{"id":53005,"date":"2023-01-17T19:02:15","date_gmt":"2023-01-17T18:02:15","guid":{"rendered":"https:\/\/pharma-trend.com\/en\/milestone-study-exploring-the-significant-impact-of-ed-drugs-on-mens-cardiac-health-published-in-the-journal-of-sexual-medicine\/"},"modified":"2023-01-17T19:02:15","modified_gmt":"2023-01-17T18:02:15","slug":"milestone-study-exploring-the-significant-impact-of-ed-drugs-on-mens-cardiac-health-published-in-the-journal-of-sexual-medicine","status":"publish","type":"post","link":"https:\/\/pharma-trend.com\/en\/milestone-study-exploring-the-significant-impact-of-ed-drugs-on-mens-cardiac-health-published-in-the-journal-of-sexual-medicine\/","title":{"rendered":"Milestone Study Exploring the Significant Impact of ED Drugs on Men\u2019s Cardiac Health Published in the Journal of Sexual Medicine"},"content":{"rendered":"<div>\n<p>PASADENA, Calif.&#8211;(BUSINESS WIRE)&#8211;A comprehensive research study manuscript examining the impact of erectile dysfunction drugs on major adverse cardiovascular events (MACE) and mortality has been published by scientists from <a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Fwww.hmri.org%2F&amp;esheet=53255741&amp;newsitemid=20230117005851&amp;lan=en-US&amp;anchor=Huntington+Medical+Research+Institutes&amp;index=1&amp;md5=bf62d7833cc306f677d0addd272ed424\" rel=\"nofollow noopener\" shape=\"rect\">Huntington Medical Research Institutes<\/a> (HMRI) in Pasadena, <a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Fwww.healthcore.com%2F&amp;esheet=53255741&amp;newsitemid=20230117005851&amp;lan=en-US&amp;anchor=HealthCore+Inc.&amp;index=2&amp;md5=02d921f07b2942968387a658ee386e5f\" rel=\"nofollow noopener\" shape=\"rect\">HealthCore Inc.<\/a> and the <a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Fwww.ucsf.edu%2F&amp;esheet=53255741&amp;newsitemid=20230117005851&amp;lan=en-US&amp;anchor=University+of+California+San+Francisco&amp;index=3&amp;md5=ed14405e726f6e2d7fa1e8b43bee0435\" rel=\"nofollow noopener\" shape=\"rect\">University of California San Francisco<\/a>.\n<\/p>\n<p><a href=\"https:\/\/mms.businesswire.com\/media\/20230117005851\/en\/1687834\/5\/HMRI-2.jpg\"><img decoding=\"async\" src=\"https:\/\/mms.businesswire.com\/media\/20230117005851\/en\/1687834\/21\/HMRI-2.jpg\"><\/a><\/p>\n<p>\nThis study marks a significant medical milestone, as it\u2019s the first time the association between the use of PDE-5i drugs and cardiovascular health has been explored in a large population of relatively low-risk men with ED in the United States. In this study, scientists analyzed health records of more than 70,000 men with ED. According to the findings of this large-population study, men who took Viagra, Cialis, Levitra and other drugs of the same class for erectile dysfunction (ED) experienced lower rates of major adverse cardiovascular events (MACE) including lower rates of heart failure and death due to heart disease compared to other men with ED not exposed to these drugs.\n<\/p>\n<p>\nAmong the men who took PDE-5i medications for ED compared to men with ED who did not take these drugs, Kloner\u2019s study identified:\n<\/p>\n<ul class=\"bwlistdisc\">\n<li>\n39% lower rate of death due to heart disease,\n<\/li>\n<li>\n22% lower rate of unstable angina,\n<\/li>\n<li>\n17% lower rate of heart failure,\n<\/li>\n<li>\n15% lower rate in the need for revascularization procedures such as angioplasty, stenting and bypass surgery,\n<\/li>\n<li>\n13% lower rate of MACE, and\n<\/li>\n<li>\n25% lower rate of death due to any cause.