{"id":53429,"date":"2023-01-30T18:03:01","date_gmt":"2023-01-30T17:03:01","guid":{"rendered":"https:\/\/pharma-trend.com\/en\/valbiotis-announces-positive-results-in-the-bioavailability-and-mode-of-action-totum854-clinical-study-against-high-blood-pressure\/"},"modified":"2023-01-30T18:03:01","modified_gmt":"2023-01-30T17:03:01","slug":"valbiotis-announces-positive-results-in-the-bioavailability-and-mode-of-action-totum854-clinical-study-against-high-blood-pressure","status":"publish","type":"post","link":"https:\/\/pharma-trend.com\/en\/valbiotis-announces-positive-results-in-the-bioavailability-and-mode-of-action-totum854-clinical-study-against-high-blood-pressure\/","title":{"rendered":"Valbiotis Announces Positive Results in the Bioavailability and Mode of Action TOTUM\u2022854 Clinical Study, Against High Blood Pressure"},"content":{"rendered":"<div>\n<ul class=\"bwlistdisc\">\n<li>\nTOTUM\u2022854 protects human cells of the vascular wall, particularly against inflammation and oxidative stress, which is key to preventing worsening of high blood pressure.\n<\/li>\n<li>\nTOTUM\u2022854 also reduces angiotensin I-converting enzyme (ACE1) activity, one of the main modes of action known to reduce blood pressure.\n<\/li>\n<li>\nThe bioavailability study also confirms the presence of 10 metabolites of interest in human serum after oral administration of 3.7 g of TOTUM\u2022854, the daily clinical dose used in the Phase II\/III INSIGHT clinical study.\n<\/li>\n<li>\nIn line with the preclinical data, these very strong results confirm the potential of TOTUM\u2022854 against mild to moderate high blood pressure in humans and provide strong prospects for late clinical development.\n<\/li>\n<li>\nWith a view to marketing TOTUM\u2022854, Valbiotis is targeting the signature of international partnerships and will market directly on the French market; the market for mild to moderate high blood pressure currently includes 123 million adults in the United States and Europe<sup>1<\/sup>.\n<\/li>\n<\/ul>\n<p>LA ROCHELLE, France&#8211;(BUSINESS WIRE)&#8211;Regulatory News:\n<\/p>\n<p><a href=\"https:\/\/mms.businesswire.com\/media\/20230130005310\/en\/1113003\/5\/LOGO-NOIR.jpg\"><img decoding=\"async\" src=\"https:\/\/mms.businesswire.com\/media\/20230130005310\/en\/1113003\/21\/LOGO-NOIR.jpg\"><\/a><\/p>\n<p>\nValbiotis (FR0013254851 \u2013 ALVAL, PEA \/ SME eligible) (Paris:ALVAL), a commercially oriented Research and Development company, with a commercial purpose, committed to scientific innovation for preventing and combating metabolic and cardiovascular diseases, announces positive results in the bioavailability and mode of action clinical study conducted on TOTUM\u2022854 against high blood pressure, the number one cardiovascular risk factor worldwide. The mode of action results demonstrate a protective effect of TOTUM\u2022854 on vascular wall cells and a reduction in angiotensin I-converting enzyme (ACE1) activity in humans. These robust data confirm the potential of TOTUM\u2022854 to reduce blood pressure at the earliest stages of arterial hypertension, which affect 123 million people in the US and Europe<sup>1<\/sup>. They hold great promise for the late-stage clinical development of TOTUM\u2022854.\n<\/p>\n<p>\nPascal SIRVENT, Director of Discovery and Preclinical and Translational Research, member of the Executive Committee, comments: <i>&#8220;These innovative bioavailability and mode of action studies once again demonstrate their scientific value for the development of our plant-based active substances. In line with our preclinical work, we can now confirm that TOTUM\u2022854 preserves the integrity of the cells of the blood vessel wall, more specifically of its endothelium. Damage to the vascular wall is a major mechanism in the progression of high blood pressure. Moreover, we also discovered that this active substance acts on the angiotensin pathway, a well-known target of anti-hypertensive strategies. This first-in-human evidence confirms the relevance of TOTUM\u2022854&#8217;s positioning in the early stages of the disease and bodes well for the ongoing Phase II\/III clinical efficacy studies in high blood pressure.