{"id":54137,"date":"2023-02-22T07:03:06","date_gmt":"2023-02-22T06:03:06","guid":{"rendered":"https:\/\/pharma-trend.com\/en\/relation-therapeutics-announces-launch-of-flagship-integrated-wet-dry-laboratory-at-the-heart-of-londons-knowledge-quarter\/"},"modified":"2023-02-22T07:03:06","modified_gmt":"2023-02-22T06:03:06","slug":"relation-therapeutics-announces-launch-of-flagship-integrated-wet-dry-laboratory-at-the-heart-of-londons-knowledge-quarter","status":"publish","type":"post","link":"https:\/\/pharma-trend.com\/en\/relation-therapeutics-announces-launch-of-flagship-integrated-wet-dry-laboratory-at-the-heart-of-londons-knowledge-quarter\/","title":{"rendered":"Relation Therapeutics announces launch of flagship integrated wet\u2013dry laboratory at the heart of London\u2019s Knowledge Quarter"},"content":{"rendered":"<div>\n<ul class=\"bwlistdisc\">\n<li>\n<i>Edith Hessel, experienced R&amp;D and biopharma executive, named as Chief Scientific Officer<\/i>\n<\/li>\n<li>\n<i>Osteoporosis announced as first indication, driven by Relation\u2019s proprietary engine for indication selection Selectomatic<sup>TM<\/sup><\/i>\n<\/li>\n<\/ul>\n<p>LONDON&#8211;(BUSINESS WIRE)&#8211;Relation Therapeutics, a leader in the use of high-resolution biology, machine learning and clinical insights to discover life-changing medicines, announced today the opening of their flagship integrated wet\u2013dry laboratory. The laboratory and offices comprise 5,500 sq ft, located at the heart of London\u2019s Knowledge Quarter, in close reach of collaborators and partners including globally renowned academic research centres and major pharma companies. Over the last year the company has grown to a 35-strong cross-disciplinary seed-stage company. The new space is another step forward in realising Relation\u2019s ambition to establish a novel transformational approach to drug discovery.\n<\/p>\n<p><a href=\"https:\/\/mms.businesswire.com\/media\/20230221005853\/en\/1718895\/4\/RTx_logo.jpg\"><img decoding=\"async\" src=\"https:\/\/mms.businesswire.com\/media\/20230221005853\/en\/1718895\/21\/RTx_logo.jpg\"><\/a><\/p>\n<p>\nThe integrated wet\u2013dry laboratory\u2019s unique value for drug discovery comes from efficiently combining the most sophisticated functional genomic techniques with extraordinary computational power and machine learning. With the acquisition of genomic data from human cells, Relation obtains direct insights into critical biological relationships, which are then fed directly into the dry laboratory\u2019s machine learning engine. The engine then automatically requests new experiments to improve its predictive ability, cutting through an otherwise undecipherable combinatorial space. This sequence of experiments is the essence of Relation\u2019s Lab-in-the-Loop and by uniting these two technologies Relation aims to radically improve the probability of success of drug discovery and development.\n<\/p>\n<p>\n\u201cDeploying machine learning to understand such a vast array of interactions between genes, proteins and drugs holds extraordinary potential for discovering new drugs,\u201d said Sir Paul Nurse, CEO of the Francis Crick Institute who alongside the executive team led the official opening. \u201cIt is pleasing to see Relation Therapeutics joining the Crick and other innovative bioscience enterprises in the Knowledge Quarter, further enhancing London\u2019s already internationally distinguished bio ecosystem.\u201d\n<\/p>\n<p>\nRelation Therapeutics further announced the appointment of Dr. Edith M. Hessel, a former GSK R&amp;D executive, as Chief Scientific Officer (CSO). Dr. Hessel will lead the drug discovery direction of the company and the progression of its pipeline to the clinic. Dr. Hessel has successfully pioneered the development of novel target discovery platforms, advanced therapeutics from inception to clinical proof of concept, and has extensive experience in founding biotech companies. As a VP at GSK, Dr. Hessel built the Refractory Respiratory Inflammation Discovery Performance Unit, which added multiple novel targets to GSK\u2019s pipeline.\n<\/p>\n<p>\n\u201cI am absolutely delighted to be part of Relation\u2019s mission to transform drug discovery, probing unexplored molecular target spaces for potentially life-changing medicines,\u201d said Edith Hessel. \u201cRelation combines a world-class team with cutting-edge technology, including access to <a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Fblogs.nvidia.com%2Fblog%2F2022%2F03%2F22%2Fstartups-harness-cambridge-1-supercomputer%2F&amp;esheet=53335020&amp;newsitemid=20230221005853&amp;lan=en-US&amp;anchor=NVIDIA%26%238217%3Bs+Cambridge-1&amp;index=1&amp;md5=b789a0926e3f0b15a09ff84b31b7f020\" rel=\"nofollow noopener\" shape=\"rect\">NVIDIA\u2019s Cambridge-1<\/a>, the UK\u2019s most powerful super-computer. Utilising first-class computational capacity to explore experimental data, clinical insights and high-resolution biology will transform drug discovery as we know it, allowing us to develop better medicines for patients.\u201d\n<\/p>\n<p>\nIn addition, Relation shared their vision for indication selection, which uses a proprietary machine learning engine &#8211; <i>Selectomatic<sup>TM<\/sup><\/i> &#8211; to recommend those indications where Relation\u2019s integrated platform enables the development of transformational therapeutics. Application of this engine led to the initiation of osteoporosis as<i> <\/i>the first disease that Relation will pursue. Osteoporosis, a metabolic bone disease, is characterised by low bone density and deterioration of bone architecture, increasing the risk of fractures.