{"id":54618,"date":"2023-03-08T12:03:04","date_gmt":"2023-03-08T11:03:04","guid":{"rendered":"https:\/\/pharma-trend.com\/en\/sepsis-pipeline-insight-2022-innovations-from-sciclone-sanofi-bioaegis-more-set-to-transform-sepsis-treatment-researchandmarkets-com\/"},"modified":"2023-03-08T12:03:04","modified_gmt":"2023-03-08T11:03:04","slug":"sepsis-pipeline-insight-2022-innovations-from-sciclone-sanofi-bioaegis-more-set-to-transform-sepsis-treatment-researchandmarkets-com","status":"publish","type":"post","link":"https:\/\/pharma-trend.com\/en\/sepsis-pipeline-insight-2022-innovations-from-sciclone-sanofi-bioaegis-more-set-to-transform-sepsis-treatment-researchandmarkets-com\/","title":{"rendered":"Sepsis &#8211; Pipeline Insight, 2022: Innovations from SciClone, Sanofi, BioAegis &amp; More Set to Transform Sepsis Treatment &#8211; ResearchAndMarkets.com"},"content":{"rendered":"<div>\n<p>DUBLIN&#8211;(BUSINESS WIRE)&#8211;The <a target=\"_blank\" href=\"https:\/\/www.researchandmarkets.com\/reports\/4989048\/sepsis-pipeline-insight-2022?utm_source=BW&amp;utm_medium=PressRelease&amp;utm_code=bdwxpx&amp;utm_campaign=1827631+-+Sepsis+-+Pipeline+Insight%2C+2022%3A+Innovations+ffrom+SciClone%2C+Sanofi%2C+BioAegis+%26+More+Set+to+Transform+Sepsis+Treatment&amp;utm_exec=como322prd\" rel=\"nofollow noopener\" shape=\"rect\">&#8220;Sepsis &#8211; Pipeline Insight, 2022&#8221;<\/a> clinical trials has been added to <strong>ResearchAndMarkets.com&#8217;s<\/strong> offering.\n<\/p>\n<p><a href=\"https:\/\/mms.businesswire.com\/media\/20230308005449\/en\/1733326\/4\/logo.jpg\"><img decoding=\"async\" src=\"https:\/\/mms.businesswire.com\/media\/20230308005449\/en\/1733326\/21\/logo.jpg\"><\/a><\/p>\n<p>\nThis &#8220;Sepsis- Pipeline Insight, 2022&#8221; report provides comprehensive insights about 40+ companies and 40+ pipeline drugs in Sepsis pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.\n<\/p>\n<p>\n<strong>Report Highlights<\/strong>\n<\/p>\n<ul>\n<li>\nThe companies and academics are working to assess challenges and seek opportunities that could influence Sepsis R&amp;D. The therapies under development are focused on novel approaches to treat\/improve Sepsis.\n<\/li>\n<\/ul>\n<p>\n<strong>Sepsis Emerging Drugs Chapters<\/strong>\n<\/p>\n<p>\nThis segment of the Sepsis report encloses its detailed analysis of various drugs in different stages of clinical development, including phase II, I, preclinical and Discovery. It also helps to understand clinical trial details, expressive pharmacological action, agreements and collaborations, and the latest news and press releases.\n<\/p>\n<p>\n<strong>Sepsis Emerging Drugs<\/strong>\n<\/p>\n<p>\n<strong>Thymosin alpha 1: SciClone Pharmaceuticals<\/strong>\n<\/p>\n<p>\nThymosin alpha 1, generically referred to as thymalfasin, is a synthetic 28-amino acid peptide with multiple biological activities primarily directed towards immune response enhancement. SciClone developed and launched Thymosin alpha 1, under the trade name Zadaxin, for the treatment of hepatitis B virus (HBV) infection and hepatitis C virus (HCV) infections. The drug is also being developed for the treatment of COVID 2019 infections. Published scientific and clinical studies have shown that Thymosin alpha 1 helps to stimulate and direct the body&#8217;s immune response to eradicate infectious diseases, such as HBV, HCV, bacterial, and fungal infections; to fight certain cancers such as melanoma and liver cancer; and to enhance response to vaccines.\n<\/p>\n<p>\nClinical trials have shown that Thymosin alpha 1 improves survival in patients in intensive care units being treated for sepsis from severe bacterial infections. The therapy is being evaluated in Phase III stage to treat Sepsis.