{"id":53047,"date":"2023-01-18T17:03:47","date_gmt":"2023-01-18T16:03:47","guid":{"rendered":"https:\/\/pharma-trend.com\/en\/feinstein-institutes-researchers-turn-on-the-vagus-nerve-control-the-inflammatory-reflex\/"},"modified":"2023-01-18T17:03:47","modified_gmt":"2023-01-18T16:03:47","slug":"feinstein-institutes-researchers-turn-on-the-vagus-nerve-control-the-inflammatory-reflex","status":"publish","type":"post","link":"https:\/\/pharma-trend.com\/en\/feinstein-institutes-researchers-turn-on-the-vagus-nerve-control-the-inflammatory-reflex\/","title":{"rendered":"Feinstein Institutes researchers turn on the vagus nerve, control the inflammatory reflex"},"content":{"rendered":"
\n

MANHASSET, N.Y.–(BUSINESS WIRE)–The vagus nerve runs from the human brainstem to major peripheral organs and acts as the main conduit for the body\u2019s inflammatory immune response to disease, bacteria and viruses. For the first time, researchers at The Feinstein Institutes for Medical Research<\/a> have shown the ability to turn on specific receptors in the vagus nerve, activating the inflammatory reflex. The study, published in the journal Molecular Medicine<\/a><\/i>, <\/i>builds on decades of research into how to control the vagus nerve through electrical stimulation, which is the foundation of bioelectronic medicine.\n<\/p>\n

<\/a>
<\/a><\/p>\n

\nThe body releases inflammatory proteins to fight disease, which is part of the immune response. The communication pathway, known as the inflammatory reflex, is signaled through the vagus nerve \u2013 the longest cranial nerve made up of more than 100,000 individual nerve fibers. Through electrical signals, the brain, via the vagus nerve, can tell the body when to stop releasing inflammatory molecules. If not regulated correctly, the inflammation can be destructive and the root cause of acute and chronic diseases like Crohn\u2019s, rheumatoid arthritis, diabetes and even cancer.\n<\/p>\n

\nAlthough the existence of a vagus nerve circuit that protects against excessive inflammation was identified more than 20 years ago, how this response is activated was previously unknown. The new research, led by the Feinstein Institutes\u2019 Sangeeta S. Chavan, PhD<\/a>, professor in the Institute of Bioelectronic Medicine<\/a>, identifies a specific subset of sensory neurons on the vagus nerve that sends inflammation-related information to the brain to trigger hypothermia and activates the anti-inflammatory response.\n<\/p>\n

\n\u201cThe vagus nerve is crucial for signaling to the brain and the body\u2019s organs when to turn on or off inflammation \u2013 this is our body\u2019s natural response to disease and infection,\u201d said Dr. Chavan, senior author on the paper. \u201cWith this new research, we have a better understanding of how to manipulate the vagus nerve\u2019s function through stimulation.\u201d\n<\/p>\n

\nIn the Molecular Medicine<\/i> paper, titled \u201cTransient Receptor Potential Ankyrin-1-expressing vagus nerve fibers mediate IL-1\u03b2 induced hypothermia and reflex anti-inflammatory responses,\u201d researchers explain how with the use of light, known as optogenetics, they were able to stimulate the mice\u2019s vagus nerve and record their physiological responses, including body temperature. Scientists studied how Interleukin-1\u03b2 (IL-1\u03b2), a proinflammatory cytokine, interacts with a sensory neuron Transient Receptor Potential Ankyrin-1 (TRPA1). TRPA1, typically a detector of cold, pain and itch, when activated by IL-1\u03b2 can slow cytokine release, reducing lethal levels of inflammation.\n<\/p>\n

\n\u201cWe continue to learn new mechanisms for vagus nerve control of inflammation,\u201d said Kevin J. Tracey, MD<\/a>, president and CEO of the Feinstein Institutes, Karches Family Distinguished Chair in Medical Research and co-senior author on the new paper. \u201cThese new findings reveal for the first time how the vagus nerve informs the brain about inflammation in the body.\u201d\n<\/p>\n

