{"id":50708,"date":"2022-11-10T15:02:23","date_gmt":"2022-11-10T14:02:23","guid":{"rendered":"https:\/\/pharma-trend.com\/en\/seagen-to-highlight-new-research-from-its-diverse-pipeline-of-targeted-cancer-therapy-candidates-at-the-society-for-immunotherapy-of-cancers-sitc-annual-meeting\/"},"modified":"2022-11-10T15:02:23","modified_gmt":"2022-11-10T14:02:23","slug":"seagen-to-highlight-new-research-from-its-diverse-pipeline-of-targeted-cancer-therapy-candidates-at-the-society-for-immunotherapy-of-cancers-sitc-annual-meeting","status":"publish","type":"post","link":"https:\/\/pharma-trend.com\/en\/seagen-to-highlight-new-research-from-its-diverse-pipeline-of-targeted-cancer-therapy-candidates-at-the-society-for-immunotherapy-of-cancers-sitc-annual-meeting\/","title":{"rendered":"Seagen to Highlight New Research from its Diverse Pipeline of Targeted Cancer Therapy Candidates at the Society for Immunotherapy of Cancer\u2019s (SITC) Annual Meeting"},"content":{"rendered":"
\n

\n\u2013 Encouraging data from ongoing Phase 1 study of SGN-B6A illustrate commitment to pioneering novel first-in-class antibody-drug conjugates (ADCs) \u2013<\/i><\/strong>\n<\/p>\n

BOTHELL, Wash.–(BUSINESS WIRE)–Seagen Inc.<\/a> (Nasdaq: SGEN) today announced that data from the company\u2019s diverse pipeline of targeted cancer therapy candidates will be presented at the Society for Immunotherapy of Cancer\u2019s (SITC) Annual Meeting being held November 8-12 in Boston. The presentations highlight data from multiple ongoing clinical and preclinical research studies that employ Seagen\u2019s proprietary antibody-drug conjugate (ADC) technology, as well as other novel cancer targeting approaches.\n<\/p>\n

<\/a><\/p>\n

\n“Seagen has a deep heritage in pioneering first-in-class antibody-drug conjugates. We are encouraged by initial results from a clinical study of SGN-B6A, a wholly owned investigational antibody-drug conjugate that demonstrated antitumor activity with an acceptable safety profile in previously treated patients with non-small cell lung cancer, head and neck cancer, and esophageal cancer,” said Megan O\u2019Meara, M.D., Senior Vice President of Early-Stage Development at Seagen. “We are also sharing new data demonstrating enhanced preclinical activity of enfortumab vetodin in combination with immune checkpoint inhibitors, as well as preclinical data that support the initiation of a first-in-human study of a bispecific molecule called SGN-BB228.”\n<\/p>\n

\nHighlights From SGN-B6A Program Presented at SITC<\/i><\/b>\n<\/p>\n

\nData from an ongoing Phase 1 study of SGN-B6A, an ADC directed to integrin beta-6, which is overexpressed in multiple solid tumors, showed early efficacy signals in at least three cancer types, including non-small cell lung cancer (NSCLC), head and neck squamous cell carcinoma (HNSCC), and esophageal squamous cell carcinoma (ESCC).\n<\/p>\n

\nDose escalation cohorts enrolled 79 participants with metastatic or unresectable solid tumors, whose disease had relapsed or was refractory to standard of care therapies and had not previously received an MMAE-containing agent or agent targeting integrin beta-6. Participants had received a median of 3 lines of therapy for metastatic disease prior to enrollment in the study. SGN-B6A demonstrated a manageable and tolerable safety profile at the explored dose levels and schedules. Intermittent dosing schedules (2Q3W, 2Q4W) are being evaluated further. The initial anti-tumor activity observed in heavily pre-treated patients is encouraging and has triggered expansion cohorts in NSCLC, HNSCC, and ESCC, which are currently ongoing. SGN-B6A is an investigational agent, and its safety and efficacy have not been established.\n<\/p>\n

\nAdditional Details of Seagen Presentations at SITC Annual Meeting 2022<\/i><\/b>\n<\/p>\n

