{"id":55411,"date":"2023-03-31T14:06:47","date_gmt":"2023-03-31T12:06:47","guid":{"rendered":"https:\/\/pharma-trend.com\/en\/anheart-therapeutics-presents-updated-efficacy-and-safety-of-taletrectinib-in-patients-with-ros1-positive-non-small-cell-lung-cancer\/"},"modified":"2023-03-31T14:06:47","modified_gmt":"2023-03-31T12:06:47","slug":"anheart-therapeutics-presents-updated-efficacy-and-safety-of-taletrectinib-in-patients-with-ros1-positive-non-small-cell-lung-cancer","status":"publish","type":"post","link":"https:\/\/pharma-trend.com\/en\/anheart-therapeutics-presents-updated-efficacy-and-safety-of-taletrectinib-in-patients-with-ros1-positive-non-small-cell-lung-cancer\/","title":{"rendered":"AnHeart Therapeutics Presents Updated Efficacy and Safety of Taletrectinib in Patients with ROS1-Positive Non\u2013Small Cell Lung Cancer"},"content":{"rendered":"
\n

\n– Taletrectinib, a potent, next-generation ROS1 TKI, continued to demonstrate clinically meaningful efficacy outcomes and favorable safety profiles in patients with ROS1 TKI-na\u00efve or crizotinib-pretreated ROS1+ NSCLC.\n<\/p>\n

<\/a><\/p>\n

NEW YORK–(BUSINESS WIRE)–#BTD<\/a>—AnHeart Therapeutics<\/a> (\u201cAnHeart\u201d), a clinical-stage global biopharmaceutical company developing novel precision oncology therapeutics, announced today updated efficacy and safety data from a regional Phase 2 clinical trial of taletrectinib (TRUST-I) in patients with ROS1-positive non-small cell lung cancer (ROS1+ NSCLC) in an oral presentation at the European Lung Cancer Congress (ELCC) 2023. Taletrectinib is a potent, next-generation, central nervous system (CNS)-active ROS1 tyrosine kinase inhibitor (TKI) with selectivity over TRKB.\n<\/p>\n

\nThe oral presentation reported the updated efficacy and safety data of the TRUST-I Phase 2 trial in China (NCT04395677) with about 1.5-year follow-up time. The confirmed objective response rate (ORR) was 92.5% (62\/67) in ROS1 TKI-na\u00efve patients and 52.6% (20\/38) in crizotinib-pretreated patients. The intracranial ORR was 91.7% (11\/12) regardless of prior ROS1 TKI treatment history. The ORR in patients with a ROS1 G2032R resistance mutation was 80.0% (4\/5).\n<\/p>\n

\nThe oral presentation also reported the updated results from a pooled analysis including patients from the TRUST-I Phase 2 trial and two Phase 1 trials conducted in the US and Japan (NCT02279433 and NCT02675491). The median progression-free survival (PFS) was 33.2 months (N=78) in ROS1 TKI-na\u00efve patients and 11.8 months (N=46) in crizotinib-pretreated patients.\n<\/p>\n

\nIn 178 patients treated with taletrectinib at 600 mg once daily (QD), most treatment-emergent adverse events (TEAEs) were grades 1 or 2. Taletrectinib demonstrated a well-tolerable safety profile with low incidence of neurological adverse events (AEs).\n<\/p>\n

\n\u201cWe\u2019re excited to see that, with longer follow-up time, taletrectinib continues to demonstrate robust efficacy outcomes and favorable safety profiles in patients with ROS1 TKI-na\u00efve or crizotinib-pretreated ROS1+ NSCLC,\u201d said Prof. Caicun Zhou, Shanghai Pulmonary Hospital and Thoracic Cancer Institute, Tongji University School of Medicine, Shanghai, China. \u201cAdditionally, taletrectinib hits a unique balance of strong intracranial activity and low incidence of neurological AEs.\u201d\n<\/p>\n