\nThe Feinstein Institutes is known as the global scientific home of bioelectronic medicine because of early discoveries in its labs. Decades ago, Dr. Tracey and his colleagues discovered the role the vagus nerve plays<\/a> in controlling our body\u2019s immune response, defining it as the inflammatory reflex. Researchers continue to build off that discovery worldwide to develop devices to cure disease.\n<\/p>\n

\nAbout Bioelectronic Medicine<\/b>\n<\/p>\n

\nThe Feinstein Institutes for Medical Research is the global scientific home of bioelectronic medicine, which combines molecular medicine, neuroscience and biomedical engineering. At the Feinstein Institutes, medical researchers use modern technology to develop new device-based therapies to treat disease and injury.\n<\/p>\n

\nBuilt on years of research in molecular mechanisms of disease and the link between the nervous and immune systems, our researchers discover neural targets that can be activated or inhibited with neuromodulation devices, like vagus nerve implants, to control the body\u2019s immune response and inflammation. If inflammation is successfully controlled, diseases \u2013 such as arthritis, pulmonary hypertension, Crohn’s disease, inflammatory bowel diseases, diabetes, cancer and autoimmune diseases \u2013 can be treated more effectively.\n<\/p>\n

\nBeyond inflammation, using novel brain-computer interfaces, our researchers developed techniques to bypass injuries of the nervous system so that people living with paralysis can regain sensation and use their limbs. By producing bioelectronic medicine knowledge, disease and injury could one day be treated with our own nerves without costly and potentially harmful pharmaceuticals.\n<\/p>\n

\nAbout the Feinstein Institutes<\/i><\/b>\n<\/p>\n

\nThe Feinstein Institutes for Medical Research<\/a><\/i> is the home of <\/i>the<\/i> research <\/i>institutes<\/i> <\/i>of Northwell Health, the largest health care provider and private employer in New York State.<\/i> <\/i>Encompassing<\/i> <\/i>50 research labs, 3,000 clinical research studies and 5,000 researchers and staff, the Feinstein Institutes raises the standard of medical innovation through its five institutes of behavioral science, bioelectronic medicine, cancer, health system science, and molecular medicine. We make breakthroughs in genetics, oncology, brain research, mental health, autoimmunity, and are the global scientific leader in bioelectronic medicine \u2013 a new field of science that has the potential to revolutionize medicine. For more information about how we produce knowledge to cure disease, visit<\/i> <\/i>http:\/\/feinstein.northwell.edu<\/a><\/i> <\/i>and follow us on<\/i> <\/i>LinkedIn<\/a><\/i>.<\/i>\n<\/p>\n

Contacts<\/b> <\/p>\n

\nMatthew Libassi
\n
631-793-5325
\n
mlibassi@northwell.edu<\/a>\n<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

