{"id":54504,"date":"2023-03-06T11:07:50","date_gmt":"2023-03-06T10:07:50","guid":{"rendered":"https:\/\/pharma-trend.com\/en\/eyebio-announces-first-asset-in-innovative-pipeline-of-retinal-disease-treatments-and-appoints-industry-leaders-to-executive-team\/"},"modified":"2023-03-06T11:07:50","modified_gmt":"2023-03-06T10:07:50","slug":"eyebio-announces-first-asset-in-innovative-pipeline-of-retinal-disease-treatments-and-appoints-industry-leaders-to-executive-team","status":"publish","type":"post","link":"https:\/\/pharma-trend.com\/en\/eyebio-announces-first-asset-in-innovative-pipeline-of-retinal-disease-treatments-and-appoints-industry-leaders-to-executive-team\/","title":{"rendered":"EyeBio Announces First Asset in Innovative Pipeline of Retinal Disease Treatments and Appoints Industry Leaders to Executive Team"},"content":{"rendered":"<div>\n<p>\n&#8211; <i>Additions to EyeBio\u2019s leadership <\/i><i>team<\/i><i> include world-class disruptors with deep experience addressing urgent unmet needs in treatment of eye diseases<br \/>\n<br \/><\/i>&#8211; <i>EyeBio <\/i><i>co-founder Anthony P. Adamis, M.D., appointed chief scientific officer to lead development of the Company\u2019s ophthalmology pipeline<br \/>\n<br \/><\/i>&#8211; <i>Company provides details on Restoret<\/i>\u2122<i>, which targets the Wnt pathway, as the lead asset in its <\/i><i>agonist antibody pipeline<\/i><i>, with plans <\/i><i>for IND <\/i><i>filing <\/i><i>in Q2 2023<\/i>\n<\/p>\n<p><a href=\"https:\/\/mms.businesswire.com\/media\/20230306005230\/en\/1730064\/5\/EyeBio_Logo.jpg\"><img decoding=\"async\" src=\"https:\/\/mms.businesswire.com\/media\/20230306005230\/en\/1730064\/21\/EyeBio_Logo.jpg\"><\/a><\/p>\n<p>LONDON &amp; NEW YORK&#8211;(BUSINESS WIRE)&#8211;<a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Feyebiotech.com%2F&amp;esheet=53356231&amp;newsitemid=20230306005230&amp;lan=en-US&amp;anchor=Eyebiotech+Limited+%28EyeBio%29&amp;index=1&amp;md5=e0537f497ed2c63012778356bfce4c6b\" rel=\"nofollow noopener\" shape=\"rect\">Eyebiotech Limited (EyeBio)<\/a>, a privately held ophthalmology biotechnology company dedicated to developing and delivering a new generation of therapies to patients with sight-threatening eye diseases, today announced several appointments to its executive team, featuring prominent industry leaders who are highly skilled in the development of multi-specific antibodies and ophthalmic drugs. The Company also announced details on Restoret\u2122, the first asset in a diversified pipeline of multi-specific agonist antibodies. These developments establish the foundation to pursue the company\u2019s mission: to protect, restore, and improve vision for people who are underserved by available eye disease therapies.\n<\/p>\n<p>\n\u201cWe founded EyeBio to capture scientific advances and translate them into effective treatments for patients with serious eye diseases,\u201d said David Guyer, M.D., co-founder, CEO, and president of EyeBio. \u201cThe world-class team we have assembled gives us the talent and resources to continue our rapid progress and success in advancing a strong pipeline. It is a privilege to be surrounded by an elite group of leaders in ophthalmology, many of whom have been working in this space since the dawn of pharmacotherapy for eye disease.\u201d\n<\/p>\n<p>\n<b>Appointments to the senior leadership team<\/b>\n<\/p>\n<p>\nEyeBio announced the following appointments to the senior leadership team:\n<\/p>\n<p>\n<b>Anthony P. Adamis, M.D., <\/b>has been appointed<b> chief scientific officer<\/b>. Dr. Adamis, who co-founded EyeBio in 2021 and Eyetech in 2002 with Dr. Guyer, previously served as senior vice president of Product Development and Development Innovation at Genentech, a member of The Roche Group. Over the course of his career, he has led development programs in multiple therapeutic areas and has overseen 25 U.S. Food and Drug Administration (FDA) approvals, the most recent of which was faricimab<sup>1<\/sup>, a novel anti-VEGF anti-Ang-2 bi-specific antibody for treating neovascular age-related macular degeneration (nAMD) and diabetic macular edema (DME).\n<\/p>\n<p>\n\u201cEyeBio is building one of the strongest ophthalmology pipelines in biopharma: Two novel and innovative agonist antibody assets, both with first-in-class and best-in-class potential,\u201d said Dr. Adamis. \u201cI am delighted to join a company that can combine such scientific potential with a global team of highly experienced ophthalmic drug developers.