) Recommended as Part of Comprehensive Treatment Strategy for Chronic Kidney Disease Associated With Type 2 Diabetes in Newly Published Clinical Recommendations - Pharma Trend\" \/>\n<meta property=\"og:description\" content=\"New guidelines from Kidney Disease: Improving Global Outcomes (KDIGO) and a consensus report jointly issued from KDIGO and the American Diabetes Association (ADA) include KERENDIA as part of a comprehensive treatment strategy for patients with chronic kidney disease (CKD) associated with type 2 diabetes (T2D) who have an estimated glomerular filtration rate of &gt;25 mL\/min\/1.73 ... 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