MANHASSET, N.Y.–(BUSINESS WIRE)–The vagus nerve runs from the human brainstem to major peripheral organs and acts as the main conduit for the body\u2019s inflammatory immune response to disease, bacteria and viruses. For the first time, researchers at The Feinstein Institutes for Medical Research have shown the ability to turn on specific receptors in the vagus … [Read more…]<\/a><\/span><\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[13],"tags":[],"class_list":{"0":"entry","1":"post","2":"publish","3":"author-business","4":"post-53047","6":"format-standard","7":"category-industry"},"yoast_head":"\nFeinstein Institutes researchers turn on the vagus nerve, control the inflammatory reflex - Pharma Trend<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/pharma-trend.com\/en\/feinstein-institutes-researchers-turn-on-the-vagus-nerve-control-the-inflammatory-reflex\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Feinstein Institutes researchers turn on the vagus nerve, control the inflammatory reflex - Pharma Trend\" \/>\n<meta property=\"og:description\" content=\"MANHASSET, N.Y.–(BUSINESS WIRE)–The vagus nerve runs from the human brainstem to major peripheral organs and acts as the main conduit for the body\u2019s inflammatory immune response to disease, bacteria and viruses. For the first time, researchers at The Feinstein Institutes for Medical Research have shown the ability to turn on specific receptors in the vagus ... [Read more...]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/pharma-trend.com\/en\/feinstein-institutes-researchers-turn-on-the-vagus-nerve-control-the-inflammatory-reflex\/\" \/>\n<meta property=\"og:site_name\" content=\"Pharma Trend\" \/>\n<meta property=\"article:published_time\" content=\"2023-01-18T16:03:47+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/mms.businesswire.com\/media\/20230118005735\/en\/1689429\/21\/Chavan_2023.jpg\" \/>\n<meta name=\"author\" content=\"Business Wire\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Business Wire\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"4 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/pharma-trend.com\\\/en\\\/feinstein-institutes-researchers-turn-on-the-vagus-nerve-control-the-inflammatory-reflex\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/pharma-trend.com\\\/en\\\/feinstein-institutes-researchers-turn-on-the-vagus-nerve-control-the-inflammatory-reflex\\\/\"},\"author\":{\"name\":\"Business Wire\",\"@id\":\"https:\\\/\\\/pharma-trend.com\\\/en\\\/#\\\/schema\\\/person\\\/02d41342c7a74fa7f0032bb35ef0bb24\"},\"headline\":\"Feinstein Institutes researchers turn on the vagus nerve, control the inflammatory reflex\",\"datePublished\":\"2023-01-18T16:03:47+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/pharma-trend.com\\\/en\\\/feinstein-institutes-researchers-turn-on-the-vagus-nerve-control-the-inflammatory-reflex\\\/\"},\"wordCount\":835,\"publisher\":{\"@id\":\"https:\\\/\\\/pharma-trend.com\\\/en\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/pharma-trend.com\\\/en\\\/feinstein-institutes-researchers-turn-on-the-vagus-nerve-control-the-inflammatory-reflex\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/mms.businesswire.com\\\/media\\\/20230118005735\\\/en\\\/1689429\\\/21\\\/Chavan_2023.jpg\",\"articleSection\":[\"Industry\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/pharma-trend.com\\\/en\\\/feinstein-institutes-researchers-turn-on-the-vagus-nerve-control-the-inflammatory-reflex\\\/\",\"url\":\"https:\\\/\\\/pharma-trend.com\\\/en\\\/feinstein-institutes-researchers-turn-on-the-vagus-nerve-control-the-inflammatory-reflex\\\/\",\"name\":\"Feinstein Institutes researchers turn on the vagus nerve, control the inflammatory reflex - Pharma