<sup>1<\/sup> It is estimated that there are approximately ten million people with osteoporosis in the USA alone,<sup>1<\/sup> with nearly one million considered to be patients at high risk of fractures. Furthermore, in Europe, 32 million people over 50 are estimated to have osteoporosis.<sup>2<\/sup> Current treatment options have a number of limitations, including safety concerns, low uptake, and limited duration of efficacy.\n<\/p>\n<p>\n\u201cThe use of single-cell profiling allows our scientists to understand bone biology with exquisite detail and provides us with the unique opportunity to be at the forefront of finding a next-generation therapy for osteoporosis,\u201d said Dr. David Roblin, Chief Executive Officer. \u201cThis access to rich single-cell data perfectly enables the power of our machine learning engine in a disease of significant unmet need.\u201d\n<\/p>\n<p>\nIn their mission to discover life-changing medicines, the team at Relation Therapeutics leverages their extensive experience in building successful biotechnology businesses. This includes Dr. Charlie Roberts, the Chairperson of Relation, who is the co-founder of Freenome, a San Francisco-based company that has raised over $1bn from investors including Roche and Novartis. In June 2022, DCVC and Magnetic Ventures co-led a $25-million round of seed financing, with participation from Khosla Ventures, OMERS Ventures, and Firstminute Capital, among others.\n<\/p>\n<p>\nTo learn more about Relation Therapeutics, please visit: <a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Fwww.relationrx.com%2F&amp;esheet=53335020&amp;newsitemid=20230221005853&amp;lan=en-US&amp;anchor=https%3A%2F%2Fwww.relationrx.com%2F&amp;index=2&amp;md5=5c077378fd0c6b2a89625ec891052a10\" rel=\"nofollow noopener\" shape=\"rect\">https:\/\/www.relationrx.com\/<\/a>.\n<\/p>\n<p>\n<b>About Relation<\/b>\n<\/p>\n<p>\nRelation is a biotechnology company focused on leveraging computational and experimental techniques to understand biology better. Central to Relation\u2019s approach is its integrated wet\u2013dry laboratory which leverages human genetics, single-cell profiling and machine learning to generate new insights with real translational validity. The company is located in London.\n<\/p>\n<p>\n<b>References<\/b>\n<\/p>\n<ol class=\"bwlistdecimal\">\n<li>\nWright N, Looker A, Saag K, et al. The recent prevalence of osteoporosis and low bone mass in the United States based on bone mineral density at the femoral neck or lumbar spine. J Bone Miner Res. 2014;29(11):2520\u20132526.\n<\/li>\n<li>\nKanis JA, et al., SCOPE 2021: a New Scorecard for Osteoporosis in Europe, Arch Osteoporos, 2021, 16(1):82.\n<\/li>\n<\/ol>\n<p> <b>Contacts<\/b> <\/p>\n<p>\n<b><i>For further queries, please contact:<\/i><\/b><br \/><i>Dr. Rosie Rodriguez \u2013 SVP, Growth, Relation Therapeutics: <a target=\"_blank\" href=\"&#x6d;&#97;i&#x6c;&#116;o&#x3a;&#x72;&#111;&#x73;&#x69;&#101;&#64;&#x72;&#101;l&#x61;&#x74;&#105;&#x6f;&#x6e;&#114;x&#x2e;&#99;o&#x6d;\" rel=\"nofollow noopener\" shape=\"rect\">&#x72;&#x6f;&#x73;&#x69;&#x65;&#64;&#114;&#101;&#108;ati&#x6f;&#x6e;&#x72;&#x78;&#x2e;&#x63;&#111;&#109;<\/a>; +44 7511 183023<\/i>\n<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Edith Hessel, experienced R&amp;D and biopharma executive, named as Chief Scientific Officer Osteoporosis announced as first indication, driven by Relation\u2019s proprietary engine for indication selection SelectomaticTM LONDON&#8211;(BUSINESS WIRE)&#8211;Relation Therapeutics, a leader in the use of high-resolution biology, machine learning and clinical insights to discover life-changing medicines, announced today the opening of their flagship integrated wet\u2013dry &#8230; <span class=\"more\"><a class=\"more-link\" href=\"https:\/\/pharma-trend.com\/en\/relation-therapeutics-announces-launch-of-flagship-integrated-wet-dry-laboratory-at-the-heart-of-londons-knowledge-quarter\/\">[Read more&#8230;]<\/a><\/span><\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[13],"tags":[],"class_list":{"0":"entry","1":"post","2":"publish","3":"author-business","4":"post-54137","6":"format-standard","7":"category-industry"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Relation Therapeutics announces launch of flagship integrated wet\u2013dry laboratory at the heart of London\u2019s Knowledge Quarter - Pharma Trend<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/pharma-trend.com\/en\/relation-therapeutics-announces-launch-of-flagship-integrated-wet-dry-laboratory-at-the-heart-of-londons-knowledge-quarter\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Relation Therapeutics announces launch of flagship integrated wet\u2013dry laboratory at the heart of London\u2019s Knowledge Quarter - Pharma Trend\" \/>\n<meta property=\"og:description\" content=\"Edith Hessel, experienced R&amp;D and biopharma executive, named as Chief Scientific Officer Osteoporosis announced as first indication, driven by Relation\u2019s proprietary engine for indication selection SelectomaticTM LONDON&#8211;(BUSINESS WIRE)&#8211;Relation Therapeutics, a leader in the use of high-resolution biology, machine learning and clinical insights to discover life-changing medicines, announced today the opening of their flagship integrated wet\u2013dry ... 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