{"id":55261,"date":"2023-03-28T15:06:26","date_gmt":"2023-03-28T13:06:26","guid":{"rendered":"https:\/\/pharma-trend.com\/en\/ambiopharm-to-utilize-ymc-twin-column-chromatography-in-large-scale-peptide-production\/"},"modified":"2023-03-28T15:06:26","modified_gmt":"2023-03-28T13:06:26","slug":"ambiopharm-to-utilize-ymc-twin-column-chromatography-in-large-scale-peptide-production","status":"publish","type":"post","link":"https:\/\/pharma-trend.com\/en\/ambiopharm-to-utilize-ymc-twin-column-chromatography-in-large-scale-peptide-production\/","title":{"rendered":"AmbioPharm To Utilize YMC Twin-Column Chromatography in Large Scale Peptide Production"},"content":{"rendered":"<div>\n<p>NORTH AUGUSTA, S.C. and DEVENS, Mass.&#8211;(BUSINESS WIRE)&#8211;<a href=\"https:\/\/twitter.com\/hashtag\/DownstreamProcessing?src=hash\" target=\"_blank\" rel=\"noopener\">#DownstreamProcessing<\/a>&#8212;<a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Fwww.ambiopharm.com%2F&amp;esheet=53369063&amp;newsitemid=20230328005358&amp;lan=en-US&amp;anchor=AmbioPharm&amp;index=1&amp;md5=b993c7e170bf7ab2712276c5dabaaa24\" rel=\"nofollow noopener\" shape=\"rect\">AmbioPharm<\/a>, a worldwide leader in peptide API CDMO services, announces the acquisition of new, disruptive, peptide purification technology developed by <a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Fwww.ymcamerica.com%2F&amp;esheet=53369063&amp;newsitemid=20230328005358&amp;lan=en-US&amp;anchor=YMC&amp;index=2&amp;md5=3c50d23ce94be4113791b7db12514c7d\" rel=\"nofollow noopener\" shape=\"rect\">YMC<\/a> which leverages several of YMC\u2019s patented<sup>1<\/sup> twin-column purification processes. Twin-column chromatography or <b>M<\/b>ulticolumn <b>C<\/b>ountercurrent <b>S<\/b>olvent <b>G<\/b>radient <b>P<\/b>urification (MCSGP) is a continuous chromatographic process which collects a high purity center cut fraction and internally recycles mixed impurity\/product-containing side fractions all while loading fresh feed and discarding impurities (see diagram).\n<\/p>\n<p><a href=\"https:\/\/mms.businesswire.com\/media\/20230328005358\/en\/1747965\/5\/MCSGP-vs-Batch-Diagram_YMC.jpg\"><img decoding=\"async\" src=\"https:\/\/mms.businesswire.com\/media\/20230328005358\/en\/1747965\/21\/MCSGP-vs-Batch-Diagram_YMC.jpg\"><\/a><br \/><a href=\"https:\/\/mms.businesswire.com\/media\/20230328005358\/en\/1747964\/5\/APi_YMC.jpg\"><img decoding=\"async\" src=\"https:\/\/mms.businesswire.com\/media\/20230328005358\/en\/1747964\/21\/APi_YMC.jpg\"><\/a><\/p>\n<p>\nThis technology offers several advantages over traditional batch purification including:\n<\/p>\n<ul class=\"bwlistdisc\">\n<li>\nHigher peptide purity\n<\/li>\n<li>\nIncreased yield\n<\/li>\n<li>\nDecreased solvent requirements\n<\/li>\n<li>\nTime savings\n<\/li>\n<li>\nSignificant reduction of fraction collection, storage, QC, blending, and reprocessing\n<\/li>\n<\/ul>\n<p>\nAs a leader in peptide manufacturing and development, AmbioPharm is continuously upgrading equipment and technologies, especially those that can improve our capacity and sustainability. Using our expertise in peptide synthesis, we are able to tackle both simple and complex peptide projects with a proven history of success at research, clinical, and commercial scales.\n<\/p>\n<p>\n<b>About AmbioPharm Inc.:<\/b>\n<\/p>\n<p>\nAmbioPharm is a leading, innovation-driven company specializing in the development and manufacture of peptides and peptide-related products. With a comprehensive range of services, AmbioPharm produces custom products for research, clinical development, and commercial application to pharmaceutical and biotechnology companies worldwide. Headquartered in the United States of America and with locations in the USA and Asia, AmbioPharm operates internationally with over 14 years of experience and expertise. Further information is available at: <a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Fwww.ambiopharm.com&amp;esheet=53369063&amp;newsitemid=20230328005358&amp;lan=en-US&amp;anchor=https%3A%2F%2Fwww.ambiopharm.com&amp;index=3&amp;md5=ba81cbd6b63431af3f778f356a8e89a1\" rel=\"nofollow noopener\" shape=\"rect\">https:\/\/www.ambiopharm.com<\/a>\n<\/p>\n<p>\n<b>About YMC:<\/b>\n<\/p>\n<p>\nYMC is a private Life Science company headquartered in Kyoto, Japan. Founded in 1980, YMC has 9 affiliates and several facilities throughout Asia, Europe, and America. Their 500+ employees are providing best-in-class lab and process solutions to the bio\/pharmaceutical industry. YMC\u2019s focus is innovation, production, and sales of packing materials, packed columns and systems for High Performance Liquid Chromatography (HPLC), Low Pressure Liquid Chromatography (LPLC), and other custom purification systems. YMC operates a CMO facility in Japan and has recently opened a new lab \/ pilot facility \u201cKyoto Works\u201d incorporating state of the art multi-column purification equipment.