&#8221;<\/i>\n<\/p>\n<p>\nTOTUM\u2022854, a patented active substance based on a combination of plant extracts, is developed to reduce blood pressure in people with mild to moderate hypertension, a risk factor for cardiovascular disease.\n<\/p>\n<p>\nMild to moderate arterial hypertension now affects 123 million adults in the United States and the 5 major European countries<sup>1<\/sup>. No non-drug product has strong clinical evidence or a specific health claim.\n<\/p>\n<p>\nTOTUM\u2022854 is currently in the final phase of clinical development before being marketed. Valbiotis aims to sign one or more international commercial partnerships while it will market this active substance in France itself, in accordance with the strategy announced on October 7, 2022 (<a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Fwww.valbiotis.com%2Fwp-content%2Fuploads%2F2022%2F10%2F2022-10-07-PR_VALBIOTIS_STRATEGY-site.pdf&amp;esheet=53293122&amp;newsitemid=20230130005310&amp;lan=en-US&amp;anchor=press+release+of+October+7%2C+2022&amp;index=1&amp;md5=ae6ab37edd5577b2c285acc55ca626da\" rel=\"nofollow noopener\" shape=\"rect\">press release of October 7, 2022<\/a>). TOTUM\u2022854 will be marketed in two stages. The first step will be based on the recommendation by healthcare professionals, thanks to the Phase II\/III results. In a second step, obtaining a proprietary health claim will strengthen the medical positioning of TOTUM\u2022854, especially with patients\/consumers.\n<\/p>\n<p>\nEnrollment in the first Phase II\/III clinical trial (INSIGHT study) is expected to be completed by half-year 2023.\n<\/p>\n<p>\nResults of the bioavailability and mode of action clinical study on TOTUM\u2022854\n<\/p>\n<p>\nThe TOTUM\u2022854 bioavailability and mode of action clinical study, conducted in 10 healthy volunteers, first confirmed the presence of 10 metabolites of interest<sup>2<\/sup>, mainly polyphenolic compounds, in volunteers&#8217; serum<sup>3<\/sup>. These analyses were performed after taking 3.7 g of TOTUM\u2022854 orally, the daily clinical dose also used in the Phase II\/III INSIGHT clinical study.\n<\/p>\n<p>\n<i>Ex vivo<\/i> mode of action analyses then demonstrated a triple protective effect of these metabolites on human blood vessel wall cells (endothelial cells):\n<\/p>\n<ul class=\"bwlistdisc\">\n<li>\nincreased resistance and viability of these cells to stress induced by excess lipids;\n<\/li>\n<li>\nstrong protection against inflammatory processes, with a significant decrease in the production of pro-inflammatory agents such as interleukin 1-\u00df (IL1-\u00df) and in the expression of MCP-1 and VCAM-2 markers;\n<\/li>\n<li>\nprotection against oxidative stress with a decrease in the concentration of free radicals and a reduced expression of the Nox2 enzyme.\n<\/li>\n<\/ul>\n<p>\nMode of action tests also revealed a reduction in angiotensin I-converting enzyme (ACE1) activity, an enzyme well known in the pathophysiology of high blood pressure.\n<\/p>\n<p>\nThis protective effect on the vascular wall in humans confirms the data already obtained in preclinical studies and presented at the annual meetings of the American Heart Association (AHA), the European Society of Cardiology (ESC) and the European Society of Hypertension (ESH) in 2022. Above all, it confirms the preventive positioning of TOTUM\u2022854 in the early stages of high blood pressure. In the initial phases of the disease, when blood pressure rises, the vascular wall undergoes damage involving inflammation and oxidative stress. Ultimately, these changes lead to the narrowing of blood vessels: hypertension worsens, becomes chronic and requires long-term pharmacological treatment. Protection of the vascular wall is therefore a major challenge in the management of early high blood pressure, in order to prevent the progression of the condition.\n<\/p>\n<p>\nThe innovative protocol of the TOTUM\u2022854 bioavailability and mode of action clinical study\n<\/p>\n<p>\nThe study was conducted on 10 healthy volunteers in an open-label setting and followed a protocol combining metabolomics and mode of action. Prof. Gis\u00e8le PICKERING, coordinator of the Clinical Investigation Center at Clermont-Ferrand University Hospital, was the principal investigator<sup>4<\/sup>.