{"id":52524,"date":"2023-01-04T15:02:22","date_gmt":"2023-01-04T14:02:22","guid":{"rendered":"https:\/\/pharma-trend.com\/en\/makana-issued-important-patent-in-europe-with-hopes-of-accelerating-xenotransplantation-worldwide\/"},"modified":"2023-01-04T15:02:22","modified_gmt":"2023-01-04T14:02:22","slug":"makana-issued-important-patent-in-europe-with-hopes-of-accelerating-xenotransplantation-worldwide","status":"publish","type":"post","link":"https:\/\/pharma-trend.com\/en\/makana-issued-important-patent-in-europe-with-hopes-of-accelerating-xenotransplantation-worldwide\/","title":{"rendered":"Makana\u2122 Issued Important Patent in Europe With Hopes of Accelerating Xenotransplantation Worldwide"},"content":{"rendered":"<div>\n<ul class=\"bwlistdisc\">\n<li>\n<b>Company in discussion with FDA regarding first-ever human clinical trial as a solution to help solve the organ donor shortage crisis<\/b>\n<\/li>\n<\/ul>\n<p>MIAMI&#8211;(BUSINESS WIRE)&#8211;Makana\u2122 Therapeutics, a global leader in the field of xenotransplantation, was granted an important European patent that will catalyze xenotransplantation efforts abroad, the company announced today. Makana is working to solve the organ shortage crisis by making genetically modified pigs for use as organ donors for human recipients. The patent was granted on the TKO pig, or \u201cTriple Knockout,\u201d which is a combination of three xenoantigen gene knockouts in the pig that effectively camouflage the cross-species grafts from the human recipient\u2019s immune system.\n<\/p>\n<p><a href=\"https:\/\/mms.businesswire.com\/media\/20230104005102\/en\/1675411\/5\/Makana-Therapeutics-Logo-TM.jpg\"><img decoding=\"async\" src=\"https:\/\/mms.businesswire.com\/media\/20230104005102\/en\/1675411\/21\/Makana-Therapeutics-Logo-TM.jpg\"><\/a><\/p>\n<p>\nMakana has demonstrated compelling results in xenotransplantation. \u201cOur knockout pigs combined with our advancements in immunosuppression and patient matching have resulted in the longest and most consistent preclinical survival data in the xenotransplantation field,\u201d said Mark Platt, the company\u2019s President and Chief Executive Officer.\n<\/p>\n<p>\nThe Triple Knockout Pig was discovered in the lab of Joe Tector, MD, PhD, FACS, who is also the founder of Makana. \u201cThe Triple Knockout Pig has fundamentally changed the xenotransplantation field,\u201d Platt said. \u201cThe organs from this animal have been shown to be an acceptable match to more than 30% of patients waiting for a kidney transplant, and likely more than 70% of patients can benefit from these organs with available pre-transplant treatment.\u201d\n<\/p>\n<p>\nAccording to the United States Renal Data System (USRDS), 23,853 kidney transplants were performed in the United States in 2020. At the end of 2020, 75,747 patients were on the waitlist for a kidney transplant. The active waiting list remains substantially larger than the supply of donor kidneys, which presents a continuing challenge.\n<\/p>\n<p>\nMakana is in talks with the U.S. Food and Drug Administration regarding next steps to conduct the first-ever human clinical trial in kidney transplant. The trial would be conducted at the University of Miami. Dr. Tector, a practicing transplant surgeon, heads up the xenotransplant program at Miami Transplant Institute (MTI), a collaboration between Jackson Memorial Hospital and the University of Miami Health System.\n<\/p>\n<p>\n\u201cThe TKO pig is widely seen as the preferred genetic profile that will enter clinical trials,\u201d Platt said. \u201cSucessfully executing our clinical trial will change the field of transplantation forever.\u201d\n<\/p>\n<p>\nThis recent development will add to Makana\u2019s portfolio of intellectual property and will help the company to serve patients in Europe who are in desperate need of a transplant. It is estimated that 75 million people in Europe suffer from chronic kidney disease, according to the European Kidney Health Alliance. Many of those individuals languish on transplant waiting lists.\n<\/p>\n<p>\n<b>About Makana Therapeutics<\/b>\n<\/p>\n<p>\nFounded in 2009, Makana Therapeutics is focused on developing swine with reduced xenoantigen expression, making human transplantation of cells, tissues and organs from these animals possible. Makana&#8217;s focus on simplified genetics, optimized pig cloning techniques and careful patient selection is expected to streamline product development and result in safer more efficacious products. For more information on Makana, please visit <a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=http%3A%2F%2Fwww.makanatherapeutics.com&amp;esheet=53157268&amp;newsitemid=20230104005102&amp;lan=en-US&amp;anchor=www.makanatherapeutics.com&amp;index=1&amp;md5=04ceaa924369f6aaea9aa8ee6eecd2ba\" rel=\"nofollow noopener\" shape=\"rect\">www.makanatherapeutics.com<\/a>.\n<\/p>\n<p> <b>Contacts<\/b> <\/p>\n<p>\nMark Leonard<br \/>\n<br \/><a target=\"_blank\" href=\"&#109;&#x61;&#x69;&#108;&#x74;&#x6f;:&#x6d;&#x61;r&#107;&#x40;r&#101;&#x61;c&#104;&#x74;h&#101;&#x6e;e&#120;&#x74;&#x6c;&#101;&#x76;&#x65;&#108;&#x2e;&#x63;o&#x6d;\" rel=\"nofollow noopener\" shape=\"rect\">&#109;&#x61;r&#x6b;&#x40;&#114;&#x65;a&#99;&#x68;&#116;&#x68;e&#110;&#x65;x&#x74;l&#101;&#x76;e&#x6c;&#x2e;&#99;&#x6f;m<\/a><br \/>847-651-9682\n<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Company in discussion with FDA regarding first-ever human clinical trial as a solution to help solve the organ donor shortage crisis MIAMI&#8211;(BUSINESS WIRE)&#8211;Makana\u2122 Therapeutics, a global leader in the field of xenotransplantation, was granted an important European patent that will catalyze xenotransplantation efforts abroad, the company announced today. Makana is working to solve the organ &#8230; <span class=\"more\"><a class=\"more-link\" href=\"https:\/\/pharma-trend.com\/en\/makana-issued-important-patent-in-europe-with-hopes-of-accelerating-xenotransplantation-worldwide\/\">[Read more&#8230;]<\/a><\/span><\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[13],"tags":[],"class_list":{"0":"entry","1":"post","2":"publish","3":"author-business","4":"post-52524","6":"format-standard","7":"category-industry"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Makana\u2122 Issued Important Patent in Europe With Hopes of Accelerating Xenotransplantation Worldwide - Pharma Trend<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/pharma-trend.com\/en\/makana-issued-important-patent-in-europe-with-hopes-of-accelerating-xenotransplantation-worldwide\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Makana\u2122 Issued Important Patent in Europe With Hopes of Accelerating Xenotransplantation Worldwide - Pharma Trend\" \/>\n<meta property=\"og:description\" content=\"Company in discussion with FDA regarding first-ever human clinical trial as a solution to help solve the organ donor shortage crisis MIAMI&#8211;(BUSINESS WIRE)&#8211;Makana\u2122 Therapeutics, a global leader in the field of xenotransplantation, was granted an important European patent that will catalyze xenotransplantation efforts abroad, the company announced today. 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