{"id":54891,"date":"2023-03-16T08:03:11","date_gmt":"2023-03-16T07:03:11","guid":{"rendered":"https:\/\/pharma-trend.com\/en\/sensorion-reports-full-year-2022-financial-results-and-business-update\/"},"modified":"2023-03-16T08:03:11","modified_gmt":"2023-03-16T07:03:11","slug":"sensorion-reports-full-year-2022-financial-results-and-business-update","status":"publish","type":"post","link":"https:\/\/pharma-trend.com\/en\/sensorion-reports-full-year-2022-financial-results-and-business-update\/","title":{"rendered":"Sensorion Reports Full-Year 2022 Financial Results and Business Update"},"content":{"rendered":"<div>\n<ul class=\"bwlistdisc\">\n<li>\n<i><b>CTA filing for OTOF-GT planned for Q2 2023<\/b><\/i>\n<\/li>\n<li>\n<i><b>Presented new preclinical data supporting continued progress of OTOF-GT, and potential for safe and efficient clinical translation of gene therapy for otoferlin delivered by a dual AAV vector at the 45th Association for Research in Otolaryngology (ARO)<\/b><\/i>\n<\/li>\n<li>\n<i><b>Promising results obtained in Proof-of-Concept studies supporting the identification of a GJB2-GT therapeutic candidate<\/b><\/i>\n<\/li>\n<li>\n<i><b>Preliminary results from Phase 2a trials of SENS-401 for hearing loss prevention due to Cisplatin-Induced Ototoxicity and cochlear implantation in Q2 2023<\/b><\/i>\n<\/li>\n<li>\n<i><b>Cash position of \u20ac26.2 million at year end provides extended cash runway until end of 2023<\/b><\/i>\n<\/li>\n<li>\n<i><b>Strengthened company leadership with the appointments of David Lawrence as Chief Financial Officer and Dr Aniz Girach as an Independent Board Director<\/b><\/i>\n<\/li>\n<li>\n<i><b>Sensorion will hold an R&amp;D Day, focused on its gene therapy programs, on April 6, 8am (2pm CEST). The event will be held at the Hearing Institute (Institut de l\u2019Audition), an Institut Pasteur center in Paris, France. A live webcast and a replay of the presentation will be made available.<\/b><\/i>\n<\/li>\n<\/ul>\n<p>MONTPELLIER, France&#8211;(BUSINESS WIRE)&#8211;Regulatory News:\n<\/p>\n<p>\n<b>Sensorion (FR0012596468 \u2013 ALSEN) <\/b>a pioneering clinical-stage biotechnology company which specializes in gene therapies in the inner ear, announces today its full-year 2022 financial results and provides a business update.\n<\/p>\n<p>\n<b>Nawal Ouzren, Chief Executive Officer commented:<\/b> \u201cDuring the year, Sensorion has put the foundations in place for a pioneering franchise in gene therapy for hearing loss disorders which we believe will support clinical development plans later this year and beyond. We\u2019re incredibly excited about the potential of our gene therapy franchise and programs, which builds on our ongoing collaboration with Institut Pasteur, to provide solutions for people with genetic hearing loss disorders.\n<\/p>\n<p>\n\u201cOur lead gene therapy candidate OTOF-GT has promising preclinical data and we are on track to submit a Clinical Trial Application in Q2 2023. We are also making encouraging progress with the identification of our GJB2-GT therapeutic candidate.\n<\/p>\n<p>\n\u201cWe are now on the threshold of advancing our gene therapy programs into clinical development and have a unique opportunity to help redefine the treatment landscape for people with hearing loss disorders. We also anticipate reporting preliminary data from our Phase 2a SENS-401 studies in mid-2023. Our focus is now on execution and capital discipline to deliver on our key catalysts.\u201d\n<\/p>\n<p>\n<b>Pipeline Highlights and Upcoming Milestones<\/b>\n<\/p>\n<p>\n<b>Gene Therapies for Hereditary Monogenic Hearing Loss<\/b>\n<\/p>\n<ul class=\"bwlistdisc\">\n<li>\n<b>OTOF-GT: continued progress with positive regulatory support<\/b>\n<\/li>\n<\/ul>\n<p>\nOTOF-GT is Sensorion\u2019s lead gene therapy program for the treatment of children born with hearing loss caused by otoferlin deficiency.\n<\/p>\n<p>\nSensorion presented preclinical data that indicated the potential for safe and efficient clinical translation of gene therapy for otoferlin delivered by a dual AAV vector at the Association for Research in Otolaryngology (ARO) conference, held in February 2022. Otoferlin <i>de novo<\/i> expression in inner hair cells (IHCs) in a DFNB9 mouse model (OTOF-KO) demonstrates long-term expression and hearing restoration for at least one year post injection. Sensorion has also developed, in non-human primates, an optimal surgical procedure close to the one used for cochlear implantation and demonstrated an effective transduction rate of the targeted IHCs.