{"id":55396,"date":"2023-03-31T03:04:18","date_gmt":"2023-03-31T01:04:18","guid":{"rendered":"https:\/\/pharma-trend.com\/en\/canbridge-announces-financial-results-and-corporate-updates-for-twelve-months-ended-december-31-2022\/"},"modified":"2023-03-31T03:04:18","modified_gmt":"2023-03-31T01:04:18","slug":"canbridge-announces-financial-results-and-corporate-updates-for-twelve-months-ended-december-31-2022","status":"publish","type":"post","link":"https:\/\/pharma-trend.com\/en\/canbridge-announces-financial-results-and-corporate-updates-for-twelve-months-ended-december-31-2022\/","title":{"rendered":"CANbridge Announces Financial Results and Corporate Updates for Twelve Months Ended December 31, 2022"},"content":{"rendered":"<div>\n<p>BEIJING &amp; CAMBRIDGE, Mass.&#8211;(BUSINESS WIRE)&#8211;CANbridge Pharmaceuticals, Inc. (\u201cCANbridge,\u201d stock code 1228.HK), a global biopharmaceutical company, with a foundation in China, committed to the research, development and commercialization of transformative therapies to treat rare diseases and oncology, today announced financial results for the twelve months ended 2022 and corporate update.\n<\/p>\n<p><a href=\"https:\/\/mms.businesswire.com\/media\/20230330005789\/en\/1043477\/5\/01_CANbridge_Logo_1.jpg\"><img decoding=\"async\" src=\"https:\/\/mms.businesswire.com\/media\/20230330005789\/en\/1043477\/21\/01_CANbridge_Logo_1.jpg\"><\/a><\/p>\n<p>\n\u201cWe have made significant progress building CANbridge and advancing our pipeline that consists of 14 drug assets targeting rare diseases, each with significant market potential,\u201d said James Xue, Ph.D., CANbridge founder, chairman and CEO. \u201cWe are anticipating an exciting year ahead and we look forward to sharing a number of important program updates that we believe will drive both near-and long-term value to our stockholder\u2019s. Specifically, over the course of the year, we are planning for important data readouts, including data from key registrational trials for CAN008 for the treatment of glioblastoma and CAN106 for the treatment of paroxysmal nocturnal hemoglobinuria. In addition to these important milestones, we are anticipating the potential approval of LIVMARLI\u00ae (maralixibat\/CAN108) for the treatment of Alagille syndrome, a rare liver disease in the first half of 2023.\u201d\n<\/p>\n<p>\n<b>Upcoming Milestones<\/b>\n<\/p>\n<ul class=\"bwlistdisc\">\n<li>\nCAN108 \u2013 Potential approval for Alagille syndrome (ALGS) in the first half of 2023\n<\/li>\n<li>\nCAN008 \u2013 Anticipate interim read out from the Phase 2 trial for glioblastoma (GBM) in the second half of 2023\n<\/li>\n<li>\nCAN106 \u2013 Plan to announce top-line data from the Phase 1b trial for paroxysmal nocturnal hemoglobinuria (PNH) mid-year 2023\n<\/li>\n<li>\nCAN103 \u2013 Anticipate filing an New Drug Application (NDA) by mid-2024 for the treatment of Gaucher disease (GD)\n<\/li>\n<li>\nGene Therapy \u2013 The Company plans to file an Investigational New Drug (IND) with the U.S. Food and Drug Administration (FDA) for its novel second-generation scAAV9 gene therapy for the treatment of spinal muscular atrophy (SMA) by the fourth quarter of 2024\n<\/li>\n<\/ul>\n<p>\n<b>Financial Highlights<\/b>\n<\/p>\n<ul class=\"bwlistdisc\">\n<li>\nRevenue increased by RMB47.8 million, or 153.2%, from RMB31.2 million for the year ended December 31, 2021, to RMB79.0 million, for the year ended December 31, 2022, which was mainly attributable to the increase of sales from Hunterase\u00ae and Nerlynx\u00ae.\n<\/li>\n<li>\nLoss for the year decreased by approximately RMB593.5 million, or 55.1%, from RMB1,077.0 million for the year ended December 31, 2021, to RMB483.5 million for the year ended December 31, 2022, which was primarily attributable to the decrease of loss on fair value changes of convertible redeemable preferred shares and R&amp;D costs.\n<\/li>\n<li>\nThe adjusted loss for the year decreased by RMB124.6 million, or 21.4%, from RMB581.3 million, for the year ended December 31, 2021, to RMB456.7 million for the year ended December 31, 2022. The adjusted loss for the year is arrived at by adjusting the IFRS loss for the year of RMB483.5 million (2021: RMB1,077.0 million) from excluding the effect of (i) a one-time, non-cash, IFRS fair value changes to pre-IPO convertible redeemable preferred shares and derivative financial instruments, (ii) the share-based payment expenses, and (iii) the listing expenses.