{"id":55802,"date":"2023-04-13T19:03:06","date_gmt":"2023-04-13T17:03:06","guid":{"rendered":"https:\/\/pharma-trend.com\/en\/certis-oncology-solutions-launches-predictive-analytics-platform\/"},"modified":"2023-04-13T19:03:06","modified_gmt":"2023-04-13T17:03:06","slug":"certis-oncology-solutions-launches-predictive-analytics-platform","status":"publish","type":"post","link":"https:\/\/pharma-trend.com\/en\/certis-oncology-solutions-launches-predictive-analytics-platform\/","title":{"rendered":"Certis Oncology Solutions Launches Predictive Analytics Platform"},"content":{"rendered":"<div>\n<p>\n<b>Bioinformatics solution combines artificial intelligence, machine learning, and functional testing to elevate precision cancer treatment<\/b><\/p>\n<p><a href=\"https:\/\/mms.businesswire.com\/media\/20230413005168\/en\/1762521\/5\/CertisAI-Full_Lockup-Color_med.jpg\"><img decoding=\"async\" src=\"https:\/\/mms.businesswire.com\/media\/20230413005168\/en\/1762521\/21\/CertisAI-Full_Lockup-Color_med.jpg\"><\/a><\/p>\n<p>SAN DIEGO&#8211;(BUSINESS WIRE)&#8211;<a href=\"https:\/\/twitter.com\/hashtag\/ArtificialIntelligence?src=hash\" target=\"_blank\" rel=\"noopener\">#ArtificialIntelligence<\/a>&#8211;Certis Oncology Solutions (\u201cCertis\u201d), a precision oncology and translational science company focused on combining functional assays and artificial intelligence to advance personalized medicine, today announced the launch of CertisAI\u2122, a new predictive medicine platform that utilizes big data, statistical algorithms, and machine learning to predict drug efficacy based on gene expression biomarkers. This pan-cancer solution can accelerate drug discovery and companion diagnostics development.<\/p>\n<p>\nUnlike common single-biomarker strategies often employed in precision medicine, CertisAI\u2122 uses multivariate machine learning algorithms to capture the nuance of biomarker interactions and bring greater accuracy to predictions of drug efficacy.<\/p>\n<p>\n\u201cWhen it comes to understanding how to treat a person\u2019s cancer, identifying oncogenic DNA mutations is just scratching the surface,\u201d said Peter Ellman, Certis President and CEO. \u201cThis common approach to precision medicine isn\u2019t capturing the nuance of gene expression levels or the complex interrelationships between multiple genetic features. These dynamics are what govern tumor response to any given therapy, but the complexity involved is too great for any human to grapple with. Computer models can,\u201d he said.<\/p>\n<p>\n<b>Bringing AI Support to Cancer Therapeutics Development<\/b><\/p>\n<p>\nDespite great progress in cancer research, fewer than 4% of oncology drugs that enter clinical trials are ultimately approved for use. Many factors contributing to this \u201ctranslation gap\u201d in cancer therapeutics could be mitigated by better-informed decision-making early in the development process. With CertisAI\u2122, researchers can effectively replace many discovery screening studies with <i>in silico<\/i> predictions, and save time and money by bringing computer-aided insight to a variety of drug development challenges, such as:<\/p>\n<ul class=\"bwlistdisc\">\n<li>\nIdentifying biomarkers that are predictive of therapeutic response<\/li>\n<li>\nUncovering biological pathway mechanisms of action<\/li>\n<li>\nRanking cancer types most likely to respond to a lead candidate<\/li>\n<li>\nElucidating synergistic potential of combinatory therapies<\/li>\n<li>\nSelecting optimal cancer models for in vitro and in vivo validation studies<\/li>\n<li>\nDeveloping stratification strategies for clinical trial patient selection<\/li>\n<li>\nPrioritizing candidates in compound libraries and\/or assessing the value of intellectual property<\/li>\n<\/ul>\n<p>\nThe origins of CertisAI\u2122 are rooted in the company\u2019s mission: finding the optimal therapy for every cancer patient, the first time, every time. Since its founding in 2016, Certis has been validating a functional approach to personalized medicine using orthotopic patient-derived xenografts\u2014sophisticated mouse models of individual cancers that enable the simultaneous testing of multiple therapeutic options. Data from these studies may be used to help inform oncologists\u2019 treatment strategies.