\nAll posters will be available at the beginning of the session, both in-person and virtually.\n<\/p>\n\n\n\n\n\n\n\n\n\n\n
\n

\nAbstract Title<\/b>\n<\/p>\n<\/td>\n

\n

\nAbstract #<\/b>\n<\/p>\n<\/td>\n

\n

\nDate<\/b>\n<\/p>\n<\/td>\n

\n

\nFirst Author<\/b>\n<\/p>\n<\/td>\n<\/tr>\n

\n

\nA first-in-human trial of an integrin beta-6 targeted antibody-drug conjugate (ADC), SGN-B6A, in patients with advanced solid tumors: Interim results of a Phase 1 study (SGNB6A-001)\n<\/p>\n<\/td>\n

\n

\n731\n<\/p>\n<\/td>\n

\n

\nThursday, Nov. 10, 2022,
\n
9:00 am – 9:00 pm\n<\/p>\n<\/td>\n

\n

\nA. Hollebecque\n<\/p>\n<\/td>\n<\/tr>\n

\n

\nSGN-BB228 is a first-in-class CD228-targeted costimulatory Antibody Anticalin\u00ae<\/sup> bispecific delivering potent and conditional 4-1BB costimulation to tumor-specific T cells\n<\/p>\n<\/td>\n

\n

\n1201\n<\/p>\n<\/td>\n

\n

\nThursday, Nov. 10, 2022,
\n
9:00 am – 9:00 pm\n<\/p>\n<\/td>\n

\n

\nB. Updegraff\n<\/p>\n<\/td>\n<\/tr>\n

\n

\nEnfortumab vedotin induces immunogenic cell death, elicits antitumor immune memory, and shows enhanced preclinical activity in combination with immune checkpoint inhibitors\n<\/p>\n<\/td>\n

\n

\n1187\n<\/p>\n<\/td>\n

\n

\nThursday, Nov. 10, 2022,
\n
9:00 am – 9:00 pm\n<\/p>\n<\/td>\n

\n

\nD. Olson\n<\/p>\n<\/td>\n<\/tr>\n

\n

\nPhase 2 multi-cohort clinical study evaluating Disitamab Vedotin alone and in combination with pembrolizumab in patients with HER2-expressing unresectable or metastatic urothelial carcinoma (RC48G001, trial in progress)\n<\/p>\n<\/td>\n

\n

\n663\n<\/p>\n<\/td>\n

\n

\nThursday, Nov. 10, 2022,
\n
9:00 am – 9:00 pm\n<\/p>\n<\/td>\n

\n

\nM. D. Galsky\n<\/p>\n<\/td>\n<\/tr>\n

\n

\nPhase 2 study of SEA-CD40 combination therapies in advanced malignancies (SGNS40-002, trial in progress)\n<\/p>\n<\/td>\n

\n

\n705\n<\/p>\n<\/td>\n

\n

\nThursday, Nov. 10, 2022,
\n
9:00 am – 9:00 pm\n<\/p>\n<\/td>\n

\n

\nA. Salama\n<\/p>\n<\/td>\n<\/tr>\n

\n

\nReversible chemical modulation of antibody effector function maintains anti-tumor activity while mitigating peripheral immune activation\n<\/p>\n<\/td>\n

\n

\n1357\n<\/p>\n<\/td>\n

\n

\nThursday, Nov. 10, 2022,
\n
9:00 am – 9:00 pm\n<\/p>\n<\/td>\n

\n

\nM. R. Levengood\n<\/p>\n<\/td>\n<\/tr>\n

\n

\nSGN-B6A induces immunogenic cell death as a secondary mechanism of action\n<\/p>\n<\/td>\n

\n

\n1186\n<\/p>\n<\/td>\n

\n

\nFriday, Nov. 11, 2022,
\n
9:00 am – 8:30 pm\n<\/p>\n<\/td>\n

\n

\nR. P. Lyon\n<\/p>\n<\/td>\n<\/tr>\n

\n

\nSGN-B7H4V induces immunomodulatory changes to the tumor microenvironment and pairs well with an anti-PD1 agent in a preclinical model\n<\/p>\n<\/td>\n