\n<\/p>\n<p>\nSensorion announced in January 2023 that it is designing and developing the injection system to administer gene therapy into the cochlea. This injection system used in the Non-Human Primate (NHP) GLP (Good Laboratory Practices) toxicology study is compliant with the defined specifications, notably those related to performance. Verification and validations steps are ongoing to allow the injection system\u2019s use in clinics. Sensorion is collaborating with Eveon, a company specialized in designing and manufacturing custom medical devices for the preparation and delivery of drugs to optimise this approach.\n<\/p>\n<p>\nSensorion achieved a development milestone in mid-2022, by successfully producing dual AAV OTOF-GT batches at 200L clinical scale to conduct the GLP (Good Laboratory Practice) toxicology study in NHPs. The in-life part of the study has been completed and analyses are ongoing.\n<\/p>\n<p>\nSensorion has also achieved significant regulatory milestones in H2 2022 which support the medical plausibility and the development plan of OTOF-GT. On September 12, 2022, the Company announced that the European Medicine Agency (EMA) had adopted a positive opinion on Sensorion\u2019s application for Orphan Drug Designation (ODD) for OTOF-GT, which was approved 30 days later by the European Commission. On November 7, 2022, the Company announced that the US Food and Drug Administration (FDA) granted, Rare Pediatric Disease Designation (RPDD) and on November 30, 2022, Orphan Drug Designation to Sensorion\u2019s lead gene therapy candidate, OTOF-GT. Sensorion has received scientific advice from regulatory agencies on preclinical, CMC and clinical development plans for OTOF-GT in Q3 2021 and in Q2 2022. The company submitted a follow-up scientific advice to the EMA in H1 2023 and expects feedback in the following weeks.\n<\/p>\n<p>\nThe European Medicines Agency\u2019s advisors welcomed the ongoing Natural History Study, Audioferline (NCT04202185), a component of the AUDINNOVE project coordinated by H\u00f4pital Necker-Enfants Malades (Necker Hospital) in partnership with Sensorion (Project ANR-18-RHUS-0007). Sensorion is expanding the study across Europe to document the natural course of disease progression in otoferlin deficiency patients and to select the most relevant and clinically meaningful endpoints. The company is on track to file a Clinical Trial Application for OTOF-GT in Q2 2023.\n<\/p>\n<ul class=\"bwlistdisc\">\n<li>\n<b>GJB2-GT program progressing with promising pre-clinical results<\/b>\n<\/li>\n<\/ul>\n<p>\nOn February 15, 2021, Sensorion announced its largest gene therapy program to date, a collaboration with Institut Pasteur, targeting the <i>GJB2<\/i> gene in pediatric and adult deafness. Research by Institut Pasteur demonstrated that anomalies in <i>GJB2 <\/i>gene<i>,<\/i> known to be the most common cause of congenital deafness, are also a broad contributor to severe age-related hearing loss in adults. Although the types of <i>GJB2<\/i> mutation in children and adults may differ, gene therapy could potentially provide solutions for both.\n<\/p>\n<p>\nSensorion&#8217;s GJB2 gene therapy programs have the potential to address three pathologies related to <i>GJB2<\/i> mutations: early onset of presbycusis in adults, progressive forms of hearing loss in children, and pediatric congenital deafness.\n<\/p>\n<p>\nProof-of-Concept (POC) studies have confirmed the potential of Sensorion\u2019s promising product candidate to improve congenital and progressive hearing loss forms related to <i>GJB2<\/i> mutations in a mouse model recapitulating both human conditions. Sensorion plans to confirm the candidate selection based on the POC results in H1 2023.\n<\/p>\n<p>\n<b>SENS-401, our small molecule for the prevention of hearing loss<\/b>\n<\/p>\n<ul class=\"bwlistdisc\">\n<li>\n<b>SENS-401 to prevent Cisplatin Induced Ototoxicity (CIO) study ongoing<\/b>\n<\/li>\n<\/ul>\n<p>\nCisplatin and other platinum compounds are essential chemotherapeutic agents for many malignancies. Unfortunately, platinum-based therapies cause ototoxicity and hearing loss, which are permanent, irreversible and particularly harmful in up to 50-60% of adult patients and 90% of pediatric patients who survive cancer. This indication represents a very significant unmet need for patients and is an attractive market with more than 500,000 patients forecast in 2025 in the G7 countries.