\n<\/p>\n<p>\nMetabolomic analysis consists of characterizing the metabolites of an active substance in serum, i.e., the molecules derived from this active substance after their intestinal absorption and their passage into the blood. After a single oral intake of 3.7 g of TOTUM\u2022854, the daily clinical dose also used in the INSIGHT Phase II\/III clinical study, analysis of the volunteers&#8217; serum confirmed the presence of 10 metabolites of interest, polyphenolic compounds mostly known to exert biological activity on metabolism. Kinetic measurements confirmed good bioavailability of these metabolites in serum within three hours after oral administration of TOTUM\u2022854.\n<\/p>\n<p>\nIn a second step, serum from volunteers was collected after oral intake of 3.7 g TOTUM\u2022854. This serum rich in active metabolites was used to conduct <i>in vitro<\/i> mode of action tests on human umbilical vein endothelial cells (HUVECs), exposed to massive lipid intake, or lipotoxic stress, generating inflammation and oxidative stress.\n<\/p>\n<p>\nAbout Valbiotis\n<\/p>\n<p>\nValbiotis is a commercially oriented Research &amp; Development company, committed to scientific innovation for preventing and combating metabolic and cardiovascular diseases in response to unmet medical needs.\n<\/p>\n<p>\nValbiotis has adopted an innovative approach, aiming to revolutionize healthcare by developing a new class of health nutrition products designed to reduce the risk of major metabolic diseases, relying on a multi-target strategy enabled by the use of plant-based terrestrial and marine resources.\n<\/p>\n<p>\nInternationally, its products are intended to be the subject of licensing or distribution agreements with global and regional health and nutrition players. In France, Valbiotis will be responsible for marketing its own products.\n<\/p>\n<p>\nCreated at the beginning of 2014 in La Rochelle, the Company has forged numerous partnerships with leading academic centers. The Company has established three sites in France \u2013 P\u00e9rigny, La Rochelle (17) and Riom (63) \u2013 and a subsidiary in Quebec City (Canada).\n<\/p>\n<p>\nValbiotis is a member of the &#8220;BPI Excellence&#8221; network and has been recognized as an &#8220;Innovative Company&#8221; by the BPI label. Valbiotis has also been awarded &#8220;Young Innovative Company&#8221; status and has received major financial support from the European Union for its research programs via the European Regional Development Fund (ERDF). Valbiotis is a PEA-SME eligible company.\n<\/p>\n<p>\nFor more information about Valbiotis, please visit: <a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=http%3A%2F%2Fwww.valbiotis.com&amp;esheet=53293122&amp;newsitemid=20230130005310&amp;lan=en-US&amp;anchor=www.valbiotis.com&amp;index=2&amp;md5=921347314fdc3d87e06ac84829ee677d\" rel=\"nofollow noopener\" shape=\"rect\">www.valbiotis.com<\/a>\n<\/p>\n<p>\nName: Valbiotis<br \/>\n<br \/>ISIN code: FR0013254851<br \/>\n<br \/>Ticker symbol: ALVAL<br \/>\n<br \/>EnterNext\u00a9 PEA-PME 150\n<\/p>\n<p>\nThis press release contains forward-looking statements about Valbiotis\u2019 objectives. Valbiotis considers that these projections are based on rational hypotheses and the information available to Valbiotis at the present time. However, in no way does this constitute a guarantee of future performance, and these projections may be affected by changes in economic conditions and financial markets, as well as certain risks and uncertainties, including those described in the Valbiotis Universal Registration Document filed to the French Financial Markets Regulator (AMF) on May 19, 2022, and completed by an amendment on November 8, 2022. This document is available on the Company\u2019s website (<a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=http%3A%2F%2Fwww.valbiotis.com%2F&amp;esheet=53293122&amp;newsitemid=20230130005310&amp;lan=en-US&amp;anchor=www.valbiotis.com&amp;index=3&amp;md5=2f8266e293eef860a3d69c222e3a0615\" rel=\"nofollow noopener\" shape=\"rect\">www.valbiotis.com<\/a>).