\n

\n1190\n<\/p>\n<\/td>\n

\n

\nFriday, Nov. 11 2022,
\n
9:00 am – 8:30 pm\n<\/p>\n<\/td>\n

\n

\nM. Ulrich\n<\/p>\n<\/td>\n<\/tr>\n<\/table>\n

\nAbout Seagen<\/b>\n<\/p>\n

\nSeagen Inc. is a global biotechnology company that discovers, develops and commercializes transformative cancer medicines to make a meaningful difference in people\u2019s lives. Seagen is headquartered in the Seattle, Washington area and has locations in California, Canada, Switzerland and the European Union. For more information on our marketed products and robust pipeline, visit www.seagen.com<\/a> and follow @SeagenGlobal<\/a> on Twitter.\n<\/p>\n

\nForward-Looking Statements<\/b>\n<\/p>\n

\nCertain of the statements made in this press release are forward-looking, such as those, among others, relating to the potential of SGN-B6A, SGN-BB228, SGN-B7H4V, SEA-CD40, enfortumab vedotin and disitamab vedotin and Seagen\u2019s other products and product candidates, their potential efficacy, safety and therapeutic uses, plans for presenting at the referenced medical conference, plans with respect to clinical trials, and the potential of the company\u2019s pipeline. Actual results or developments may differ materially from those projected or implied in these forward-looking statements. Factors that may cause such a difference include, without limitation, the difficulty and uncertainty of pharmaceutical product development even after encouraging results in early-stage trials or preclinical research, the risk of adverse events or safety signals, the inability to show sufficient efficacy in clinical trials and the possibility of adverse regulatory actions. More information about the risks and uncertainties faced by Seagen is contained under the caption \u201cRisk Factors\u201d included in the company\u2019s Quarterly Report on Form 10\u2011Q for the quarter ended September 30, 2022, filed with the Securities and Exchange Commission. Seagen disclaims any intention or obligation to update or revise any forward-looking statements, whether as a result of new information, future events or otherwise, except as required by law.\n<\/p>\n

Contacts<\/b> <\/p>\n

\nFor Media<\/i>
David Caouette
\n
(310) 430-3476
\n
dcaouette@seagen.com<\/a>\n<\/p>\n

\nFor Investors<\/i>
Douglas Maffei, Ph.D.
\n
(425) 527-4881
\n
dmaffei@seagen.com<\/a>\n<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

\u2013 Encouraging data from ongoing Phase 1 study of SGN-B6A illustrate commitment to pioneering novel first-in-class antibody-drug conjugates (ADCs) \u2013 BOTHELL, Wash.–(BUSINESS WIRE)–Seagen Inc. (Nasdaq: SGEN) today announced that data from the company\u2019s diverse pipeline of targeted cancer therapy candidates will be presented at the Society for Immunotherapy of Cancer\u2019s (SITC) Annual Meeting being held … [Read more…]<\/a><\/span><\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[13],"tags":[],"class_list":{"0":"entry","1":"post","2":"publish","3":"author-business","4":"post-50708","6":"format-standard","7":"category-industry"},"yoast_head":"\nSeagen to Highlight New Research from its Diverse Pipeline of Targeted Cancer Therapy Candidates at the Society for Immunotherapy of Cancer\u2019s (SITC) Annual Meeting - Pharma Trend<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/pharma-trend.com\/en\/seagen-to-highlight-new-research-from-its-diverse-pipeline-of-targeted-cancer-therapy-candidates-at-the-society-for-immunotherapy-of-cancers-sitc-annual-meeting\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Seagen to Highlight New Research from its Diverse Pipeline of Targeted Cancer Therapy Candidates at the Society for Immunotherapy of Cancer\u2019s (SITC) Annual Meeting - Pharma Trend\" \/>\n<meta property=\"og:description\" content=\"\u2013 Encouraging data from ongoing Phase 1 study of SGN-B6A illustrate commitment to pioneering novel first-in-class antibody-drug conjugates (ADCs) \u2013 BOTHELL, Wash.–(BUSINESS WIRE)–Seagen Inc. 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(Nasdaq: SGEN) today announced that data from the company\u2019s diverse pipeline of targeted cancer therapy candidates will be presented at the Society for Immunotherapy of Cancer\u2019s (SITC) Annual Meeting being held ... 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