\n<\/p>\n<p>\nIn late 2021, Sensorion filed a POC clinical trial application in CIO to evaluate the potential of SENS-401 treatment. The NOTOXIS clinical trial application (CTA) has been approved earlier in 2022. Following extensive analysis of the AUDIBLE-S study data beginning of 2022, Sensorion has adapted the design of this trial to focus on the prevention of hearing loss. The amended Phase 2a POC Clinical Trial of SENS-401 in Cisplatin-Induced Ototoxicity was approved in France on October 24, 2022.\n<\/p>\n<p>\nThe exploratory Phase 2a, multicenter, randomized, controlled, open-label study, NOTOXIS, aims at evaluating the efficacy of SENS-401 to prevent ototoxicity induced by cisplatin in adult patients with a neoplastic disease. The trial also assesses a number of outcome measures, including the rate and severity of ototoxicity, the change in Pure Tone Audiometry (PTA) (dB) throughout the study and the tolerance.\n<\/p>\n<p>\nThe first patient was enrolled in December 2022 and Sensorion anticipates preliminary results in Q2 2023.\n<\/p>\n<ul class=\"bwlistdisc\">\n<li>\n<b>SENS-401 to prevent residual hearing loss after cochlear implantation study ongoing<\/b>\n<\/li>\n<\/ul>\n<p>\nAt the beginning of 2021, Sensorion released positive preclinical data demonstrating that the combination of its SENS-401 molecule and a cochlear implantation helped reduce loss of residual hearing at a frequency located beyond the electrode array. Preservation of \u2018natural\u2019 hearing is particularly important in speech recognition.\n<\/p>\n<p>\nFollowing this initial success, Sensorion and its partner Cochlear Limited (Cochlear) announced on September 8, 2021, the initiation of a POC clinical trial of SENS-401 (Arazasetron) in patients scheduled for cochlear implantation. Regulatory authorities in Australia and France have respectively approved the initiation of the trial on July 1, 2022, and on October 24, 2022.\n<\/p>\n<p>\nThe Phase 2a trial is a multicentric, randomized, controlled, open-label trial aimed at evaluating the presence of SENS-401 in the cochlea (perilymph) after 7 days of twice-daily oral administration in adult participants prior to cochlear implantation due to moderately severe to profound hearing impairment. Following implantation, patients will continue to receive SENS-401 for 42 days. The study also assesses a number of secondary endpoints, including the change of hearing threshold from baseline to the end of the study in the implanted ear at several frequencies.\n<\/p>\n<p>\nThe first patient was enrolled in September 2022 and the Company expects to release preliminary data in mid-2023.\n<\/p>\n<p>\n<b>Expansion of technology platform<\/b>\n<\/p>\n<p>\nIn 2022, to further strengthen its technology base, Sensorion has expanded its CMC (Chemistry, Manufacturing and Control) gene therapy platform. The Company has acquired bioreactors (2L, 10L and 50L scale) to develop the AAV process in suspension and automates to increase the throughput analysis for process and product characterization.\n<\/p>\n<p>\nThis great achievement strengthens Sensorion\u2019s autonomy in process and analytical development and eases technology transfer to CDMOs.\n<\/p>\n<p>\n<b>Corporate Highlights:<\/b>\n<\/p>\n<p>\n<b>Strengthening the Board of Directors and senior leadership<\/b>\n<\/p>\n<p>\nOn January 4, 2022, Sensorion appointed Dr. Aniz Girach as Independent Board Member. He brings over 22 years\u2019 experience in the industry. He is currently serving as Chief Medical Officer at ProQR Therapeutics NV, where he is leading the development of genetic therapies for inherited retinal diseases.\n<\/p>\n<p>\nOn March 1st, 2023, after the period end, Sensorion appointed David Lawrence as Chief Financial Officer. Mr Lawrence has over 30 years\u2019 experience of leadership roles in life sciences, ranging from large biopharma companies such as GSK to start-ups and earlier stage companies. He brings extensive industry experience including strategy, business development and M&amp;A, and currently sits on the Boards of Enterobiotix Limited and is an advisor to ACM Biolabs Pty.\n<\/p>\n<p>\n<b>2023 Outlook<\/b>\n<\/p>\n<p>\nAs of December 31, 2022, the Company had \u20ac26.2 million in cash. Based on its cash position and its forecasted expenses, the Company believes it will be able to fund its operations up to the end of 2023.