\n<\/p>\n<p>\nThis press release and the information it contains do not constitute an offer to sell or subscribe, or a solicitation to purchase or subscribe to Valbiotis\u2019 shares or financial securities in any country.\n<\/p>\n<p>\n<sup>1<\/sup>Elevated LDL, pre-HTA and NAFL preliminary market estimation, AEC Partners, 2020.<br \/>\n<br \/><sup>2<\/sup>Molecules from TOTUM\u2022854, after they have been absorbed from the intestine and passed into the bloodstream.<br \/>\n<br \/><sup>3<\/sup>The fraction of blood remaining after all blood cells (red blood cells, leukocytes, platelets) and fibrinogen (a protein involved in coagulation) have been removed.<br \/>\n<br \/><sup>4<\/sup>ID-RCB: 2021-A02695-36\n<\/p>\n<p> <b>Contacts<\/b> <\/p>\n<p>\nCorporate communication \/ Valbiotis<br \/>\n<br \/>Carole ROCHER<br \/>\n<br \/>Communications and Public Affairs Director<br \/>\n<br \/>+ 33 6 77 82 56 88\n<\/p>\n<p>\nMarc DELAUNAY<br \/>\n<br \/>Communication Manager<br \/>\n<br \/><a target=\"_blank\" href=\"ma&#105;&#108;&#116;&#111;&#x3a;&#x6d;&#x65;&#x64;&#x69;a&#64;&#118;&#97;&#108;&#98;&#x69;&#x6f;&#x74;&#x69;&#x73;&#46;c&#111;&#109;\" rel=\"nofollow noopener\" shape=\"rect\">&#x6d;&#101;d&#x69;&#x61;&#64;v&#x61;&#108;b&#x69;&#x6f;&#116;i&#x73;&#46;c&#x6f;&#x6d;<\/a>\n<\/p>\n<p>\nFinancial communication \/ Seitosei Actifin<br \/>\n<br \/>St\u00e9phane Ruiz<br \/>\n<br \/>Associate Director<br \/>\n<br \/>+33 1 56 88 11 14<br \/>\n<br \/><a target=\"_blank\" href=\"&#x6d;&#x61;&#x69;&#x6c;&#x74;&#x6f;&#58;&#115;&#114;&#117;iz&#64;a&#x63;&#x74;&#x69;&#x66;&#x69;&#x6e;&#46;&#102;&#114;\" rel=\"nofollow noopener\" shape=\"rect\">&#x73;&#x72;&#117;&#105;&#122;&#64;&#x61;&#x63;&#x74;&#105;&#102;in&#x2e;&#x66;&#x72;<\/a>\n<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>TOTUM\u2022854 protects human cells of the vascular wall, particularly against inflammation and oxidative stress, which is key to preventing worsening of high blood pressure. TOTUM\u2022854 also reduces angiotensin I-converting enzyme (ACE1) activity, one of the main modes of action known to reduce blood pressure. The bioavailability study also confirms the presence of 10 metabolites of &#8230; <span class=\"more\"><a class=\"more-link\" href=\"https:\/\/pharma-trend.com\/en\/valbiotis-announces-positive-results-in-the-bioavailability-and-mode-of-action-totum854-clinical-study-against-high-blood-pressure\/\">[Read more&#8230;]<\/a><\/span><\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[13],"tags":[],"class_list":{"0":"entry","1":"post","2":"publish","3":"author-business","4":"post-53429","6":"format-standard","7":"category-industry"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Valbiotis Announces Positive Results in the Bioavailability and Mode of Action TOTUM\u2022854 Clinical Study, Against High Blood Pressure - Pharma Trend<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/pharma-trend.com\/en\/valbiotis-announces-positive-results-in-the-bioavailability-and-mode-of-action-totum854-clinical-study-against-high-blood-pressure\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Valbiotis Announces Positive Results in the Bioavailability and Mode of Action TOTUM\u2022854 Clinical Study, Against High Blood Pressure - Pharma Trend\" \/>\n<meta property=\"og:description\" content=\"TOTUM\u2022854 protects human cells of the vascular wall, particularly against inflammation and oxidative stress, which is key to preventing worsening of high blood pressure. TOTUM\u2022854 also reduces angiotensin I-converting enzyme (ACE1) activity, one of the main modes of action known to reduce blood pressure. The bioavailability study also confirms the presence of 10 metabolites of ... [Read more...]