{"id":53333,"date":"2023-01-26T13:02:52","date_gmt":"2023-01-26T12:02:52","guid":{"rendered":"https:\/\/pharma-trend.com\/en\/jacc-publication-guides-use-of-caredxs-heartcare-transplant-rejection-surveillance-in-clinical-practice\/"},"modified":"2023-01-26T13:02:52","modified_gmt":"2023-01-26T12:02:52","slug":"jacc-publication-guides-use-of-caredxs-heartcare-transplant-rejection-surveillance-in-clinical-practice","status":"publish","type":"post","link":"https:\/\/pharma-trend.com\/en\/jacc-publication-guides-use-of-caredxs-heartcare-transplant-rejection-surveillance-in-clinical-practice\/","title":{"rendered":"JACC Publication Guides Use of CareDx\u2019s HeartCare Transplant Rejection Surveillance in Clinical Practice"},"content":{"rendered":"<div>\n<p class=\"bwalignc\">\n<i>Guide Helps Transplant Centers Continue the Evolution from<\/i><i> Endomyocardial Biopsies to Noninvasive Surveillance Using AlloMap GEP and AlloSure dd-cfDNA<\/i>\n<\/p>\n<p>BRISBANE, Calif.&#8211;(BUSINESS WIRE)&#8211;CareDx, Inc. (Nasdaq: CDNA) \u2013 The Transplant Company\u2122 focused on the discovery, development, and commercialization of clinically differentiated, high-value healthcare solutions for transplant patients and caregivers \u2013 today announced that the <i>Journal of the American College of Cardiology (JACC): Heart Failure <\/i>has published a <a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Fwww.sciencedirect.com%2Fscience%2Farticle%2Fabs%2Fpii%2FS2213177922006436%3Fvia%253Dihub&amp;esheet=53291557&amp;newsitemid=20230126005387&amp;lan=en-US&amp;anchor=detailed+guide&amp;index=1&amp;md5=bbff6f6f602924bf8b5162cb97580fb5\" rel=\"nofollow noopener\" shape=\"rect\">detailed guide<\/a><sup>1<\/sup> to help clinicians transition from routine invasive endomyocardial biopsy (EMB) to a less invasive acute rejection monitoring protocol in clinical practice.\n<\/p>\n<p><a href=\"https:\/\/mms.businesswire.com\/media\/20230126005387\/en\/1498832\/4\/CareDx_Logo.jpg\"><img decoding=\"async\" src=\"https:\/\/mms.businesswire.com\/media\/20230126005387\/en\/1498832\/21\/CareDx_Logo.jpg\"><\/a><\/p>\n<p>\nThe publication<sup>1<\/sup> reviews the clinical evidence for noninvasive surveillance, much of which evaluates the multicenter study data demonstrating the clinical utility of AlloMap<sup>\u00ae<\/sup> gene-expression profiling (GEP) and AlloSure<sup>\u00ae<\/sup> donor-derived cell-free DNA (dd-cfDNA). The authors also discuss the complementary role of GEP and dd-cfDNA and review the data suggesting that the tests can be used together for effective noninvasive rejection surveillance in heart transplant patients.\n<\/p>\n<p>\n\u201cCareDx is very proud to have helped clinicians shift their reliance on invasive EMBs to non-invasive solutions for routine heart transplant surveillance. We\u2019ve led the way by delivering an extensive body of clinical evidence in support of our HeartCare<sup>\u00ae<\/sup> testing services, AlloMap and AlloSure,\u201d said Reg Seeto, CEO and President of CareDx. \u201cI am delighted to see the publication of the <i>JACC: Heart Failure <\/i>guide on the heels of the new International Society for Heart and Lung Transplantation guidelines<sup>2<\/sup> that support the routine use of both GEP and dd-cfDNA.\u201d\n<\/p>\n<p>\n<b>Key Highlights:<\/b>\n<\/p>\n<ul class=\"bwlistdisc\">\n<li>\nRejection surveillance using GEP and dd-cfDNA, such as AlloMap and AlloSure is noninferior to endomyocardial biopsy.\n<\/li>\n<li>\nThe use of multimodal solutions including GEP to assess immune quiescence and dd-cfDNA to identify graft injury, offers a robust strategy for the surveillance of heart transplant recipients.\n<\/li>\n<li>\nAlloSure and AlloMap have been tested and validated for acute rejection surveillance in numerous multicenter studies.\n<\/li>\n<li>\nNon-invasive surveillance indicators of rejection can precede pathological rejection diagnosis.