{"id":54804,"date":"2023-03-14T12:06:24","date_gmt":"2023-03-14T11:06:24","guid":{"rendered":"https:\/\/pharma-trend.com\/en\/newron-announces-2022-financial-results-and-provides-outlook-for-2023\/"},"modified":"2023-03-14T12:06:24","modified_gmt":"2023-03-14T11:06:24","slug":"newron-announces-2022-financial-results-and-provides-outlook-for-2023","status":"publish","type":"post","link":"https:\/\/pharma-trend.com\/en\/newron-announces-2022-financial-results-and-provides-outlook-for-2023\/","title":{"rendered":"Newron Announces 2022 Financial Results and Provides Outlook For 2023"},"content":{"rendered":"<div>\n<p class=\"bwalignc\">\n<b>Ad hoc announcement pursuant to Art. 53 LR<\/b>\n<\/p>\n<p>MILAN&#8211;(BUSINESS WIRE)&#8211;Newron Pharmaceuticals S.p.A. (\u201cNewron\u201d) (SIX: NWRN, XETRA: NP5), a biopharmaceutical company focused on the development of novel therapies for patients with diseases of the central and peripheral nervous system, today announced its financial results and operational highlights for the business year ended December 31, 2022, and provided an outlook for 2023.\n<\/p>\n<p><a href=\"https:\/\/mms.businesswire.com\/media\/20230313005891\/en\/682845\/5\/logo_color_high_res.jpg\"><img decoding=\"async\" src=\"https:\/\/mms.businesswire.com\/media\/20230313005891\/en\/682845\/21\/logo_color_high_res.jpg\"><\/a><\/p>\n<p>\n<b>Highlights 2022:<\/b>\n<\/p>\n<p>\n<b>Evenamide (Schizophrenia)<\/b>\n<\/p>\n<ul class=\"bwlistdisc\">\n<li>\nStriking interim efficacy and safety results from world-first Phase II clinical trial evaluating evenamide as add-on therapy for patients with treatment-resistant schizophrenia (TRS), after six weeks and, post-period, six months and one year\n<\/li>\n<li>\nEnrolment of patients in study 014 completed, with 161 subjects randomized (post-period); full results from the study after six weeks of treatment expected in March 2023\n<\/li>\n<li>\nFollowing the interim data in patients suffering from TRS, study 003, a potentially pivotal, multinational, randomized, double-blind, ten-week, placebo-controlled study assessing the efficacy, safety and tolerability of 15 and 30 mg bid of evenamide as an add-on treatment in patients with TRS, is expected to commence in 2023\n<\/li>\n<li>\nPatient recruitment in potentially pivotal study 008A to evaluate evenamide in patients with chronic schizophrenia who are not classed as treatment resistant is ongoing, results from the study are expected in 2023\n<\/li>\n<\/ul>\n<p>\n<b>Xadago\u00ae\/safinamide (Parkinson\u2019s disease)<\/b>\n<\/p>\n<ul class=\"bwlistdisc\">\n<li>\nNewron and its partners Zambon and Supernus continue to work to protect intellectual property rights associated with Xadago\u00ae\/safinamide in the US, responding to Paragraph IV Notice Letters regarding Abbreviated New Drug Applications submitted from generic pharmaceutical manufacturers\n<\/li>\n<\/ul>\n<p>\n<b>Corporate<\/b>\n<\/p>\n<ul class=\"bwlistdisc\">\n<li>\nNewron continues its dialogue with industry partners around potential future collaboration opportunities for the development of evenamide. The company also continues to explore a number of potential opportunities to expand its pipeline in central nervous system diseases\n<\/li>\n<li>\nGillian Dines proposed for election as new member to the Board of Directors at the AGM on April 18, 2023\n<\/li>\n<li>\nDevelopment of ESG strategy completed, with focus areas and objectives for 2023 \u2013 Reporting will be based on 10 out of the 17 Sustainable Development Goals, as defined by the UN\n<\/li>\n<\/ul>\n<p>\n<b>Stefan Weber, CEO of Newron, commented:<\/b>\n<\/p>\n<p>\n\u201cThe last twelve months have been an exciting period for our Company, particularly given the announcement of three sets of compelling interim efficacy results from our ongoing Phase II clinical study 014\/015 with evenamide in patients with treatment-resistant schizophrenia (TRS). We have also made significant progress with the Phase III study of evenamide (study 008A) in another indication \u2013 patients with chronic schizophrenia currently being treated with a second-generation antipsychotic, but who are not classed as having TRS \u2013 and have strengthened both our management team and our Environment, Social and Governance (ESG) efforts\u201d.\n<\/p>\n<p>\n<b>Evenamide<\/b>\n<\/p>\n<p>\nIn June 2022, Newron was excited to share the first set of data from its Phase II study with evenamide, a new chemical entity being developed for the treatment of patients with schizophrenia. The results showed that the addition of evenamide improved symptoms of psychosis in patients with TRS. This was reflected by an approximately 12% reduction in the Positive and Negative Syndrome Scale (PANSS) score, Clinical Global Impression \u2013 Severity of illness (CGI-S) improvement of 0.7, and Clinical Global Impression \u2013 Change from baseline (CGI-C) ratings indicating that 77% of patients responded to the treatment.