<\/p>\n<p>\n<b>Relieving the Validation Bottleneck<\/b><\/p>\n<p>\nIn addition to developing the predictive platform, Certis is tackling a persistent problem in the AI-driven healthcare landscape\u2014how to<i> efficiently <\/i>validate in silico predictions. Conducting clinical trials and waiting for long-term outcomes is inherently slow, making validation a bottleneck to progress.<\/p>\n<p>\nCertis draws on deep experience developing orthotopic patient-derived xenograft (O-PDX) models, performing mouse clinical trials to validate CertisAI\u2122 predictions. Results from these studies generate training data to inform the platform\u2019s machine learning algorithms, improving predictive accuracy.<\/p>\n<p>\nMost genomic testing companies that include possible matched treatments in their reports consider only drugs already approved for companion biomarkers. The Certis predictive algorithms look outside standard-of-care, including off-label uses of approved drugs as well as investigational drugs in clinical trials. The company reports that internal cross-validation results show CertisAI\u2122 predictions are highly accurate in mono and combination therapies (&gt;90% and 83% combined, respectively), and external validation on O-PDX models has shown promising results.<\/p>\n<p>\nFor more information, visit <a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=http%3A%2F%2Fwww.certisoncology.com&amp;esheet=53380420&amp;newsitemid=20230413005168&amp;lan=en-US&amp;anchor=www.certisoncology.com&amp;index=1&amp;md5=2eced0bf6b3d754c5518a63d3ea3ebdb\" rel=\"nofollow noopener\" shape=\"rect\">www.certisoncology.com<\/a>.<\/p>\n<p>\n<b>About Certis Oncology Solutions<\/b><\/p>\n<p>\nCertis Oncology Solutions is a life science technology company committed to realizing the promise of precision oncology. Our product is Oncology Intelligence\u2122 \u2014 highly predictive therapeutic response data derived from advanced biological models of cancer and enhanced with AI-driven bioinformatics. Our proprietary platform can help inform personalized cancer care and accelerates the development of new cancer therapies.<\/p>\n<p> <b>Contacts<\/b> <\/p>\n<p>\nCertis Oncology Solutions<br \/>\n<br \/>Kristein King<br \/>\n<br \/><a target=\"_blank\" href=\"&#x6d;&#97;i&#x6c;&#116;o&#x3a;&#x6b;&#107;&#x69;&#x6e;&#103;&#64;&#x63;&#101;r&#x74;&#x69;&#115;&#x6f;&#x6e;&#99;o&#x6c;&#111;g&#x79;&#x2e;&#99;&#x6f;&#x6d;\" rel=\"nofollow noopener\" shape=\"rect\">&#107;&#107;&#x69;n&#103;&#x40;&#x63;e&#114;&#x74;&#x69;s&#111;&#x6e;c&#111;&#x6c;&#x6f;g&#121;&#x2e;&#x63;o&#109;<\/a><br \/>573-818-4528<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Bioinformatics solution combines artificial intelligence, machine learning, and functional testing to elevate precision cancer treatment SAN DIEGO&#8211;(BUSINESS WIRE)&#8211;#ArtificialIntelligence&#8211;Certis Oncology Solutions (\u201cCertis\u201d), a precision oncology and translational science company focused on combining functional assays and artificial intelligence to advance personalized medicine, today announced the launch of CertisAI\u2122, a new predictive medicine platform that utilizes big data, &#8230; <span class=\"more\"><a class=\"more-link\" href=\"https:\/\/pharma-trend.com\/en\/certis-oncology-solutions-launches-predictive-analytics-platform\/\">[Read more&#8230;]<\/a><\/span><\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[13],"tags":[],"class_list":{"0":"entry","1":"post","2":"publish","3":"author-business","4":"post-55802","6":"format-standard","7":"category-industry"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Certis Oncology Solutions Launches Predictive Analytics Platform - Pharma Trend<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/pharma-trend.com\/en\/certis-oncology-solutions-launches-predictive-analytics-platform\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Certis Oncology Solutions Launches Predictive Analytics Platform - Pharma Trend\" \/>\n<meta property=\"og:description\" content=\"Bioinformatics solution combines artificial intelligence, machine learning, and functional testing to elevate precision cancer treatment SAN DIEGO&#8211;(BUSINESS WIRE)&#8211;#ArtificialIntelligence&#8211;Certis Oncology Solutions (\u201cCertis\u201d), a precision oncology and translational science company focused on combining functional assays and artificial intelligence to advance personalized medicine, today announced the launch of CertisAI\u2122, a new predictive medicine platform that utilizes big data, ... 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