{"id":51782,"date":"2022-12-09T14:02:24","date_gmt":"2022-12-09T13:02:24","guid":{"rendered":"https:\/\/pharma-trend.com\/en\/new-clinical-data-for-zanidatamab-in-her2-hr-metastatic-breast-cancer-presented-today-at-2022-sabcs\/"},"modified":"2022-12-09T14:02:24","modified_gmt":"2022-12-09T13:02:24","slug":"new-clinical-data-for-zanidatamab-in-her2-hr-metastatic-breast-cancer-presented-today-at-2022-sabcs","status":"publish","type":"post","link":"https:\/\/pharma-trend.com\/en\/new-clinical-data-for-zanidatamab-in-her2-hr-metastatic-breast-cancer-presented-today-at-2022-sabcs\/","title":{"rendered":"New Clinical Data for Zanidatamab in HER2+ \/HR+ Metastatic Breast Cancer Presented Today at 2022 SABCS"},"content":{"rendered":"<div>\n<ul class=\"bwlistdisc\">\n<li>\n<i>Results show overall confirmed objective response rate (cORR) of 33%, disease control rate (DCR) of 92%, and median progression-free survival (mPFS) of 9.6 months<\/i>\n<\/li>\n<li>\n<i>Data support further investigation of zanidatamab in combination with palbociclib and fulvestrant as a potential chemotherapy-free therapeutic option for patients with HER2-positive metastatic breast cancer and the trial is ongoing<\/i>\n<\/li>\n<\/ul>\n<p>VANCOUVER, British Columbia&#8211;(BUSINESS WIRE)&#8211;Zymeworks Inc. (NYSE: ZYME), a clinical-stage biopharmaceutical company developing multifunctional biotherapeutics, today presented new clinical data for zanidatamab, the company\u2019s investigational HER2-targeted bispecific antibody, in combination with palbociclib, a CDK4\/6 inhibitor, and fulvestrant, a selective estrogen receptor degrader, in patients with heavily pretreated HER2-positive hormone-receptor positive metastatic breast cancer. The data were presented today in a spotlight poster session entitled <i>Treatment of HER2-positive (HER2+) hormone-receptor positive (HR+) metastatic breast cancer (mBC) with the novel combination of zanidatamab, palbociclib, and fulvestrant<\/i> during the San Antonio Breast Cancer Symposium (SABCS) taking place in San Antonio, Texas and virtually.\n<\/p>\n<p><a href=\"https:\/\/mms.businesswire.com\/media\/20221209005084\/en\/183056\/5\/Logo.jpg\"><img decoding=\"async\" src=\"https:\/\/mms.businesswire.com\/media\/20221209005084\/en\/183056\/21\/Logo.jpg\"><\/a><\/p>\n<p>\n<b>Clinical Data Highlights<\/b>\n<\/p>\n<p>\nThe data presented at SABCS are from a clinical study of 45 patients with heavily pretreated HER2-positive HR-positive metastatic breast cancer who received zanidatamab in combination with palbociclib and fulvestrant. Patients had received prior regimens containing HER2-targeted agents including trastuzumab (100%), pertuzumab (80%), T-DM1 (98%), and other available options.\n<\/p>\n<p>\nIn 36 efficacy-evaluable patients, treatment with zanidatamab in combination with palbociclib and fulvestrant resulted in a cORR of 33% and DCR of 92%, and the majority of patients experienced a decrease in tumor size. The mPFS was 9.6 months with seven patients still on study at the time of data cutoff (August 31, 2022). The regimen was generally well-tolerated, with the majority of treatment-related adverse events considered mild to moderate in severity (Grade 1 or 2).\n<\/p>\n<p>\n\u201cZanidatamab together with palbociclib and fulvestrant shows encouraging antitumor activity and a manageable tolerability profile in patients with HER2\u2011positive hormone-receptor positive breast cancer that has progressed after treatment with multiple HER2-targeted agents,\u201d said Neil Josephson, M.D., Chief Medical Officer at Zymeworks. \u201cWe are encouraged by the durability of disease control and median progression-free survival in this heavily pretreated patient population indicating that this regimen has the potential to be developed as a chemotherapy-free treatment option for these patients.