\u201d\n<\/p>\n<p>\n\u201cIt is a real pleasure to work once again with Tony Adamis, following our successful collaboration at Roche in developing Vabysmo<sup>\u00ae<\/sup>, which made a significant difference in patients\u2019 lives,\u201d commented Andreas Wallnoefer, Ph.D., partner at Jeito Capital.\n<\/p>\n<p>\nIn addition to Dr. Adamis, EyeBio announced senior leadership appointments that further expand its international team of executives and investors with a track record for developing ground-breaking ophthalmology therapies:\n<\/p>\n<ul class=\"bwlistdisc\">\n<li>\nLoni Da Silva, chief regulatory officer, brings extensive ophthalmology regulatory leadership experience and led the first retinal drug approval (Macugen);\n<\/li>\n<li>\nFrances Betts, global head, clinical operations, has recruited thousands of patients into more than 20 ophthalmology clinical trials;\n<\/li>\n<li>\nMike Davies, chemistry, manufacturing, and control (CMC) lead, drug development, led protein sciences for the development of bispecific antibodies at F-Star Therapeutics; and\n<\/li>\n<li>\nEric Ng, Ph.D., senior vice president, biology, developed novel therapeutics and animal models in ophthalmology as an Associate Professor at Harvard University.\n<\/li>\n<\/ul>\n<p>\nThese individuals join EyeBio\u2019s established team, which includes:\n<\/p>\n<ul class=\"bwlistdisc\">\n<li>\nDr. Guyer, Co-Founder, CEO, and president, co-founded Eyetech and Iveric Bio and brings expansive medical, drug development, and commercial experience in ophthalmology;\n<\/li>\n<li>\nSarah Milsom, chief operating officer, brings experience in life sciences strategy, development, and commercialization;\n<\/li>\n<li>\nJonathan Prenner, M.D., chief medical officer, is a noted retinal specialist, researcher, and biotech adviser; and\n<\/li>\n<li>\nPaul Stephens, senior vice president, CMC and drug discovery, previously oversaw the transition of novel biologic entities from research to development at UCB Pharma.\n<\/li>\n<\/ul>\n<p>\n\u201cI&#8217;m thrilled to see EyeBio grow from the idea on a sheet of paper we developed with David Guyer in 2021 to such a robust, exciting, new company,\u201d said Kate Bingham, EyeBio board chair and managing partner at SV Health Investors. \u201cIt is a testament to David and the outstanding team he has brought together. The new additions to the EyeBio leadership team reflect the promise of the company\u2019s science and the potential of its pipeline to benefit patients living with difficult-to-treat ophthalmic diseases.\u201d\n<\/p>\n<p>\n\u201cI met with Eyetech, the first company David and Tony founded together, on my first day as a biotech investor at JPMorgan Partners, and it was my first investment,\u201d said Srinivas Akkaraju, M.D., Ph.D., Founder and Managing Partner of Samsara BioCapital. \u201cEver since, I have continued to support their work to address unmet need in ophthalmology and am thrilled to be working with them again.\u201d\n<\/p>\n<p>\n<b>Restoret<\/b> <b>and the importance of the Wnt pathway<\/b>\n<\/p>\n<p>\nRestoret is a tri-specific Wnt agonist antibody designed to address urgent unmet medical need in patients with back-of-the-eye diseases. The result of a breakthrough in molecular design, Restoret will enable the clinical translation of the extensively studied Wnt pathway for the first time in the eye. Since the discovery that Wnt genes code for proteins that drive normal development and maintenance of the blood-retinal barrier, the Wnt pathway has been a focus of many top research institutes. Published research has shown that Wnt signaling in the retina plays a central role in the maintenance of vascular integrity, and defects in Wnt signaling cause retinal vascular leakage. A mimetic of norrin, which is the natural Wnt ligand in the eye, Restoret has demonstrated efficacy in preclinical ophthalmic models, including validation in genetic models.\n<\/p>\n<p>\nThe EyeBio team plans to file for clinical trial authorizations to enable a global Phase 1b\/2 clinical trial of Restoret in the second quarter of 2023.\n<\/p>\n<p>\n<b>A growing, dynamic pipeline<\/b>\n<\/p>\n<p>\nEyeBio has also in-licensed a second bispecific agonist antibody asset for the treatment of retinal diseases, with a separate and complementary mechanism of action to Restoret. These assets signal a diverse pipeline that leverages a core strength in developing multi-specific antibodies and intravitreal retinal therapies.