\n<\/li>\n<\/ul>\n<p>\n\u201cMuch innovation has occurred over the past decade and there is strong evidence for using noninvasive rejection surveillance. By using both GEP and dd-cfDNA, it is conceivable that transplant programs could perform noninvasive surveillance for a growing number of heart transplant recipients,\u201d said Luise Holzhauser, MD, lead author, Assistant Professor of Clinical Medicine at University of Pennsylvania Advanced Heart Failure and Transplant Cardiology. \u201cWe are at the precipice of evolving to a new standard of care in heart transplant surveillance, from routine endomyocardial biopsies to noninvasive surveillance, using GEP and dd-cfDNA, and I am proud to have worked with a fantastic group of co-authors to develop this practical guide to help make this evolution possible.\u201d\n<\/p>\n<p>\nSince the introduction of AlloMap Heart in 2005 and AlloSure Heart in 2020 as part of HeartCare, many leading heart transplant centers across the U.S. have independently established their own HeartCare surveillance testing protocols in their clinical practice based on the extensive published literature and their own experience of the services\u2019 clinical value. HeartCare is used in more than 90 percent of the nation\u2019s heart transplant centers and in more than 1 in 2 newly transplanted patients.\n<\/p>\n<p>\n<b>About CareDx \u2013 The Transplant Company<\/b>\n<\/p>\n<p>\nCareDx, Inc., headquartered in Brisbane, California, is a leading precision medicine solutions company focused on the discovery, development, and commercialization of clinically differentiated, high-value healthcare solutions for transplant patients and caregivers. CareDx offers testing services, products, and digital healthcare solutions along the pre- and post-transplant patient journey and is the leading provider of genomics-based information for transplant patients. For more information, please visit: <a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Fwww.globenewswire.com%2FTracker%3Fdata%3DsWnL28Pb_K30zJRpgfjew75u1_dSglQOqWOeGrjgO2uxVy0YtSuZEPQNSxvHMTXZ8fA8wgKL0bgkOfUhosOnhg%3D%3D&amp;esheet=53291557&amp;newsitemid=20230126005387&amp;lan=en-US&amp;anchor=www.CareDx.com&amp;index=2&amp;md5=5993eeda2eb4f41d905b1bc163c35965\" rel=\"nofollow noopener\" shape=\"rect\"><b>www.CareDx.com<\/b><\/a>.\n<\/p>\n<p>\n<b>Forward Looking Statements<\/b>\n<\/p>\n<p>\nThis press release includes forward-looking statements related to CareDx, Inc., including statements regarding the potential benefits and results that may be achieved with CareDx\u2019s HeartCare, including AlloSure and AlloMap testing services, and JACC publication\u2019s support of the use of AlloSure and AlloMap. These forward-looking statements are based upon information that is currently available to CareDx and its current expectations, speak only as of the date hereof, and are subject to risks and uncertainties that could cause actual results to differ materially from those projected, including risks that CareDx does not realize the expected benefits of HeartCare, AlloSure and AlloMap; risks that the JACC publication\u2019s review on the use of AlloSure and AlloMap may not be accurate; general economic and market factors; and other risks discussed in CareDx\u2019s filings with the SEC, including the Annual Report on Form 10-K for the fiscal year ended December 31, 2021 filed by CareDx with the SEC on February 24, 2022, the quarterly report on Form 10-Q for the quarter ended March 31, 2022 filed by CareDx with the SEC on May 5, 2022, the quarterly report on Form 10-Q for the quarter ended June 30, 2022 filed by CareDx with the SEC on August 4, 2022, the quarterly report on Form 10-Q for the quarter ended September 30, 2022 filed by CareDx with the SEC on November 3, 2022, and other reports that CareDx has filed with the SEC. Any of these may cause CareDx\u2019s actual results, performance, or achievements to differ materially and adversely from those anticipated or implied by CareDx\u2019s forward-looking statements. CareDx expressly disclaims any obligation, except as required by law, or undertaking to update or revise any such forward-looking statements.\n<\/p>\n<p>\n<b>References:<\/b>\n<\/p>\n<ol class=\"bwlistdecimal\">\n<li>\nHolzhauser L, DeFilippis E, Nikolova A, et al. The End of Endomyocardial Biopsy? <i>J Am Coll Cardiol HF. <\/i>null2023, 0 (0).