{"id":50488,"date":"2022-11-04T07:03:12","date_gmt":"2022-11-04T06:03:12","guid":{"rendered":"https:\/\/pharma-trend.com\/en\/innate-pharma-to-present-results-from-a-preliminary-analysis-of-the-tellomak-phase-2-trial-in-patients-with-advanced-sezary-syndrome-and-anket-platform-at-ash-2022\/"},"modified":"2022-11-04T07:03:12","modified_gmt":"2022-11-04T06:03:12","slug":"innate-pharma-to-present-results-from-a-preliminary-analysis-of-the-tellomak-phase-2-trial-in-patients-with-advanced-sezary-syndrome-and-anket-platform-at-ash-2022","status":"publish","type":"post","link":"https:\/\/pharma-trend.com\/en\/innate-pharma-to-present-results-from-a-preliminary-analysis-of-the-tellomak-phase-2-trial-in-patients-with-advanced-sezary-syndrome-and-anket-platform-at-ash-2022\/","title":{"rendered":"Innate Pharma to Present Results From a Preliminary Analysis of the TELLOMAK Phase 2 Trial in Patients With Advanced Sezary Syndrome and ANKET\u2122 Platform at ASH 2022"},"content":{"rendered":"<div>\n<ul class=\"bwlistdisc\">\n<li>\n<b><i>Innate will share preliminary results of the cohort evaluating lacutamab in Sezary syndrome patients post-mogamulizumab from the ongoing TELLOMAK Phase 2 trial<\/i><\/b>\n<\/li>\n<li>\n<b><i>Chief Scientific Officer, Eric Vivier, DVM, PhD, to give an oral presentation on multispecific antibodies platform: ANKET<sup>TM<\/sup><\/i><\/b>\n<\/li>\n<li>\n<b><i>Partner Sanofi will display two posters on <\/i>SAR\u2019579\/IPH6101 and SAR\u2019514\/IPH6401<\/b>\n<\/li>\n<\/ul>\n<p>MARSEILLE, France&#8211;(BUSINESS WIRE)&#8211;Regulatory News:\n<\/p>\n<p><a href=\"https:\/\/mms.businesswire.com\/media\/20221103006229\/en\/1245155\/4\/INNATEvertnoirDS.jpg\"><img decoding=\"async\" src=\"https:\/\/mms.businesswire.com\/media\/20221103006229\/en\/1245155\/21\/INNATEvertnoirDS.jpg\"><\/a><\/p>\n<p>\nInnate Pharma SA (Euronext Paris: IPH; Nasdaq: IPHA) (\u201c<b>Innate<\/b>\u201d or the \u201c<b>Company<\/b>\u201d) today announced that the following presentations will be presented at the 64<sup>th<\/sup> ASH (American Society Hematology) Annual Meeting taking place from December 10-13, 2022, in New Orleans, Louisiana.\n<\/p>\n<ul class=\"bwlistdisc\">\n<li>\n<b>Lacutamab in patients with advanced Sezary syndrome: results from an interim analysis of the TELLOMAK phase 2 trial<\/b><\/p>\n<ul class=\"bwlistcircle\">\n<li>\nAbstract Number: <a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Fash.confex.com%2Fash%2F2022%2Fwebprogram%2FPaper160239.html&amp;esheet=52960676&amp;newsitemid=20221103006229&amp;lan=en-US&amp;anchor=1631&amp;index=1&amp;md5=51349e6ca5328211cac93086505b36f1\" rel=\"nofollow noopener\" shape=\"rect\">1631<\/a>\n<\/li>\n<li>\nSession Name: 626. Aggressive Lymphomas: Prospective Therapeutic Trials: Poster I\n<\/li>\n<li>\nSession Date and Time: Saturday, December 10, 2022, 5:30 PM &#8211; 7:30 PM\n<\/li>\n<li>\nLocation: Ernest N. Morial Convention Center, Hall D\n<\/li>\n<li>\nPresenter: Dr Pierluigi Porcu, Director, Division of Medical Oncology and Hematopoietic Stem Cell Transplantation, Thomas Jefferson University Hospitals, Philadelphia\n<\/li>\n<\/ul>\n<\/li>\n<li>\n<b>Scientific Symposia: Antibody-Based NK Cell Engager Therapeutics<\/b><\/p>\n<ul class=\"bwlistcircle\">\n<li>\nSession Title: <a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Fwww.hematology.org%2Fmeetings%2Fannual-meeting%2Fprograms%2Fspecial-scientific-symposia%2322713&amp;esheet=52960676&amp;newsitemid=20221103006229&amp;lan=en-US&amp;anchor=Biology+and+Translation+of+NK+Cells&amp;index=2&amp;md5=93be1913d14a3fbfd89a06e666df3a0e\" rel=\"nofollow