\n<\/p>\n<p>\nPost-period, in Q1 2023, Newron was able to announce interim data from study 014 as well as its extension arm, study 015, showing results in the first 100 patients in the study after six months (30 weeks) and one year (52 weeks) of treatment with evenamide:\n<\/p>\n<ul class=\"bwlistdisc\">\n<li>\nIn January 2023, Newron announced six-month interim data which demonstrated a continued improvement in TRS symptoms following treatment with evenamide, as well as a substantially greater proportion of patients experiencing a meaningful improvement when compared to six weeks of treatment.\n<\/li>\n<li>\nClosely following, in February 2023, the Company disclosed one-year interim data from study 014\/015. Results provided further striking new evidence of the sustained efficacy of the addition of evenamide to antipsychotics in TRS patients by demonstrating substantially greater benefit at one year than noted at the six-week and six-month datapoints.\n<\/li>\n<\/ul>\n<p>\nThese results after six months and one year were highly compelling, statistically significant (paired t-test), and clinically meaningful, as not only was evenamide well tolerated with few adverse effects, but there was a sustained and continued improvement at all doses. Newron was particularly struck by data suggesting there is a continued improvement over time in these measures. While recognizing that this study has no control arm, clinically meaningful improvements over baseline in key efficacy measures after one year are, to the Company\u2019s knowledge, unprecedented in patients with diagnosed TRS.\n<\/p>\n<p>\nThe enrolment of study 014 has now been completed with 161 subjects. The Company expects to announce the full results from this study still in March 2023, which will include six-week data from all 161 patients enrolled into the study. One-year data from all 161 patients in extension study 015 is expected by Q1 2024.\n<\/p>\n<p>\nStudy 003 is planned to be a potentially pivotal, multinational, randomized, placebo-controlled, ten-week global study to assess the efficacy, safety and tolerability of evenamide (15\/30 mg bid) as an add-on treatment in outpatients with treatment-resistant schizophrenia (TRS) not responding adequately to their monotherapy treatment with atypical antipsychotics (including clozapine). Positive data from this study would confirm the potential of evenamide as the first medication that could be added to an antipsychotic and improve symptoms of TRS in patients. Newron plans to initiate this study in 2023.\n<\/p>\n<p>\nAlongside the R&amp;D-work with evenamide in TRS, the Company is also conducting study 008A, a four-week, randomised, double-blind and placebo-controlled study assessing the efficacy, tolerability, and safety (including electroencephalogram effects) of evenamide (30 mg bid) in patients with chronic schizophrenia currently being treated with a second-generation antipsychotic, but who demonstrate an inadequate response to that treatment. Recruitment at treatment centers in Europe, Asia and Latin America is ongoing and results are expected in 2023. If results from the study are positive, it would represent the first well-controlled, potentially pivotal study of evenamide in schizophrenia patients who demonstrate an inadequate response to treatment with atypical antipsychotics.\n<\/p>\n<p>\n<b>Xadago<sup>\u00ae<\/sup>\/safinamide<\/b>\n<\/p>\n<p>\nIn partnership with Zambon and Supernus, Newron continues to further develop and market its product, Xadago\u00ae\/safinamide.\n<\/p>\n<p>\nIn reference to the receipt of several Paragraph IV Notice Letters in May 2021 regarding the submission by generic manufacturers of an Abbreviated New Drug Application to the US Food and Drug Administration (FDA), seeking approval to engage in the commercial manufacture, use or sale of safinamide mesylate drug product in the US before expiration of certain US patents, Newron and its partners Zambon and Supernus filed an infringement case against these manufacturers to secure its intellectual property rights. Newron continues to challenge these submissions and note that its patents on Xadago\u00ae (safinamide) tablets remain protected by three patents in the FDA Approved Drugs Product List (Orange Book) until at least 2027.\n<\/p>\n<p>\nNewron and Zambon have reached an agreement to discontinue their plans to initiate a clinical study with safinamide in Parkinson\u2019s disease patients with levodopa-induced dyskinesia (PD LID). As a matter of settlement, Zambon will advance an undisclosed fee to Newron.