\n<\/li>\n<li>\nResearch and development (\u201cR&amp;D\u201d) expenses decreased by approximately RMB116.5 million, or 27.2%, from RMB427.7 million for the year ended December 31, 2021 to RMB311.2 million for the year ended December 31, 2022, which was primarily attributable to decreased upfront and milestone payments made to licensing partners, partially offset by increased testing and clinical trial expenses.\n<\/li>\n<li>\nR&amp;D expense excluding milestone payments increased by RMB37.8 million, from RMB213.9 million for the year ended December 31, 2021 to RMB251.7 million for the year ended December 31, 2022.\n<\/li>\n<li>\nThe Company\u2019s cash and bank balances as of December 31, 2022 were RMB463.1 million.\n<\/li>\n<\/ul>\n<p>\n<b>Recent Highlights<\/b>\n<\/p>\n<p>\n<b>Hunterase (CAN101), an enzyme replacement therapy for the treatment of MPS II, also known as Hunter syndrome. MPS II has been included in the \u201cFirst National List of Rare Diseases\u201d since May 2018.<\/b>\n<\/p>\n<ul class=\"bwlistdisc\">\n<li>\nLaunched in May 2021 in mainland China as the first and the only enzyme replacement therapy (ERT) for MPS II. Identification of new patients is accelerating as is the expansion of commercial insurance coverage. Since the launch, the Company has identified 667 patients as of December 31, 2022. In addition, in China, Hunterase has entered into 78 cities\u2019 commercial insurance program (\u201cHuiminbao\u201d).\n<\/li>\n<\/ul>\n<p>\n<b>LIVMARLI, an oral, minimally absorbed reversible inhibitor of the ileal bile acid transporter (IBAT) that is under development to treat rare cholestatic liver diseases. CANbridge has the exclusive rights to develop, commercialize, and under certain conditions, manufacture LIVMARLI in Greater China.<\/b>\n<\/p>\n<ul class=\"bwlistdisc\">\n<li>\nLIVMARLI is approved to treat ALGS in the United States (U.S.) and Europe and is under investigation for the treatment of progressive familial intrahepatic cholestasis (PFIC) and biliary atresia (BA)-.\n<\/li>\n<li>\nDosed the first patient in the Phase 2 study of LIVMARLI in biliary atresia (BA) in China-. This clinical trial in BA is being conducted by Mirum and supported by CANbridge under the license agreement with Mirum-.\n<\/li>\n<li>\nLIVMARLI has also been granted priority review by the National Medical Products Administration (NMPA) with the potential to be approved in the first half of 2023\n<\/li>\n<\/ul>\n<p>\n<b>CAN106, a novel, long-acting monoclonal antibody for the treatment of complement-mediated diseases, including PNH, myasthenia gravis (MG) and various other complement-mediated diseases that are targeted by anti-C5 antibodies. PNH has been included in the \u201cFirst National List of Rare Diseases\u201d in China since May 2018.<\/b>\n<\/p>\n<ul class=\"bwlistdisc\">\n<li>\nReceived FDA Orphan Drug Designation for the treatment of MG in November 2022\n<\/li>\n<li>\nReported positive top-line Phase 1 data from the Singapore trial first reported in February 2022. Results suggest complete blockade of complement function at safe and well-tolerated doses\n<\/li>\n<li>\nDosed the first patient in the CAN106 Phase 1b\/2 trial for treatment of PNH in China in March 2022. The ongoing Phase 1b part consists of 3 cohorts and is on track for top-line data mid-year 2023\n<\/li>\n<\/ul>\n<p>\n<b>CAN008, a glycosylated CD95-Fc fusion protein being developed for the treatment of glioblastoma multiforme (GBM).<\/b>\n<\/p>\n<ul class=\"bwlistdisc\">\n<li>\nCompleted Phase 2 trial enrollment in March 2023 and the potential interim read out is anticipated in the second half of 2023\n<\/li>\n<li>\nExpect to commercialize CAN008 in China as a combination therapy with the standard of care for GBM (radiotherapy plus chemotherapy)\n<\/li>\n<li>\nCANbridge owns the rights to CAN008 for all potential indications in Greater China, including as a potential novel treatment option to treat COVID-19\n<\/li>\n<\/ul>\n<p>\n<b>CAN103, an ERT for the treatment of GD. GD has been included in the \u201cFirst National List of Rare Diseases\u201d in China since May 2018.