{"id":51833,"date":"2022-12-12T01:02:30","date_gmt":"2022-12-12T00:02:30","guid":{"rendered":"https:\/\/pharma-trend.com\/en\/ajax-therapeutics-presents-preclinical-data-on-aj1-10502-a-next-generation-type-ii-jak2-inhibitor-at-the-american-society-of-hematology-annual-meeting\/"},"modified":"2022-12-12T01:02:30","modified_gmt":"2022-12-12T00:02:30","slug":"ajax-therapeutics-presents-preclinical-data-on-aj1-10502-a-next-generation-type-ii-jak2-inhibitor-at-the-american-society-of-hematology-annual-meeting","status":"publish","type":"post","link":"https:\/\/pharma-trend.com\/en\/ajax-therapeutics-presents-preclinical-data-on-aj1-10502-a-next-generation-type-ii-jak2-inhibitor-at-the-american-society-of-hematology-annual-meeting\/","title":{"rendered":"Ajax Therapeutics Presents Preclinical Data on AJ1-10502, a Next Generation Type II JAK2 Inhibitor, at the American Society of Hematology Annual Meeting"},"content":{"rendered":"
\n

\n\u2013 AJ1-10502 demonstrates enhanced selectivity and improved efficacy with significant reductions in mutant cell fraction, compared to the leading Type I JAK2 inhibitor, ruxolitinib, in multiple disease models of myeloproliferative neoplasms (MPNs) \u2013<\/i>\n<\/p>\n

<\/a><\/p>\n

NEW YORK–(BUSINESS WIRE)–Ajax Therapeutics<\/a>, Inc., a biopharmaceutical company applying computational chemistry and structure-based technologies to develop novel, selective small molecules for myeloproliferative neoplasms (MPNs), today announced the presentation of preclinical data on the company\u2019s next generation Type II JAK2 inhibitor, AJ1-10502, at a poster session held today at the 64th American Society of Hematology (ASH) Annual Meeting and Exposition in New Orleans.\n<\/p>\n

\nThe poster, entitled \u201cThe Second Generation Type II JAK2 inhibitor, AJ1-10502, Demonstrates Enhanced Selectivity, Improved Therapeutic Efficacy and Reduced Mutant Cell Fraction Compared to Type I JAK2 inhibitors in Models of Myeloproliferative Neoplasms (MPNs),\u201d highlights the improved efficacy and disease modifying features of Ajax\u2019s Type II JAK2 inhibitor, AJ1-10502, when compared to the investigational, first generation Type II inhibitor, CHZ868, and the approved market-leading Type I inhibitor, ruxolitinib, in two different mouse models of MPNs.\n<\/p>\n

\nIn both MPN models studied, AJ1-10502 demonstrated dose dependent improvements in efficacy over ruxolitinib on key blood cell parameters, including reticulocytes and hematocrit, associated with MPNs, as well as superior reductions in spleen weights on par with JAK2 deletion. More importantly, AJ1-10502 caused significant reductions in mutant cell fraction within bone marrow and spleen not observed with ruxolitinib. Distinct from all currently approved JAK2 inhibitors, including ruxolitinib, that bind the Type I conformation of the JAK2 kinase and allow continued JAK\/STAT signaling which leads to disease persistence, AJ1-10502 is designed to bind the Type II conformation of the JAK2 kinase. In preclinical studies, investigational Type II JAK2 inhibitors have been shown to overcome disease persistence to ruxolitinib and, most significantly, reduce mutant JAK2 allele burden that drives MPN disease progression. The ASH poster presentation is available on Ajax\u2019s website<\/a>.\n<\/p>\n

\n\u201cWe\u2019re very encouraged by the first preclinical data on our Type II JAK2 inhibitor program being presented today at the ASH Annual Meeting,\u201d said Craig E. Masse, PhD, Senior Vice President, Discovery Research at Ajax Therapeutics. \u201cOur unique drug discovery capabilities, including state-of-the-art computational and structure-based technologies, have enabled us to develop Type II JAK2 inhibitors, such as AJ1-10502, that target JAK2 with greater precision and potency, while overcoming the limitations of current JAK2 therapies that interact with other JAK-family members and related kinases which limits their efficacy and leads to unwanted side effects.\u201d\n<\/p>\n