\n<\/p>\n<p>\n<b>ESG commitment and reporting<\/b>\n<\/p>\n<p>\nSustainability is one of the most crucial current challenges, for every company, regardless of size or industry. Newron has already issued several policies and procedures and taken some specific actions that are part of ESG best practices, but in 2022 the strategic process started formally with a materiality analysis in close dialogue with internal and external stakeholders to best understand how each one of them could relate with relevance of all the possible areas to Newron\u2019s ESG efforts. An ESG strategy based on a key materiality review has been developed, and Sustainable Development Goals that the Company can contribute to have been identified. ESG focus areas and objectives for 2023 have been defined and Newron\u2019s Annual ESG reporting efforts commence with the Annual Report 2022 published today.\n<\/p>\n<p>\n<b>Financial Key takeaways 2022:<\/b>\n<\/p>\n<ul class=\"bwlistdisc\">\n<li>\nIn 2022, Newron reported a net loss of EUR 17.5 million, compared to EUR 14.9 million in 2021\n<\/li>\n<li>\nCash used in operating activities has decreased to EUR 11.1 million from EUR 11.4 million in 2021\n<\/li>\n<li>\nXadago\u00ae revenues from Zambon increased from EUR 5.8 million in 2021 to EUR 6.0 million in the reporting period\n<\/li>\n<li>\nNewron\u2019s R&amp;D expenses have risen to EUR 12.0 million from EUR 10.7 million in 2021\n<\/li>\n<li>\nG&amp;A expenses were stable at EUR 7.4 million\n<\/li>\n<li>\nCash and Other current financial assets as at December 31, 2022, were at EUR 22.8 million, compared to EUR 34.6 million at the beginning of the year\n<\/li>\n<\/ul>\n<p>\n<b>Financial Summary (IFRS) 2022 and 2021:<\/b>\n<\/p>\n<p>\nIn thousand EUR (except per share information)\n<\/p>\n<table cellspacing=\"0\" class=\"bwtablemarginb bwblockalignl\">\n<tr>\n<td class=\"bwvertalignt bwtopsingle bwsinglebottom bwleftsingle bwrightsingle bwpadl0\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwcellpmargin\">\n\u00a0\n<\/p>\n<\/td>\n<td class=\"bwtopsingle bwsinglebottom bwpadl0 bwpadr0 bwvertalignb\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwalignr bwcellpmargin\">\n<b>2022<\/b>\n<\/p>\n<\/td>\n<td class=\"bwtopsingle bwsinglebottom bwrightsingle bwpadl0 bwpadr0 bwvertalignb\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwcellpmargin bwalignl\">\n\u00a0\n<\/p>\n<\/td>\n<td class=\"bwsinglebottom bwtopsingle\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"bwtopsingle bwsinglebottom bwpadl0 bwpadr0 bwvertalignb\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwalignr bwcellpmargin\">\n<b>2021<\/b>\n<\/p>\n<\/td>\n<td class=\"bwtopsingle bwsinglebottom bwrightsingle bwpadl0 bwpadr0 bwvertalignb\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwcellpmargin bwalignl\">\n\u00a0\n<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"bwvertalignt bwsinglebottom bwleftsingle bwrightsingle bwpadl0\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwcellpmargin\">\nLicence income from contracts with customers\n<\/p>\n<\/td>\n<td class=\"bwsinglebottom bwpadl0 bwpadr0 bwvertalignb\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwalignr bwcellpmargin\">\n14\n<\/p>\n<\/td>\n<td class=\"bwsinglebottom bwrightsingle bwpadl0 bwpadr0 bwvertalignb\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwcellpmargin bwalignl\">\n\u00a0\n<\/p>\n<\/td>\n<td class=\"bwsinglebottom\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"bwsinglebottom bwpadl0 bwpadr0 bwvertalignb\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwalignr bwcellpmargin\">\n34\n<\/p>\n<\/td>\n<td class=\"bwsinglebottom bwrightsingle bwpadl0 bwpadr0 bwvertalignb\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwcellpmargin bwalignl\">\n\u00a0\n<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"bwvertalignt bwsinglebottom bwleftsingle bwrightsingle bwpadl0\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwcellpmargin\">\nRoyalties from contracts with customers\n<\/p>\n<\/td>\n<td class=\"bwsinglebottom bwpadl0 bwpadr0 bwvertalignb\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwalignr bwcellpmargin\">\n5,936\n<\/p>\n<\/td>\n<td class=\"bwsinglebottom bwrightsingle bwpadl0 bwpadr0 bwvertalignb\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwcellpmargin bwalignl\">\n\u00a0\n<\/p>\n<\/td>\n<td class=\"bwsinglebottom\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"bwsinglebottom bwpadl0 bwpadr0 bwvertalignb\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwalignr bwcellpmargin\">\n5,728\n<\/p>\n<\/td>\n<td class=\"bwsinglebottom bwrightsingle bwpadl0 bwpadr0 bwvertalignb\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwcellpmargin bwalignl\">\n\u00a0\n<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"bwvertalignt bwsinglebottom bwleftsingle bwrightsingle