\n<\/p>\n<p>\nSensorion is on track to file a Clinical Trial Application for OTOF-GT in Q2 2023 and to select a gene therapy candidate to treat hearing loss related to mutations in <i>GJB2<\/i> gene in collaboration with the Hearing Institute (Institut de l\u2018Audition), a center of the Institut Pasteur. The company expects the publication of its ongoing clinical trials\u2019 interim results of SENS-401 in association with cochlear implants to prevent residual hearing loss, with partner Cochlear, and to prevent Cisplatin-Induced Ototoxicity in 1H 2023.\n<\/p>\n<p>\nExpected future milestones and estimated timelines:\n<\/p>\n<ul class=\"bwlistdisc\">\n<li>\nApril 6, 2023 \u2013 Sensorion to host a Gene Therapy R&amp;D day\n<\/li>\n<li>\nQ2 2023 \u2013 SENS-401 in combination with cochlear implants: Interim results\n<\/li>\n<li>\nQ2 2023 \u2013 SENS-401 CIO: Interim results\n<\/li>\n<li>\nQ2 2023 \u2013 OTOF-GT: Submission of the Clinical Trial Application (CTA)\n<\/li>\n<li>\nQ2 2023 \u2013 GJB2-GT: Candidate selection\n<\/li>\n<\/ul>\n<p>\n<b>2022 financial results<\/b>\n<\/p>\n<p>\nThe annual accounts at December 31<sup>st<\/sup>, 2022, drawn up according to IFRS standards and approved by the Board of Directors on March 15<sup>th<\/sup>, 2023<sup>1<\/sup>.\n<\/p>\n<p>\nThe simplified income statement as of 31 December 2022 is as follows:\n<\/p>\n<table cellspacing=\"0\" class=\"bwtablemarginb bwblockalignl\">\n<tr>\n<td class=\"bwsinglebottom bwpadl0\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwcellpmargin\">\n<i>In Euros \u2013 IFRS standards<\/i>\n<\/p>\n<\/td>\n<td class=\"bwsinglebottom\" colspan=\"1\" rowspan=\"1\">\u00a0<\/td>\n<td class=\"bwsinglebottom bwpadl0 bwvertalignb bwpadr0\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwalignr bwcellpmargin\">\n<b>31.12.2022<\/b>\n<\/p>\n<\/td>\n<td class=\"bwsinglebottom\" colspan=\"1\" rowspan=\"1\">\u00a0<\/td>\n<td class=\"bwsinglebottom bwpadl0 bwvertalignb bwpadr0\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwalignr bwcellpmargin\">\n<b>31.12.2021<\/b>\n<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"bwsinglebottom bwpadl0\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwcellpmargin\">\n<b>Operating income<\/b>\n<\/p>\n<\/td>\n<td class=\"bwsinglebottom\" colspan=\"1\" rowspan=\"1\">\u00a0<\/td>\n<td class=\"bwsinglebottom bwpadl0 bwpadr0 bwvertalignb\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwalignr bwcellpmargin\">\n<b>5.005.515<\/b>\n<\/p>\n<\/td>\n<td class=\"bwsinglebottom\" colspan=\"1\" rowspan=\"1\">\u00a0<\/td>\n<td class=\"bwsinglebottom bwpadl0 bwpadr0 bwvertalignb\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwalignr bwcellpmargin\">\n<b>4.348.647<\/b>\n<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"bwsinglebottom bwpadl0\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwcellpmargin\">\nResearch &amp; Development expenses\n<\/p>\n<\/td>\n<td class=\"bwsinglebottom\" colspan=\"1\" rowspan=\"1\">\u00a0<\/td>\n<td class=\"bwsinglebottom bwpadl0 bwpadr0 bwvertalignb\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwalignr bwcellpmargin\">\n-22.924.960\n<\/p>\n<\/td>\n<td class=\"bwsinglebottom\" colspan=\"1\" rowspan=\"1\">\u00a0<\/td>\n<td class=\"bwsinglebottom bwpadl0 bwpadr0 bwvertalignb\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwalignr bwcellpmargin\">\n-14.623.652\n<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"bwsinglebottom bwpadl0\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwcellpmargin\">\nGeneral &amp; Administrative expenses\n<\/p>\n<\/td>\n<td class=\"bwsinglebottom\" colspan=\"1\" rowspan=\"1\">\u00a0<\/td>\n<td class=\"bwsinglebottom bwpadl0 bwpadr0 bwvertalignb\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwalignr bwcellpmargin\">\n-5.217.203\n<\/p>\n<\/td>\n<td class=\"bwsinglebottom\" colspan=\"1\" rowspan=\"1\">\u00a0<\/td>\n<td class=\"bwsinglebottom bwpadl0 bwpadr0 bwvertalignb\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwalignr bwcellpmargin\">\n-4.749.593\n<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"bwsinglebottom bwpadl0\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwcellpmargin\">\n<b>Total operating expenses<\/b>\n<\/p>\n<\/td>\n<td class=\"bwsinglebottom\" colspan=\"1\" rowspan=\"1\">\u00a0<\/td>\n<td class=\"bwsinglebottom bwpadl0 bwpadr0 bwvertalignb\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwalignr bwcellpmargin\">\n<b>-28.142.143<\/b>\n<\/p>\n<\/td>\n<td class=\"bwsinglebottom\" colspan=\"1\" rowspan=\"1\">\u00a0<\/td>\n<td class=\"bwsinglebottom bwpadl0 bwpadr0 bwvertalignb\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwalignr bwcellpmargin\">\n<b>-19.373.245<\/b>\n<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"bwsinglebottom bwpadl0\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwcellpmargin\">\n<b>Operating loss<\/b>\n<\/p>\n<\/td>\n<td class=\"bwsinglebottom\" colspan=\"1\" rowspan=\"1\">\u00a0<\/td>\n<td class=\"bwsinglebottom bwpadl0 bwpadr0 bwvertalignb\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwalignr bwcellpmargin\">\n<b>-23.136.648<\/b>\n<\/p>\n<\/td>\n<td class=\"bwsinglebottom\" colspan=\"1\" rowspan=\"1\">\u00a0<\/td>\n<td class=\"bwsinglebottom bwpadl0 bwpadr0 bwvertalignb\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwalignr bwcellpmargin\">\n<b>-15,024,597<\/b>\n<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"bwsinglebottom bwpadl0\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwcellpmargin\">\nFinancial result\n<\/p>\n<\/td>\n<td class=\"bwsinglebottom\" colspan=\"1\" rowspan=\"1\">\u00a0<\/td>\n<td class=\"bwsinglebottom bwpadl0 bwpadr0 bwvertalignb\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwalignr bwcellpmargin\">\n-72.442\n<\/p>\n<\/td>\n<td class=\"bwsinglebottom\" colspan=\"1\" rowspan=\"1\">\u00a0<\/td>\n<td class=\"bwsinglebottom bwpadl0 bwpadr0 bwvertalignb\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwalignr bwcellpmargin\">\n-112.192\n<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"bwsinglebottom bwpadl0\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwcellpmargin\">\n<b>Net loss<\/b>\n<\/p>\n<\/td>\n<td class=\"bwsinglebottom\" colspan=\"1\" rowspan=\"1\">\u00a0<\/td>\n<td class=\"bwsinglebottom bwpadl0 bwpadr0 bwvertalignb\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwalignr bwcellpmargin\">\n<b>-23.209.090<\/b>\n<\/p>\n<\/td>\n<td class=\"bwsinglebottom\" colspan=\"1\" rowspan=\"1\">\u00a0<\/td>\n<td class=\"bwsinglebottom bwpadl0 bwpadr0 bwvertalignb\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwalignr bwcellpmargin\">\n<b>-15.136.789<\/b>\n<\/p>\n<\/td>\n<\/tr>\n<\/table>\n<p>\nFor the year ended 31<sup>st<\/sup> December 2022, Sensorion reported <b>operating income<\/b> of \u20ac5.0 million, which included \u20ac3.9 million in research tax credit (including \u20ac3.7m in France and \u20ac0.2m in Australia) and \u20ac1.0 million in grants from the Audinnove<sup>2<\/sup> (RHU), and Patriot<sup>3<\/sup> (PSPC) collaborations.\n<\/p>\n<p>\n<b>Operating expenses <\/b>increased by 45% from \u20ac19.4 million in 2021 to \u20ac28.1 million for fiscal year 2022. In 2022, our R&amp;D expenses and General &amp; Administrative expenses account approximately for 81% and 19% respectively of our operating expenses, against 75% and 25% respectively in 2021.\n<\/p>\n<ul class=\"bwlistdisc\">\n<li>\n<b>R&amp;D expenses <\/b>increased by 57% from \u20ac14.6 million in 2021 to \u20ac22.9m in 2022. The increase was primarily due to increased efforts in OTOF-GT CTA-enabling studies including increased costs in preclinical and in manufacturing.\n<\/li>\n<li>\n<b>G&amp;A expenses<\/b> are up 10% from \u20ac4.8m in 2021 to \u20ac5.2 million in 2022, due mostly to an increase in headcount in order to support the growth of R&amp;D activities.\n<\/li>\n<\/ul>\n<p>\n<b>Operating loss <\/b>at 31 December 2022 was -\u20ac23.1 million compared with -\u20ac15.0 million at 31 December 2021.\n<\/p>\n<p>\nThe net financial loss decreased by \u20ac0.04 million compared to 2021, mainly due to an increase in financial income.\n<\/p>\n<p>\n<b>Net<\/b> <b>loss<\/b> was -\u20ac23.2 million at 31 December 2022 compared with -\u20ac15.1 million at 31 December 2021.\n<\/p>\n<p>\nAs of 31 December 2022, the company employed 46 people.\n<\/p>\n<p>\n<b>Financial structure<\/b>\n<\/p>\n<p>\nThe simplified balance sheet at December 31<sup>st<\/sup>, 2022 is as follows:\n<\/p>\n<table cellspacing=\"0\" class=\"bwtablemarginb bwblockalignl\">\n<tr>\n<td class=\"bwsinglebottom bwpadl0\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwcellpmargin\">\n<i>In Euros \u2013 IFRS standards<\/i>\n<\/p>\n<\/td>\n<td class=\"bwsinglebottom\" colspan=\"1\" rowspan=\"1\">\u00a0<\/td>\n<td class=\"bwsinglebottom bwpadl0 bwvertalignb bwpadr0\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwalignr bwcellpmargin\">\n<b>31.12.2022<\/b>\n<\/p>\n<\/td>\n<td class=\"bwsinglebottom\" colspan=\"1\" rowspan=\"1\">\u00a0<\/td>\n<td class=\"bwsinglebottom bwpadl0 bwvertalignb bwpadr0\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwalignr bwcellpmargin\">\n<b>31.12.2021<\/b>\n<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"bwsinglebottom