Trend\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/pharma-trend.com\\\/en\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/pharma-trend.com\\\/en\\\/feinstein-institutes-researchers-turn-on-the-vagus-nerve-control-the-inflammatory-reflex\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/pharma-trend.com\\\/en\\\/feinstein-institutes-researchers-turn-on-the-vagus-nerve-control-the-inflammatory-reflex\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/mms.businesswire.com\\\/media\\\/20230118005735\\\/en\\\/1689429\\\/21\\\/Chavan_2023.jpg\",\"datePublished\":\"2023-01-18T16:03:47+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/pharma-trend.com\\\/en\\\/feinstein-institutes-researchers-turn-on-the-vagus-nerve-control-the-inflammatory-reflex\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/pharma-trend.com\\\/en\\\/feinstein-institutes-researchers-turn-on-the-vagus-nerve-control-the-inflammatory-reflex\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/pharma-trend.com\\\/en\\\/feinstein-institutes-researchers-turn-on-the-vagus-nerve-control-the-inflammatory-reflex\\\/#primaryimage\",\"url\":\"https:\\\/\\\/mms.businesswire.com\\\/media\\\/20230118005735\\\/en\\\/1689429\\\/21\\\/Chavan_2023.jpg\",\"contentUrl\":\"https:\\\/\\\/mms.businesswire.com\\\/media\\\/20230118005735\\\/en\\\/1689429\\\/21\\\/Chavan_2023.jpg\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/pharma-trend.com\\\/en\\\/feinstein-institutes-researchers-turn-on-the-vagus-nerve-control-the-inflammatory-reflex\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Startseite\",\"item\":\"https:\\\/\\\/pharma-trend.com\\\/en\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Feinstein Institutes researchers turn on the vagus nerve, control the inflammatory reflex\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/pharma-trend.com\\\/en\\\/#website\",\"url\":\"https:\\\/\\\/pharma-trend.com\\\/en\\\/\",\"name\":\"Pharma Trend\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\\\/\\\/pharma-trend.com\\\/en\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/pharma-trend.com\\\/en\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/pharma-trend.com\\\/en\\\/#organization\",\"name\":\"Pharma Trend\",\"url\":\"https:\\\/\\\/pharma-trend.com\\\/en\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/pharma-trend.com\\\/en\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"\",\"contentUrl\":\"\",\"caption\":\"Pharma Trend\"},\"image\":{\"@id\":\"https:\\\/\\\/pharma-trend.com\\\/en\\\/#\\\/schema\\\/logo\\\/image\\\/\"}},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/pharma-trend.com\\\/en\\\/#\\\/schema\\\/person\\\/02d41342c7a74fa7f0032bb35ef0bb24\",\"name\":\"Business Wire\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Feinstein Institutes researchers turn on the vagus nerve, control the inflammatory reflex - Pharma Trend","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/pharma-trend.com\/en\/feinstein-institutes-researchers-turn-on-the-vagus-nerve-control-the-inflammatory-reflex\/","og_locale":"en_US","og_type":"article","og_title":"Feinstein Institutes researchers turn on the vagus nerve, control the inflammatory reflex - Pharma Trend","og_description":"MANHASSET, N.Y.–(BUSINESS WIRE)–The vagus nerve runs from the human brainstem to major peripheral organs and acts as the main conduit for the body\u2019s inflammatory immune response to disease, bacteria and viruses. For the first time, researchers at The Feinstein Institutes for Medical Research have shown the ability to turn on specific receptors in the vagus ... [Read more...]","og_url":"https:\/\/pharma-trend.com\/en\/feinstein-institutes-researchers-turn-on-the-vagus-nerve-control-the-inflammatory-reflex\/","og_site_name":"Pharma Trend","article_published_time":"2023-01-18T16:03:47+00:00","og_image":[{"url":"https:\/\/mms.businesswire.com\/media\/20230118005735\/en\/1689429\/21\/Chavan_2023.jpg","type":"","width":"","height":""}],"author":"Business Wire","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Business Wire","Est. reading time":"4 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/pharma-trend.com\/en\/feinstein-institutes-researchers-turn-on-the-vagus-nerve-control-the-inflammatory-reflex\/#article","isPartOf":{"@id":"https:\/\/pharma-trend.com\/en\/feinstein-institutes-researchers-turn-on-the-vagus-nerve-control-the-inflammatory-reflex\/"},"author":{"name":"Business Wire","@id":"https:\/\/pharma-trend.com\/en\/#\/schema\/person\/02d41342c7a74fa7f0032bb35ef0bb24"},"headline":"Feinstein Institutes researchers turn on the vagus nerve, control the inflammatory