bwpadl0\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwcellpmargin\">\n<b>Revenue<\/b>\n<\/p>\n<\/td>\n<td class=\"bwsinglebottom bwpadl0 bwpadr0 bwvertalignb\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwalignr bwcellpmargin\">\n<b>6,094<\/b>\n<\/p>\n<\/td>\n<td class=\"bwsinglebottom bwrightsingle bwpadl0 bwpadr0 bwvertalignb\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwcellpmargin bwalignl\">\n\u00a0\n<\/p>\n<\/td>\n<td class=\"bwsinglebottom\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"bwsinglebottom bwpadl0 bwpadr0 bwvertalignb\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwalignr bwcellpmargin\">\n<b>5,762<\/b>\n<\/p>\n<\/td>\n<td class=\"bwsinglebottom bwrightsingle bwpadl0 bwpadr0 bwvertalignb\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwcellpmargin bwalignl\">\n\u00a0\n<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"bwvertalignt bwsinglebottom bwleftsingle bwrightsingle bwpadl0\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwcellpmargin\">\nResearch and development expenses, net\n<\/p>\n<\/td>\n<td class=\"bwsinglebottom bwpadl0 bwpadr0 bwvertalignb\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwalignr bwcellpmargin\">\n(12,005\n<\/p>\n<\/td>\n<td class=\"bwsinglebottom bwrightsingle bwpadl0 bwpadr0 bwvertalignb\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwcellpmargin bwalignl\">\n)\n<\/p>\n<\/td>\n<td class=\"bwsinglebottom\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"bwsinglebottom bwpadl0 bwpadr0 bwvertalignb\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwalignr bwcellpmargin\">\n(10,725\n<\/p>\n<\/td>\n<td class=\"bwsinglebottom bwrightsingle bwpadl0 bwpadr0 bwvertalignb\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwcellpmargin bwalignl\">\n)\n<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"bwvertalignt bwsinglebottom bwleftsingle bwrightsingle bwpadl0\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwcellpmargin\">\n<b>Operating Result<\/b>\n<\/p>\n<\/td>\n<td class=\"bwsinglebottom bwpadl0 bwpadr0 bwvertalignb\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwalignr bwcellpmargin\">\n<b>(13,302<\/b>\n<\/p>\n<\/td>\n<td class=\"bwsinglebottom bwrightsingle bwpadl0 bwpadr0 bwvertalignb\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwcellpmargin bwalignl\">\n<b>)<\/b>\n<\/p>\n<\/td>\n<td class=\"bwsinglebottom\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"bwsinglebottom bwpadl0 bwpadr0 bwvertalignb\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwalignr bwcellpmargin\">\n<b>(12,357<\/b>\n<\/p>\n<\/td>\n<td class=\"bwsinglebottom bwrightsingle bwpadl0 bwpadr0 bwvertalignb\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwcellpmargin bwalignl\">\n<b>)<\/b>\n<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"bwvertalignt bwsinglebottom bwleftsingle bwrightsingle bwpadl0\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwcellpmargin\">\nFinancial result, net\n<\/p>\n<\/td>\n<td class=\"bwsinglebottom bwpadl0 bwpadr0 bwvertalignb\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwalignr bwcellpmargin\">\n(4,170\n<\/p>\n<\/td>\n<td class=\"bwsinglebottom bwrightsingle bwpadl0 bwpadr0 bwvertalignb\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwcellpmargin bwalignl\">\n)\n<\/p>\n<\/td>\n<td class=\"bwsinglebottom\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"bwsinglebottom bwpadl0 bwpadr0 bwvertalignb\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwalignr bwcellpmargin\">\n(2,527\n<\/p>\n<\/td>\n<td class=\"bwsinglebottom bwrightsingle bwpadl0 bwpadr0 bwvertalignb\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwcellpmargin bwalignl\">\n)\n<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"bwvertalignt bwsinglebottom bwleftsingle bwrightsingle bwpadl0\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwcellpmargin\">\n<b>Net loss<\/b>\n<\/p>\n<\/td>\n<td class=\"bwsinglebottom bwpadl0 bwpadr0 bwvertalignb\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwalignr bwcellpmargin\">\n<b>(17,493<\/b>\n<\/p>\n<\/td>\n<td class=\"bwsinglebottom bwrightsingle bwpadl0 bwpadr0 bwvertalignb\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwcellpmargin bwalignl\">\n<b>)<\/b>\n<\/p>\n<\/td>\n<td class=\"bwsinglebottom\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"bwsinglebottom bwpadl0 bwpadr0 bwvertalignb\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwalignr bwcellpmargin\">\n<b>(14,901<\/b>\n<\/p>\n<\/td>\n<td class=\"bwsinglebottom bwrightsingle bwpadl0 bwpadr0 bwvertalignb\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwcellpmargin bwalignl\">\n<b>)<\/b>\n<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"bwvertalignt bwsinglebottom bwleftsingle bwrightsingle bwpadl0\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwcellpmargin\">\nLoss