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/pharma-trend.com\/en\/valbiotis-announces-positive-results-in-the-bioavailability-and-mode-of-action-totum854-clinical-study-against-high-blood-pressure\/\" \/>\n<meta property=\"og:site_name\" content=\"Pharma Trend\" \/>\n<meta property=\"article:published_time\" content=\"2023-01-30T17:03:01+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/mms.businesswire.com\/media\/20230130005310\/en\/1113003\/21\/LOGO-NOIR.jpg\" \/>\n<meta name=\"author\" content=\"Business Wire\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Business Wire\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"8 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/pharma-trend.com\\\/en\\\/valbiotis-announces-positive-results-in-the-bioavailability-and-mode-of-action-totum854-clinical-study-against-high-blood-pressure\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/pharma-trend.com\\\/en\\\/valbiotis-announces-positive-results-in-the-bioavailability-and-mode-of-action-totum854-clinical-study-against-high-blood-pressure\\\/\"},\"author\":{\"name\":\"Business Wire\",\"@id\":\"https:\\\/\\\/pharma-trend.com\\\/en\\\/#\\\/schema\\\/person\\\/02d41342c7a74fa7f0032bb35ef0bb24\"},\"headline\":\"Valbiotis Announces Positive Results in the Bioavailability and Mode of Action TOTUM\u2022854 Clinical Study, Against High Blood Pressure\",\"datePublished\":\"2023-01-30T17:03:01+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/pharma-trend.com\\\/en\\\/valbiotis-announces-positive-results-in-the-bioavailability-and-mode-of-action-totum854-clinical-study-against-high-blood-pressure\\\/\"},\"wordCount\":1539,\"publisher\":{\"@id\":\"https:\\\/\\\/pharma-trend.com\\\/en\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/pharma-trend.com\\\/en\\\/valbiotis-announces-positive-results-in-the-bioavailability-and-mode-of-action-totum854-clinical-study-against-high-blood-pressure\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/mms.businesswire.com\\\/media\\\/20230130005310\\\/en\\\/1113003\\\/21\\\/LOGO-NOIR.jpg\",\"articleSection\":[\"Industry\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/pharma-trend.com\\\/en\\\/valbiotis-announces-positive-results-in-the-bioavailability-and-mode-of-action-totum854-clinical-study-against-high-blood-pressure\\\/\",\"url\":\"https:\\\/\\\/pharma-trend.com\\\/en\\\/valbiotis-announces-positive-results-in-the-bioavailability-and-mode-of-action-totum854-clinical-study-against-high-blood-pressure\\\/\",\"name\":\"Valbiotis Announces Positive Results in the Bioavailability and Mode of Action TOTUM\u2022854 Clinical Study, Against High Blood Pressure - Pharma Trend\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/pharma-trend.com\\\/en\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/pharma-trend.com\\\/en\\\/valbiotis-announces-positive-results-in-the-bioavailability-and-mode-of-action-totum854-clinical-study-against-high-blood-pressure\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/pharma-trend.com\\\/en\\\/valbiotis-announces-positive-results-in-the-bioavailability-and-mode-of-action-totum854-clinical-study-against-high-blood-pressure\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/mms.businesswire.com\\\/media\\\/20230130005310\\\/en\\\/1113003\\\/21\\\/LOGO-NOIR.jpg\",\"datePublished\":\"2023-01-30T17:03:01+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/pharma-trend.com\\\/en\\\/valbiotis-announces-positive-results-in-the-bioavailability-and-mode-of-action-totum854-clinical-study-against-high-blood-pressure\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/pharma-trend.com\\\/en\\\/valbiotis-announces-positive-results-in-the-bioavailability-and-mode-of-action-totum854-clinical-study-against-high-blood-pressure\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/pharma-trend.com\\\/en\\\/valbiotis-announces-positive-results-in-the-bioavailability-and-mode-of-action-totum854-clinical-study-against-high-blood-pressure\\\/#primaryimage\",\"url\":\"https:\\\/\\\/mms.businesswire.com\\\/media\\\/20230130005310\\\/en\\\/1113003\\\/21\\\/LOGO-NOIR.jpg\",\"contentUrl\":\"https:\\\/\\\/mms.businesswire.com\\\/media\\\/20230130005310\\\/en\\\/1113003\\\/21\\\/LOGO-NOIR.jpg\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/pharma-trend.com\\\/en\\\/valbiotis-announces-positive-results-in-the-bioavailability-and-mode-of-action-totum854-clinical-study-against-high-blood-pressure\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Startseite\",\"item\":\"https:\\\/\\\/pharma-trend.com\\\/en\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Valbiotis