<a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Fdoi.org%2F10.1016%2Fj.jchf.2022.11.002&amp;esheet=53291557&amp;newsitemid=20230126005387&amp;lan=en-US&amp;anchor=https%3A%2F%2Fdoi.org%2F10.1016%2Fj.jchf.2022.11.002&amp;index=3&amp;md5=fa5b8bc945655269a965c4c50b898b4d\" rel=\"nofollow noopener\" shape=\"rect\"><b>https:\/\/doi.org\/10.1016\/j.jchf.2022.11.002<\/b><\/a>\n<\/li>\n<li>\nVelleca A, Shullo MA, Dhital K, et al. The International Society for Heart and Lung Transplantation (ISHLT) Guidelines for the Care of Heart Transplant Recipients. <i>Journal of Heart and Lung Transplantation<\/i>. S1053-2498(22)02185-4. <a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Fdoi.org%2F10.1016%2Fj.healun.2022.10.015&amp;esheet=53291557&amp;newsitemid=20230126005387&amp;lan=en-US&amp;anchor=https%3A%2F%2Fdoi.org%2F10.1016%2Fj.healun.2022.10.015&amp;index=4&amp;md5=4ba9f5082ce3602a79c8390dc8f9fb61\" rel=\"nofollow noopener\" shape=\"rect\"><b>https:\/\/doi.org\/10.1016\/j.healun.2022.10.015<\/b><\/a>\n<\/li>\n<\/ol>\n<p> <b>Contacts<\/b> <\/p>\n<p>\n<b>CareDx, Inc.<\/b><br \/>Media Relations<br \/>\n<br \/>Anna Czene<br \/>\n<br \/>818-731-2203<br \/>\n<br \/><a target=\"_blank\" href=\"ma&#105;&#108;&#116;&#111;&#x3a;&#x61;&#x63;&#x7a;&#x65;ne&#64;&#99;&#97;&#114;&#x65;&#x64;&#x78;&#x2e;&#x63;om\" rel=\"nofollow noopener\" shape=\"rect\">a&#99;&#x7a;&#x65;n&#101;&#64;&#x63;&#x61;r&#101;&#100;&#x78;&#x2e;c&#111;&#x6d;<\/a>\n<\/p>\n<p>\nInvestor Relations<br \/>\n<br \/>Ian Cooney<br \/>\n<br \/>(415) 722-4563<br \/>\n<br \/><a target=\"_blank\" href=\"&#x6d;&#x61;&#x69;&#108;&#116;o:&#x69;&#x6e;&#x76;&#x65;&#115;&#116;or&#x40;&#x43;&#x61;&#114;&#101;&#68;x&#46;&#x63;&#x6f;&#x6d;\" rel=\"nofollow noopener\" shape=\"rect\">i&#110;&#x76;&#x65;&#x73;t&#111;&#x72;&#x40;&#x43;a&#114;&#x65;&#x44;&#x78;&#46;&#99;&#x6f;&#x6d;<\/a>\n<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Guide Helps Transplant Centers Continue the Evolution from Endomyocardial Biopsies to Noninvasive Surveillance Using AlloMap GEP and AlloSure dd-cfDNA BRISBANE, Calif.&#8211;(BUSINESS WIRE)&#8211;CareDx, Inc. (Nasdaq: CDNA) \u2013 The Transplant Company\u2122 focused on the discovery, development, and commercialization of clinically differentiated, high-value healthcare solutions for transplant patients and caregivers \u2013 today announced that the Journal of the &#8230; <span class=\"more\"><a class=\"more-link\" href=\"https:\/\/pharma-trend.com\/en\/jacc-publication-guides-use-of-caredxs-heartcare-transplant-rejection-surveillance-in-clinical-practice\/\">[Read more&#8230;]<\/a><\/span><\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[13],"tags":[],"class_list":{"0":"entry","1":"post","2":"publish","3":"author-business","4":"post-53333","6":"format-standard","7":"category-industry"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>JACC Publication Guides Use of CareDx\u2019s HeartCare Transplant Rejection Surveillance in Clinical Practice - Pharma Trend<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/pharma-trend.com\/en\/jacc-publication-guides-use-of-caredxs-heartcare-transplant-rejection-surveillance-in-clinical-practice\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"JACC Publication Guides Use of CareDx\u2019s HeartCare Transplant Rejection Surveillance in Clinical Practice - Pharma Trend\" \/>\n<meta property=\"og:description\" content=\"Guide Helps Transplant Centers Continue the Evolution from Endomyocardial Biopsies to Noninvasive Surveillance Using AlloMap GEP and AlloSure dd-cfDNA BRISBANE, Calif.&#8211;(BUSINESS WIRE)&#8211;CareDx, Inc. (Nasdaq: CDNA) \u2013 The Transplant Company\u2122 focused on the discovery, development, and commercialization of clinically differentiated, high-value healthcare solutions for transplant patients and caregivers \u2013 today announced that the Journal of the ... 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(Nasdaq: CDNA) \u2013 The Transplant Company\u2122 focused on the discovery, development, and commercialization of clinically differentiated, high-value healthcare solutions for transplant patients and caregivers \u2013 today announced that the Journal of the ... 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