{"id":50719,"date":"2022-11-10T17:02:19","date_gmt":"2022-11-10T16:02:19","guid":{"rendered":"https:\/\/pharma-trend.com\/en\/the-gut-microbiomes-supersized-role-in-shaping-molecules-in-our-blood\/"},"modified":"2022-11-10T17:02:19","modified_gmt":"2022-11-10T16:02:19","slug":"the-gut-microbiomes-supersized-role-in-shaping-molecules-in-our-blood","status":"publish","type":"post","link":"https:\/\/pharma-trend.com\/en\/the-gut-microbiomes-supersized-role-in-shaping-molecules-in-our-blood\/","title":{"rendered":"The Gut Microbiome\u2019s Supersized Role In Shaping Molecules In Our Blood"},"content":{"rendered":"
\n

\nScientists from the Institute for Systems Biology have shown which blood metabolites are associated with the gut microbiome, genetics, or the interplay between both. Their findings, published in the journal Nature Metabolism, have promising implications for guiding targeted therapies designed to alter the composition of the blood metabolome to improve human health.<\/i>\n<\/p>\n

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SEATTLE–(BUSINESS WIRE)–The nearly 200-year-old phrase \u201cyou are what you eat\u201d has some new evidence. ISB researchers have found that the gut microbiome, including what we feed it, is largely responsible for the variation in circulating blood metabolites across people. This knowledge will help guide targeted interventions designed to alter the composition of the human blood metabolome. The findings were published today in Nature Metabolism<\/i><\/a>.\n<\/p>\n

\n\u201cWe know that person-to-person variation in the blood metabolome \u2013 the small molecules found in the bloodstream that can interact with all the systems of our body \u2013 can tell us a lot about health and disease status. Figuring out what governs this variation is a necessary step that gets us closer to precision approaches to healthcare,\u201d said Dr. Sean Gibbons, an ISB faculty member and co-corresponding author of the paper.\n<\/p>\n

\nThe research team examined 930 blood metabolites that were present in more than 1,500 individuals. Over 60 percent of the detected metabolites were significantly associated with either host genetics or the gut microbiome. \u201cNotably, 69 percent of these associations were driven solely by the microbiome, with 15 percent driven solely by genetics and 16 percent were under hybrid genetic-microbiome control,\u201d said ISB Senior Research Scientist Dr. Christian Diener, lead author of the study. Diener and co-lead author Chengzhen Dai analyzed the de-identified metabolomic, genomic, and microbiome data from consenting patients in a consumer scientific wellness program.\n<\/p>\n

\nThey found that the blood metabolite variation explained by the microbiome was largely independent of the variation explained by the genome, even for hybrid metabolites that were significantly associated with both genetics and microbes. Additionally, certain metabolite-microbe associations were only significant in individuals with specific genetic backgrounds, indicating a nuanced interplay between the microbiome and host genetics in shaping the blood metabolome.\n<\/p>\n

\nThese new findings are promising for a couple of reasons. First, the high number of microbiome-specific metabolites suggests that much of our blood metabolome could be modified through dietary, probiotic, and other lifestyle interventions. Second, metabolites that are under stricter genetic control may not be responsive to lifestyle modification, making them targets for pharmacological interventions that directly target host pathways.\n<\/p>\n

\n\u201cA deeper understanding of the determinants of the blood metabolome will provide us with a window into how these circulating metabolite levels can be engineered and optimized for health,\u201d said Dr. Andrew Magis, co-corresponding author of the paper. \u201cUnderstanding which circulating small molecules fall predominantly under host versus microbiome control will help guide interventions designed to prevent and\/or treat a range of diseases.\u201d\n<\/p>\n

\nThis research was supported by the National Institutes of Health under award number <\/i>R01DK133468, as well as by funds from Dr. Gibbons\u2019 Washington Research Foundation Distinguished Investigator Award. <\/i>The content published in Nature Metabolism is solely the responsibility of the paper\u2019s authors and does not necessarily represent the official views of the National Institutes of Health.<\/i>\n<\/p>\n

\nAbout ISB<\/b>\n<\/p>\n

\nInstitute for Systems Biology (ISB) is a Seattle-based non-profit biomedical research organization. We focus on some of the most pressing issues in human health, including aging, brain health, cancer, COVID-19, and many infectious diseases. ISB is an affiliate of Providence, one of the nation\u2019s largest not-for-profit health care systems. Follow us at www.isbscience.org<\/a> and on YouTube<\/a>, Facebook<\/a>, LinkedIn<\/a> and Twitter<\/a>.\n<\/p>\n

Contacts<\/b> <\/p>\n

\nJoe Myxter
\n
Director of Communications, ISB
\n
jmyxter@isbscience.org<\/a>
206.732.2157\n<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Scientists from the Institute for Systems Biology have shown which blood metabolites are associated with the gut microbiome, genetics, or the interplay between both. Their findings, published in the journal Nature Metabolism, have promising implications for guiding targeted therapies designed to alter the composition of the blood metabolome to improve human health. SEATTLE–(BUSINESS WIRE)–The nearly … [Read more…]<\/a><\/span><\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[13],"tags":[],"class_list":{"0":"entry","1":"post","2":"publish","3":"author-business","4":"post-50719","6":"format-standard","7":"category-industry"},"yoast_head":"\nThe Gut Microbiome\u2019s Supersized Role In Shaping Molecules In Our Blood - Pharma Trend<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/pharma-trend.com\/en\/the-gut-microbiomes-supersized-role-in-shaping-molecules-in-our-blood\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The Gut Microbiome\u2019s Supersized Role In Shaping Molecules In Our Blood - Pharma Trend\" \/>\n<meta property=\"og:description\" content=\"Scientists from the Institute for Systems Biology have shown which blood metabolites are associated with the gut microbiome, genetics, or the interplay between both. 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