\u201d\n<\/p>\n<p>\nThe presentation is available to conference registrants on the SABCS conference website and is also available on the publications page of the Zymeworks website at <a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Fwww.zymeworks.com%2Fpublications&amp;esheet=53035145&amp;newsitemid=20221209005084&amp;lan=en-US&amp;anchor=https%3A%2F%2Fwww.zymeworks.com%2Fpublications&amp;index=1&amp;md5=b8929e4ff6169611ca6124dad99ddcba\" rel=\"nofollow noopener\" shape=\"rect\">https:\/\/www.zymeworks.com\/publications<\/a>.\n<\/p>\n<p>\nTitle: <i>Treatment of HER2-positive (HER2+) hormone-receptor positive (HR+) metastatic breast cancer (mBC) with the novel combination of zanidatamab, palbociclib, and fulvestrant<\/i>\n<\/p>\n<p>\nLead Author: Santiago Escriv\u00e1-de-Romani, MD, Vall d\u2019Hebron Institute of Oncology (VHIO), Vall d\u2019Hebron University Hospital; Barcelona, Spain\n<\/p>\n<p>\nProgram Number: PD18-10\n<\/p>\n<p>\n<b>About Zanidatamab<\/b>\n<\/p>\n<p>\nZanidatamab is a bispecific antibody, based on Zymeworks&#8217; Azymetric\u2122 platform, that can simultaneously bind two non-overlapping epitopes of HER2, known as biparatopic binding. This unique design results in multiple mechanisms of action including dual HER2 signal blockade, increased binding and removal of HER2 protein from the cell surface, and potent effector function leading to encouraging antitumor activity in patients. Zymeworks is developing zanidatamab in multiple Phase 1, Phase 2 and pivotal clinical trials globally as a targeted treatment option for patients with solid tumors that express HER2. Zymeworks has entered into separate agreements with each of BeiGene, Ltd. (BeiGene) and Jazz Pharmaceuticals Ireland Limited (Jazz), granting each of BeiGene and Jazz with exclusive rights to develop and commercialize zanidatamab throughout various counties around world.\n<\/p>\n<p>\n<b>About Zymeworks Inc.<\/b>\n<\/p>\n<p>\nZymeworks is a clinical-stage biopharmaceutical company dedicated to the discovery, development and commercialization of next-generation multifunctional biotherapeutics. Zymeworks\u2019 suite of therapeutic platforms and its fully integrated drug development engine enable precise engineering of highly differentiated product candidates. Zymeworks\u2019 lead clinical candidate, zanidatamab, is a novel Azymetric\u2122 HER2-targeted bispecific antibody currently being evaluated in multiple Phase 1, Phase 2, and pivotal clinical trials globally as a targeted treatment option for patients with solid tumors that express HER2. Zymeworks\u2019 second clinical candidate, zanidatamab zovodotin (ZW49), is a novel bispecific HER2 \u2011targeted antibody-drug conjugate currently in Phase 1 clinical development and combines the unique design and antibody framework of zanidatamab with Zymeworks\u2019 proprietary ZymeLink\u2122 linker and cytotoxin. Zymeworks is also advancing a deep preclinical pipeline in oncology (including immuno-oncology agents) and other therapeutic areas. In addition, its therapeutic platforms are being leveraged through strategic partnerships with global biopharmaceutical companies. For more information on our ongoing clinical trials visit <a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=http%3A%2F%2Fwww.zymeworksclinicaltrials.com&amp;esheet=53035145&amp;newsitemid=20221209005084&amp;lan=en-US&amp;anchor=www.zymeworksclinicaltrials.com&amp;index=2&amp;md5=eda967cd8c1db901dc50fb9ddc38323b\" rel=\"nofollow noopener\" shape=\"rect\">www.zymeworksclinicaltrials.com<\/a>. For additional information about Zymeworks, visit <a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=http%3A%2F%2Fwww.zymeworks.com&amp;esheet=53035145&amp;newsitemid=20221209005084&amp;lan=en-US&amp;anchor=www.zymeworks.com&amp;index=3&amp;md5=0f997e74f8febc2c5fc248e60d8f43c0\" rel=\"nofollow noopener\" shape=\"rect\">www.zymeworks.com<\/a> and follow <a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Ftwitter.com%2FZymeworksInc&amp;esheet=53035145&amp;newsitemid=20221209005084&amp;lan=en-US&amp;anchor=%40ZymeworksInc&amp;index=4&amp;md5=4272e6fc267d62fcc54354b976e24155\" rel=\"nofollow noopener\" shape=\"rect\">@ZymeworksInc<\/a> on Twitter.