\nTRUST-I is a multicenter, open-label, single-arm clinical trial with two cohorts: ROS1 TKI-na\u00efve and crizotinib-pretreated patients. The key study endpoints included IRC-confirmed ORR, duration of response (DoR), disease control rate (DCR), PFS and safety.\n<\/p>\n

\nA pivotal global Phase 2 trial of taletrectinib (TRUST-II, NCT04919811) is actively enrolling patients at clinical sites in North America, Europe and Asia.\n<\/p>\n

\nTaletrectinib has been granted Breakthrough Therapy Designation (BTD) by both US FDA and China NMPA for the treatment of patients with advanced or metastatic ROS1+ NSCLC, who are either ROS1 TKI treatment na\u00efve or previously treated with crizotinib.\n<\/p>\n

\nAbout AnHeart Therapeutics<\/b>\n<\/p>\n

\nAnHeart Therapeutics (\u201cAnHeart\u201d) is a clinical-stage global biopharmaceutical company developing a broad pipeline of novel precision oncology therapeutics with high unmet medical needs. Its lead asset, taletrectinib, is a potential best-in-class next-generation ROS1 inhibitor currently in Phase 2 trials for ROS1 TKI-na\u00efve and TKI-pretreated patients with ROS1 fusion-positive non-small cell lung cancer (NSCLC). Taletrectinib has received Breakthrough Therapy Designation (BTD) from both the US FDA and China NMPA for the treatment of patients with advanced or metastatic ROS1+ NSCLC, who are either ROS1 TKI treatment na\u00efve or previously treated with crizotinib. The Company\u2019s pipeline also includes safusidenib, a mIDH1 inhibitor in Phase 2 trials with good brain penetration for multiple solid tumors with mIDH1 mutations and AB-329, an AXL inhibitor in Phase 1 studies to be used in combination with checkpoint inhibitor or chemotherapies in NSCLC or other solid tumors. The Company operates from offices in the US and China. For more information, visit www.anhearttherapeutics.com<\/a>.\n<\/p>\n

Contacts<\/b> <\/p>\n

\nInvestor:
\n
Weiqing Wang, PhD
\n
212-466-6378
\n
ir@anhearttherapeutics.com<\/a>\n<\/p>\n

\nMedia:
\n
Kimberly Ha
\n
KKH Advisors
\n
917-291-5744
\n
kimberly.ha@kkhadvisors.com<\/a>\n<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

– Taletrectinib, a potent, next-generation ROS1 TKI, continued to demonstrate clinically meaningful efficacy outcomes and favorable safety profiles in patients with ROS1 TKI-na\u00efve or crizotinib-pretreated ROS1+ NSCLC. NEW YORK–(BUSINESS WIRE)–#BTD—AnHeart Therapeutics (\u201cAnHeart\u201d), a clinical-stage global biopharmaceutical company developing novel precision oncology therapeutics, announced today updated efficacy and safety data from a regional Phase 2 clinical … [Read more…]<\/a><\/span><\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[13],"tags":[],"class_list":{"0":"entry","1":"post","2":"publish","3":"author-business","4":"post-55411","6":"format-standard","7":"category-industry"},"yoast_head":"\nAnHeart Therapeutics Presents Updated Efficacy and Safety of Taletrectinib in Patients with ROS1-Positive Non\u2013Small Cell Lung Cancer - Pharma Trend<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/pharma-trend.com\/en\/anheart-therapeutics-presents-updated-efficacy-and-safety-of-taletrectinib-in-patients-with-ros1-positive-non-small-cell-lung-cancer\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"AnHeart Therapeutics Presents Updated Efficacy and Safety of Taletrectinib in Patients with ROS1-Positive Non\u2013Small Cell Lung Cancer - Pharma Trend\" \/>\n<meta property=\"og:description\" content=\"– Taletrectinib, a potent, next-generation ROS1 TKI, continued to demonstrate clinically meaningful efficacy outcomes and favorable safety profiles in patients with ROS1 TKI-na\u00efve or crizotinib-pretreated ROS1+ NSCLC. 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