<\/b>\n<\/p>\n<ul class=\"bwlistdisc\">\n<li>\nCompleted Part A of the ongoing Phase 1\/2 clinical trial in China and initiated Part B in the first quarter of 2023, which will serve as a potential registrational trial. CANbridge expects to file an NDA by mid-2024\n<\/li>\n<li>\nCAN103 is the first clinical stage ERT being developed for GD in China\n<\/li>\n<\/ul>\n<p>\n<b>Gene Therapy, advanced the world-class CANbridge gene therapy platform, focusing on <\/b><b>adeno-associated virus (AAV) as a gene delivery vehicle, with potential as a one-time durable <\/b><b>therapy for many genetic diseases. Programs in Fabry disease and SMA have been included in the \u201cFirst National List of Rare Diseases\u201d since May 2018.<\/b>\n<\/p>\n<ul class=\"bwlistdisc\">\n<li>\nOpened the CANbridge Next-Generation Innovation and Process Development Facility in July 2022, a full in-house gene therapy research and development facility to develop novel potentially curative, gene therapies for rare genetic diseases, including Pompe disease, Fabry disease, SMA, and other neuromuscular conditions.\n<\/li>\n<li>\nPresented initial gene therapy data from the research agreement with the Horae Gene Therapy Center, at the UMass Chan Medical School, at the European Society of Gene and Cell Therapy (ESGCT) 29th Annual Congress in October 2022 and at the 2022 American Society of Gene and Cell Therapy (ASGCT) Annual Meeting in May 2022. Data from a novel second-generation scAAV9 gene therapy, expressing co-hSMN1 from an endogenous hSMN1 promoter, demonstrated superior potency, efficacy and safety in mice with SMA, compared to the benchmark vector, scAAV9-CMVen\/CB-hSMN1, which is similar to the vector used in the gene therapy approved by the FDA for the treatment of SMA.\n<\/li>\n<li>\nAnnounced an in-license agreement with the UMass Chan Medical School for the global development and commercialization rights to a novel second-generation scAAV9 gene therapy, expressing co-hSMN1 from an endogenous hSMN1 promoter, for the treatment of SMA. CANbridge plans to file a U.S. IND by the fourth quarter of 2024.\n<\/li>\n<li>\nObtained non-exclusive worldwide rights to the LogicBio (a wholly owned subsidiary of Alexion, AstraZeneca Rare Disease) proprietary manufacturing process for the development of Fabry and Pompe gene therapies in the second half of 2022. CANbridge completed the full technology transfer of these gene therapy products in late 2022.\n<\/li>\n<\/ul>\n<p>\n<b>Organizational Updates<\/b>\n<\/p>\n<ul class=\"bwlistdisc\">\n<li>\nFormed a world-class Complement Disease Scientific Advisory Board (the Board) focused on the global development of CAN106, a novel, long-acting monoclonal antibody directed against C5 complement. The Board will offer guidance on the CAN106 clinical development program, as well as explore the potential for CAN106 in other indications.\n<\/li>\n<\/ul>\n<p>\n<b>About CANbridge Pharmaceuticals Inc.<\/b>\n<\/p>\n<p>\nCANbridge Pharmaceuticals Inc. (HKEX:1228) is a China and U.S.-based global biopharmaceutical company committed to the research, development and commercialization of transformative therapies for rare disease and rare oncology. CANbridge has a differentiated drug portfolio, with three approved drugs and a pipeline of 11 assets, targeting prevalent rare disease and rare oncology indications that have unmet needs and significant market potential. These include Hunter syndrome and other lysosomal storage disorders, complement-mediated disorders, hemophilia A, metabolic disorders, rare cholestatic liver diseases and neuromuscular diseases, as well as glioblastoma multiforme. CANbridge is also building next-generation gene therapy development capability through a combination of collaboration with world-leading researchers and biotech companies and internal capacity. CANbridge global partners include: Apogenix, GC Pharma, Mirum, Wuxi Biologics, Privus, the UMass Chan Medical School, the University of Washington School of Medicine, Scriptr Global and LogicBio.\n<\/p>\n<p>\nFor more on CANbridge Pharmaceuticals Inc., please go to: <a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=http%3A%2F%2Fwww.canbridgepharma.com&amp;esheet=53371467&amp;newsitemid=20230330005789&amp;lan=en-US&amp;anchor=www.canbridgepharma.com&amp;index=1&amp;md5=40d016dbd4e738b7b556d5e20c6c4d6c\" rel=\"nofollow noopener\" shape=\"rect\">www.canbridgepharma.com<\/a>.