Announces Positive Results in the Bioavailability and Mode of Action TOTUM\u2022854 Clinical Study, Against High Blood Pressure\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/pharma-trend.com\\\/en\\\/#website\",\"url\":\"https:\\\/\\\/pharma-trend.com\\\/en\\\/\",\"name\":\"Pharma Trend\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\\\/\\\/pharma-trend.com\\\/en\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/pharma-trend.com\\\/en\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/pharma-trend.com\\\/en\\\/#organization\",\"name\":\"Pharma Trend\",\"url\":\"https:\\\/\\\/pharma-trend.com\\\/en\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/pharma-trend.com\\\/en\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"\",\"contentUrl\":\"\",\"caption\":\"Pharma Trend\"},\"image\":{\"@id\":\"https:\\\/\\\/pharma-trend.com\\\/en\\\/#\\\/schema\\\/logo\\\/image\\\/\"}},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/pharma-trend.com\\\/en\\\/#\\\/schema\\\/person\\\/02d41342c7a74fa7f0032bb35ef0bb24\",\"name\":\"Business Wire\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Valbiotis Announces Positive Results in the Bioavailability and Mode of Action TOTUM\u2022854 Clinical Study, Against High Blood Pressure - Pharma Trend","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/pharma-trend.com\/en\/valbiotis-announces-positive-results-in-the-bioavailability-and-mode-of-action-totum854-clinical-study-against-high-blood-pressure\/","og_locale":"en_US","og_type":"article","og_title":"Valbiotis Announces Positive Results in the Bioavailability and Mode of Action TOTUM\u2022854 Clinical Study, Against High Blood Pressure - Pharma Trend","og_description":"TOTUM\u2022854 protects human cells of the vascular wall, particularly against inflammation and oxidative stress, which is key to preventing worsening of high blood pressure. TOTUM\u2022854 also reduces angiotensin I-converting enzyme (ACE1) activity, one of the main modes of action known to reduce blood pressure. The bioavailability study also confirms the presence of 10 metabolites of ... [Read more...]","og_url":"https:\/\/pharma-trend.com\/en\/valbiotis-announces-positive-results-in-the-bioavailability-and-mode-of-action-totum854-clinical-study-against-high-blood-pressure\/","og_site_name":"Pharma Trend","article_published_time":"2023-01-30T17:03:01+00:00","og_image":[{"url":"https:\/\/mms.businesswire.com\/media\/20230130005310\/en\/1113003\/21\/LOGO-NOIR.jpg","type":"","width":"","height":""}],"author":"Business Wire","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Business Wire","Est. reading time":"8 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/pharma-trend.com\/en\/valbiotis-announces-positive-results-in-the-bioavailability-and-mode-of-action-totum854-clinical-study-against-high-blood-pressure\/#article","isPartOf":{"@id":"https:\/\/pharma-trend.com\/en\/valbiotis-announces-positive-results-in-the-bioavailability-and-mode-of-action-totum854-clinical-study-against-high-blood-pressure\/"},"author":{"name":"Business Wire","@id":"https:\/\/pharma-trend.com\/en\/#\/schema\/person\/02d41342c7a74fa7f0032bb35ef0bb24"},"headline":"Valbiotis Announces Positive Results in the Bioavailability and Mode of Action TOTUM\u2022854 Clinical Study, Against High Blood Pressure","datePublished":"2023-01-30T17:03:01+00:00","mainEntityOfPage":{"@id":"https:\/\/pharma-trend.com\/en\/valbiotis-announces-positive-results-in-the-bioavailability-and-mode-of-action-totum854-clinical-study-against-high-blood-pressure\/"},"wordCount":1539,"publisher":{"@id":"https:\/\/pharma-trend.com\/en\/#organization"},"image":{"@id":"https:\/\/pharma-trend.com\/en\/valbiotis-announces-positive-results-in-the-bioavailability-and-mode-of-action-totum854-clinical-study-against-high-blood-pressure\/#primaryimage"},"thumbnailUrl":"https:\/\/mms.businesswire.com\/media\/20230130005310\/en\/1113003\/21\/LOGO-NOIR.jpg","articleSection":["Industry"],"inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/pharma-trend.com\/en\/valbiotis-announces-positive-results-in-the-bioavailability-and-mode-of-action-totum854-clinical-study-against-high-blood-pressure\/","url":"https:\/\/pharma-trend.com\/en\/valbiotis-announces-positive-results-in-the-bioavailability-and-mode-of-action-totum854-clinical-study-against-high-blood-pressure\/","name":"Valbiotis