\n<\/p>\n<p>\n<strong>Alirocumab: Regeneron\/Sanofi<\/strong>\n<\/p>\n<p>\nAlirocumab injection is in a class of medications called proprotein convertase subtilisin kexin type 9 (PCSK9) inhibitor monoclonal antibodies. It works by blocking the production of LDL cholesterol in the body therefore decreasing the amount of cholesterol that may build up on the walls of the arteries.\n<\/p>\n<p>\n<strong>Recombinant human plasma gelsolin: BioAegis Therapeutics<\/strong>\n<\/p>\n<p>\nRhu-plasma gelsolin is a host-directed immunotherapy treatment. It is expected to be effective against pneumonia caused by many different types of bacteria (bacterial pneumonia) and influenza (viral pneumonia), the severe inflammation resulting from covid 19 pneumonia, and sepsis which is often caused by pneumonia. Rhu-pGSN is a broad-acting threat-agnostic product that improves immune cell function at sites of injury by enhancing pathogen killing while also resolving inflammation.\n<\/p>\n<p>\nThe product will target severe systemic inflammatory responses due to infection or injury to mitigate poor outcomes. A key step for this product is to initiate the next clinical trial and to scale up manufacturing to provide additional clinical supplies for these studies in more severely ill patients at risk for sepsis. This will move the program into Phase IIb to demonstrate proof of impact on clinical outcomes and to optimize cost of goods for clinical supplies and commercialization.\n<\/p>\n<p>\n<strong>M6229: Matisse Pharmaceuticals<\/strong>\n<\/p>\n<p>\nMatisse&#8217;s platform technology is based on the discovery that in many patients suffering from sepsis, proteins called histones are released by the innate immune system and dying cells into the blood stream, where they are toxic to other cells. Due to a self-enforcing cascade, people may die from organ failure within one or two days. Preclinical results have shown that by neutralizing the toxic histones with Matisse&#8217;s product M6229, the negative cascade is terminated by neutralization of cationic histones by anionic M6229. Matisse claims to have identified an elegant solution for treating one of the major complications in sepsis by using a non-anticoagulant fraction of heparin called M6229 to neutralize toxic circulatory histones.\n<\/p>\n<p>\n<strong>STC3141: CGE Healthcare<\/strong>\n<\/p>\n<p>\nSTC3141 is a global innovative small molecule compound with a new mechanism of action independently developed by the CGE Healthcare Group. It can reverse the organ damage caused by the body&#8217;s excessive immune response by neutralizing extracellular free histones and neutrophil traps. It can be used for a variety of severe indications. The product has approved to conduct Phase Ib clinical studies for the treatment of sepsis in Australia in May 2020 and in Belgium in April 2022, respectively. STC3141 is now conducting Phase Ib clinical studies for the treatment of sepsis in Australia and Belgium, respectively.\n<\/p>\n<p>\n<strong>Sepsis: Therapeutic Assessment<\/strong>\n<\/p>\n<p>\nThis segment of the report provides insights about the different Sepsis drugs segregated based on following parameters that define the scope of the report, such as:\n<\/p>\n<p>\n<strong>Major Players in Sepsis<\/strong>\n<\/p>\n<p>\nThere are approx. 40+ key companies which are developing the therapies for Sepsis. The companies which have their Sepsis drug candidates in the most advanced stage, i.e. phase III include, SciClone Pharmaceuticals.