{"id":52646,"date":"2023-01-06T18:02:26","date_gmt":"2023-01-06T17:02:26","guid":{"rendered":"https:\/\/pharma-trend.com\/en\/feinstein-institutes-researchers-discover-a-molecule-to-clear-invading-bacteria-in-septic-patients\/"},"modified":"2023-01-06T18:02:26","modified_gmt":"2023-01-06T17:02:26","slug":"feinstein-institutes-researchers-discover-a-molecule-to-clear-invading-bacteria-in-septic-patients","status":"publish","type":"post","link":"https:\/\/pharma-trend.com\/en\/feinstein-institutes-researchers-discover-a-molecule-to-clear-invading-bacteria-in-septic-patients\/","title":{"rendered":"Feinstein Institutes Researchers Discover a Molecule to Clear Invading Bacteria in Septic Patients"},"content":{"rendered":"
\n

\nThe sepsis study, led by Ping Wang, MD, was recently published in <\/i>Springer Nature\u2019s Cellular and Molecular Immunology<\/i>\n<\/p>\n

MANHASSET, N.Y.–(BUSINESS WIRE)–Sepsis often leads to shock and multiple organ failure, making it one of the leading causes of in-hospital deaths worldwide. While much of the mystery surrounding sepsis remains, Feinstein Institutes for Medical Research<\/a> scientists published in Cellular & Molecular Immunology<\/a> <\/i>the discovery of a protein that inhibits the body\u2019s ability to clear bacteria, opening new avenues of therapeutic research.\n<\/p>\n

<\/a>
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\nThe new study explores how extracellular cold-inducible RNA-binding protein (eCIRP) \u2013 an alarm molecule released during sepsis \u2013 causes immune dysfunction. Specifically, eCIRP disrupts the cells within the immune system, which ingest bacteria and secrete both pro-inflammatory and antimicrobial mediators, known as macrophages. Macrophages play an important role in eliminating invading bacteria and damaged or dead cells from the body; however, new research shows how eCIRP dysregulates its normal function and contributes to sepsis progression.\n<\/p>\n

\nThe research, led by Feinstein Institutes\u2019 Ping Wang, MD<\/a>, explains how eCIRP disrupts the cytoskeleton \u2013 the structure that maintains a cell\u2019s shape \u2013 in lab mice, ultimately leading to the impairment of macrophage bacterial digestion during sepsis. Conversely, eCIRP-deficient, or eCIRP-neutralizing antibody-treated mice restored the macrophage function and reduced bacterial load. Indeed, the mice without eCIRP proteins displayed better survival outcomes.\n<\/p>\n

\n\u201cThere is no single specific treatment for patients with sepsis and it remains an enigmatic disease for researchers globally,\u201d said Dr. Wang, professor and chief scientific officer at the Feinstein Institutes. \u201cBy reducing eCIRP molecules, we can lower the bacteria in septic patients and improve their outcome. This new information opens new avenues of research for effective therapies.\u201d\n<\/p>\n

\nSepsis impacts at least 1.7 million Americans annually<\/a>, leading to the death of 270,000 patients and accounting for 30 percent of all hospital deaths. Sepsis occurs when the body\u2019s immune system triggers inflammation to help fight against infection. If out of control, this inflammatory response can cause damage to multiple organ systems and often leads to death. Septic patients often exhibit the simultaneous occurrence of pro- and anti-inflammatory pathways, which can lead them to suffer from immunosuppression, the inability to eradicate invading bacteria and eventually become susceptible to secondary infections. Macrophages clear pathogens in the body, but during sepsis, the macrophage\u2019s bacterial phagocytic ability is compromised. This results in bacterial overgrowth that can ultimately cause tissue injury and death.\n<\/p>\n

\nThe study suggests that because of these findings, new therapies for sepsis could be provided. Currently, targeting sepsis-induced immunosuppression is one of the most striking therapeutic directions being studied. Correcting the function of macrophages for efficient clearance of pathogens could be an important therapeutic strategy to safeguard patients from sepsis. It could also provide a new therapeutic avenue to restore host defense against pathogens to improve the outcomes of sepsis, and potentially other inflammatory disease conditions.\n<\/p>\n

\n\u201cSepsis affects millions of people annually, and effective therapies are needed,\u201d said Kevin J. Tracey, MD<\/a>, president and CEO of the Feinstein Institutes. \u201cThe discoveries from Dr. Wang, and his lab, pave the way to exploring new mechanisms that may one day lead to new treatments.\u201d\n<\/p>\n

\nThe Feinstein Institutes continues to lead research studying the molecular mechanisms of sepsis to develop treatments. Most recently, Dr. Wang and co-principal investigators received $3.8 million from the National Institute of Health<\/a> to study sepsis and radiation exposure.\n<\/p>\n

\nAbout the Feinstein Institutes
\n
<\/i><\/b>The Feinstein Institutes for Medical Research<\/a><\/i> is <\/i>the<\/i> home of <\/i>the<\/i> research <\/i>institutes<\/i> <\/i>of Northwell Health, the largest health care provider and private employer in New York State.<\/i> <\/i>Encompassing<\/i> <\/i>50 research labs, 3,000 clinical research studies and 5,000 researchers and staff, the Feinstein Institutes raises the standard of medical innovation through its five institutes of behavioral science, bioelectronic medicine, cancer, health system science, and molecular medicine. We make breakthroughs in genetics, oncology, brain research, mental health, autoimmunity, and are the global scientific leader in bioelectronic medicine \u2013 a new field of science that has the potential to revolutionize medicine. For more information about how we produce knowledge to cure disease, visit<\/i> <\/i>http:\/\/feinstein.northwell.edu<\/a><\/i> <\/i>and follow us on <\/i>LinkedIn<\/a><\/i>.<\/i>\n<\/p>\n

Contacts<\/b> <\/p>\n

\nJulianne Mosher Allen
\n
516-880-4824
\n
jmosherallen@northwell.edu<\/a>\n<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

The sepsis study, led by Ping Wang, MD, was recently published in Springer Nature\u2019s Cellular and Molecular Immunology MANHASSET, N.Y.–(BUSINESS WIRE)–Sepsis often leads to shock and multiple organ failure, making it one of the leading causes of in-hospital deaths worldwide. While much of the mystery surrounding sepsis remains, Feinstein Institutes for Medical Research scientists published … [Read more…]<\/a><\/span><\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[13],"tags":[],"class_list":{"0":"entry","1":"post","2":"publish","3":"author-business","4":"post-52646","6":"format-standard","7":"category-industry"},"yoast_head":"\nFeinstein Institutes Researchers Discover a Molecule to Clear Invading Bacteria in Septic Patients - Pharma Trend<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/pharma-trend.com\/en\/feinstein-institutes-researchers-discover-a-molecule-to-clear-invading-bacteria-in-septic-patients\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Feinstein Institutes Researchers Discover a Molecule to Clear Invading Bacteria in Septic Patients - Pharma Trend\" \/>\n<meta property=\"og:description\" content=\"The sepsis study, led by Ping Wang, MD, was recently published in Springer Nature\u2019s Cellular and Molecular Immunology MANHASSET, N.Y.–(BUSINESS WIRE)–Sepsis often leads to shock and multiple organ failure, making it one of the leading causes of in-hospital deaths worldwide. 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