\n\u201cIt\u2019s exciting to see Ajax\u2019s next generation Type II JAK2 inhibitor, AJ1-10502, demonstrate enhanced selectivity and efficacy with a much-improved safety profile than first generation Type II inhibitors,\u201d said Ross Levine, MD, Chair of Ajax\u2019s Scientific Advisory Board and Deputy Physician-in-Chief, Translational Research, Laurence Joseph Dineen Chair in Leukemia Research and Member of the Human Oncology and Pathogenesis Program at Memorial Sloan Kettering Cancer Center. \u201cThis data supports our findings that Type II JAK2 inhibitors can significantly reduce the mutant allele burden that drives MPNs which is not observed with Type I JAK2 inhibitors, such as ruxolitinib. We believe that more selective and potent JAK2 inhibitors, like AJ1-10502, could provide much needed new targeted therapies for MPN patients who are not well served by currently approved JAK2 inhibitors.\u201d\n<\/p>\n

\nAbout Ajax Therapeutics<\/b>\n<\/p>\n

\nAjax Therapeutics<\/a>, Inc. is pursuing uniquely selective approaches to develop novel first-in-class therapeutics for myeloproliferative neoplasms (MPNs), including Myelofibrosis. By combining the deep cancer and structural biology insights of our founding scientists with the industry\u2019s most advanced computational drug discovery and protein structure platforms from our founding partner, Schr\u00f6dinger, Inc., we aim to discover and develop more precisely designed therapies to address significant unmet needs for patients with MPNs.\n<\/p>\n

\nPlease find more information at www.ajaxtherapeutics.com<\/a>.\n<\/p>\n

\nNOTE: Dr. Ross Levine serves on the board of directors of, has provided advisory services for, and has equity interests in Ajax Therapeutics. Dr. Levine also has intellectual property rights and interests that MSK has licensed to Ajax. MSK has intellectual property rights and other financial interests related to Ajax.\n<\/p>\n

Contacts<\/b> <\/p>\n

\nMedia:<\/b>
Kathryn Morris, The Yates Network LLC
\n
914-204-6412
\n
kathryn@theyatesnetwork.com<\/a>\n<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

\u2013 AJ1-10502 demonstrates enhanced selectivity and improved efficacy with significant reductions in mutant cell fraction, compared to the leading Type I JAK2 inhibitor, ruxolitinib, in multiple disease models of myeloproliferative neoplasms (MPNs) \u2013 NEW YORK–(BUSINESS WIRE)–Ajax Therapeutics, Inc., a biopharmaceutical company applying computational chemistry and structure-based technologies to develop novel, selective small molecules for myeloproliferative … [Read more…]<\/a><\/span><\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[13],"tags":[],"class_list":{"0":"entry","1":"post","2":"publish","3":"author-business","4":"post-51833","6":"format-standard","7":"category-industry"},"yoast_head":"\nAjax Therapeutics Presents Preclinical Data on AJ1-10502, a Next Generation Type II JAK2 Inhibitor, at the American Society of Hematology Annual Meeting - Pharma Trend<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/pharma-trend.com\/en\/ajax-therapeutics-presents-preclinical-data-on-aj1-10502-a-next-generation-type-ii-jak2-inhibitor-at-the-american-society-of-hematology-annual-meeting\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Ajax Therapeutics Presents Preclinical Data on AJ1-10502, a Next Generation Type II JAK2 Inhibitor, at the American Society of Hematology Annual Meeting - Pharma Trend\" \/>\n<meta property=\"og:description\" content=\"\u2013 AJ1-10502 demonstrates enhanced selectivity and improved efficacy with significant reductions in mutant cell fraction, compared to the leading Type I JAK2 inhibitor, ruxolitinib, in multiple disease models of myeloproliferative neoplasms (MPNs) \u2013 NEW YORK–(BUSINESS WIRE)–Ajax Therapeutics, Inc., a biopharmaceutical company applying computational chemistry and structure-based technologies to develop novel, selective small molecules for myeloproliferative ... 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