\n<\/p>\n<p>\n<b>Forward-Looking Statements<\/b>\n<\/p>\n<p>\nThe forward-looking statements made in this article relate only to the events or information as of the date on which the statements are made in this article. Except as required by law, we undertake no obligation to update or revise publicly any forward-looking statements, whether as a result of new information, future events or otherwise, after the data on which the statements are made or to reflect the occurrence of unanticipated events. You should read this article completely and with the understanding that our actual future results or performance may be materially different from what we expect. In this article, statements of, or references to, our intentions or those of any of our Directors or our Company are made as of the date of this article. Any of these intentions may alter in light of future development.\n<\/p>\n<p> <b>Contacts<\/b> <\/p>\n<p>\n<b>U.S. Investor Relations:<\/b><br \/>Chris Brinzey<br \/>\n<br \/>ICR Westwicke<br \/>\n<br \/><a target=\"_blank\" href=\"&#109;&#x61;&#105;&#x6c;&#116;&#x6f;:&#x43;h&#114;&#x69;&#115;&#x2e;&#98;&#x72;i&#x6e;z&#101;&#x79;&#64;&#x77;&#101;&#x73;&#116;&#x77;i&#x63;k&#101;&#x2e;&#99;&#x6f;&#109;\" rel=\"nofollow noopener\" shape=\"rect\">&#67;&#x68;r&#105;&#x73;&#46;&#98;&#x72;i&#x6e;&#x7a;&#101;&#x79;&#64;&#119;&#x65;s&#116;&#x77;i&#x63;&#x6b;&#101;&#x2e;&#x63;&#111;&#x6d;<\/a><\/p>\n<p><b>China Investor Relations<\/b><br \/>CANbridge Pharmaceuticals Inc.<br \/>\n<br \/><a target=\"_blank\" href=\"ma&#105;&#108;&#116;&#111;&#x3a;&#x69;&#x72;&#x40;&#x63;an&#98;&#114;&#105;&#100;&#x67;&#x65;&#x70;&#x68;&#x61;rm&#97;&#46;&#99;&#111;&#x6d;\" rel=\"nofollow noopener\" shape=\"rect\">&#105;&#x72;&#64;&#99;&#x61;n&#98;&#x72;i&#100;&#x67;e&#112;&#x68;a&#114;&#x6d;a&#46;&#x63;o&#109;<\/a><\/p>\n<p><b>Media:<\/b><br \/>Deanne Eagle<br \/>\n<br \/>Planet Communications<br \/>\n<br \/><a target=\"_blank\" href=\"&#x6d;&#x61;&#105;l&#x74;&#x6f;&#58;de&#x61;&#x6e;&#110;e&#x40;&#x70;&#108;&#97;n&#x65;&#x74;&#99;o&#x6d;&#x6d;&#117;&#110;i&#x63;&#x61;&#116;i&#x6f;&#x6e;&#115;&#46;n&#x79;&#x63;\" rel=\"nofollow noopener\" shape=\"rect\">&#x64;&#x65;&#x61;&#x6e;&#110;&#101;&#64;&#112;lan&#x65;&#x74;&#x63;&#x6f;&#x6d;&#109;&#117;&#110;ica&#x74;&#x69;&#x6f;&#x6e;&#x73;&#46;&#110;&#121;c<\/a><br \/>917.837.5866\n<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>BEIJING &amp; CAMBRIDGE, Mass.&#8211;(BUSINESS WIRE)&#8211;CANbridge Pharmaceuticals, Inc. (\u201cCANbridge,\u201d stock code 1228.HK), a global biopharmaceutical company, with a foundation in China, committed to the research, development and commercialization of transformative therapies to treat rare diseases and oncology, today announced financial results for the twelve months ended 2022 and corporate update. \u201cWe have made significant progress building &#8230; <span class=\"more\"><a class=\"more-link\" href=\"https:\/\/pharma-trend.com\/en\/canbridge-announces-financial-results-and-corporate-updates-for-twelve-months-ended-december-31-2022\/\">[Read more&#8230;]<\/a><\/span><\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[13],"tags":[],"class_list":{"0":"entry","1":"post","2":"publish","3":"author-business","4":"post-55396","6":"format-standard","7":"category-industry"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>CANbridge Announces Financial Results and Corporate Updates for Twelve Months Ended December 31, 2022 - Pharma Trend<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/pharma-trend.com\/en\/canbridge-announces-financial-results-and-corporate-updates-for-twelve-months-ended-december-31-2022\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"CANbridge Announces Financial Results and Corporate Updates for Twelve Months Ended December 31, 2022 - Pharma Trend\" \/>\n<meta property=\"og:description\" content=\"BEIJING &amp; CAMBRIDGE, Mass.&#8211;(BUSINESS WIRE)&#8211;CANbridge Pharmaceuticals, Inc. (\u201cCANbridge,\u201d stock code 1228.HK), a global biopharmaceutical company, with a foundation in China, committed to the research, development and commercialization of transformative therapies to treat rare diseases and oncology, today announced financial results for the twelve months ended 2022 and corporate update. \u201cWe have made significant progress building ... 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(\u201cCANbridge,\u201d stock code 1228.HK), a global biopharmaceutical company, with a foundation in China, committed to the research, development and commercialization of transformative therapies to treat rare diseases and oncology, today announced financial results for the twelve months ended 2022 and corporate update. \u201cWe have made significant progress building ... 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