{"id":50254,"date":"2022-10-31T11:02:30","date_gmt":"2022-10-31T10:02:30","guid":{"rendered":"https:\/\/pharma-trend.com\/en\/turnstone-biologics-announces-fda-clearance-of-ind-for-tidal-01-a-next-generation-til-therapy-for-solid-tumors\/"},"modified":"2022-10-31T11:02:30","modified_gmt":"2022-10-31T10:02:30","slug":"turnstone-biologics-announces-fda-clearance-of-ind-for-tidal-01-a-next-generation-til-therapy-for-solid-tumors","status":"publish","type":"post","link":"https:\/\/pharma-trend.com\/en\/turnstone-biologics-announces-fda-clearance-of-ind-for-tidal-01-a-next-generation-til-therapy-for-solid-tumors\/","title":{"rendered":"Turnstone Biologics Announces FDA Clearance of IND for TIDAL-01, a Next-Generation TIL Therapy for Solid Tumors"},"content":{"rendered":"
\n

\nTurnstone\u2019s innovative approach with TIDAL-01 focuses on selecting and manufacturing the most potent tumor-reactive T-cells (Selected TILs) to overcome the limitations of current TIL-based therapies<\/i>\n<\/p>\n

<\/a><\/p>\n

SAN DIEGO–(BUSINESS WIRE)–#SelectedTILs<\/a>–Turnstone Biologics Corp, a clinical-stage biotechnology company developing next-generation immunotherapies to treat and cure solid tumors, today announced that the U.S. Food and Drug Administration (FDA) has cleared its Investigational New Drug (IND) for Turnstone\u2019s lead selected tumor-infiltrating lymphocyte (TIL) therapy program, TIDAL-01. Turnstone is expected to commence a multi-site Phase 1 clinical trial later this year that will evaluate its safety and anti-tumor activity. This trial represents the second Phase 1 clinical study of TIDAL-01, which separately is being evaluated in collaboration with Moffitt Cancer Center.\n<\/p>\n

\n\u201cClearance of our IND is a critical milestone for Turnstone in the advancement of our novel TIL therapy pipeline<\/i>,\u201d said Sammy Farah, Ph.D., M.B.A., President and Chief Executive Officer, Turnstone Biologics. \u201cTIDAL-01 is a potentially transformative approach to improving the potency of TILs and bringing the clinical benefit of Selected TILs to patients with solid tumor cancers where the unmet medical need is high. We are eager to commence the clinical study for TIDAL-01 and to progress this candidate through the clinic<\/i>.\u201d\n<\/p>\n

\nSelected TILs represent the foundational therapeutic modality driving Turnstone\u2019s cancer immunotherapy pipeline and leverage decades of work anchored in academic research that has demonstrated the promise of this approach. By identifying, selecting, and expanding the most potent subsets of patient specific tumor-reactive T-cells, Turnstone aims to improve and broaden the clinical efficacy of TILs, and to overcome the limitations of current TIL-based therapies to achieve positive outcomes in harder to treat, lower mutational burden cancers. The STARLING trial, Turnstone\u2019s multi-site Phase 1 clinical trial of TIDAL-01, will enroll patients with advanced solid tumors including breast cancer and colorectal cancer. Additionally, TIDAL-01 is being evaluated in a Moffitt Cancer Center-sponsored Phase 1 clinical study in additional solid tumors, including cutaneous and non-cutaneous melanoma.\n<\/p>\n

\n\u201cTo achieve success against solid tumors, we are applying a differentiated approach with TILs to overcome what we believe to be the greatest barrier to more effective cell therapies: the low amount of T-cells that recognize and attack the tumor,\u201d said Stewart Abbot, Ph.D., Chief Scientific Officer, Turnstone Biologics. \u201cIn identifying, selecting and expanding these tumor-reactive T-cells, we aim to drive more potent solid tumor killing and improved clinical outcomes in multiple different cancer indications.\u201d\n<\/p>\n

\nAbout Turnstone Biologics<\/b>\n<\/p>\n

\nTurnstone Biologics, a clinical stage biotechnology company, is developing new medicines to treat and cure solid tumors by pioneering a differentiated approach with a clinically validated technology, tumor infiltrating lymphocyte (TIL) therapy. Turnstone\u2019s innovative TIL therapy, which is designed to extend the efficacy of TILs to multiple solid tumor indications by selecting and manufacturing the most potent tumor-reactive T-cells (Selected TILs) for tumor eradication, represents the Company\u2019s foundational therapeutic modality driving its cancer immunotherapy pipeline. The Company\u2019s lead Selected TIL therapy candidate, TIDAL-01, is expected to initiate clinical trials in 2022. Turnstone is developing additional strategies to further potentiate the clinical benefit of Selected TILs, including use in combination with their novel viral immunotherapy.\n<\/p>\n

\nFor more information, please visit www.turnstonebio.com<\/a>, and follow us on LinkedIn<\/a>.\n<\/p>\n

Contacts<\/b> <\/p>\n

\nAhmed Aneizi
\n
Turnstone Biologics
\n
(347) 897-5988
\n
ahmed.aneizi@turnstonebio.com<\/a>\n<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Turnstone\u2019s innovative approach with TIDAL-01 focuses on selecting and manufacturing the most potent tumor-reactive T-cells (Selected TILs) to overcome the limitations of current TIL-based therapies SAN DIEGO–(BUSINESS WIRE)–#SelectedTILs–Turnstone Biologics Corp, a clinical-stage biotechnology company developing next-generation immunotherapies to treat and cure solid tumors, today announced that the U.S. Food and Drug Administration (FDA) has cleared … [Read more…]<\/a><\/span><\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[13],"tags":[],"class_list":{"0":"entry","1":"post","2":"publish","3":"author-business","4":"post-50254","6":"format-standard","7":"category-industry"},"yoast_head":"\nTurnstone Biologics Announces FDA Clearance of IND for TIDAL-01, a Next-Generation TIL Therapy for Solid Tumors - Pharma Trend<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/pharma-trend.com\/en\/turnstone-biologics-announces-fda-clearance-of-ind-for-tidal-01-a-next-generation-til-therapy-for-solid-tumors\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Turnstone Biologics Announces FDA Clearance of IND for TIDAL-01, a Next-Generation TIL Therapy for Solid Tumors - Pharma Trend\" \/>\n<meta property=\"og:description\" content=\"Turnstone\u2019s innovative approach with TIDAL-01 focuses on selecting and manufacturing the most potent tumor-reactive T-cells (Selected TILs) to overcome the limitations of current TIL-based therapies SAN DIEGO–(BUSINESS WIRE)–#SelectedTILs–Turnstone Biologics Corp, a clinical-stage biotechnology company developing next-generation immunotherapies to treat and cure solid tumors, today announced that the U.S. Food and Drug Administration (FDA) has cleared ... 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