{"id":55376,"date":"2023-03-30T19:04:29","date_gmt":"2023-03-30T17:04:29","guid":{"rendered":"https:\/\/pharma-trend.com\/en\/exai-bio-and-quantum-leap-healthcare-collaborative-announce-expanded-participation-in-i-spy-2-trial-to-advance-exais-novel-rna-based-liquid-biopsy-platform-in-breast-cancer\/"},"modified":"2023-03-30T19:04:29","modified_gmt":"2023-03-30T17:04:29","slug":"exai-bio-and-quantum-leap-healthcare-collaborative-announce-expanded-participation-in-i-spy-2-trial-to-advance-exais-novel-rna-based-liquid-biopsy-platform-in-breast-cancer","status":"publish","type":"post","link":"https:\/\/pharma-trend.com\/en\/exai-bio-and-quantum-leap-healthcare-collaborative-announce-expanded-participation-in-i-spy-2-trial-to-advance-exais-novel-rna-based-liquid-biopsy-platform-in-breast-cancer\/","title":{"rendered":"Exai Bio and Quantum Leap Healthcare Collaborative Announce Expanded Participation in I-SPY 2 Trial to Advance Exai\u2019s Novel RNA-based Liquid Biopsy Platform in Breast Cancer"},"content":{"rendered":"<div>\n<p class=\"bwalignc\">\n<i>Based on Initial Positive Data, Exai to <\/i><i>Study a Larger Cohort of Patients to Evaluate oncRNAs as a Predictive and Prognostic Biomarker Across Multiple Therapies<\/i>\n<\/p>\n<p>PALO ALTO, Calif.&#8211;(BUSINESS WIRE)&#8211;Exai Bio today announced a collaboration agreement with Quantum Leap Healthcare Collaborative\u2122 (QLHC) to broaden the use of Exai\u2019s novel, RNA-based liquid biopsy platform to monitor patients\u2019 treatment response and disease burden in the I-SPY 2 TRIAL. The expanded agreement is based on positive initial <a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Fglobal-uploads.webflow.com%2F6331c352f5d5d86766131bba%2F63629e2164da07069f0858c7_SABCS_poster.pdf&amp;esheet=53371083&amp;newsitemid=20230330005224&amp;lan=en-US&amp;anchor=data&amp;index=1&amp;md5=1a0a93f913e4a7a4b9fe0b2a5d39161e\" rel=\"nofollow noopener\" shape=\"rect\">data<\/a> using Exai\u2019s platform in the trial, which demonstrated that oncRNAs were a significant predictor of patient outcomes. I-SPY 2 is the largest and longest-running &#8216;platform&#8217; trial that provides a regulatory framework to study multiple novel therapeutic treatment arms for women with newly diagnosed, locally advanced breast cancer.\n<\/p>\n<p><a href=\"https:\/\/mms.businesswire.com\/media\/20230330005224\/en\/1751532\/5\/Exai_biz_wire_logo_feb_2023.jpg\"><img decoding=\"async\" src=\"https:\/\/mms.businesswire.com\/media\/20230330005224\/en\/1751532\/21\/Exai_biz_wire_logo_feb_2023.jpg\"><\/a><\/p>\n<p>\nExai\u2019s liquid biopsy platform is based on the discovery of orphan non-coding RNAs (oncRNAs), a novel class of small RNA biomarkers with high sensitivity and specificity. This next phase of the collaboration is expected to increase the evidence for oncRNAs as a predictor of clinical outcomes and measurement of treatment response in a larger cohort of patients and across more therapies within I-SPY 2.\n<\/p>\n<p>\n\u201cBreast cancer patients are in need of simple, accessible and more effective tools to monitor treatment response,\u201d said Dr. Laura Esserman, co-principal investigator of the I-SPY TRIALs and founder of QLHC. \u201cLiquid biopsy has the potential to enable clinicians to act and change course during treatment. Based on the initial findings using Exai\u2019s RNA-based approach, we are excited to investigate the impact that this novel platform could have. Their technology fits into our strategy of testing new approaches and tools to predict response early in the course of care. We are broadening our collaboration to include more patients and therapies, and we are thrilled to have this opportunity.\u201d\n<\/p>\n<p>\n\u201cAt the heart of I-SPY 2, we are changing the way new treatments are developed for breast cancer, expanding indications and expediting these personalized options for patients in need,\u201d said Dr. Laura van \u2018t Veer, who leads the Biomarker Working Group for the I-SPY TRIALs. \u201cThe success of the trial depends on partnering with advanced diagnostics companies like Exai that are bringing forth the next generation of predictive and prognostic biomarkers. The role of oncRNAs in predicting clinical outcomes and informing treatment decisions for breast cancer patients is very promising.