{"id":54921,"date":"2023-03-16T16:05:20","date_gmt":"2023-03-16T15:05:20","guid":{"rendered":"https:\/\/pharma-trend.com\/en\/agendia-announces-first-patient-enrolled-in-proofs-registry-trial-to-determine-optimal-treatment-and-ability-to-forgo-chemotherapy-for-premenopausal-women-with-early-hr-breast-cancer\/"},"modified":"2023-03-16T16:05:20","modified_gmt":"2023-03-16T15:05:20","slug":"agendia-announces-first-patient-enrolled-in-proofs-registry-trial-to-determine-optimal-treatment-and-ability-to-forgo-chemotherapy-for-premenopausal-women-with-early-hr-breast-cancer","status":"publish","type":"post","link":"https:\/\/pharma-trend.com\/en\/agendia-announces-first-patient-enrolled-in-proofs-registry-trial-to-determine-optimal-treatment-and-ability-to-forgo-chemotherapy-for-premenopausal-women-with-early-hr-breast-cancer\/","title":{"rendered":"Agendia Announces First Patient Enrolled in PROOFS Registry Trial to Determine Optimal Treatment and Ability to Forgo Chemotherapy for Premenopausal Women with Early HR+ Breast Cancer"},"content":{"rendered":"<div>\n<ul class=\"bwlistdisc\">\n<li>\n<i>Agendia partners with the West German Study Group to determine the benefit of ovarian function suppression, potentially reducing overtreatment with chemotherapy<\/i>\n<\/li>\n<li>\n<i>Trial reinforces Agendia\u2019s progress in developing practice-changing evidence to improve personalized cancer care<\/i>\n<\/li>\n<\/ul>\n<p>IRVINE, Calif. &amp; AMSTERDAM &amp; M\u00d6NCHENGLADBACH, Germany&#8211;(BUSINESS WIRE)&#8211;<a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=http%3A%2F%2Fwww.agendia.com%2F&amp;esheet=53362794&amp;newsitemid=20230316005188&amp;lan=en-US&amp;anchor=Agendia%2C+Inc.&amp;index=1&amp;md5=3be8da4eb31efe16095b7c529e794548\" rel=\"nofollow noopener\" shape=\"rect\">Agendia, Inc.<\/a>, a leader in gene expression profiling for early-stage breast cancer, today announced the first patient has been enrolled in the PROOFS Registry trial. In partnership with the West German Study Group (WSG), the study aims to determine whether premenopausal women with early HR+ breast cancer, originally defined as clinically high-risk and classified as MammaPrint Low Risk, can avoid chemotherapy, and maintain strong outcomes by opting instead for temporary ovarian function suppression (OFS) in combination with endocrine therapy. By determining the drivers behind a young woman\u2019s response to chemotherapy, the trial\u2019s results could empower young women with the ability to safely forgo chemotherapy toxicities and preserve their fertility and quality of life.\n<\/p>\n<p><a href=\"https:\/\/mms.businesswire.com\/media\/20230316005188\/en\/1655327\/5\/Agendia_Logo_-_600x600.jpg\"><img decoding=\"async\" src=\"https:\/\/mms.businesswire.com\/media\/20230316005188\/en\/1655327\/21\/Agendia_Logo_-_600x600.jpg\"><\/a><\/p>\n<p>\nBreast cancer uses estrogen to grow, and chemotherapy suppresses the ovaries\u2019 production of estrogen to cut off the cancer\u2019s fuel source. While MINDACT study data found a small 3-5% chemotherapy benefit in premenopausal women with MammaPrint Low Risk tumors, the authors later concluded it is likely due to the chemotherapy-induced ovarian function suppression (OFS), rather than the effect of chemotherapy on the cancer itself. The PROOFS Registry trial intends to show this perceived benefit is merely a side effect of chemotherapy-induced OFS, deeming chemotherapy unnecessary and replaceable by temporarily suppressing the ovaries. Every young woman with early-stage breast cancer deserves the right to make truly informed treatment decisions tailored to her unique biology.