Announces Positive Results in the Bioavailability and Mode of Action TOTUM\u2022854 Clinical Study, Against High Blood Pressure - Pharma Trend","isPartOf":{"@id":"https:\/\/pharma-trend.com\/en\/#website"},"primaryImageOfPage":{"@id":"https:\/\/pharma-trend.com\/en\/valbiotis-announces-positive-results-in-the-bioavailability-and-mode-of-action-totum854-clinical-study-against-high-blood-pressure\/#primaryimage"},"image":{"@id":"https:\/\/pharma-trend.com\/en\/valbiotis-announces-positive-results-in-the-bioavailability-and-mode-of-action-totum854-clinical-study-against-high-blood-pressure\/#primaryimage"},"thumbnailUrl":"https:\/\/mms.businesswire.com\/media\/20230130005310\/en\/1113003\/21\/LOGO-NOIR.jpg","datePublished":"2023-01-30T17:03:01+00:00","breadcrumb":{"@id":"https:\/\/pharma-trend.com\/en\/valbiotis-announces-positive-results-in-the-bioavailability-and-mode-of-action-totum854-clinical-study-against-high-blood-pressure\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/pharma-trend.com\/en\/valbiotis-announces-positive-results-in-the-bioavailability-and-mode-of-action-totum854-clinical-study-against-high-blood-pressure\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/pharma-trend.com\/en\/valbiotis-announces-positive-results-in-the-bioavailability-and-mode-of-action-totum854-clinical-study-against-high-blood-pressure\/#primaryimage","url":"https:\/\/mms.businesswire.com\/media\/20230130005310\/en\/1113003\/21\/LOGO-NOIR.jpg","contentUrl":"https:\/\/mms.businesswire.com\/media\/20230130005310\/en\/1113003\/21\/LOGO-NOIR.jpg"},{"@type":"BreadcrumbList","@id":"https:\/\/pharma-trend.com\/en\/valbiotis-announces-positive-results-in-the-bioavailability-and-mode-of-action-totum854-clinical-study-against-high-blood-pressure\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Startseite","item":"https:\/\/pharma-trend.com\/en\/"},{"@type":"ListItem","position":2,"name":"Valbiotis Announces Positive Results in the Bioavailability and Mode of Action TOTUM\u2022854 Clinical Study, Against High Blood Pressure"}]},{"@type":"WebSite","@id":"https:\/\/pharma-trend.com\/en\/#website","url":"https:\/\/pharma-trend.com\/en\/","name":"Pharma Trend","description":"","publisher":{"@id":"https:\/\/pharma-trend.com\/en\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/pharma-trend.com\/en\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/pharma-trend.com\/en\/#organization","name":"Pharma Trend","url":"https:\/\/pharma-trend.com\/en\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/pharma-trend.com\/en\/#\/schema\/logo\/image\/","url":"","contentUrl":"","caption":"Pharma Trend"},"image":{"@id":"https:\/\/pharma-trend.com\/en\/#\/schema\/logo\/image\/"}},{"@type":"Person","@id":"https:\/\/pharma-trend.com\/en\/#\/schema\/person\/02d41342c7a74fa7f0032bb35ef0bb24","name":"Business Wire"}]}},"_links":{"self":[{"href":"https:\/\/pharma-trend.com\/en\/wp-json\/wp\/v2\/posts\/53429","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pharma-trend.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pharma-trend.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pharma-trend.com\/en\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/pharma-trend.com\/en\/wp-json\/wp\/v2\/comments?post=53429"}],"version-history":[{"count":0,"href":"https:\/\/pharma-trend.com\/en\/wp-json\/wp\/v2\/posts\/53429\/revisions"}],"wp:attachment":[{"href":"https:\/\/pharma-trend.com\/en\/wp-json\/wp\/v2\/media?parent=53429"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pharma-trend.com\/en\/wp-json\/wp\/v2\/categories?post=53429"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pharma-trend.com\/en\/wp-json\/wp\/v2\/tags?post=53429"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}