bwpadl0\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwcellpmargin\">\n<b>Non-current Assets<\/b>\n<\/p>\n<\/td>\n<td class=\"bwsinglebottom\" colspan=\"1\" rowspan=\"1\">\u00a0<\/td>\n<td class=\"bwsinglebottom bwpadl0 bwpadr0 bwvertalignb\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwalignr bwcellpmargin\">\n<b>3.175.915<\/b>\n<\/p>\n<\/td>\n<td class=\"bwsinglebottom\" colspan=\"1\" rowspan=\"1\">\u00a0<\/td>\n<td class=\"bwsinglebottom bwpadl0 bwpadr0 bwvertalignb\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwalignr bwcellpmargin\">\n<b>2.142.885<\/b>\n<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"bwsinglebottom bwpadl0\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwcellpmargin\">\nOther Current Assets\n<\/p>\n<\/td>\n<td class=\"bwsinglebottom\" colspan=\"1\" rowspan=\"1\">\u00a0<\/td>\n<td class=\"bwsinglebottom bwpadl0 bwpadr0 bwvertalignb\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwalignr bwcellpmargin\">\n9.565.307\n<\/p>\n<\/td>\n<td class=\"bwsinglebottom\" colspan=\"1\" rowspan=\"1\">\u00a0<\/td>\n<td class=\"bwsinglebottom bwpadl0 bwpadr0 bwvertalignb\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwalignr bwcellpmargin\">\n6.946.055\n<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"bwsinglebottom bwpadl0\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwcellpmargin\">\nCash &amp; cash equivalent\n<\/p>\n<\/td>\n<td class=\"bwsinglebottom\" colspan=\"1\" rowspan=\"1\">\u00a0<\/td>\n<td class=\"bwsinglebottom bwpadl0 bwpadr0 bwvertalignb\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwalignr bwcellpmargin\">\n26.203.905\n<\/p>\n<\/td>\n<td class=\"bwsinglebottom\" colspan=\"1\" rowspan=\"1\">\u00a0<\/td>\n<td class=\"bwsinglebottom bwpadl0 bwpadr0 bwvertalignb\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwalignr bwcellpmargin\">\n50.001.110\n<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"bwsinglebottom bwpadl0\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwcellpmargin\">\n<b>Total Assets<\/b>\n<\/p>\n<\/td>\n<td class=\"bwsinglebottom\" colspan=\"1\" rowspan=\"1\">\u00a0<\/td>\n<td class=\"bwsinglebottom bwpadl0 bwpadr0 bwvertalignb\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwalignr bwcellpmargin\">\n<b>38.945.127<\/b>\n<\/p>\n<\/td>\n<td class=\"bwsinglebottom\" colspan=\"1\" rowspan=\"1\">\u00a0<\/td>\n<td class=\"bwsinglebottom bwpadl0 bwpadr0 bwvertalignb\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwalignr bwcellpmargin\">\n<b>59.090.050<\/b>\n<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"bwsinglebottom bwpadl0\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwcellpmargin\">\n<b>Equity<\/b>\n<\/p>\n<\/td>\n<td class=\"bwsinglebottom\" colspan=\"1\" rowspan=\"1\">\u00a0<\/td>\n<td class=\"bwsinglebottom bwpadl0 bwpadr0 bwvertalignb\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwalignr bwcellpmargin\">\n<b>21.885.121<\/b>\n<\/p>\n<\/td>\n<td class=\"bwsinglebottom\" colspan=\"1\" rowspan=\"1\">\u00a0<\/td>\n<td class=\"bwsinglebottom bwpadl0 bwpadr0 bwvertalignb\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwalignr bwcellpmargin\">\n<b>44.055.803<\/b>\n<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"bwsinglebottom bwpadl0\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwcellpmargin\">\nNon-current Liabilities\n<\/p>\n<\/td>\n<td class=\"bwsinglebottom\" colspan=\"1\" rowspan=\"1\">\u00a0<\/td>\n<td class=\"bwsinglebottom bwpadl0 bwpadr0 bwvertalignb\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwalignr bwcellpmargin\">\n3.467.116\n<\/p>\n<\/td>\n<td class=\"bwsinglebottom\" colspan=\"1\" rowspan=\"1\">\u00a0<\/td>\n<td class=\"bwsinglebottom bwpadl0 bwpadr0 bwvertalignb\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwalignr bwcellpmargin\">\n4.504.691\n<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"bwsinglebottom bwpadl0\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwcellpmargin\">\nCurrent Liabilities\n<\/p>\n<\/td>\n<td class=\"bwsinglebottom\" colspan=\"1\" rowspan=\"1\">\u00a0<\/td>\n<td class=\"bwsinglebottom bwpadl0 bwpadr0 bwvertalignb\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwalignr bwcellpmargin\">\n13.592.890\n<\/p>\n<\/td>\n<td class=\"bwsinglebottom\" colspan=\"1\" rowspan=\"1\">\u00a0<\/td>\n<td class=\"bwsinglebottom bwpadl0 bwpadr0 bwvertalignb\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwalignr bwcellpmargin\">\n10.529.556\n<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"bwsinglebottom