\n<\/p>\n<p>\n<b>Cautionary Note Regarding Forward-Looking Statements<\/b>\n<\/p>\n<p>\nThis press release includes \u201cforward-looking statements\u201d or information within the meaning of the applicable securities legislation, including Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended. Forward-looking statements in this press release include, but are not limited to, statements that relate to the potential therapeutic effects of zanidatamab and Zymeworks\u2019 other product candidates; Zymeworks\u2019 clinical development of its product candidates and enrollment in its clinical trials; anticipated clinical data presentations; expectations regarding future regulatory filings and the timing thereof, the commercial potential of technology platforms and product candidates; and other information that is not historical information. When used herein, words such as \u201cplan\u201d, \u201cbelieve\u201d, \u201cexpect\u201d, \u201cmay\u201d, \u201canticipate\u201d, \u201cpotential\u201d, and similar expressions are intended to identify forward-looking statements. In addition, any statements or information that refer to expectations, beliefs, plans, projections, objectives, performance or other characterizations of future events or circumstances, including any underlying assumptions, are forward-looking. All forward-looking statements are based upon Zymeworks\u2019 current expectations and various assumptions. Zymeworks believes there is a reasonable basis for its expectations and beliefs, but they are inherently uncertain. Zymeworks may not realize its expectations, and its beliefs may not prove correct. Actual results could differ materially from those described or implied by such forward-looking statements as a result of various factors, including, without limitation: future clinical trials may not demonstrate safety and efficacy of any of Zymeworks\u2019 or its collaborators\u2019 product candidates; any of Zymeworks\u2019 or its partners\u2019 product candidates may fail in development, may not receive required regulatory approvals, or may be delayed to a point where they are not commercially viable; regulatory agencies may impose additional requirements or delay the initiation of clinical trials; the impact of the COVID-19 pandemic on Zymeworks\u2019 business, research and clinical development plans and timelines and results of operations, including impact on its clinical trial sites, collaborators, and contractors who act for or on Zymeworks\u2019 behalf, may be more severe and more prolonged than currently anticipated; the impact of new or changing laws and regulations; market conditions; inability to maintain or enter into new partnerships or strategic collaborations; and the factors described under \u201cRisk Factors\u201d in Zymeworks\u2019 quarterly and annual reports filed with the Securities and Exchange Commission, including its Quarterly Report on Form 10-Q for its quarter ended September 30, 2022 (a copy of which may be obtained at <a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=http%3A%2F%2Fwww.sec.gov&amp;esheet=53035145&amp;newsitemid=20221209005084&amp;lan=en-US&amp;anchor=www.sec.gov&amp;index=5&amp;md5=4d7084e68268092388dd99f854d6e186\" rel=\"nofollow noopener\" shape=\"rect\">www.sec.gov<\/a> and <a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=http%3A%2F%2Fwww.sedar.com&amp;esheet=53035145&amp;newsitemid=20221209005084&amp;lan=en-US&amp;anchor=www.sedar.com&amp;index=6&amp;md5=30d94ce17b17ae16a88ac0cccfb1871f\" rel=\"nofollow noopener\" shape=\"rect\">www.sedar.com<\/a>). Although Zymeworks believes that such forward-looking statements are reasonable, there can be no assurance they will prove to be correct. Investors should not place undue reliance on forward-looking statements. The above assumptions, risks and uncertainties are not exhaustive. Forward-looking statements are made as of the date hereof and, except as may be required by law, Zymeworks undertakes no obligation to update, republish, or revise any forward-looking statements to reflect new information, future events or circumstances, or to reflect the occurrences of unanticipated events.\n<\/p>\n<p> <b>Contacts<\/b> <\/p>\n<p>\n<b>Investor inquiries:<\/b><br \/>Jack Spinks<br \/>\n<br \/>(604) 678-1388<br \/>\n<br \/><a target=\"_blank\" href=\"&#x6d;&#97;i&#x6c;&#116;&#111;&#x3a;&#x69;&#114;&#64;&#x7a;&#121;m&#x65;&#x77;&#111;r&#x6b;&#115;&#46;&#x63;&#x6f;&#109;\" rel=\"nofollow noopener\" shape=\"rect\">ir&#64;&#122;&#x79;&#x6d;&#x65;&#x77;or&#107;&#115;&#x2e;&#x63;&#x6f;&#x6d;<\/a><\/p>\n<p><b>Media inquiries:<\/b><br \/>Diana Papove<br \/>\n<br \/>(604) 678-1388<br \/>\n<br \/><a target=\"_blank\" href=\"&#109;&#x61;&#x69;l&#116;&#x6f;:&#109;&#x65;&#x64;&#105;&#x61;&#x40;z&#121;&#x6d;e&#119;&#x6f;&#x72;&#107;&#x73;&#x2e;c&#111;&#x6d;\" rel=\"nofollow noopener\" shape=\"rect\">&#x6d;&#101;&#100;&#x69;&#x61;&#64;&#122;&#x79;&#x6d;&#101;&#119;&#x6f;&#x72;&#107;&#115;&#x2e;&#x63;&#111;&#109;<\/a>\n<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Results show overall confirmed objective response rate (cORR) of 33%, disease control rate (DCR) of 92%, and median progression-free survival (mPFS) of 9.6 months Data support further investigation of zanidatamab in combination with palbociclib and fulvestrant as a potential chemotherapy-free therapeutic option for patients with HER2-positive metastatic breast cancer and the trial is ongoing VANCOUVER, &#8230; <span class=\"more\"><a class=\"more-link\" href=\"https:\/\/pharma-trend.com\/en\/new-clinical-data-for-zanidatamab-in-her2-hr-metastatic-breast-cancer-presented-today-at-2022-sabcs\/\">[Read more&#8230;]<\/a><\/span><\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[13],"tags":[],"class_list":{"0":"entry","1":"post","2":"publish","3":"author-business","4":"post-51782","6":"format-standard","7":"category-industry"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>New Clinical Data for Zanidatamab in HER2+ \/HR+ Metastatic Breast Cancer Presented Today at 2022 SABCS - Pharma Trend<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/pharma-trend.com\/en\/new-clinical-data-for-zanidatamab-in-her2-hr-metastatic-breast-cancer-presented-today-at-2022-sabcs\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"New Clinical Data for Zanidatamab in HER2+ \/HR+ Metastatic Breast Cancer Presented Today at 2022 SABCS - Pharma Trend\" \/>\n<meta property=\"og:description\" content=\"Results show overall confirmed objective response rate (cORR) of 33%, disease control rate (DCR) of 92%, and median progression-free survival (mPFS) of 9.6 months Data support further investigation of zanidatamab in combination with palbociclib and fulvestrant as a potential chemotherapy-free therapeutic option for patients with HER2-positive metastatic breast cancer and the trial is ongoing VANCOUVER, ... [Read more...]