{"id":51893,"date":"2022-12-13T10:02:07","date_gmt":"2022-12-13T09:02:07","guid":{"rendered":"https:\/\/pharma-trend.com\/en\/aop-health-presents-latest-updates-on-besremi-ropeginterferon-alfa-2b-in-polycythaemia-vera-at-the-american-society-of-hematology-ash-2022-annual-meeting\/"},"modified":"2022-12-13T10:02:07","modified_gmt":"2022-12-13T09:02:07","slug":"aop-health-presents-latest-updates-on-besremi-ropeginterferon-alfa-2b-in-polycythaemia-vera-at-the-american-society-of-hematology-ash-2022-annual-meeting","status":"publish","type":"post","link":"https:\/\/pharma-trend.com\/en\/aop-health-presents-latest-updates-on-besremi-ropeginterferon-alfa-2b-in-polycythaemia-vera-at-the-american-society-of-hematology-ash-2022-annual-meeting\/","title":{"rendered":"AOP Health presents latest updates on BESREMi\u00ae (Ropeginterferon alfa-2b) in Polycythaemia Vera at the American Society of Hematology (ASH) 2022 Annual Meeting"},"content":{"rendered":"
\n

VIENNA–(BUSINESS WIRE)–AOP Health announced its latest updates on Ropeginterferon alfa-2b in patients with Polycythaemia Vera (PV) from AOP Health\u00b4s CONTINUATION-PV study (Reference Kiladjian et al. ASH 2022<\/a>) and the LOW-PV trial, which is an independent investigator-initiated trial supported by AOP Health (Reference Barbui et al. ASH 2022<\/a>) presented at ASH 2022 Annual Meeting, New Orleans, USA.\n<\/p>\n

<\/a>
<\/a><\/p>\n

\nAOP Health has been conducting a pivotal clinical development program in Europe since 2010, including the studies PEGINVERA,<\/a> PROUD-PV<\/a>, PEN-PV<\/a>, CONTINUATION-PV<\/a> and (post-approval) PASS-PV. With this development program AOP Health obtained the first marketing authorization ever of BESREMi\u00ae<\/sup> for the treatment of Polycythaemia Vera by the European Commission (2019), followed by Switzerland, Liechtenstein and Israel. AOP Health’s clinical development program was also the basis for marketing authorization in Taiwan, Korea and most recently in the USA in November 2021.\n<\/p>\n

\n\u201cThe by now global marketing authorizations of BESREMi\u00ae<\/sup>, all based on AOP Health\u00b4s clinical development program conducted in Europe, are proof of the integrated drug development and commercialization expertise at AOP Health. Our success and know-how allow us to further pursue our goal of making drugs for rare and special diseases available to patients worldwide.\u201d<\/i> commented Dr. Rudolf Widman, Founder and Member of the Board of the AOP Health Group.\n<\/p>\n

\nBenefits of treatment confirmed
\n
<\/b>During the ASH 2022 Annual Meeting Prof. Jean-Jacques Kiladjian (Paris) presented results on final data of AOP Health\u00b4s CONTINUATION-PV, an open-label, multicenter, phase IIIb study assessing the long-term (up-to 7,3 years) efficacy and safety of Ropeginterferon alfa-2b versus hydroxyurea (HU) or best available treatment (BAT). This new analysis focused on efficacy and safety on either high-risk or low-risk PV patients. The benefits of treatment with Ropeginterferon alfa-2b over BAT, were confirmed in both groups. The results further suggested that low-risk patients may benefit more, thus supporting early treatment start. (Reference Kiladjian et al. ASH 2022<\/a>)\n<\/p>\n

\nThe latter was also a main conclusion from the final results of the Low-PV trial, presented by Prof. Tiziano Barbui (Bergamo): In an early, low-risk PV patient population treatment with Ropeginterferon alfa-2b proved superior in maintaining haematocrit targets, as compared to management by phlebotomy only. (Reference Barbui et al. ASH 2022<\/a>)\n<\/p>\n

\nProf. Barbui said, \u201cSince its first approval in Europe in 2019, Ropeginterferon alfa-2b has become the first line therapy of choice for many PV patients and has already led to a change of treatment paradigm for patients with P. vera as reflected by the updated ELN treatment guidelines.\u201d (Reference to Marchetti et al. 2022<\/a>)<\/i>\u201d\n<\/p>\n