noopener\" shape=\"rect\">Biology and Translation of NK Cells<\/a>\n<\/li>\n<li>\nSession date and Time: Saturday December 10th, 2022, 2:00 PM &#8211; 3:15 PM\n<\/li>\n<li>\nLocation: Ernest N. Morial Convention Center, 293-294\n<\/li>\n<li>\nPresenter: Eric Vivier, DVM, PhD, Chief Scientific Officer of Innate Pharma\n<\/li>\n<\/ul>\n<\/li>\n<li>\n<b>An open-label, first-in-human, dose-escalation study of SAR443579 administered as single agent by intravenous infusion in patients with relapsed or refractory acute myeloid leukemia (R\/R AML), B-cell acute lymphoblastic leukemia (B-ALL) or high-risk myelodysplasia (HR-MDS) (Sanofi)<\/b><\/p>\n<ul class=\"bwlistcircle\">\n<li>\nAbstract Number: <a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Fash.confex.com%2Fash%2F2022%2Fwebprogram%2FPaper166000.html&amp;esheet=52960676&amp;newsitemid=20221103006229&amp;lan=en-US&amp;anchor=3329&amp;index=3&amp;md5=dc52715ea901a1584a132e3e8800b399\" rel=\"nofollow noopener\" shape=\"rect\">3329<\/a>\n<\/li>\n<li>\nSession Name: 704. Cellular Immunotherapies: Early Phase and Investigational Therapies: Poster II\n<\/li>\n<li>\nSession Date and Time: Sunday, December 11, 2022, 6:00 PM &#8211; 8:00 PM\n<\/li>\n<li>\nLocation: Ernest N. Morial Convention Center, Hall D\n<\/li>\n<li>\nPresenter: Anthony Stein, MD\n<\/li>\n<\/ul>\n<\/li>\n<li>\n<b>The Novel Trifunctional Anti-BCMA NK Cell Engager SAR\u2019514 Has Potent in-Vitro and in-Vivo Anti-Myeloma Effect through Dual NK Cell Engagement (Sanofi)<\/b><\/p>\n<ul class=\"bwlistcircle\">\n<li>\nAbstract Number: <a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Fash.confex.com%2Fash%2F2022%2Fwebprogram%2FPaper166187.html&amp;esheet=52960676&amp;newsitemid=20221103006229&amp;lan=en-US&amp;anchor=4486&amp;index=4&amp;md5=01106470474302090ac402f3e4867643\" rel=\"nofollow noopener\" shape=\"rect\">4486<\/a>\n<\/li>\n<li>\nSession Name: 651. Multiple Myeloma and Plasma Cell Dyscrasias: Basic and Translational: Poster III\n<\/li>\n<li>\nSession Date and Time: Monday, December 12, 2022, 6:00 PM &#8211; 8:00 PM\n<\/li>\n<li>\nLocation: Ernest N. Morial Convention Center, Hall D\n<\/li>\n<li>\nPresenter: Alexandre Tang, Ph.D\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<div class=\"bwpagebreakafter\">\n<\/div>\n<p>\nThe posters and presentation will be available on the <a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Fwww.innate-pharma.com%2Fscience%2Fpublications-presentations&amp;esheet=52960676&amp;newsitemid=20221103006229&amp;lan=en-US&amp;anchor=Publications+section&amp;index=5&amp;md5=f72bfd1af335aa5b8f763e3b99dbdd33\" rel=\"nofollow noopener\" shape=\"rect\">Publications section<\/a> of innate-pharma.com following the meeting.\n<\/p>\n<p>\n<b>About Lacutamab:<\/b>\n<\/p>\n<p>\nLacutamab is a first-in-class anti-KIR3DL2 humanized cytotoxicity-inducing antibody that is currently in clinical trials for treatment of cutaneous T-cell lymphoma (CTCL), an orphan disease, and peripheral T cell lymphoma (PTCL). Rare cutaneous lymphomas of T lymphocytes has a poor prognosis with few efficacious and safe therapeutic options at advanced stages.\n<\/p>\n<p>\nKIR3DL2 is an inhibitory receptor of the KIR family, expressed by approximately 65% of patients across all CTCL subtypes and expressed by up 90% of patients with certain aggressive CTCL subtypes, in particular, S\u00e9zary syndrome. It is expressed by up to 50% of patients with mycosis fungoides and peripheral T-cell lymphoma (PTCL). It has a restricted expression on normal tissues.