{"id":52020,"date":"2022-12-15T13:02:39","date_gmt":"2022-12-15T12:02:39","guid":{"rendered":"https:\/\/pharma-trend.com\/en\/anumana-and-pfizer-partner-to-enable-early-detection-of-underdiagnosed-cardiovascular-disease\/"},"modified":"2022-12-15T13:02:39","modified_gmt":"2022-12-15T12:02:39","slug":"anumana-and-pfizer-partner-to-enable-early-detection-of-underdiagnosed-cardiovascular-disease","status":"publish","type":"post","link":"https:\/\/pharma-trend.com\/en\/anumana-and-pfizer-partner-to-enable-early-detection-of-underdiagnosed-cardiovascular-disease\/","title":{"rendered":"Anumana and Pfizer Partner to Enable Early Detection of Underdiagnosed Cardiovascular Disease"},"content":{"rendered":"
\n

\nCompanies initiate research agreement supporting development of new AI-ECG algorithm <\/i><\/b>to help identify patients who may be at risk of cardiac amyloidosis<\/i><\/b>\n<\/p>\n

CAMBRIDGE, Mass.–(BUSINESS WIRE)–#AI<\/a>—Anumana, Inc.<\/a>, an AI-driven health technology company and portfolio company of nference<\/a>, has entered into a multi-year agreement with Pfizer, Inc. for Anumana to develop an artificial intelligence electrocardiogram algorithm (AI-ECG) designed to enable the early suspicion of cardiac amyloidosis. Anumana will conduct a clinical validation trial and pursue De Novo classification for the algorithm as a Software-as-a-Medical-Device (SaMD) and aims to gain regulatory approval for the algorithm as an SaMD for the detection of cardiac amyloidosis in the U.S., Europe and Japan.\n<\/p>\n

<\/a><\/p>\n

\nCardiac amyloidosis is a serious, progressive, and underdiagnosed rare disease that leads to heart failure.1 <\/sup>In patients with cardiac amyloidosis, the heart walls become stiff, making it difficult for the left ventricle to properly relax and fill with blood, while at the same time hampering its ability to squeeze and pump blood out of the heart. Symptoms and comorbidities associated with cardiac amyloidosis, such as shortness of breath, knee pain, bilateral carpal tunnel syndrome, kidney disease, and gastrointestinal issues, can vary and seem unrelated, making diagnosis difficult.2,3<\/sup>\n<\/p>\n

\n\u201cThe challenge in diagnosing cardiac amyloidosis can prevent patients from getting treatment while the disease continues to progress,\u201d said David McMullin, chief business officer of Anumana. \u201cWe believe this collaboration will demonstrate the power of Anumana\u2019s AI-ECG algorithms to help clinicians intervene earlier, giving them greater ability to improve patient outcomes and prolong lives.\u201d\n<\/p>\n

\nThe research agreement with Pfizer will help deepen Anumana\u2019s efforts to implement AI-enabled early detection software that can reveal signals from ECGs that humans cannot interpret. The ubiquitous nature of the painless, non-invasive 100-year-old ECG test gives AI-ECG algorithms the potential to reach a larger number of patients earlier.\n<\/p>\n

\n\u201cAI-ECG solutions alert clinicians to humanly imperceptible patterns in ECG signals, providing an early warning for serious occult or impending disease,\u201d said Paul Friedman, M.D., Chair of the Department of Cardiovascular Medicine at Mayo Clinic and Chair of Anumana\u2019s Mayo Clinic Board of Advisors. \u201cThis stands to improve the lives of people with cardiac amyloidosis by improving the speed of triage and care of this group.\u201d\n<\/p>\n