\n<\/p>\n<p>\nYMC America, formerly YMC Process Technologies (YPT) in Devens, MA USA, has supplied GMP scale downstream process system for nearly 20 years. Acquired by YMC in December 2018, YPT Bio\/Pharma Systems Group along with its sister affiliate YMC ChromaCon AG (Zurich, Switzerland), is a leading supplier of lab and production scale single and multi-column chromatography systems. YMC\u2019s intellectual assets and know-how, cultivated from many years of experience, will continue to push the limits to create a prosperous future for the production and purification of small and large molecule therapies. More at: <a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Fwww.ymcamerica.com%2F&amp;esheet=53369063&amp;newsitemid=20230328005358&amp;lan=en-US&amp;anchor=https%3A%2F%2Fwww.ymcamerica.com%2F&amp;index=4&amp;md5=e214cfbf3db24105536bfa10adf27bd2\" rel=\"nofollow noopener\" shape=\"rect\">https:\/\/www.ymcamerica.com\/<\/a>\n<\/p>\n<table cellspacing=\"0\" class=\"bwtablemarginb bwblockalignl\">\n<tr>\n<td class=\"bwvertalignt bwpadl0\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwcellpmargin\">\n<sup>1<\/sup>MCSGP \/ Autopeak: US patents 7.837.881, 8.496.836\n<\/p>\n<\/td>\n<\/tr>\n<\/table>\n<p>\n\u00a0\n<\/p>\n<p> <b>Contacts<\/b> <\/p>\n<p>\n<b>AmbioPharm<\/b><br \/>Mark DaFonseca, EVP, Sales &amp; Global Business Development<br \/>\n<br \/><a target=\"_blank\" href=\"m&#97;&#x69;&#x6c;&#x74;o&#58;&#109;&#x61;&#x72;k&#46;&#100;&#x61;&#x66;on&#115;&#x65;&#x63;&#x61;&#64;&#97;&#x6d;&#x62;&#x69;o&#112;&#104;&#x61;&#x72;m&#46;&#99;&#x6f;&#x6d;\" rel=\"nofollow noopener\" shape=\"rect\">&#109;&#x61;r&#x6b;&#x2e;&#100;&#x61;f&#111;&#x6e;&#115;&#x65;c&#97;&#x40;a&#x6d;b&#105;&#x6f;p&#x68;&#x61;&#114;&#x6d;&#46;&#99;&#x6f;&#109;<\/a>\n<\/p>\n<p>\n<b>YMC America<\/b><br \/>Wayne Nettnay, Global Sales Director<br \/>\n<br \/><a target=\"_blank\" href=\"m&#97;&#105;&#108;&#x74;&#x6f;&#x3a;wn&#101;&#116;&#x74;&#x6e;&#x61;&#x79;&#64;y&#109;&#99;&#x70;&#x74;&#x2e;&#x63;o&#109;\" rel=\"nofollow noopener\" shape=\"rect\">&#x77;&#x6e;&#x65;&#116;&#116;na&#x79;&#x40;&#x79;&#109;&#99;pt&#x2e;&#x63;&#x6f;&#109;<\/a>\n<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>NORTH AUGUSTA, S.C. and DEVENS, Mass.&#8211;(BUSINESS WIRE)&#8211;#DownstreamProcessing&#8212;AmbioPharm, a worldwide leader in peptide API CDMO services, announces the acquisition of new, disruptive, peptide purification technology developed by YMC which leverages several of YMC\u2019s patented1 twin-column purification processes. Twin-column chromatography or Multicolumn Countercurrent Solvent Gradient Purification (MCSGP) is a continuous chromatographic process which collects a high purity &#8230; <span class=\"more\"><a class=\"more-link\" href=\"https:\/\/pharma-trend.com\/en\/ambiopharm-to-utilize-ymc-twin-column-chromatography-in-large-scale-peptide-production\/\">[Read more&#8230;]<\/a><\/span><\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[13],"tags":[],"class_list":{"0":"entry","1":"post","2":"publish","3":"author-business","4":"post-55261","6":"format-standard","7":"category-industry"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>AmbioPharm To Utilize YMC Twin-Column Chromatography in Large Scale Peptide Production - Pharma Trend<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/pharma-trend.com\/en\/ambiopharm-to-utilize-ymc-twin-column-chromatography-in-large-scale-peptide-production\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"AmbioPharm To Utilize YMC Twin-Column Chromatography in Large Scale Peptide Production - Pharma Trend\" \/>\n<meta property=\"og:description\" content=\"NORTH AUGUSTA, S.C. and DEVENS, Mass.&#8211;(BUSINESS WIRE)&#8211;#DownstreamProcessing&#8212;AmbioPharm, a worldwide leader in peptide API CDMO services, announces the acquisition of new, disruptive, peptide purification technology developed by YMC which leverages several of YMC\u2019s patented1 twin-column purification processes. 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