per share\n<\/p>\n<\/td>\n<td class=\"bwsinglebottom bwpadl0 bwpadr0 bwvertalignb\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwalignr bwcellpmargin\">\n(0.98\n<\/p>\n<\/td>\n<td class=\"bwsinglebottom bwrightsingle bwpadl0 bwpadr0 bwvertalignb\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwcellpmargin bwalignl\">\n)\n<\/p>\n<\/td>\n<td class=\"bwsinglebottom\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"bwsinglebottom bwpadl0 bwpadr0 bwvertalignb\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwalignr bwcellpmargin\">\n(0.84\n<\/p>\n<\/td>\n<td class=\"bwsinglebottom bwrightsingle bwpadl0 bwpadr0 bwvertalignb\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwcellpmargin bwalignl\">\n)\n<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"bwvertalignt bwsinglebottom bwleftsingle bwrightsingle bwpadl0\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwcellpmargin\">\nCash used in operating activities\n<\/p>\n<\/td>\n<td class=\"bwsinglebottom bwpadl0 bwpadr0 bwvertalignb\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwalignr bwcellpmargin\">\n(11,092\n<\/p>\n<\/td>\n<td class=\"bwsinglebottom bwrightsingle bwpadl0 bwpadr0 bwvertalignb\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwcellpmargin bwalignl\">\n)\n<\/p>\n<\/td>\n<td class=\"bwsinglebottom\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"bwsinglebottom bwpadl0 bwpadr0 bwvertalignb\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwalignr bwcellpmargin\">\n(11,445\n<\/p>\n<\/td>\n<td class=\"bwsinglebottom bwrightsingle bwpadl0 bwpadr0 bwvertalignb\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwcellpmargin bwalignl\">\n)\n<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"bwvertalignt bwsinglebottom bwleftsingle bwrightsingle bwpadl0\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwcellpmargin\">\nCash, cash equivalents and Other current financial assets\n<\/p>\n<\/td>\n<td class=\"bwsinglebottom bwpadl0 bwpadr0 bwvertalignb\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwalignr bwcellpmargin\">\n22,774\n<\/p>\n<\/td>\n<td class=\"bwsinglebottom bwrightsingle bwpadl0 bwpadr0 bwvertalignb\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwcellpmargin bwalignl\">\n\u00a0\n<\/p>\n<\/td>\n<td class=\"bwsinglebottom\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"bwsinglebottom bwpadl0 bwpadr0 bwvertalignb\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwalignr bwcellpmargin\">\n34,594\n<\/p>\n<\/td>\n<td class=\"bwsinglebottom bwrightsingle bwpadl0 bwpadr0 bwvertalignb\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwcellpmargin bwalignl\">\n\u00a0\n<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"bwvertalignt bwsinglebottom bwleftsingle bwrightsingle bwpadl0\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwcellpmargin\">\nTotal assets\n<\/p>\n<\/td>\n<td class=\"bwsinglebottom bwpadl0 bwpadr0 bwvertalignb\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwalignr bwcellpmargin\">\n37,195\n<\/p>\n<\/td>\n<td class=\"bwsinglebottom bwrightsingle bwpadl0 bwpadr0 bwvertalignb\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwcellpmargin bwalignl\">\n\u00a0\n<\/p>\n<\/td>\n<td class=\"bwsinglebottom\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"bwsinglebottom bwpadl0 bwpadr0 bwvertalignb\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwalignr bwcellpmargin\">\n50,486\n<\/p>\n<\/td>\n<td class=\"bwsinglebottom bwrightsingle bwpadl0 bwpadr0 bwvertalignb\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwcellpmargin bwalignl\">\n\u00a0\n<\/p>\n<\/td>\n<\/tr>\n<\/table>\n<p>\nNewron\u2019s Annual Report 2022 is available for download on the Company\u2019s website: <a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=http%3A%2F%2Fwww.newron.com%2Finvestors%2Freports-and-presentation%2Fyear%2F20221&amp;esheet=53361723&amp;newsitemid=20230313005891&amp;lan=en-US&amp;anchor=www.newron.com%2Finvestors%2Freports-and-presentation%2Fyear%2F2022&amp;index=1&amp;md5=c571c51e55e71c59c2b71fd87cd81b62\" rel=\"nofollow noopener\" shape=\"rect\">www.newron.com\/investors\/reports-and-presentation\/year\/2022<\/a>\n<\/p>\n<p>\n<b>Outlook 2023:<\/b>\n<\/p>\n<p>\nThe Company anticipates that 2023 will be another exciting year, with further clinical updates from its evenamide program. Following the striking six-month and one-year results in TRS, Newron is continuing its dialogue with industry partners around potential future collaboration opportunities for the development of evenamide and to potentially expand its pipeline of CNS drugs.