bwpadl0\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwcellpmargin\">\n<b>Total Liabilities<\/b>\n<\/p>\n<\/td>\n<td class=\"bwsinglebottom\" colspan=\"1\" rowspan=\"1\">\u00a0<\/td>\n<td class=\"bwsinglebottom bwpadl0 bwpadr0 bwvertalignb\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwalignr bwcellpmargin\">\n<b>38.145.127<\/b>\n<\/p>\n<\/td>\n<td class=\"bwsinglebottom\" colspan=\"1\" rowspan=\"1\">\u00a0<\/td>\n<td class=\"bwsinglebottom bwpadl0 bwpadr0 bwvertalignb\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwalignr bwcellpmargin\">\n<b>59.090.550<\/b>\n<\/p>\n<\/td>\n<\/tr>\n<\/table>\n<p>\n<b>Non-current assets<\/b> increased by \u20ac1.0 million mainly due to investments in equipment for manufacturing.\n<\/p>\n<p>\n<b>Other current assets <\/b>increased by \u20ac2.6 million mainly due to the increase of research tax credit expected for 2022 which amounts \u20ac3.9 million and a decrease in prepaid expenses.\n<\/p>\n<p>\n<b>Cash and cash equivalents<\/b> amounted to \u20ac26.2 million at 31 December 2022 compared to \u20ac50.0 million at December 31<sup>st<\/sup>, 2021.\n<\/p>\n<p>\n<b>Total equity<\/b> amounted to \u20ac21.9 million as of December 31<sup>st<\/sup>, 2022 compared to \u20ac44.1 million at December 31<sup>st<\/sup>, 2021; this decrease of -\u20ac22.2 million is mainly related to the net loss of -\u20ac23.2 million for the period.\n<\/p>\n<p>\n<b>Current liabilities<\/b> increased by \u20ac3.1 million mainly explained by an increase in R&amp;D expenses.\n<\/p>\n<p>\n<b>About Sensorion<br \/>\n<br \/><\/b>Sensorion is a pioneering clinical-stage biotech company, which specializes in the development of gene therapies to restore hearing loss disorders, a significant global unmet medical need.\n<\/p>\n<p>\nSensorion has built a unique R&amp;D technology platform to expand its understanding of the pathophysiology and etiology of inner ear related diseases, enabling it to select the best targets and mechanisms of action for drug candidates.\n<\/p>\n<p>\nIt has two gene therapy programs aimed at correcting hereditary monogenic forms of deafness, developed in the framework of its broad strategic collaboration focused on the genetics of hearing with the Institut Pasteur. OTOF-GT targets deafness caused by mutations of the gene encoding for otoferlin and GJB2-GT targets hearing loss related to mutations in <i>GJB2<\/i> gene to potentially address important hearing loss segments in adults and children. The Company is also working on the identification of biomarkers to improve diagnosis of these underserved illnesses.\n<\/p>\n<p>\nSensorion\u2019s portfolio also comprises clinical-stage small molecule programs for the treatment and prevention of hearing loss disorders.\n<\/p>\n<p>\nSensorion\u2019s clinical-stage portfolio includes one Phase 2 product: SENS-401 (Arazasetron) progressing in a Phase 2 proof of concept clinical study of SENS-401 in Cisplatin-Induced Ototoxicity (CIO) and, with partner Cochlear Limited, in a study of SENS-401 in patients scheduled for cochlear implantation. A Phase 2 study of SENS-401 was also completed in Sudden Sensorineural Hearing Loss (SSNHL) in January 2022.\n<\/p>\n<p>\n<a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=http%3A%2F%2Fwww.sensorion.com&amp;esheet=53362721&amp;newsitemid=20230315005839&amp;lan=en-US&amp;anchor=www.sensorion.com&amp;index=1&amp;md5=06dcaa96b42973c615ebf8eaedddeb96\" rel=\"nofollow noopener\" shape=\"rect\">www.sensorion.com<\/a>\n<\/p>\n<p class=\"bwalignl\">\nLabel: <b>SENSORION<br \/>\n<br \/><\/b>ISIN: <b>FR0012596468<br \/>\n<br \/><\/b>Mnemonic: <b>ALSEN<\/b>\n<\/p>\n<p>\n<b>Disclaimer<br \/>\n<br \/><\/b>This press release contains certain forward-looking statements concerning Sensorion and its business. Such forward looking statements are based on assumptions that Sensorion considers to be reasonable. The forward-looking statements contained in this press release are also subject to risks not yet known to Sensorion or not currently considered material by Sensorion. However, there can be no assurance that such forward-looking statements will be verified, which statements are subject to numerous risks, including the risks set forth in the documentation published by the company and available on our website and to the development of economic conditions, financial markets and the markets in which Sensorion operates. The occurrence of all or part of such risks could cause actual results, financial conditions, performance or achievements of Sensorion to be materially different from such forward-looking statements. This press release and the information that it contains do not constitute an offer to sell or subscribe for, or a solicitation of an offer to purchase or subscribe for, Sensorion shares in any country. The communication of this press release in certain countries may constitute a violation of local laws and regulations. Any recipient of this press release must inform oneself of any such local restrictions and comply therewith.