\n<\/p>\n<p>\nEyeBio welcomes inquiries regarding in-licensing and acquisition of assets into the company pipeline. Please visit <a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=http%3A%2F%2Fwww.eyebiotech.com&amp;esheet=53356231&amp;newsitemid=20230306005230&amp;lan=en-US&amp;anchor=www.eyebiotech.com&amp;index=2&amp;md5=baae5d255c0c3f936053f46bf93fde56\" rel=\"nofollow noopener\" shape=\"rect\">www.eyebiotech.com<\/a> to learn more.\n<\/p>\n<p>\n<b>About EyeBio (Eyebiotech Limited)<\/b>\n<\/p>\n<p>\nEyebiotech Limited (EyeBio) is a privately held ophthalmology biotechnology company dedicated to developing and delivering a new generation of therapies to protect, restore, and improve vision in patients with sight-threatening eye diseases. Founded in August 2021 by David Guyer, M.D., and Anthony P. Adamis, M.D., EyeBio has a leadership team composed of serial disruptors in ophthalmology drug development. With operations in the United States and the United Kingdom, EyeBio is building and advancing a pipeline of ocular therapies that combine scientifically robust targets with innovative translational approaches. EyeBio was seeded and created by SV Health Investors and raised a $65 million Series A in February 2022 led by SV Health Investors, alongside Samsara BioCapital and Jeito Capital, with additional financial backing from MRL Ventures. For more information, please see <a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=http%3A%2F%2Fwww.eyebiotech.com&amp;esheet=53356231&amp;newsitemid=20230306005230&amp;lan=en-US&amp;anchor=www.eyebiotech.com&amp;index=3&amp;md5=7d5687840e535719f2cf35605e9def73\" rel=\"nofollow noopener\" shape=\"rect\">www.eyebiotech.com<\/a>.\n<\/p>\n<p>\n______________________\n<\/p>\n<p>\n<sup>1<\/sup> Vabysmo<sup>\u00ae<\/sup> (faricimab-svoa) is approved by the FDA for the treatment of neovascular age-related macular degeneration (nAMD) and diabetic macular edema (DME)\n<\/p>\n<p> <b>Contacts<\/b> <\/p>\n<p>\n<b>Media:<\/b><br \/>SmithSolve<br \/>\n<br \/>Matt Pera<br \/>\n<br \/>(973) 886-9150<br \/>\n<br \/><a target=\"_blank\" href=\"&#x6d;&#x61;&#x69;&#x6c;&#x74;&#x6f;&#x3a;&#x4d;&#x61;&#x74;&#x74;&#x2e;&#x50;&#x65;&#114;&#97;&#64;&#115;&#109;&#105;&#116;&#104;&#115;&#111;&#108;ve&#46;com\" rel=\"nofollow noopener\" shape=\"rect\">Matt&#46;&#80;&#101;&#114;&#97;&#x40;&#x73;&#x6d;&#x69;&#x74;&#x68;&#x73;olve&#46;&#99;&#111;&#109;<\/a>\n<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>&#8211; Additions to EyeBio\u2019s leadership team include world-class disruptors with deep experience addressing urgent unmet needs in treatment of eye diseases &#8211; EyeBio co-founder Anthony P. Adamis, M.D., appointed chief scientific officer to lead development of the Company\u2019s ophthalmology pipeline &#8211; Company provides details on Restoret\u2122, which targets the Wnt pathway, as the lead asset &#8230; <span class=\"more\"><a class=\"more-link\" href=\"https:\/\/pharma-trend.com\/en\/eyebio-announces-first-asset-in-innovative-pipeline-of-retinal-disease-treatments-and-appoints-industry-leaders-to-executive-team\/\">[Read more&#8230;]<\/a><\/span><\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[13],"tags":[],"class_list":{"0":"entry","1":"post","2":"publish","3":"author-business","4":"post-54504","6":"format-standard","7":"category-industry"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>EyeBio Announces First Asset in Innovative Pipeline of Retinal Disease Treatments and Appoints Industry Leaders to Executive Team - Pharma Trend<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/pharma-trend.com\/en\/eyebio-announces-first-asset-in-innovative-pipeline-of-retinal-disease-treatments-and-appoints-industry-leaders-to-executive-team\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"EyeBio Announces First Asset in Innovative Pipeline of Retinal Disease Treatments and Appoints Industry Leaders to Executive Team - Pharma Trend\" \/>\n<meta property=\"og:description\" content=\"&#8211; Additions to EyeBio\u2019s leadership team include world-class disruptors with deep experience addressing urgent unmet needs in treatment of eye diseases &#8211; EyeBio co-founder Anthony P. 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Adamis, M.D., appointed chief scientific officer to lead development of the Company\u2019s ophthalmology pipeline &#8211; Company provides details on Restoret\u2122, which targets the Wnt pathway, as the lead asset ... 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