\nAnumana was founded in 2021 in collaboration with the Mayo Clinic Platform<\/a>. Anumana has licensed Mayo Clinic AI-ECG algorithms for low ejection fraction, pulmonary hypertension, and hyperkalemia, all of which have received Breakthrough Device Designation from the U.S. FDA. These algorithms have been validated by over 75 peer-reviewed publications, including a first of its kind prospective clinical impact study on low ventricular ejection fraction that was published in Nature Medicine<\/i><\/a> in 2021, and another first of its kind batch enrolled prospective clinical impact study that demonstrated the effectiveness of AI-ECG to screen for undetected atrial fibrillation in normal sinus rhythm that was published in The <\/i>Lancet<\/i><\/a> <\/i>in 2022.\n<\/p>\n

\nAbout Anumana<\/b>\n<\/p>\n

\nAnumana, an AI-driven health technology company and portfolio company of nference<\/a>, is harnessing industry-leading AI and translational science to unlock the electrical language of the heart as never before. Anumana algorithms have been developed, trained, and validated using clinical data from Mayo Clinic and other leading institutions to detect hidden diseases using AI-ECG algorithms and to enhance and improve interventional procedures through real-time AI techniques. Multiple Anumana algorithms have received FDA Breakthrough Device Designation and are currently undergoing rigorous clinical trial validation. Anumana software devices are designed for real-world physician use, integrating into existing workflows at the point of care to reduce costs and enhance quality of life. Anumana algorithms are investigational medical devices and have not yet received regulatory approval or clearance. For more information, visit anumana.ai<\/a> and follow Anumana on LinkedIn<\/a> and Twitter<\/a>.\n<\/p>\n

\nReferences\n<\/p>\n

    \n
  1. \nRapezzi C, Lorenzini M, Longhi S et al. Cardiac amyloidosis: the great pretender. Heart Fail Rev. 2015;20(2):117-124.\n<\/li>\n
  2. \nMaurer MS, Elliott P, Comenzo R, Semigran M, Rapezzi C. Addressing Common Questions Encountered in the Diagnosis and Management of Cardiac Amyloidosis. Circulation. 2017;135(14):1357-1377.\n<\/li>\n
  3. \nAsh S, Shorer E, Ramgobin D, Vo M, Gibbons J, Golamari R, Jain R, Jain R. Cardiac amyloidosis-A review of current literature for the practicing physician. Clin Cardiol. 2021 Mar;44(3):322-331.\n<\/li>\n<\/ol>\n

    Contacts<\/b> <\/p>\n

    \nSam Choinski
    \n
    Pazanga Health Communications for Anumana
    \n
    schoinski@pazangahealth.com<\/a>
    (860) 301-5058\n<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

    Companies initiate research agreement supporting development of new AI-ECG algorithm to help identify patients who may be at risk of cardiac amyloidosis CAMBRIDGE, Mass.–(BUSINESS WIRE)–#AI—Anumana, Inc., an AI-driven health technology company and portfolio company of nference, has entered into a multi-year agreement with Pfizer, Inc. for Anumana to develop an artificial intelligence electrocardiogram algorithm (AI-ECG) … [Read more…]<\/a><\/span><\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[13],"tags":[],"class_list":{"0":"entry","1":"post","2":"publish","3":"author-business","4":"post-52020","6":"format-standard","7":"category-industry"},"yoast_head":"\nAnumana and Pfizer Partner to Enable Early Detection of Underdiagnosed Cardiovascular Disease - Pharma Trend<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/pharma-trend.com\/en\/anumana-and-pfizer-partner-to-enable-early-detection-of-underdiagnosed-cardiovascular-disease\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Anumana and Pfizer Partner to Enable Early Detection of Underdiagnosed Cardiovascular Disease - Pharma Trend\" \/>\n<meta property=\"og:description\" content=\"Companies initiate research agreement supporting development of new AI-ECG algorithm to help identify patients who may be at risk of cardiac amyloidosis CAMBRIDGE, Mass.–(BUSINESS WIRE)–#AI—Anumana, Inc., an AI-driven health technology company and portfolio company of nference, has entered into a multi-year agreement with Pfizer, Inc. for Anumana to develop an artificial intelligence electrocardiogram algorithm (AI-ECG) ... 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