\n<\/p>\n<p>\nNewron looks forward to presenting the full results from study 014 with evenamide in March 2023 and one-year results from extension study 015 in all patients by Q1 2024. The Company also remains on track to commence study 003 in 2023, the first potentially pivotal study of evenamide in TRS. In patients with chronic schizophrenia currently being treated with a second-generation antipsychotic, but who are not classed as having TRS, Newron looks forward to reporting data from study 008A in the second half of 2023.\n<\/p>\n<p>\nNewron\u2019s total available cash resources will fund the Company\u2019s planned development programs and operations well into 2024.\n<\/p>\n<p>\n<b>2023 Shareholders\u2019 Meeting Agenda:<\/b>\n<\/p>\n<p>\nNewron\u2019s Board of Directors has approved the below agenda for the April 18, 2023, Shareholders\u2019 meeting, which will take place at the Company\u2019s registered office (Via Antonio Meucci 3) in Bresso (Mi), Italy, starting at 10 am CET. The formal invitation to shareholders will be issued and disclosed in the statutory papers on or around March 14, 2023.\n<\/p>\n<p>\nThe full invitation and supporting material will be made available on the Company\u2019s website (<a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=http%3A%2F%2Fwww.newron.com%2Finvestors%2Fshareholders-meeting&amp;esheet=53361723&amp;newsitemid=20230313005891&amp;lan=en-US&amp;anchor=www.newron.com%2Finvestors%2Fshareholders-meeting&amp;index=2&amp;md5=b45d22b33afdeaa141f98fef8448c2f7\" rel=\"nofollow noopener\" shape=\"rect\">www.newron.com\/investors\/shareholders-meeting<\/a>) on the same date. The agenda is as follows:\n<\/p>\n<p>\n1. Approval of the balance sheet as at 31 December 2022. Connected and consequent resolutions;\n<\/p>\n<p>\n2. Appointment of the members of the Board of Directors, for the financial years 2023, 2024 and 2025 and, therefore, until the approval of the financial statements as of December 31st, 2025, as follows:\n<\/p>\n<p>\n\u00a0\u00a0\u00a02.1. determination of the relevant number,\n<\/p>\n<p>\n\u00a0\u00a0\u00a02.2. proposal to appoint:\n<\/p>\n<ul class=\"bwlistdisc\">\n<li>\nUlrich K\u00f6stlin in quality of Chairman of the Board and non-executive director;\n<\/li>\n<li>\nStefan Weber, in quality of executive director;\n<\/li>\n<li>\nPatrick Langlois in quality of non-executive director;\n<\/li>\n<li>\nLuca Benatti in quality of non-executive director; and,\n<\/li>\n<li>\nGillian Dines in quality of non-executive director*.\n<\/li>\n<\/ul>\n<p>\n\u00a0\u00a0\u00a02.3. Determination of the remuneration of the Board of Directors. Connected and consequent resolutions.\n<\/p>\n<p>\n<b>* Gillian Dines &#8211; introduction as new candidate for non-executive director position:<\/b>\n<\/p>\n<p>\nGillian Dines is the Senior Vice President and Head of Research and Early Development at Jazz Pharmaceuticals. Prior to that she was SVP R&amp;D Operations at GW Pharmaceuticals and VP, Head of R&amp;D Strategic Planning at UCB. One of her key roles in 2008 was Company Director and Chief Development Officer at RespiVert, a UK based biotech that delivered clinical phase assets from start-up to acquisition by global pharma player in only 18 months, with a budget of \u00a320M. Her previous experience covers various leadership roles at GlaxoSmithKline. In her career she led 20+ novel medicines and devices through successful IND and clinical submissions in areas of respiratory, immunology, rare disease, anti-infective and neurology therapy areas. She has a MSc in Toxicology from the University of Surrey and a BSc from University of Leeds in Biochemistry and Genetics. She is English.\n<\/p>\n<p>\n<b>Dial-in details to the media\/analyst\/investor conference call on March 14, 2023, 3 pm CET<\/b>\n<\/p>\n<p>\nNewron\u2019s management team will present the 2022 full-year results and provide an update and guidance for 2023.\n<\/p>\n<p>\n<b>Please dial in<\/b> five to ten minutes prior to the beginning of the call using one of the following telephone numbers:\n<\/p>\n<p>\nSwitzerland\/Europe: +41 (0)58 310 50 00<br \/>\n<br \/>United Kingdom: +44 (0)207 107 0613<br \/>\n<br \/>United States: +1 (1)631 570 5613\n<\/p>\n<p>\n<b>or connect to the webcast<\/b>\n<\/p>\n<p>\nParticipants\u2019 Link: <a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Fmedia.choruscall.eu%2Fmediaframe%2Fwebcast.html%3Fwebcastid%3DhMiCgav4&amp;esheet=53361723&amp;newsitemid=20230313005891&amp;lan=en-US&amp;anchor=https%3A%2F%2Fmedia.choruscall.eu%2Fmediaframe%2Fwebcast.html%3Fwebcastid%3DhMiCgav4&amp;index=3&amp;md5=b49a095fda715e19fb6d4bd1e17c5c1a\" rel=\"nofollow noopener\" shape=\"rect\">https:\/\/media.choruscall.eu\/mediaframe\/webcast.html?webcastid=hMiCgav4<\/a>\n<\/p>\n<p>\nThe investor presentation is available on 14 March as of 7 am CET at <a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=http%3A%2F%2Fwww.newron.com%2Finvestors%2Freports-and-presentation%2Fyear%2F20221&amp;esheet=53361723&amp;newsitemid=20230313005891&amp;lan=en-US&amp;anchor=www.newron.com%2Finvestors%2Freports-and-presentation%2Fyear%2F2022&amp;index=4&amp;md5=c3db7b5a678dcecbf579b75d3f6ee5be\" rel=\"nofollow noopener\" shape=\"rect\">www.newron.com\/investors\/reports-and-presentation\/year\/2022<\/a>\n<\/p>\n<p>\n<b>Financial calendar<\/b>\n<\/p>\n<ul class=\"bwlistdisc\">\n<li>\nAGM 2023: April 18, 2023\n<\/li>\n<li>\nHalf-year report 2023: September 14, 2023\n<\/li>\n<\/ul>\n<p>\n<b>About Newron Pharmaceuticals<\/b>\n<\/p>\n<p>\nNewron (SIX: NWRN, XETRA: NP5) is a biopharmaceutical company focused on the development of novel therapies for patients with diseases of the central and peripheral nervous system. The Company is headquartered in Bresso near Milan, Italy. Xadago\u00ae\/safinamide has received marketing authorization for the treatment of Parkinson\u2019s disease in the European Union, Switzerland, the UK, the USA, Australia, Canada, Latin America, Israel, the United Arab Emirates, Japan and South Korea, and is commercialized by Newron\u2019s Partner Zambon. Supernus Pharmaceuticals holds the commercialization rights in the USA. Meiji Seika has the rights to develop and commercialize the compound in Japan and other key Asian territories. Newron is also developing evenamide as the potential first add-on therapy for the treatment of patients with symptoms of schizophrenia. For more information, please visit: <a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=http%3A%2F%2Fwww.newron.com&amp;esheet=53361723&amp;newsitemid=20230313005891&amp;lan=en-US&amp;anchor=www.newron.com&amp;index=5&amp;md5=1dca1dabd40e8324d17c0297d9f6e2ab\" rel=\"nofollow noopener\" shape=\"rect\">www.newron.com<\/a>\n<\/p>\n<p>\n<b>Important Notices<\/b>\n<\/p>\n<p>\nThis document contains forward-looking statements, including (without limitation) about (1) Newron\u2019 s ability to develop and expand its business, successfully complete development of its current product candidates, the timing of commencement of various clinical trials and receipt of data and current and future collaborations for the development and commercialization of its product candidates, (2) the market for drugs to treat CNS diseases and pain conditions, (3) Newron\u2019s financial resources, and (4) assumptions underlying any such statements. In some cases, these statements and assumptions can be identified by the fact that they use words such as \u201cwill\u201d, \u201canticipate\u201d, \u201cestimate\u201d, \u201cexpect\u201d, \u201cproject\u201d, \u201cintend\u201d, \u201cplan\u201d, \u201cbelieve\u201d, \u201ctarget\u201d, and other words and terms of similar meaning. All statements, other than historical facts, contained herein regarding Newron&#8217;s strategy, goals, plans, future financial position, projected revenues and costs and prospects are forward-looking statements. By their very nature, such statements and assumptions involve inherent risks and uncertainties, both general and specific, and risks exist that predictions, forecasts, projections and other outcomes described, assumed or implied therein will not be achieved. Future events and actual results could differ materially from those set out in, contemplated by or underlying the forward-looking statements due to a number of important factors. These factors include (without limitation) (1) uncertainties in the discovery, development or marketing of products, including without limitation difficulties in enrolling clinical trials, negative results of clinical trials or research projects or unexpected side effects, (2) delay or inability in obtaining regulatory approvals or bringing products to market, (3) future market acceptance of products, (4) loss of or inability to obtain adequate protection for intellectual property rights, (5) inability to raise additional funds, (6) success of existing and entry into future collaborations and licensing agreements, (7) litigation, (8) loss of key executive or other employees, (9) adverse publicity and news coverage, and (10) competition, regulatory, legislative and judicial developments or changes in market and\/or overall economic conditions. Newron may not actually achieve the plans, intentions or expectations disclosed in forward-looking statements and assumptions underlying any such statements may prove wrong. Investors should therefore not place undue reliance on them. There can be no assurance that actual results of Newron&#8217;s research programs, development activities, commercialization plans, collaborations and operations will not differ materially from the expectations set out in such forward-looking statements or underlying assumptions. Newron does not undertake any obligation to publicly update or revise forward-looking statements except as may be required by applicable regulations of the SIX Swiss Exchange or the Dusseldorf Stock Exchange where the shares of Newron are listed. This document does not contain or constitute an offer or invitation to purchase or subscribe for any securities of Newron and no part of it shall form the basis of or be relied upon in connection with any contract or commitment whatsoever.