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/pharma-trend.com\/en\/new-clinical-data-for-zanidatamab-in-her2-hr-metastatic-breast-cancer-presented-today-at-2022-sabcs\/\" \/>\n<meta property=\"og:site_name\" content=\"Pharma Trend\" \/>\n<meta property=\"article:published_time\" content=\"2022-12-09T13:02:24+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/mms.businesswire.com\/media\/20221209005084\/en\/183056\/21\/Logo.jpg\" \/>\n<meta name=\"author\" content=\"Business Wire\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Business Wire\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"6 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/pharma-trend.com\\\/en\\\/new-clinical-data-for-zanidatamab-in-her2-hr-metastatic-breast-cancer-presented-today-at-2022-sabcs\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/pharma-trend.com\\\/en\\\/new-clinical-data-for-zanidatamab-in-her2-hr-metastatic-breast-cancer-presented-today-at-2022-sabcs\\\/\"},\"author\":{\"name\":\"Business Wire\",\"@id\":\"https:\\\/\\\/pharma-trend.com\\\/en\\\/#\\\/schema\\\/person\\\/02d41342c7a74fa7f0032bb35ef0bb24\"},\"headline\":\"New Clinical Data for Zanidatamab in HER2+ \\\/HR+ Metastatic Breast Cancer Presented Today at 2022 SABCS\",\"datePublished\":\"2022-12-09T13:02:24+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/pharma-trend.com\\\/en\\\/new-clinical-data-for-zanidatamab-in-her2-hr-metastatic-breast-cancer-presented-today-at-2022-sabcs\\\/\"},\"wordCount\":1249,\"publisher\":{\"@id\":\"https:\\\/\\\/pharma-trend.com\\\/en\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/pharma-trend.com\\\/en\\\/new-clinical-data-for-zanidatamab-in-her2-hr-metastatic-breast-cancer-presented-today-at-2022-sabcs\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/mms.businesswire.com\\\/media\\\/20221209005084\\\/en\\\/183056\\\/21\\\/Logo.jpg\",\"articleSection\":[\"Industry\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/pharma-trend.com\\\/en\\\/new-clinical-data-for-zanidatamab-in-her2-hr-metastatic-breast-cancer-presented-today-at-2022-sabcs\\\/\",\"url\":\"https:\\\/\\\/pharma-trend.com\\\/en\\\/new-clinical-data-for-zanidatamab-in-her2-hr-metastatic-breast-cancer-presented-today-at-2022-sabcs\\\/\",\"name\":\"New Clinical Data for Zanidatamab in HER2+ \\\/HR+ Metastatic Breast Cancer Presented Today at 2022 SABCS - Pharma Trend\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/pharma-trend.com\\\/en\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/pharma-trend.com\\\/en\\\/new-clinical-data-for-zanidatamab-in-her2-hr-metastatic-breast-cancer-presented-today-at-2022-sabcs\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/pharma-trend.com\\\/en\\\/new-clinical-data-for-zanidatamab-in-her2-hr-metastatic-breast-cancer-presented-today-at-2022-sabcs\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/mms.businesswire.com\\\/media\\\/20221209005084\\\/en\\\/183056\\\/21\\\/Logo.jpg\",\"datePublished\":\"2022-12-09T13:02:24+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/pharma-trend.com\\\/en\\\/new-clinical-data-for-zanidatamab-in-her2-hr-metastatic-breast-cancer-presented-today-at-2022-sabcs\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/pharma-trend.com\\\/en\\\/new-clinical-data-for-zanidatamab-in-her2-hr-metastatic-breast-cancer-presented-today-at-2022-sabcs\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/pharma-trend.com\\\/en\\\/new-clinical-data-for-zanidatamab-in-her2-hr-metastatic-breast-cancer-presented-today-at-2022-sabcs\\\/#primaryimage\",\"url\":\"https:\\\/\\\/mms.businesswire.com\\\/media\\\/20221209005084\\\/en\\\/183056\\\/21\\\/Logo.jpg\",\"contentUrl\":\"https:\\\/\\\/mms.businesswire.com\\\/media\\\/20221209005084\\\/en\\\/183056\\\/21\\\/Logo.jpg\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/pharma-trend.com\\\/en\\\/new-clinical-data-for-zanidatamab-in-her2-hr-metastatic-breast-cancer-presented-today-at-2022-sabcs\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Startseite\",\"item\":\"https:\\\/\\\/pharma-trend.com\\\/en\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"New