\nAbout BESREMi\u00ae<\/sup>
<\/b>BESREMi\u00ae is the first and currently only interferon approved for polycythaemia vera, a myelo\u00adproliferative neoplasm (MPN), indicated in the European Union as monotherapy in adults for treatment of polycythaemia vera without symptomatic enlarged spleen. Its overall safety and efficacy were demonstrated in multiple clinical studies.\n<\/p>\n

\nBESREMi\u00ae<\/sup> (ropeginterferon alfa-2b) is a long-acting, mono-pegylated proline interferon (ATC L03AB15). It is administered once every 2 weeks initially, or up to every 4 weeks after stabilization of blood values. BESREMi\u00ae<\/sup> is designed to be self-administered subcutaneously with a pre-filled pen.\n<\/p>\n

\nFor the EMA Summary of Product Characteristics please visit: BESREMi\u00ae<\/sup>\n<\/p>\n

\nLink BESREMi<\/i>\u00ae<\/sup> Summary of Product Characteristics:<\/i> <\/i><\/b>https:\/\/www.ema.europa.eu\/en\/documents\/product-information\/besremi-epar-product-information_en.pdf<\/a><\/i><\/span>\n<\/p>\n

\nAbout AOP Health
\n
<\/b>The AOP Health Group incorporates several companies including AOP Orphan Pharmaceuticals GmbH with its seat in Vienna, Austria (\u201cAOP Health\u201d). The AOP Health Group is the European pioneer for integrated therapies for rare diseases and in critical care. Over the past 25 years, the Group has become an established provider of integrated therapy solutions operating from its headquarters in Vienna, its subsidiaries and representative offices throughout Europe and the Middle East, as well as through partners worldwide. This development has been made possible by a continually high level of investment in research and development on the one hand and a highly consistent and pragmatic orientation towards the needs of all its stakeholders on the other \u2013 especially the patients and their families as well as also the healthcare professionals treating them.\n<\/p>\n

Contacts<\/b> <\/p>\n

\nMag. Nina Roth
\n
Nina.Roth@aop-health.com<\/a>
+43-676-3131509\n<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

VIENNA–(BUSINESS WIRE)–AOP Health announced its latest updates on Ropeginterferon alfa-2b in patients with Polycythaemia Vera (PV) from AOP Health\u00b4s CONTINUATION-PV study (Reference Kiladjian et al. ASH 2022) and the LOW-PV trial, which is an independent investigator-initiated trial supported by AOP Health (Reference Barbui et al. ASH 2022) presented at ASH 2022 Annual Meeting, New Orleans, … [Read more…]<\/a><\/span><\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[13],"tags":[],"class_list":{"0":"entry","1":"post","2":"publish","3":"author-business","4":"post-51893","6":"format-standard","7":"category-industry"},"yoast_head":"\nAOP Health presents latest updates on BESREMi\u00ae (Ropeginterferon alfa-2b) in Polycythaemia Vera at the American Society of Hematology (ASH) 2022 Annual Meeting - Pharma Trend<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/pharma-trend.com\/en\/aop-health-presents-latest-updates-on-besremi-ropeginterferon-alfa-2b-in-polycythaemia-vera-at-the-american-society-of-hematology-ash-2022-annual-meeting\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"AOP Health presents latest updates on BESREMi\u00ae (Ropeginterferon alfa-2b) in Polycythaemia Vera at the American Society of Hematology (ASH) 2022 Annual Meeting - Pharma Trend\" \/>\n<meta property=\"og:description\" content=\"VIENNA–(BUSINESS WIRE)–AOP Health announced its latest updates on Ropeginterferon alfa-2b in patients with Polycythaemia Vera (PV) from AOP Health\u00b4s CONTINUATION-PV study (Reference Kiladjian et al. ASH 2022) and the LOW-PV trial, which is an independent investigator-initiated trial supported by AOP Health (Reference Barbui et al. ASH 2022) presented at ASH 2022 Annual Meeting, New Orleans, ... 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ASH 2022) and the LOW-PV trial, which is an independent investigator-initiated trial supported by AOP Health (Reference Barbui et al. ASH 2022) presented at ASH 2022 Annual Meeting, New Orleans, ... 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