\n<\/p>\n<p> <b>Contacts<\/b> <\/p>\n<p>\n<b>For more information: <\/b>\n<\/p>\n<p>\n<b>N<\/b><b>ewron<\/b><br \/>Stefan Weber \u2013 CEO, +39 02 6103 46 26, <a target=\"_blank\" href=\"m&#97;&#x69;&#x6c;t&#111;&#58;&#x70;&#x72;&#64;&#110;&#101;&#x77;&#x72;o&#110;&#x2e;&#x63;&#x6f;m\" rel=\"nofollow noopener\" shape=\"rect\">&#x70;&#x72;&#x40;&#x6e;&#x65;&#x77;&#x72;&#x6f;&#x6e;&#x2e;&#x63;&#x6f;&#x6d;<\/a>\n<\/p>\n<p>\n<b>UK\/Europe<\/b><br \/>Simon Conway \/ Ciara Martin \/ Natalie Garland-Collins, FTI Consulting, +44 20 3727 1000, <a target=\"_blank\" href=\"&#x6d;&#x61;&#105;l&#x74;&#x6f;&#58;SC&#x6e;&#x65;&#119;r&#x6f;&#x6e;&#64;&#102;t&#x69;&#x63;&#111;n&#x73;&#x75;&#108;&#116;i&#x6e;&#x67;&#46;c&#x6f;&#x6d;\" rel=\"nofollow noopener\" shape=\"rect\">&#x53;&#x43;&#x6e;&#x65;&#119;&#114;&#111;n&#64;&#x66;&#x74;&#x69;&#x63;&#x6f;&#110;&#115;&#117;lt&#x69;&#x6e;&#x67;&#x2e;&#x63;&#111;&#109;<\/a>\n<\/p>\n<p>\n<b>Switzerland<\/b><br \/>Valentin Handschin, IRF , +41 43 244 81 54, <a target=\"_blank\" href=\"&#x6d;&#x61;&#x69;&#x6c;&#116;&#111;&#58;&#104;and&#x73;&#x63;&#x68;&#x69;&#x6e;&#64;&#105;&#114;f-r&#x65;&#x70;&#x75;&#x74;&#x61;&#116;&#105;&#111;n&#46;c&#x68;\" rel=\"nofollow noopener\" shape=\"rect\">h&#97;&#110;&#x64;&#x73;ch&#105;&#110;&#x40;&#x69;rf&#45;&#114;&#x65;&#x70;ut&#97;&#x74;&#x69;&#x6f;n&#46;&#99;&#x68;<\/a>\n<\/p>\n<p>\n<b>Germany\/Europe<\/b><br \/>Anne Hennecke \/ Caroline Bergmann, MC Services, +49 211 52925222, <a target=\"_blank\" href=\"&#109;&#x61;&#105;&#x6c;t&#x6f;:&#110;&#x65;&#119;&#x72;&#111;&#x6e;&#64;&#x6d;c&#45;&#x73;&#101;&#x72;v&#x69;c&#x65;&#x73;&#46;&#x65;&#117;\" rel=\"nofollow noopener\" shape=\"rect\">newron&#64;mc-se&#114;&#118;&#105;&#99;&#101;&#115;&#46;&#101;&#117;<\/a>\n<\/p>\n<p>\n<b>USA<\/b><br \/>Paul Sagan, LaVoieHealthScience, +1 617 374 8800, Ext. 112, <a target=\"_blank\" href=\"&#109;&#x61;&#x69;&#108;&#x74;&#x6f;&#58;&#x70;&#x73;&#97;&#x67;&#x61;&#110;&#x40;&#x6c;&#97;&#x76;&#x6f;&#105;&#x65;&#x68;&#101;&#x61;&#x6c;&#116;&#x68;&#x73;c&#x69;&#x65;n&#x63;&#x65;&#46;&#99;&#x6f;m\" rel=\"nofollow noopener\" shape=\"rect\">&#112;&#x73;a&#103;&#x61;n&#64;&#x6c;a&#118;&#x6f;i&#101;&#x68;&#101;&#x61;&#x6c;&#116;&#x68;&#x73;&#99;&#x69;e&#110;&#x63;e&#46;&#x63;o&#109;<\/a>\n<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Ad hoc announcement pursuant to Art. 53 LR MILAN&#8211;(BUSINESS WIRE)&#8211;Newron Pharmaceuticals S.p.A. (\u201cNewron\u201d) (SIX: NWRN, XETRA: NP5), a biopharmaceutical company focused on the development of novel therapies for patients with diseases of the central and peripheral nervous system, today announced its financial results and operational highlights for the business year ended December 31, 2022, and &#8230; <span class=\"more\"><a class=\"more-link\" href=\"https:\/\/pharma-trend.com\/en\/newron-announces-2022-financial-results-and-provides-outlook-for-2023\/\">[Read more&#8230;]<\/a><\/span><\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[13],"tags":[],"class_list":{"0":"entry","1":"post","2":"publish","3":"author-business","4":"post-54804","6":"format-standard","7":"category-industry"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Newron Announces 2022 Financial Results and Provides Outlook For 2023 - Pharma Trend<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/pharma-trend.com\/en\/newron-announces-2022-financial-results-and-provides-outlook-for-2023\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Newron Announces 2022 Financial Results and Provides Outlook For 2023 - Pharma Trend\" \/>\n<meta property=\"og:description\" content=\"Ad hoc announcement pursuant to Art. 53 LR MILAN&#8211;(BUSINESS WIRE)&#8211;Newron Pharmaceuticals S.p.A. (\u201cNewron\u201d) (SIX: NWRN, XETRA: NP5), a biopharmaceutical company focused on the development of novel therapies for patients with diseases of the central and peripheral nervous system, today announced its financial results and operational highlights for the business year ended December 31, 2022, and ... 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(\u201cNewron\u201d) (SIX: NWRN, XETRA: NP5), a biopharmaceutical company focused on the development of novel therapies for patients with diseases of the central and peripheral nervous system, today announced its financial results and operational highlights for the business year ended December 31, 2022, and ... 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