\n<\/p>\n<p>\n______________________________<br \/>\n<br \/><sup>1<\/sup> The audit procedures on individual and consolidated financial statements have been carried out. The audit reports will be issued after completion of the procedures required for the publication of the annual financial report.<br \/>\n<br \/><sup>2<\/sup> Audinnove is a project coordinated by H\u00f4pital Necker-Enfants maladies to develop new diagnostic and therapeutic approaches for congenital deafness (Project ANR-18-RHUS-0007). The consortium includes AP-HP, the Pasteur Institute, the Hearing Foundation and Sensorion<br \/>\n<br \/><sup>3<\/sup> The \u201cPATRIOT\u201d consortium (PSPC14 \u2013 n\u00b02019), of which Sensorion is the leader, also involves the Institut de recherche biom\u00e9dicale des Arm\u00e9es en anglais?, the Institut Pasteur and the company Electronique du Mazet. This project aims to protect and preserve inner ear tissue from damage that could lead to deafness.\n<\/p>\n<p> <b>Contacts<\/b> <\/p>\n<p>\n<b>Investor Relations<\/b><br \/>David Lawrence, Chief Financial Officer (US\/UK)<br \/>\n<br \/>No\u00e9mie Djokovic, Investor Relations and Communications (Europe\/France)<br \/>\n<br \/><a target=\"_blank\" href=\"&#109;&#x61;i&#x6c;&#x74;&#111;&#x3a;i&#x72;&#x2e;&#99;&#x6f;n&#x74;&#x61;&#99;&#x74;&#64;&#x73;&#x65;&#110;&#x73;o&#x72;&#x69;&#111;&#x6e;-&#x70;&#x68;&#97;&#x72;m&#x61;&#x2e;&#99;&#x6f;m\" rel=\"nofollow noopener\" shape=\"rect\">i&#114;&#x2e;&#x63;&#x6f;n&#116;&#x61;&#x63;&#x74;&#64;&#115;&#x65;&#x6e;&#x73;o&#114;&#x69;&#x6f;&#x6e;-&#112;&#x68;&#x61;&#x72;m&#97;&#x2e;&#x63;&#x6f;m<\/a>\n<\/p>\n<p>\n<b>International Media Relations<\/b><br \/>Consilium Strategic Communications<br \/>\n<br \/>Matthew Cole\/Jessica Hodgson\/Sue Stuart<br \/>\n<br \/>+44 7593 572720<br \/>\n<br \/>+44 7561 424788<br \/>\n<br \/><a target=\"_blank\" href=\"m&#97;&#x69;&#x6c;t&#111;&#x3a;&#x53;e&#110;&#115;&#x6f;&#x72;i&#111;&#x6e;&#x40;c&#111;&#x6e;&#x73;i&#108;&#105;&#x75;&#x6d;-&#99;&#x6f;&#x6d;m&#115;&#x2e;&#x63;o&#109;\" rel=\"nofollow noopener\" shape=\"rect\">S&#101;&#110;&#x73;&#x6f;&#x72;&#x69;o&#110;&#64;&#99;&#x6f;&#x6e;&#x73;il&#105;&#117;&#x6d;&#x2d;&#x63;om&#109;&#115;&#x2e;&#x63;&#x6f;m<\/a>\n<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>CTA filing for OTOF-GT planned for Q2 2023 Presented new preclinical data supporting continued progress of OTOF-GT, and potential for safe and efficient clinical translation of gene therapy for otoferlin delivered by a dual AAV vector at the 45th Association for Research in Otolaryngology (ARO) Promising results obtained in Proof-of-Concept studies supporting the identification of &#8230; <span class=\"more\"><a class=\"more-link\" href=\"https:\/\/pharma-trend.com\/en\/sensorion-reports-full-year-2022-financial-results-and-business-update\/\">[Read more&#8230;]<\/a><\/span><\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[13],"tags":[],"class_list":{"0":"entry","1":"post","2":"publish","3":"author-business","4":"post-54891","6":"format-standard","7":"category-industry"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Sensorion Reports Full-Year 2022 Financial Results and Business Update - Pharma Trend<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/pharma-trend.com\/en\/sensorion-reports-full-year-2022-financial-results-and-business-update\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Sensorion Reports Full-Year 2022 Financial Results and Business Update - Pharma Trend\" \/>\n<meta property=\"og:description\" content=\"CTA filing for OTOF-GT planned for Q2 2023 Presented new preclinical data supporting continued progress of OTOF-GT, and potential for safe and efficient clinical translation of gene therapy for otoferlin delivered by a dual AAV vector at the 45th Association for Research in Otolaryngology (ARO) Promising results obtained in Proof-of-Concept studies supporting the identification of ... 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