\n<\/li>\n<\/ul>\n<p>\nPrincipal investigator <a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Fwww.hmri.org%2Fresearchers%2Frobert-a-kloner%2F&amp;esheet=53255741&amp;newsitemid=20230117005851&amp;lan=en-US&amp;anchor=Robert+A.+Kloner&amp;index=4&amp;md5=e56032124e09e3a9e06a9fb908802de3\" rel=\"nofollow noopener\" shape=\"rect\">Robert A. Kloner<\/a>, MD, PhD, chief science officer and scientific director of cardiovascular research at HMRI, and Professor of Medicine at the Keck School of Medicine of University of Southern California, and his co-investigators\u2014Julia E. Bradsher of HMRI; Eric Stanek, Christopher L. Crowe, Mukul Singhal, and Rebecca S. Pepe of HealthCore Inc.; and Raymond Rosen of University of California San Francisco\u2014drew anonymized patient records from a large U.S. commercial and Medicare insurance claims database. The study, funded by a grant from <a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Fwww.sanofi.com%2F&amp;esheet=53255741&amp;newsitemid=20230117005851&amp;lan=en-US&amp;anchor=Sanofi&amp;index=5&amp;md5=a1da70e679a4d1db9b1e56c62bd68cbf\" rel=\"nofollow noopener\" shape=\"rect\">Sanofi<\/a>, examined records over approximately 14 years.\n<\/p>\n<p>\nThe overall benefit in reduction of cardiac events was observed in men who also had risk factors for cardiovascular disease including diabetes. Due to the retrospective nature of the study, the research team cannot say anything about the cause of the benefit, only that there was an association between the exposure to PDE 5 inhibitors and lower rates of cardiovascular events. These results raise the possibility that the PDE5 inhibitors may have cardioprotective properties. Large scale prospective, placebo controlled, randomized clinical trials are needed.\n<\/p>\n<p>\nThe full manuscript can be read <a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Facademic.oup.com%2Fjsm%2Fadvance-article%2Fdoi%2F10.1093%2Fjsxmed%2Fqdac005%2F6986842%3Fsearchresult%3D1&amp;esheet=53255741&amp;newsitemid=20230117005851&amp;lan=en-US&amp;anchor=here&amp;index=6&amp;md5=29f90d8a879ed8cdbe394c99d228ed68\" rel=\"nofollow noopener\" shape=\"rect\">here<\/a>.\n<\/p>\n<p>\n<b>About HMRI<\/b>\n<\/p>\n<p>\nHuntington Medical Research Institutes (HMRI) is an independent, nonprofit organization located in Pasadena, California. Since its beginnings in 1952, HMRI research has led to the development of diagnostics, medical devices and therapies that improve the lives of millions of patients worldwide. HMRI conducts life-changing studies of the heart, the brain and the vascular intersection between the two. The institute\u2019s scientists seek solutions to daunting cardiovascular and neurological challenges, like heart disease, Alzheimer\u2019s disease, migraine and mental illness. For more information, visit <a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Fwww.hmri.org%2F&amp;esheet=53255741&amp;newsitemid=20230117005851&amp;lan=en-US&amp;anchor=HMRI.org&amp;index=7&amp;md5=10e9078b247cf5984a0c7fbc6858cf50\" rel=\"nofollow noopener\" shape=\"rect\">HMRI.org<\/a>.\n<\/p>\n<p>\n<b>About the International Society for Sexual Medicine (ISSM)<\/b>\n<\/p>\n<p>\nThe International Society for Sexual Medicine was established in 1978. The goals of the ISSM are to encourage the highest standards of practice, education, and research in the field of human sexuality; to develop and assist in developing scientific methods for the diagnosis, prevention, and treatment of conditions affecting human sexual function; and to promote the publication and encourage contributions to the medical and scientific literature in the field of sexual function. The ISSM has over 3,000 members from all five continents and from 100+ nations. For more information about the ISSM, visit <a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Fwww.issm.info&amp;esheet=53255741&amp;newsitemid=20230117005851&amp;lan=en-US&amp;anchor=https%3A%2F%2Fwww.issm.info&amp;index=8&amp;md5=cc744c5282e7468089259b9925432d45\" rel=\"nofollow noopener\" shape=\"rect\">https:\/\/www.issm.info<\/a>.