\n<\/p>\n<p>\nLacutamab is granted European Medicines Agency (EMA) PRIME designation and US Food and Drug Administration (FDA) granted Fast Track designation for the treatment of patients with relapsed or refractory S\u00e9zary syndrome who have received at least two prior systemic therapies.\n<\/p>\n<p>\n<b>About ANKET<sup>TM<\/sup>:<\/b>\n<\/p>\n<p>\nANKET<sup>TM<\/sup> (<b>A<\/b>ntibody-based <b>NK<\/b> cell <b>E<\/b>ngager <b>T<\/b>herapeutics) is Innate&#8217;s proprietary platform for developing next-generation, multi-specific natural killer (NK) cell engagers to treat certain types of cancer.\n<\/p>\n<p>\nThis versatile, fit-for-purpose technology is creating an entirely new class of molecules to induce synthetic immunity against cancer. It leverages the advantages of harnessing NK cell effector functions against cancer cells and also provides proliferation and activation signals targeted to NK cells.\n<\/p>\n<p>\nOur latest innovation, the tetra-specific ANKET molecule, is the first NK cell engager technology to engage activating receptors (NKp46 and CD16), a tumor antigen and an interleukin-2 receptor (via an IL-2 variant, IL-2v) via a single molecule.\n<\/p>\n<div class=\"bwpagebreakafter\">\n<\/div>\n<p>\n<b>About Innate Pharma:<\/b>\n<\/p>\n<p>\nInnate Pharma S.A. is a global, clinical-stage oncology-focused biotech company dedicated to improving treatment and clinical outcomes for patients through therapeutic antibodies that harness the immune system to fight cancer.\n<\/p>\n<p>\nInnate Pharma\u2019s broad pipeline of antibodies includes several potentially first-in-class clinical and preclinical candidates in cancers with high unmet medical need.\n<\/p>\n<p>\nInnate is a pioneer in the understanding of Natural Killer cell biology and has expanded its expertise in the tumor microenvironment and tumor-antigens, as well as antibody engineering. This innovative approach has resulted in a diversified proprietary portfolio and major alliances with leaders in the biopharmaceutical industry including Bristol-Myers Squibb, Novo Nordisk A\/S, Sanofi, and a multi-products collaboration with AstraZeneca.\n<\/p>\n<p>\nHeadquartered in Marseille, France with a US office in Rockville, MD, Innate Pharma is listed on Euronext Paris and Nasdaq in the US.\n<\/p>\n<p>\nLearn more about Innate Pharma at <a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=http%3A%2F%2Fwww.innate-pharma.com&amp;esheet=52960676&amp;newsitemid=20221103006229&amp;lan=en-US&amp;anchor=www.innate-pharma.com&amp;index=6&amp;md5=acc98c6202fb0644601d915864e1660e\" rel=\"nofollow noopener\" shape=\"rect\">www.innate-pharma.com<\/a>\n<\/p>\n<p>\n<b>Information about Innate Pharma shares:<\/b>\n<\/p>\n<table cellspacing=\"0\" class=\"bwtablemarginb bwblockalignl\" style=\"width:368px;\">\n<tr>\n<td class=\"bwvertalignt bwpadl0\" colspan=\"1\" rowspan=\"1\" style=\"width:183px;\">\n<p class=\"bwalignl bwcellpmargin\">\n<b>ISIN code<\/b><br \/><b>Ticker code<\/b><br \/><b>LEI<\/b>\n<\/p>\n<\/td>\n<td class=\"bwvertalignt bwpadl0\" colspan=\"1\" rowspan=\"1\" style=\"width:186px;\">\n<p class=\"bwcellpmargin\">\nFR0010331421\n<\/p>\n<p class=\"bwcellpmargin\">\nEuronext: IPH Nasdaq: IPHA\n<\/p>\n<p class=\"bwcellpmargin\">\n9695002Y8420ZB8HJE29\n<\/p>\n<\/td>\n<\/tr>\n<\/table>\n<p>\n<b>Disclaimer on forward-looking information and risk factors:<\/b>\n<\/p>\n<p>\nThis press release contains certain forward-looking statements, including those within the meaning of the Private Securities Litigation Reform Act of 1995. The use of certain words, including \u201cbelieve,\u201d \u201cpotential,\u201d \u201cexpect\u201d and \u201cwill\u201d and similar expressions, is