\n<\/p>\n<p>\n<strong>Phases<\/strong>\n<\/p>\n<p>\nThe report covers around 40+ products under different phases of clinical development like\n<\/p>\n<ul>\n<li>\nLate stage products (Phase III)\n<\/li>\n<li>\nMid-stage products (Phase II)\n<\/li>\n<li>\nEarly-stage product (Phase I) along with the details of\n<\/li>\n<li>\nPre-clinical and Discovery stage candidates\n<\/li>\n<li>\nDiscontinued &amp; Inactive candidates\n<\/li>\n<li>\nRoute of Administration\n<\/li>\n<\/ul>\n<p>\n<strong>Sepsis pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs such as<\/strong>\n<\/p>\n<ul>\n<li>\nIntra-articular\n<\/li>\n<li>\nIntraocular\n<\/li>\n<li>\nIntrathecal\n<\/li>\n<li>\nIntravenous\n<\/li>\n<li>\nOphthalmic\n<\/li>\n<li>\nOral\n<\/li>\n<li>\nParenteral\n<\/li>\n<li>\nSubcutaneous\n<\/li>\n<li>\nTopical\n<\/li>\n<li>\nTransdermal\n<\/li>\n<li>\nMolecule Type\n<\/li>\n<\/ul>\n<p>\n<strong>Products have been categorized under various Molecule types such as<\/strong>\n<\/p>\n<ul>\n<li>\nOligonucleotide\n<\/li>\n<li>\nPeptide\n<\/li>\n<li>\nSmall molecule\n<\/li>\n<li>\nProduct Type\n<\/li>\n<\/ul>\n<p>\nDrugs have been categorized under various product types like Mono, Combination and Mono\/Combination.\n<\/p>\n<p>\n<strong>Sepsis: Pipeline Development Activities<\/strong>\n<\/p>\n<p>\nThe report provides insights into different therapeutic candidates in phase II, I, preclinical and discovery stage. It also analyses Sepsis therapeutic drugs key players involved in developing key drugs.\n<\/p>\n<p>\n<strong>Pipeline Development Activities<\/strong>\n<\/p>\n<p>\nThe report covers the detailed information of collaborations, acquisition and merger, licensing along with a thorough therapeutic assessment of emerging Sepsis drugs.\n<\/p>\n<p>\n<strong>Sepsis Report Insights<\/strong>\n<\/p>\n<ul>\n<li>\nSepsis Pipeline Analysis\n<\/li>\n<li>\nTherapeutic Assessment\n<\/li>\n<li>\nUnmet Needs\n<\/li>\n<li>\nImpact of Drugs\n<\/li>\n<\/ul>\n<p>\n<strong>Sepsis Report Assessment<\/strong>\n<\/p>\n<ul>\n<li>\nPipeline Product Profiles\n<\/li>\n<li>\nTherapeutic Assessment\n<\/li>\n<li>\nPipeline Assessment\n<\/li>\n<li>\nInactive drugs assessment\n<\/li>\n<li>\nUnmet Needs\n<\/li>\n<\/ul>\n<p>\n<strong>Key Questions Answered<\/strong>\n<\/p>\n<p>\nCurrent Treatment Scenario and Emerging Therapies:\n<\/p>\n<ul>\n<li>\nHow many companies are developing Sepsis drugs?\n<\/li>\n<li>\nHow many Sepsis drugs are developed by each company?\n<\/li>\n<li>\nHow many emerging drugs are in mid-stage, and late-stage of development for the treatment of Sepsis?\n<\/li>\n<li>\nWhat are the key collaborations (Industry-Industry, Industry-Academia), Mergers and acquisitions, licensing activities related to the Sepsis therapeutics?\n<\/li>\n<li>\nWhat are the recent trends, drug types and novel technologies developed to overcome the limitation of existing therapies?\n<\/li>\n<li>\nWhat are the clinical studies going on for Sepsis and their status?\n<\/li>\n<li>\nWhat are the key designations that have been granted to the emerging drugs?\n<\/li>\n<\/ul>\n<p>\n<strong>Key Products<\/strong>\n<\/p>\n<ul>\n<li>\nThymosin alpha 1\n<\/li>\n<li>\nAlbutein\n<\/li>\n<li>\nART-123\n<\/li>\n<li>\nAlirocumab\n<\/li>\n<li>\nRecombinant human plasma gelsolin\n<\/li>\n<li>\nCenthaquine\n<\/li>\n<li>\nARTICE therapy\n<\/li>\n<li>\nVBI-S\n<\/li>\n<li>\nCefiderocol\n<\/li>\n<li>\nCYT107\n<\/li>\n<li>\nNangibotide\n<\/li>\n<li>\nAllocetra-OTS\n<\/li>\n<li>\nAdrecizumab\n<\/li>\n<li>\nKukoamine B\n<\/li>\n<li>\nSY 005\n<\/li>\n<li>\nM6229\n<\/li>\n<li>\nSTC3141\n<\/li>\n<li>\nRECCE 327\n<\/li>\n<li>\nST266\n<\/li>\n<li>\nHY-209\n<\/li>\n<\/ul>\n<p>\n<strong>A selection of companies mentioned in this report includes<\/strong>\n<\/p>\n<ul>\n<li>\nSciClone Pharmaceuticals\n<\/li>\n<li>\nGrifols\n<\/li>\n<li>\nAsahi Kasei Pharma\n<\/li>\n<li>\nRegeneron\/Sanofi\n<\/li>\n<li>\nBioAegis Therapeutics\n<\/li>\n<li>\nPharmazz\n<\/li>\n<li>\nARTCLINE GmbH\n<\/li>\n<li>\nVivacelle Bio\n<\/li>\n<li>\nShionogi\n<\/li>\n<li>\nRevimmune SAS\n<\/li>\n<li>\nInotrem\n<\/li>\n<li>\nEnlivex Therapeutics\n<\/li>\n<li>\nAdrenomed\n<\/li>\n<li>\nTianjin Chasesun Pharmaceutical Co., LTD\n<\/li>\n<li>\nSuzhou Yabao Pharmaceutical R&amp;D Co., Ltd.