\n<\/p>\n<p>\n\u201cSeveral studies have shown chemotherapy can have an irreversible impact on fertility, therefore the right treatment decision is critical in a woman\u2019s potential family planning,\u201d said PD Dr. Oleg Gluz, Scientific Director of the WSG and leader of the Breast Center Niederrhein, Ev. Hospital Bethesda, M\u00f6nchengladbach and PD at the University of Cologne. \u201cThis study could potentially show that young women with breast cancer could be treated with endocrine therapy and OFS without compromising outcomes and without the risk of permanently affecting their fertility \u2013 all based on insights from her tumor\u2019s unique gene expression profile.\u201d\n<\/p>\n<p>\n\u201cWhile chemotherapy is often assumed to be necessary for all young women with hormone receptor positive breast cancer, we have been able to harness the power of gene expression profiling to understand the biology of each breast cancer beyond the effects of age and standard pathology, and better define the true benefit of treatment. These insights could allow some young women with breast cancer to forgo chemotherapy and avoid unnecessary toxicity,\u201d said William Audeh, MD, Chief Medical Officer at Agendia. \u201cIf their small chemotherapy benefit indeed stems from OFS as the PROOF Registry trial seeks to prove, more young women can forgo the potentially serious and sometimes life-threatening effects of chemotherapy. We\u2019re proud to partner with WSG on this important step to advance personalized treatment planning, reduce overtreatment, and help more women with breast cancer maintain their quality of life.\u201d\n<\/p>\n<p>\nThe PROOFS Registry trial intends to enroll 1,500 patients via 100 sites in Germany by January 2025. Right now, it is critical young women with early breast cancer be afforded the opportunity for shared decision-making when weighing the small perceived chemotherapy benefit against its impact on their future fertility and quality of life. By the close of the PROOFS Registry study, providers may be in a position to confidently recommend OFS as an alternative to toxic chemotherapy and preserve a woman\u2019s fertility while maintaining the best chance at survival. Together with WSG, Agendia continues to enable more personalized treatments in breast cancer care.\n<\/p>\n<p>\n<b>About Agendia<\/b>\n<\/p>\n<p>\nAgendia is a mission-driven, commercial stage company focused on enabling optimized decision-making by providing physicians with next-generation diagnostic and information solutions that can be used to help improve outcomes for breast cancer patients worldwide. The company currently offers two commercially-available genomic profiling tests that help surgeons, oncologists and pathologists to personalize treatment for women at critical intervention points throughout their patient journey.\n<\/p>\n<p>\nMammaPrint<sup>\u00ae<\/sup> is a 70-gene prognostic test that, along with other clinicopathologic factors, determines a specific patient\u2019s breast cancer recurrence risk. BluePrint<sup>\u00ae<\/sup> is an 80-gene molecular subtyping test that identifies the underlying biology of an individual breast cancer to provide information about its behavior, long-term prognosis and potential response to systemic therapy. Together, MammaPrint<sup>\u00ae<\/sup> and BluePrint<sup>\u00ae<\/sup> provide a holistic view of the biology underlying an individual patient\u2019s breast cancer, enabling physicians to objectively select the best treatment plan.\n<\/p>\n<p>\n<b>About the West German Study Group (WSG)<\/b>\n<\/p>\n<p>\nThe West German Study Group (WSG) is a collaborative research group that focuses on the design, organization, and implementation of clinical studies in the field of breast cancer. The goals of its studies are to optimize existing therapies in terms of effectiveness and tolerability, avoid unnecessary therapies and individualize breast cancer therapy.