\u201d\n<\/p>\n<p>\nOncRNAs are abundant, stable, and actively secreted from cancer cells into the blood, making them a valuable class of biomarkers. Exai combines this underlying cancer biology with artificial intelligence (AI) to identify cancer-specific patterns based on its proprietary catalog of hundreds of thousands of oncRNAs. This approach results in a universal platform for test development that is efficient, accessible, and can be used across multiple products and cancer care settings such as screening and early detection, monitoring, molecular residual disease and therapy selection.\n<\/p>\n<p>\nIn the monitoring and neoadjuvant setting, Exai\u2019s unique and reliable method to determine disease burden in the blood of cancer patients does not require prior tumor sequencing or individualization of a test for each patient, can be rapidly generated, and could prove complementary and more sensitive than tests that rely on ctDNA. In addition to using oncRNAs in the therapy selection and monitoring settings, Exai has presented <a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Fglobal-uploads.webflow.com%2F6331c352f5d5d86766131bba%2F6388e4c47b1b3f779e701be2_exai_bio_sabcs_poster_2022.pdf&amp;esheet=53371083&amp;newsitemid=20230330005224&amp;lan=en-US&amp;anchor=data&amp;index=2&amp;md5=b0bdea049653c91a069fe8d8235be3de\" rel=\"nofollow noopener\" shape=\"rect\">data<\/a> supporting use in screening and early detection at the 2022 San Antonio Breast Cancer Symposium demonstrating that its RNA-based technology accurately detected breast cancer at the earliest stages and smallest tumor sizes.\n<\/p>\n<p>\n\u201cWe are delighted to extend our participation in such a groundbreaking trial, and to continue to demonstrate that our RNA-based approach can more effectively inform care decisions in a larger cohort of patients and across multiple therapies,\u201d said Pat Arensdorf, Chief Executive Officer at Exai. \u201cOur goal is to provide a novel tool for biopharmaceutical companies to include in clinical trials to monitor early therapy response and efficacy, predict end-points, and enrich patient populations in an effective manner.\u201d\n<\/p>\n<p>\n<b>About the I-SPY TRIALS<\/b>\n<\/p>\n<p>\nThe I-SPY TRIAL (Investigation of Serial Studies to Predict Your Therapeutic Response with Imaging And moLecular Analysis) was designed to rapidly screen promising experimental treatments and identify those most effective in specific patient subgroups based on molecular characteristics (biomarker signatures). The trial is a unique collaborative effort by a consortium that includes the Food and Drug Administration (FDA), industry, patient advocates, philanthropic sponsors, and clinicians from 16 major U.S. cancer research centers. Under the terms of the collaboration agreement, Quantum Leap Healthcare Collaborative is the trial sponsor and manages all study operations. For more information, visit <a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Fispytrials.org%2F&amp;esheet=53371083&amp;newsitemid=20230330005224&amp;lan=en-US&amp;anchor=ispytrials.org&amp;index=3&amp;md5=1789771c031fe82663bc98e3bdf134d2\" rel=\"nofollow noopener\" shape=\"rect\">ispytrials.org<\/a>.\n<\/p>\n<p>\n<b>About Quantum Leap Healthcare Collaborative<\/b>\n<\/p>\n<p>\nQuantum Leap Healthcare Collaborative is a 501c(3) charitable organization established in 2005 as a collaboration between medical researchers at University of California, San Francisco and Silicon Valley entrepreneurs. Our mission is to integrate care and research, and to foster high-impact trials with embedded clinical processes and systems technology and improved data management, greater access to clinical trial matching, and greater benefit to patients, providers, and researchers. Our goal is to improve and save lives. Quantum Leap provides operational, financial, and regulatory oversight to I-SPY. For more information, visit <a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Fwww.quantumleaphealth.org%2F&amp;esheet=53371083&amp;newsitemid=20230330005224&amp;lan=en-US&amp;anchor=https%3A%2F%2Fwww.quantumleaphealth.org%2F&amp;index=4&amp;md5=b07579db1f2e38ffaf7af4c7ed8b4477\" rel=\"nofollow noopener\" shape=\"rect\">https:\/\/www.quantumleaphealth.org\/<\/a>.