\n<\/p>\n<p> <b>Contacts<\/b> <\/p>\n<p>\nAudrey Chittick<br \/>\n<br \/>mPR on behalf of HMRI<br \/>\n<br \/><a target=\"_blank\" href=\"&#109;&#x61;&#105;&#x6c;&#116;&#x6f;:&#x61;u&#100;&#x72;&#101;&#x79;&#64;&#x6d;p&#x75;b&#108;&#x69;&#99;&#x72;&#101;&#x6c;&#97;&#x74;i&#x6f;n&#115;&#x2e;&#99;&#x6f;&#109;\" rel=\"nofollow noopener\" shape=\"rect\">&#97;u&#x64;r&#x65;y&#x40;m&#x70;&#117;&#x62;&#108;&#x69;&#99;&#x72;&#101;l&#97;t&#x69;o&#x6e;s&#x2e;&#99;&#x6f;&#109;<\/a>\n<\/p>\n<p>\nMr. David Casalod<br \/>\n<br \/>Executive Director, International Society for Sexual Medicine (ISSM)<br \/>\n<br \/><a target=\"_blank\" href=\"&#x6d;&#97;i&#x6c;&#116;o&#x3a;&#x6f;&#102;&#x66;&#x69;&#99;e&#x40;&#105;s&#x73;&#x6d;&#46;&#x69;&#x6e;&#102;o\" rel=\"nofollow noopener\" shape=\"rect\">&#111;&#x66;f&#105;&#x63;e&#64;&#x69;s&#115;&#x6d;&#46;&#105;&#x6e;f&#111;<\/a>\n<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>PASADENA, Calif.&#8211;(BUSINESS WIRE)&#8211;A comprehensive research study manuscript examining the impact of erectile dysfunction drugs on major adverse cardiovascular events (MACE) and mortality has been published by scientists from Huntington Medical Research Institutes (HMRI) in Pasadena, HealthCore Inc. and the University of California San Francisco. This study marks a significant medical milestone, as it\u2019s the first &#8230; <span class=\"more\"><a class=\"more-link\" href=\"https:\/\/pharma-trend.com\/en\/milestone-study-exploring-the-significant-impact-of-ed-drugs-on-mens-cardiac-health-published-in-the-journal-of-sexual-medicine\/\">[Read more&#8230;]<\/a><\/span><\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[13],"tags":[],"class_list":{"0":"entry","1":"post","2":"publish","3":"author-business","4":"post-53005","6":"format-standard","7":"category-industry"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Milestone Study Exploring the Significant Impact of ED Drugs on Men\u2019s Cardiac Health Published in the Journal of Sexual Medicine - Pharma Trend<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/pharma-trend.com\/en\/milestone-study-exploring-the-significant-impact-of-ed-drugs-on-mens-cardiac-health-published-in-the-journal-of-sexual-medicine\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Milestone Study Exploring the Significant Impact of ED Drugs on Men\u2019s Cardiac Health Published in the Journal of Sexual Medicine - Pharma Trend\" \/>\n<meta property=\"og:description\" content=\"PASADENA, Calif.&#8211;(BUSINESS WIRE)&#8211;A comprehensive research study manuscript examining the impact of erectile dysfunction drugs on major adverse cardiovascular events (MACE) and mortality has been published by scientists from Huntington Medical Research Institutes (HMRI) in Pasadena, HealthCore Inc. and the University of California San Francisco. This study marks a significant medical milestone, as it\u2019s the first ... 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This study marks a significant medical milestone, as it\u2019s the first ... 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