Clinical Data for Zanidatamab in HER2+ \\\/HR+ Metastatic Breast Cancer Presented Today at 2022 SABCS\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/pharma-trend.com\\\/en\\\/#website\",\"url\":\"https:\\\/\\\/pharma-trend.com\\\/en\\\/\",\"name\":\"Pharma Trend\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\\\/\\\/pharma-trend.com\\\/en\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/pharma-trend.com\\\/en\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/pharma-trend.com\\\/en\\\/#organization\",\"name\":\"Pharma Trend\",\"url\":\"https:\\\/\\\/pharma-trend.com\\\/en\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/pharma-trend.com\\\/en\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"\",\"contentUrl\":\"\",\"caption\":\"Pharma Trend\"},\"image\":{\"@id\":\"https:\\\/\\\/pharma-trend.com\\\/en\\\/#\\\/schema\\\/logo\\\/image\\\/\"}},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/pharma-trend.com\\\/en\\\/#\\\/schema\\\/person\\\/02d41342c7a74fa7f0032bb35ef0bb24\",\"name\":\"Business Wire\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"New Clinical Data for Zanidatamab in HER2+ \/HR+ Metastatic Breast Cancer Presented Today at 2022 SABCS - Pharma Trend","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/pharma-trend.com\/en\/new-clinical-data-for-zanidatamab-in-her2-hr-metastatic-breast-cancer-presented-today-at-2022-sabcs\/","og_locale":"en_US","og_type":"article","og_title":"New Clinical Data for Zanidatamab in HER2+ \/HR+ Metastatic Breast Cancer Presented Today at 2022 SABCS - Pharma Trend","og_description":"Results show overall confirmed objective response rate (cORR) of 33%, disease control rate (DCR) of 92%, and median progression-free survival (mPFS) of 9.6 months Data support further investigation of zanidatamab in combination with palbociclib and fulvestrant as a potential chemotherapy-free therapeutic option for patients with HER2-positive metastatic breast cancer and the trial is ongoing VANCOUVER, ... [Read more...]","og_url":"https:\/\/pharma-trend.com\/en\/new-clinical-data-for-zanidatamab-in-her2-hr-metastatic-breast-cancer-presented-today-at-2022-sabcs\/","og_site_name":"Pharma Trend","article_published_time":"2022-12-09T13:02:24+00:00","og_image":[{"url":"https:\/\/mms.businesswire.com\/media\/20221209005084\/en\/183056\/21\/Logo.jpg","type":"","width":"","height":""}],"author":"Business Wire","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Business Wire","Est. reading time":"6 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/pharma-trend.com\/en\/new-clinical-data-for-zanidatamab-in-her2-hr-metastatic-breast-cancer-presented-today-at-2022-sabcs\/#article","isPartOf":{"@id":"https:\/\/pharma-trend.com\/en\/new-clinical-data-for-zanidatamab-in-her2-hr-metastatic-breast-cancer-presented-today-at-2022-sabcs\/"},"author":{"name":"Business Wire","@id":"https:\/\/pharma-trend.com\/en\/#\/schema\/person\/02d41342c7a74fa7f0032bb35ef0bb24"},"headline":"New Clinical Data for Zanidatamab in HER2+ \/HR+ Metastatic Breast Cancer Presented Today at 2022 SABCS","datePublished":"2022-12-09T13:02:24+00:00","mainEntityOfPage":{"@id":"https:\/\/pharma-trend.com\/en\/new-clinical-data-for-zanidatamab-in-her2-hr-metastatic-breast-cancer-presented-today-at-2022-sabcs\/"},"wordCount":1249,"publisher":{"@id":"https:\/\/pharma-trend.com\/en\/#organization"},"image":{"@id":"https:\/\/pharma-trend.com\/en\/new-clinical-data-for-zanidatamab-in-her2-hr-metastatic-breast-cancer-presented-today-at-2022-sabcs\/#primaryimage"},"thumbnailUrl":"https:\/\/mms.businesswire.com\/media\/20221209005084\/en\/183056\/21\/Logo.jpg","articleSection":["Industry"],"inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/pharma-trend.com\/en\/new-clinical-data-for-zanidatamab-in-her2-hr-metastatic-breast-cancer-presented-today-at-2022-sabcs\/","url":"https:\/\/pharma-trend.com\/en\/new-clinical-data-for-zanidatamab-in-her2-hr-metastatic-breast-cancer-presented-today-at-2022-sabcs\/","name":"New