\n<\/p>\n<p>\n<b>About Exai Bio<\/b>\n<\/p>\n<p>\n<a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Fwww.exai.bio&amp;esheet=53371083&amp;newsitemid=20230330005224&amp;lan=en-US&amp;anchor=Exai+Bio&amp;index=5&amp;md5=fd163c049375931f17f1441b24dd21fd\" rel=\"nofollow noopener\" shape=\"rect\">Exai Bio<\/a> is a next-generation liquid biopsy company. Its mission is to enable a world where cancer can be detected early, diagnosed accurately, treated in a personalized and targeted way, and ultimately cured. The company\u2019s proprietary RNA and artificial intelligence-based liquid biopsy technology delivers clinical insights into cancer biology to enable the earliest, most accurate diagnosis of cancer.\n<\/p>\n<p> <b>Contacts<\/b> <\/p>\n<p>\n<b>Exai Bio Media Contact:<\/b><br \/>Brad Hennig<br \/>\n<br \/><a target=\"_blank\" href=\"&#109;&#x61;&#x69;&#108;&#x74;&#x6f;:&#x62;&#x72;a&#100;&#x68;&#64;&#101;&#x78;a&#105;&#x2e;b&#105;&#x6f;\" rel=\"nofollow noopener\" shape=\"rect\">brad&#104;&#64;&#101;&#120;&#97;&#105;&#46;&#x62;&#x69;&#x6f;<\/a><br \/>(415) 307-7856\n<\/p>\n<p>\n<b>Quantum Leap Healthcare Collaborative Media Contact:<\/b><br \/>Jacqueline Murray<br \/>\n<br \/>Director, Marketing and Communications<br \/>\n<br \/><a target=\"_blank\" href=\"&#109;&#x61;i&#108;&#x74;o&#x3a;&#x6a;&#46;&#x6d;u&#114;&#x72;a&#121;&#x40;&#113;&#x75;a&#110;&#x74;u&#109;&#x6c;&#101;&#x61;&#x70;&#104;&#x65;a&#108;&#x74;h&#x2e;&#x6f;&#114;&#x67;\" rel=\"nofollow noopener\" shape=\"rect\">&#x6a;&#46;&#x6d;&#117;r&#x72;&#97;&#x79;&#x40;q&#x75;&#97;n&#x74;&#117;&#x6d;&#108;e&#x61;&#112;h&#x65;&#97;&#x6c;&#116;h&#x2e;&#111;&#x72;&#x67;<\/a><br \/>(415) 839-8082\n<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Based on Initial Positive Data, Exai to Study a Larger Cohort of Patients to Evaluate oncRNAs as a Predictive and Prognostic Biomarker Across Multiple Therapies PALO ALTO, Calif.&#8211;(BUSINESS WIRE)&#8211;Exai Bio today announced a collaboration agreement with Quantum Leap Healthcare Collaborative\u2122 (QLHC) to broaden the use of Exai\u2019s novel, RNA-based liquid biopsy platform to monitor patients\u2019 &#8230; <span class=\"more\"><a class=\"more-link\" href=\"https:\/\/pharma-trend.com\/en\/exai-bio-and-quantum-leap-healthcare-collaborative-announce-expanded-participation-in-i-spy-2-trial-to-advance-exais-novel-rna-based-liquid-biopsy-platform-in-breast-cancer\/\">[Read more&#8230;]<\/a><\/span><\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[13],"tags":[],"class_list":{"0":"entry","1":"post","2":"publish","3":"author-business","4":"post-55376","6":"format-standard","7":"category-industry"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Exai Bio and Quantum Leap Healthcare Collaborative Announce Expanded Participation in I-SPY 2 Trial to Advance Exai\u2019s Novel RNA-based Liquid Biopsy Platform in Breast Cancer - Pharma Trend<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/pharma-trend.com\/en\/exai-bio-and-quantum-leap-healthcare-collaborative-announce-expanded-participation-in-i-spy-2-trial-to-advance-exais-novel-rna-based-liquid-biopsy-platform-in-breast-cancer\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Exai Bio and Quantum Leap Healthcare Collaborative Announce Expanded Participation in I-SPY 2 Trial to Advance Exai\u2019s Novel RNA-based Liquid Biopsy Platform in Breast Cancer - Pharma Trend\" \/>\n<meta property=\"og:description\" content=\"Based on Initial Positive Data, Exai to Study a Larger Cohort of Patients to Evaluate oncRNAs as a Predictive and Prognostic Biomarker Across Multiple Therapies PALO ALTO, Calif.&#8211;(BUSINESS WIRE)&#8211;Exai Bio today announced a collaboration agreement with Quantum Leap Healthcare Collaborative\u2122 (QLHC) to broaden the use of Exai\u2019s novel, RNA-based liquid biopsy platform to monitor patients\u2019 ... 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