reflex","datePublished":"2023-01-18T16:03:47+00:00","mainEntityOfPage":{"@id":"https:\/\/pharma-trend.com\/en\/feinstein-institutes-researchers-turn-on-the-vagus-nerve-control-the-inflammatory-reflex\/"},"wordCount":835,"publisher":{"@id":"https:\/\/pharma-trend.com\/en\/#organization"},"image":{"@id":"https:\/\/pharma-trend.com\/en\/feinstein-institutes-researchers-turn-on-the-vagus-nerve-control-the-inflammatory-reflex\/#primaryimage"},"thumbnailUrl":"https:\/\/mms.businesswire.com\/media\/20230118005735\/en\/1689429\/21\/Chavan_2023.jpg","articleSection":["Industry"],"inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/pharma-trend.com\/en\/feinstein-institutes-researchers-turn-on-the-vagus-nerve-control-the-inflammatory-reflex\/","url":"https:\/\/pharma-trend.com\/en\/feinstein-institutes-researchers-turn-on-the-vagus-nerve-control-the-inflammatory-reflex\/","name":"Feinstein Institutes researchers turn on the vagus nerve, control the inflammatory reflex - Pharma Trend","isPartOf":{"@id":"https:\/\/pharma-trend.com\/en\/#website"},"primaryImageOfPage":{"@id":"https:\/\/pharma-trend.com\/en\/feinstein-institutes-researchers-turn-on-the-vagus-nerve-control-the-inflammatory-reflex\/#primaryimage"},"image":{"@id":"https:\/\/pharma-trend.com\/en\/feinstein-institutes-researchers-turn-on-the-vagus-nerve-control-the-inflammatory-reflex\/#primaryimage"},"thumbnailUrl":"https:\/\/mms.businesswire.com\/media\/20230118005735\/en\/1689429\/21\/Chavan_2023.jpg","datePublished":"2023-01-18T16:03:47+00:00","breadcrumb":{"@id":"https:\/\/pharma-trend.com\/en\/feinstein-institutes-researchers-turn-on-the-vagus-nerve-control-the-inflammatory-reflex\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/pharma-trend.com\/en\/feinstein-institutes-researchers-turn-on-the-vagus-nerve-control-the-inflammatory-reflex\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/pharma-trend.com\/en\/feinstein-institutes-researchers-turn-on-the-vagus-nerve-control-the-inflammatory-reflex\/#primaryimage","url":"https:\/\/mms.businesswire.com\/media\/20230118005735\/en\/1689429\/21\/Chavan_2023.jpg","contentUrl":"https:\/\/mms.businesswire.com\/media\/20230118005735\/en\/1689429\/21\/Chavan_2023.jpg"},{"@type":"BreadcrumbList","@id":"https:\/\/pharma-trend.com\/en\/feinstein-institutes-researchers-turn-on-the-vagus-nerve-control-the-inflammatory-reflex\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Startseite","item":"https:\/\/pharma-trend.com\/en\/"},{"@type":"ListItem","position":2,"name":"Feinstein Institutes researchers turn on the vagus nerve, control the inflammatory reflex"}]},{"@type":"WebSite","@id":"https:\/\/pharma-trend.com\/en\/#website","url":"https:\/\/pharma-trend.com\/en\/","name":"Pharma Trend","description":"","publisher":{"@id":"https:\/\/pharma-trend.com\/en\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/pharma-trend.com\/en\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/pharma-trend.com\/en\/#organization","name":"Pharma Trend","url":"https:\/\/pharma-trend.com\/en\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/pharma-trend.com\/en\/#\/schema\/logo\/image\/","url":"","contentUrl":"","caption":"Pharma Trend"},"image":{"@id":"https:\/\/pharma-trend.com\/en\/#\/schema\/logo\/image\/"}},{"@type":"Person","@id":"https:\/\/pharma-trend.com\/en\/#\/schema\/person\/02d41342c7a74fa7f0032bb35ef0bb24","name":"Business Wire"}]}},"_links":{"self":[{"href":"https:\/\/pharma-trend.com\/en\/wp-json\/wp\/v2\/posts\/53047","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pharma-trend.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pharma-trend.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pharma-trend.com\/en\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/pharma-trend.com\/en\/wp-json\/wp\/v2\/comments?post=53047"}],"version-history":[{"count":0,"href":"https:\/\/pharma-trend.com\/en\/wp-json\/wp\/v2\/posts\/53047\/revisions"}],"wp:attachment":[{"href":"https:\/\/pharma-trend.com\/en\/wp-json\/wp\/v2\/media?parent=53047"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pharma-trend.com\/en\/wp-json\/wp\/v2\/categories?post=53047"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pharma-trend.com\/en\/wp-json\/wp\/v2\/tags?post=53047"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}