Clinical Data for Zanidatamab in HER2+ \/HR+ Metastatic Breast Cancer Presented Today at 2022 SABCS - Pharma Trend","isPartOf":{"@id":"https:\/\/pharma-trend.com\/en\/#website"},"primaryImageOfPage":{"@id":"https:\/\/pharma-trend.com\/en\/new-clinical-data-for-zanidatamab-in-her2-hr-metastatic-breast-cancer-presented-today-at-2022-sabcs\/#primaryimage"},"image":{"@id":"https:\/\/pharma-trend.com\/en\/new-clinical-data-for-zanidatamab-in-her2-hr-metastatic-breast-cancer-presented-today-at-2022-sabcs\/#primaryimage"},"thumbnailUrl":"https:\/\/mms.businesswire.com\/media\/20221209005084\/en\/183056\/21\/Logo.jpg","datePublished":"2022-12-09T13:02:24+00:00","breadcrumb":{"@id":"https:\/\/pharma-trend.com\/en\/new-clinical-data-for-zanidatamab-in-her2-hr-metastatic-breast-cancer-presented-today-at-2022-sabcs\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/pharma-trend.com\/en\/new-clinical-data-for-zanidatamab-in-her2-hr-metastatic-breast-cancer-presented-today-at-2022-sabcs\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/pharma-trend.com\/en\/new-clinical-data-for-zanidatamab-in-her2-hr-metastatic-breast-cancer-presented-today-at-2022-sabcs\/#primaryimage","url":"https:\/\/mms.businesswire.com\/media\/20221209005084\/en\/183056\/21\/Logo.jpg","contentUrl":"https:\/\/mms.businesswire.com\/media\/20221209005084\/en\/183056\/21\/Logo.jpg"},{"@type":"BreadcrumbList","@id":"https:\/\/pharma-trend.com\/en\/new-clinical-data-for-zanidatamab-in-her2-hr-metastatic-breast-cancer-presented-today-at-2022-sabcs\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Startseite","item":"https:\/\/pharma-trend.com\/en\/"},{"@type":"ListItem","position":2,"name":"New Clinical Data for Zanidatamab in HER2+ \/HR+ Metastatic Breast Cancer Presented Today at 2022 SABCS"}]},{"@type":"WebSite","@id":"https:\/\/pharma-trend.com\/en\/#website","url":"https:\/\/pharma-trend.com\/en\/","name":"Pharma Trend","description":"","publisher":{"@id":"https:\/\/pharma-trend.com\/en\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/pharma-trend.com\/en\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/pharma-trend.com\/en\/#organization","name":"Pharma Trend","url":"https:\/\/pharma-trend.com\/en\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/pharma-trend.com\/en\/#\/schema\/logo\/image\/","url":"","contentUrl":"","caption":"Pharma Trend"},"image":{"@id":"https:\/\/pharma-trend.com\/en\/#\/schema\/logo\/image\/"}},{"@type":"Person","@id":"https:\/\/pharma-trend.com\/en\/#\/schema\/person\/02d41342c7a74fa7f0032bb35ef0bb24","name":"Business Wire"}]}},"_links":{"self":[{"href":"https:\/\/pharma-trend.com\/en\/wp-json\/wp\/v2\/posts\/51782","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pharma-trend.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pharma-trend.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pharma-trend.com\/en\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/pharma-trend.com\/en\/wp-json\/wp\/v2\/comments?post=51782"}],"version-history":[{"count":0,"href":"https:\/\/pharma-trend.com\/en\/wp-json\/wp\/v2\/posts\/51782\/revisions"}],"wp:attachment":[{"href":"https:\/\/pharma-trend.com\/en\/wp-json\/wp\/v2\/media?parent=51782"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pharma-trend.com\/en\/wp-json\/wp\/v2\/categories?post=51782"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pharma-trend.com\/en\/wp-json\/wp\/v2\/tags?post=51782"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}