\n<\/li>\n<li>\nMatisse Pharmaceuticals\n<\/li>\n<li>\nCGE Healthcare\n<\/li>\n<\/ul>\n<p>\nFor more information about this clinical trials report visit <a target=\"_blank\" href=\"https:\/\/www.researchandmarkets.com\/reports\/4989048\/sepsis-pipeline-insight-2022?utm_source=BW&amp;utm_medium=PressRelease&amp;utm_code=bdwxpx&amp;utm_campaign=1827631+-+Sepsis+-+Pipeline+Insight%2C+2022%3A+Innovations+ffrom+SciClone%2C+Sanofi%2C+BioAegis+%26+More+Set+to+Transform+Sepsis+Treatment&amp;utm_exec=como322prd\" rel=\"nofollow noopener\" shape=\"rect\">https:\/\/www.researchandmarkets.com\/r\/8m4kr8<\/a>\n<\/p>\n<p>\n<strong>About ResearchAndMarkets.com<\/strong>\n<\/p>\n<p>\nResearchAndMarkets.com is the world&#8217;s leading source for international market research reports and market data. We provide you with the latest data on international and regional markets, key industries, the top companies, new products and the latest trends.\n<\/p>\n<p> <b>Contacts<\/b> <\/p>\n<p>\nResearchAndMarkets.com<br \/>\n<br \/>Laura Wood, Senior Press Manager<br \/>\n<br \/><a target=\"_blank\" href=\"&#x6d;&#97;&#x69;&#108;t&#x6f;&#58;p&#x72;&#101;&#x73;&#x73;&#64;&#x72;&#101;s&#x65;&#97;&#x72;&#x63;h&#x61;&#110;d&#x6d;&#97;r&#x6b;&#101;&#x74;&#115;&#46;&#x63;&#111;m\" rel=\"nofollow noopener\" shape=\"rect\">&#x70;&#x72;&#x65;&#x73;&#x73;&#x40;&#x72;&#x65;&#x73;&#x65;&#x61;&#114;&#99;&#104;&#97;&#110;&#100;&#109;arkets&#x2e;&#x63;&#x6f;&#x6d;<\/a><br \/>For E.S.T Office Hours Call 1-917-300-0470<br \/>\n<br \/>For U.S.\/ CAN Toll Free Call 1-800-526-8630<br \/>\n<br \/>For GMT Office Hours Call +353-1-416-8900\n<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>DUBLIN&#8211;(BUSINESS WIRE)&#8211;The &#8220;Sepsis &#8211; Pipeline Insight, 2022&#8221; clinical trials has been added to ResearchAndMarkets.com&#8217;s offering. This &#8220;Sepsis- Pipeline Insight, 2022&#8221; report provides comprehensive insights about 40+ companies and 40+ pipeline drugs in Sepsis pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product &#8230; <span class=\"more\"><a class=\"more-link\" href=\"https:\/\/pharma-trend.com\/en\/sepsis-pipeline-insight-2022-innovations-from-sciclone-sanofi-bioaegis-more-set-to-transform-sepsis-treatment-researchandmarkets-com\/\">[Read more&#8230;]<\/a><\/span><\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[13],"tags":[],"class_list":{"0":"entry","1":"post","2":"publish","3":"author-business","4":"post-54618","6":"format-standard","7":"category-industry"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Sepsis - Pipeline Insight, 2022: Innovations from SciClone, Sanofi, BioAegis &amp; More Set to Transform Sepsis Treatment - ResearchAndMarkets.com - Pharma Trend<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/pharma-trend.com\/en\/sepsis-pipeline-insight-2022-innovations-from-sciclone-sanofi-bioaegis-more-set-to-transform-sepsis-treatment-researchandmarkets-com\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Sepsis - Pipeline Insight, 2022: Innovations from SciClone, Sanofi, BioAegis &amp; More Set to Transform Sepsis Treatment - ResearchAndMarkets.com - Pharma Trend\" \/>\n<meta property=\"og:description\" content=\"DUBLIN&#8211;(BUSINESS WIRE)&#8211;The &#8220;Sepsis &#8211; Pipeline Insight, 2022&#8221; clinical trials has been added to ResearchAndMarkets.com&#8217;s offering. 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