\n<\/p>\n<p>\nFor more information on Agendia\u2019s assays and ongoing trials, please visit <a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=http%3A%2F%2Fwww.agendia.com&amp;esheet=53362794&amp;newsitemid=20230316005188&amp;lan=en-US&amp;anchor=www.agendia.com&amp;index=2&amp;md5=c87db6f59817178dc07e91f3d831fea8\" rel=\"nofollow noopener\" shape=\"rect\">www.agendia.com<\/a>.\n<\/p>\n<p>\nFor more information on WSG\u2019s activities and ongoing trials, please visit <a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Fwsg-online.com%2F&amp;esheet=53362794&amp;newsitemid=20230316005188&amp;lan=en-US&amp;anchor=wsg-online.com&amp;index=3&amp;md5=58565114c6c04b98b243725931e8555d\" rel=\"nofollow noopener\" shape=\"rect\">wsg-online.com<\/a>.\n<\/p>\n<p> <b>Contacts<\/b> <\/p>\n<p>\nKerry Harrington<br \/>\n<br \/>FleishmanHillard for Agendia<br \/>\n<br \/><a target=\"_blank\" href=\"&#109;&#x61;&#105;&#x6c;&#116;&#x6f;:&#x4b;e&#x72;r&#121;&#x2e;&#104;&#x61;&#114;&#x72;&#105;&#x6e;g&#x74;o&#x6e;&#64;&#102;&#x6c;&#101;&#x69;&#115;&#x68;&#109;&#x61;n&#x2e;c&#x6f;m\" rel=\"nofollow noopener\" shape=\"rect\">&#75;e&#x72;r&#x79;&#46;&#x68;a&#x72;&#114;&#x69;&#110;&#x67;&#116;&#x6f;&#110;&#64;&#102;l&#x65;i&#x73;h&#x6d;&#97;&#x6e;&#46;&#x63;&#111;&#x6d;<\/a>\n<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Agendia partners with the West German Study Group to determine the benefit of ovarian function suppression, potentially reducing overtreatment with chemotherapy Trial reinforces Agendia\u2019s progress in developing practice-changing evidence to improve personalized cancer care IRVINE, Calif. &amp; AMSTERDAM &amp; M\u00d6NCHENGLADBACH, Germany&#8211;(BUSINESS WIRE)&#8211;Agendia, Inc., a leader in gene expression profiling for early-stage breast cancer, today announced &#8230; <span class=\"more\"><a class=\"more-link\" href=\"https:\/\/pharma-trend.com\/en\/agendia-announces-first-patient-enrolled-in-proofs-registry-trial-to-determine-optimal-treatment-and-ability-to-forgo-chemotherapy-for-premenopausal-women-with-early-hr-breast-cancer\/\">[Read more&#8230;]<\/a><\/span><\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[13],"tags":[],"class_list":{"0":"entry","1":"post","2":"publish","3":"author-business","4":"post-54921","6":"format-standard","7":"category-industry"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Agendia Announces First Patient Enrolled in PROOFS Registry Trial to Determine Optimal Treatment and Ability to Forgo Chemotherapy for Premenopausal Women with Early HR+ Breast Cancer - Pharma Trend<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/pharma-trend.com\/en\/agendia-announces-first-patient-enrolled-in-proofs-registry-trial-to-determine-optimal-treatment-and-ability-to-forgo-chemotherapy-for-premenopausal-women-with-early-hr-breast-cancer\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Agendia Announces First Patient Enrolled in PROOFS Registry Trial to Determine Optimal Treatment and Ability to Forgo Chemotherapy for Premenopausal Women with Early HR+ Breast Cancer - Pharma Trend\" \/>\n<meta property=\"og:description\" content=\"Agendia partners with the West German Study Group to determine the benefit of ovarian function suppression, potentially reducing overtreatment with chemotherapy Trial reinforces Agendia\u2019s progress in developing practice-changing evidence to improve personalized cancer care IRVINE, Calif. &amp; AMSTERDAM &amp; M\u00d6NCHENGLADBACH, Germany&#8211;(BUSINESS WIRE)&#8211;Agendia, Inc., a leader in gene expression profiling for early-stage breast cancer, today announced ... 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