intended to identify forward-looking statements. Although the company believes its expectations are based on reasonable assumptions, these forward-looking statements are subject to numerous risks and uncertainties, which could cause actual results to differ materially from those anticipated. These risks and uncertainties include, among other things, the uncertainties inherent in research and development, including related to safety, progression of and results from its ongoing and planned clinical trials and preclinical studies, review and approvals by regulatory authorities of its product candidates, the Company\u2019s commercialization efforts and the Company\u2019s continued ability to raise capital to fund its development. For an additional discussion of risks and uncertainties which could cause the company&#8217;s actual results, financial condition, performance or achievements to differ from those contained in the forward-looking statements, please refer to the Risk Factors (\u201cFacteurs de Risque&#8221;) section of the Universal Registration Document filed with the French Financial Markets Authority (\u201cAMF\u201d), which is available on the AMF website <a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=http%3A%2F%2Fwww.amf-france.org&amp;esheet=52960676&amp;newsitemid=20221103006229&amp;lan=en-US&amp;anchor=http%3A%2F%2Fwww.amf-france.org&amp;index=7&amp;md5=f8e08b9d92489afc56cfd0193ecd2d20\" rel=\"nofollow noopener\" shape=\"rect\">http:\/\/www.amf-france.org<\/a> or on Innate Pharma\u2019s website, and public filings and reports filed with the U.S. Securities and Exchange Commission (\u201cSEC\u201d), including the Company\u2019s Annual Report on Form 20-F for the year ended December 31, 2021, and subsequent filings and reports filed with the AMF or SEC, or otherwise made public, by the Company.\n<\/p>\n<p>\nThis press release and the information contained herein do not constitute an offer to sell or a solicitation of an offer to buy or subscribe to shares in Innate Pharma in any country.\n<\/p>\n<p> <b>Contacts<\/b> <\/p>\n<p>\n<b><span class=\"bwuline\">Investors and Media<\/span><\/b><\/p>\n<p><b>Innate Pharma<\/b><br \/>Henry Wheeler<br \/>\n<br \/>Tel.: +33 (0)4 84 90 32 88<br \/>\n<br \/><a target=\"_blank\" href=\"ma&#105;&#108;&#116;&#111;&#x3a;&#x48;&#x65;&#x6e;&#x72;y&#46;&#119;&#104;&#101;&#101;&#x6c;&#x65;&#x72;&#x40;&#x69;nn&#97;&#116;&#101;&#45;&#x70;&#x68;&#x61;&#x72;&#x6d;a&#46;f&#114;\" rel=\"nofollow noopener\" shape=\"rect\">&#x48;&#x65;&#110;&#114;&#121;&#46;&#x77;&#x68;&#x65;&#101;&#108;er&#x40;&#x69;&#x6e;&#110;&#97;t&#x65;&#x2d;&#x70;&#104;&#97;&#114;m&#x61;&#x2e;&#x66;&#114;<\/a><\/p>\n<p><b>NewCap<\/b><br \/>Arthur Rouill\u00e9<br \/>\n<br \/>Tel.: +33 (0)1 44 71 00 15<br \/>\n<br \/><a target=\"_blank\" href=\"&#x6d;&#97;&#x69;&#x6c;t&#x6f;&#58;i&#x6e;&#110;a&#x74;&#101;&#x40;&#x6e;e&#x77;&#99;a&#x70;&#46;e&#x75;\" rel=\"nofollow noopener\" shape=\"rect\">&#x69;&#x6e;&#x6e;&#x61;&#x74;&#x65;&#x40;&#x6e;&#x65;&#x77;&#x63;&#x61;&#x70;&#x2e;&#x65;&#x75;<\/a>\n<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Innate will share preliminary results of the cohort evaluating lacutamab in Sezary syndrome patients post-mogamulizumab from the ongoing TELLOMAK Phase 2 trial Chief Scientific Officer, Eric Vivier, DVM, PhD, to give an oral presentation on multispecific antibodies platform: ANKETTM Partner Sanofi will display two posters on SAR\u2019579\/IPH6101 and SAR\u2019514\/IPH6401 MARSEILLE, France&#8211;(BUSINESS WIRE)&#8211;Regulatory News: Innate Pharma &#8230; 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